艾迪注射液对晚期胃癌患者癌因性疲乏及免疫功能的影响观察
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摘要
目的:探讨艾迪注射液对晚期胃癌化疗患者癌因性疲乏(CRF)和免疫功能的影响。方法:经病理学或组织学检查确诊116例的晚期胃癌患者随机分为观察组和对照组。对照组56例采取奥沙利铂+卡培他滨化疗,观察组60例采取艾迪注射液联合奥沙利铂+卡培他滨化疗,艾迪注射液共使用14 d。治疗前后采用Piper疲乏量表(PFS)对患者的疲乏进行评估,同时比较两组患者CD4、CD8等外周血T淋巴细胞亚群、血红蛋白及生活质量变化。结果:治疗后,观察组各项PFS评分均显著低于治疗前(P <0. 05),Hb含量和CD3及CD4较治疗前增高(P <0. 05),CD8比值较治疗前明显下降(P <0. 05),QLQ-30总分明显高于治疗前(P <0. 05);且上述指标均显著优于对照组(P <0. 05)。观察组患者骨髓抑制程度明显轻于对照组(P <0. 05)。结论:艾迪注射液能改善胃癌癌因性疲乏并能增强患者的免疫功能。
Objective: To study the effects of Addie injection on cancer-related fatigue in patients with advanced gastric cancer receiving chemotherapy and its impacts on the immune function. Methods: The patients with advanced gastric cancer diagnosed by pathology or cytology were randomly divided into the experimental group and the control group. The experimental group( 60 cases) was treated with Addie injection for 14 days combined with oxaliplatin and capecitabine,while the control group( 56 cases) was treated with chemotherapy only. Piper fatigue scale( PFS) was used to evaluate the patients' state of tiredness before and after the chemotherapy,meanwhile,hemoglobin,the quality of life and immune function( CD3,CD4 and CD8) were also analyzed. Results: After the treatment,the scores of PFS were all lower than those before the treatment in the exprimental group( P < 0. 05),and the Hb content and CD3 and CD4 all increased( P < 0. 05),CD8 rate decreased( P < 0. 05),and the total QLQ-3 score was higher than that before the treatment( P < 0. 05). The above indices of the observation group were all better than those of the control group( P < 0. 05),and the bone marrow inhibition in the exprimental group was lower than that in the control group( P < 0. 05). Conclusion: Addie injection can reduce the cancer-related fatigue and improve the immune function of patients with advanced gastric cancer,which is worthy of clinical use.
Objective: To study the effects of Addie injection on cancer-related fatigue in patients with advanced gastric cancer receiving chemotherapy and its impacts on the immune function. Methods: The patients with advanced gastric cancer diagnosed by pathology or cytology were randomly divided into the experimental group and the control group. The experimental group( 60 cases) was treated with Addie injection for 14 days combined with oxaliplatin and capecitabine,while the control group( 56 cases) was treated with chemotherapy only. Piper fatigue scale( PFS) was used to evaluate the patients' state of tiredness before and after the chemotherapy,meanwhile,hemoglobin,the quality of life and immune function( CD3,CD4 and CD8) were also analyzed. Results: After the treatment,the scores of PFS were all lower than those before the treatment in the exprimental group( P < 0. 05),and the Hb content and CD3 and CD4 all increased( P < 0. 05),CD8 rate decreased( P < 0. 05),and the total QLQ-3 score was higher than that before the treatment( P < 0. 05). The above indices of the observation group were all better than those of the control group( P < 0. 05),and the bone marrow inhibition in the exprimental group was lower than that in the control group( P < 0. 05). Conclusion: Addie injection can reduce the cancer-related fatigue and improve the immune function of patients with advanced gastric cancer,which is worthy of clinical use.
引文
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2 Tabrizi FM,Alizadeh S.Cancer related fatigue in breast cancer survivors:in correlation to demographic factors[J].Maedica(Buchar),2017,12(2):106-111
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4林允照,顾华.癌因性疲乏研究进展[J].浙江预防医学,2014,26(8):796-802
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7吉兆奕,徐咏梅,王笑民.癌症相关性疲乏(CRF)患者疲劳的特征与中医辨证(TCM)的临床研究[J].现代肿瘤医学,2010,18(12):2473-2478
8 Cavanna L,Bodini FC,Stroppa EM,et a1.Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel,cisplatin and 5 fluorouracil[J].Chemotherapy,2014,60(4):224-227
9马鸣.艾迪注射液联合GP化疗治疗气阴两虚型晚期NSCLC患者的疗效及对患者免疫功能和凝血功能的影响[J].亚太传统医药,2017,13(21):108-110
10 Hong N,Yoo H,Gwak HS,et al.Outcome of surgical resection of symptomatic cerebral lesions in non-small cell lung cancerpatients with multiple brain metastases[J].Brain Tumor Res Treat,2013,1(2):64-70
11郑积华,周娟,谢波,等.不同化疗方案治疗老年晚期胃癌患者的疗效与安全性比较[J].实用医学杂志,2014,30(13):2086-2087
12廖亚勇,管静,陈耀成,等.晚期胃癌患者血红蛋白含量与化疗效果及预后的相关性研究[J].中华临床医师杂志(电子版),2016,10(7):943-946
13 Minton O,Richardson A,Sharpe M,et al.A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue[J].J Natl Cancer Inst,2008,100(16):1155-1166
14张淑平,吴梦,柯星,等.卵巢癌患者CD4+T细胞中调节性T细胞相关分子标志物的表达特点及临床意义[J].实用医学杂志,2015,31(3):370-373
15解婧,李睿,钱建新,等.恶性肿瘤患者癌因性疲乏的质性研究[J].中国肿瘤,2010,19(3):171-174
16王静,史忠梅,韩锐,等.中药注射剂辅助放化疗治疗对肿瘤患者生活质量影响的初步观察[J].中国药师,2018,21(6):1074-1076
17徐洁,居文政,谈恒山.艾迪注射液药理作用及临床应用研究概况[J].药学与临床研究,2012,20(1):48-52
18 Yennurajalingam S,Reddy A,Tannir NM,et al.High-dose asian ginseng(panax ginseng)for cancer-related fatigue:a preliminary report[J].Integr Cancer Ther,2015,14(5):419-427
19郑智茵,尹利明,庄海峰,等.人参二醇组皂苷提取物对再生障碍性贫血小鼠免疫调节作用的研究[J].中国药理学通报,2015,31(6):790-795
20梁可,马进,曲怡,等.黄芪皂苷对小鼠化疗贫血模型白介素-2、白介素-4和白介素-6的影响[J].中国医药导报,2015,12(18):16-18
21罗桂平,练文华,叶小汉,等.黄芪、刺五加对过敏性紫癜患儿免疫功能的调节[J].中国全科医学,2009,7(6):583-584
22李明晶,杨炎,景年财,等.负性共刺激分子在人参皂苷Rg3治疗晚期非小细胞肺癌患者中的表达及其对外周血T细胞的影响[J].中国老年学杂志,2016,36(2):346-348
23陈奕霖,杨卫兵.斑蝥酸钠维生素B6注射液联合化疗对非小细胞肺癌患者免疫功能的影响[J].中国老年学杂志,2015,35(20):5806-5807
2 Tabrizi FM,Alizadeh S.Cancer related fatigue in breast cancer survivors:in correlation to demographic factors[J].Maedica(Buchar),2017,12(2):106-111
3 Husson O,Mols F,Poll-Franse LVD,et al.Variation in fatigue among 6011(long-term)cancer survivors and a normative population:a study from the population-based PROFILES registry[J].Supportive Care in Cancer,2015,23(7):2165-2174
4林允照,顾华.癌因性疲乏研究进展[J].浙江预防医学,2014,26(8):796-802
5 Gerber LH.Cancer-related fatigue:persistent,pervasive,and problematic[J].Phys Med Rehabil Clin N Am,2017,28(1):65-88
6 Tomlinson D,Diorio C,Beyene J,et al.Effect of exercise on cancerrelated fatigue:a meta-analysis[J].Am J Phys Med Rehabil,2014,93(8):675-686
7吉兆奕,徐咏梅,王笑民.癌症相关性疲乏(CRF)患者疲劳的特征与中医辨证(TCM)的临床研究[J].现代肿瘤医学,2010,18(12):2473-2478
8 Cavanna L,Bodini FC,Stroppa EM,et a1.Advanced gastric cancer with liver and lymph node metastases successfully resected after induction chemotherapy with docetaxel,cisplatin and 5 fluorouracil[J].Chemotherapy,2014,60(4):224-227
9马鸣.艾迪注射液联合GP化疗治疗气阴两虚型晚期NSCLC患者的疗效及对患者免疫功能和凝血功能的影响[J].亚太传统医药,2017,13(21):108-110
10 Hong N,Yoo H,Gwak HS,et al.Outcome of surgical resection of symptomatic cerebral lesions in non-small cell lung cancerpatients with multiple brain metastases[J].Brain Tumor Res Treat,2013,1(2):64-70
11郑积华,周娟,谢波,等.不同化疗方案治疗老年晚期胃癌患者的疗效与安全性比较[J].实用医学杂志,2014,30(13):2086-2087
12廖亚勇,管静,陈耀成,等.晚期胃癌患者血红蛋白含量与化疗效果及预后的相关性研究[J].中华临床医师杂志(电子版),2016,10(7):943-946
13 Minton O,Richardson A,Sharpe M,et al.A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue[J].J Natl Cancer Inst,2008,100(16):1155-1166
14张淑平,吴梦,柯星,等.卵巢癌患者CD4+T细胞中调节性T细胞相关分子标志物的表达特点及临床意义[J].实用医学杂志,2015,31(3):370-373
15解婧,李睿,钱建新,等.恶性肿瘤患者癌因性疲乏的质性研究[J].中国肿瘤,2010,19(3):171-174
16王静,史忠梅,韩锐,等.中药注射剂辅助放化疗治疗对肿瘤患者生活质量影响的初步观察[J].中国药师,2018,21(6):1074-1076
17徐洁,居文政,谈恒山.艾迪注射液药理作用及临床应用研究概况[J].药学与临床研究,2012,20(1):48-52
18 Yennurajalingam S,Reddy A,Tannir NM,et al.High-dose asian ginseng(panax ginseng)for cancer-related fatigue:a preliminary report[J].Integr Cancer Ther,2015,14(5):419-427
19郑智茵,尹利明,庄海峰,等.人参二醇组皂苷提取物对再生障碍性贫血小鼠免疫调节作用的研究[J].中国药理学通报,2015,31(6):790-795
20梁可,马进,曲怡,等.黄芪皂苷对小鼠化疗贫血模型白介素-2、白介素-4和白介素-6的影响[J].中国医药导报,2015,12(18):16-18
21罗桂平,练文华,叶小汉,等.黄芪、刺五加对过敏性紫癜患儿免疫功能的调节[J].中国全科医学,2009,7(6):583-584
22李明晶,杨炎,景年财,等.负性共刺激分子在人参皂苷Rg3治疗晚期非小细胞肺癌患者中的表达及其对外周血T细胞的影响[J].中国老年学杂志,2016,36(2):346-348
23陈奕霖,杨卫兵.斑蝥酸钠维生素B6注射液联合化疗对非小细胞肺癌患者免疫功能的影响[J].中国老年学杂志,2015,35(20):5806-5807