中药发育毒性研究进展
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摘要
发育毒性是在畸胎学发展基础上发展起来的毒理学分支,包括了传统"三致"毒性中的"致畸"作用。斑马鱼、体外全胚胎、干细胞等研究工具和荧光原位杂交技术、组学技术等先进研究技术是近年来药物发育毒性研究的新方法和新技术,推动了发育毒性的发展。既往中药发育毒性被忽略,随着中药毒性在全球范围内的关注,中药发育毒性逐渐受到重视,将成为中药现代化的重要研究方面之一。
Developmental toxicity is a toxicological branch of the developed teratology, including the teratogenicity of the traditional three toxicities. Zebrafish, in vitro whole embryos, stem cells and other research tools and fluorescence in situ hybridization technology, omics technology and other advanced technology are widely applied in the research of developmental toxicity in recent years, which have promoted the development of developmental toxicity. However, in the past, the developmental toxicity of traditional Chinese medicine has been neglected. With the global attention of Chinese medicine toxicity, the developmental toxicity of Chinese medicine has been paid more attention to and will become an important part of the modern research of traditional Chinese medicine.
Developmental toxicity is a toxicological branch of the developed teratology, including the teratogenicity of the traditional three toxicities. Zebrafish, in vitro whole embryos, stem cells and other research tools and fluorescence in situ hybridization technology, omics technology and other advanced technology are widely applied in the research of developmental toxicity in recent years, which have promoted the development of developmental toxicity. However, in the past, the developmental toxicity of traditional Chinese medicine has been neglected. With the global attention of Chinese medicine toxicity, the developmental toxicity of Chinese medicine has been paid more attention to and will become an important part of the modern research of traditional Chinese medicine.
引文
[1]庄志雄.靶器官毒理学[M]北京:化学工业出版社,2006.
[2]王心如.毒理学基础[M].北京:人民卫生出版社,2013.
[3]岳苹,王明明,徐建亚.中药胚胎毒性在体外实验中的研究进展[J].辽宁中医杂志,2017,44(2):416.
[4]孟欣,张树峰,吴金洋,等.中药生殖毒性的研究概况[J].承德医学院学报,2016(01):35.
[5]韩佳寅,易艳,梁爱华,等.中药生殖毒性研究思路和方法[J].药学学报,2014(11):1498.
[6]Wu.C.Overview.of.developmental.and.reproductive.toxicity.research.in.China:history,funding mechanisms,and frontiers of the research[J].Birth Def(Part B),2010,89(1):9.
[7]陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1993.
[8]俞超芹.中药胚胎毒性及生殖毒性的再认识:全国中西医结合妊娠期疾患专题学术会议,银川,2011[C].
[9]林娜,胡建平.中药胚胎毒性的研究现状和展望[J].中国中药杂志,2005(17):1317.
[10]ICH.Detection of toxicity to reproduction for medicinal products&toxicity to male fertility(S5(R2)[M].ICH,2005:1.
[11]周会芳,王丽,张艳军,等.胚胎干细胞的代谢组学方法在毒理学中的应用进展[J].中国药理学通报,2011,27(2):149.
[12]GenschowE,SpielmannH,Scholz G,et al.The ECVAM international validation Study on in vitro embryotoxicitytests:esults of the definitive phase and evaluation of prediction models Altern Lab Anim,2002,30(2):151.
[13]韩佳寅,梁爱华.全胚胎培养技术及其应用研究进展[J].中国中药杂志,2010,35(5):549.
[14]赵丽颖.中药生殖发育及胚胎毒性试验研究进展[J].时珍国医国药,2015(03):697.
[15]周莉,崇立明,何强,等.藏药红花如意丸对大鼠胚胎-胎仔发育的影响[J].中国新药杂志,2017(01):77.
[16]岳苹,张衎,单进军,等.生半夏汤与干姜人参半夏汤对小鼠一般毒性和胚胎发育的影响[J].中国实验方剂学杂志,2016(19):105.
[17]宋翼升,张立将,周国亮,等.云南白药对大鼠的胚胎-胎仔发育毒性的影响[J].中华中医药学刊,2014(07):1609.
[18]周国亮,张立将,宋翼升,等.云南白药对大鼠生育力与早期胚胎发育毒性的影响[J].中华中医药学刊,2014(08):1886.
[19]陈蓉芳,朱玉平,马玺里,等.雷公藤提取物对大鼠致畸敏感期毒性试验研究[J].中国新药杂志,2004(S1):1334.
[20]王海凤,郭兵,马旭平,等.大黄水提取物对妊娠早期孕鼠生殖毒性作用及其机理的初步研究[J].中国免疫学杂志,2016(02):184.
[21]Brown NA,Fabro S.Quantitation of rat embryonic development invitro:A morphological scoring system[J].Teratology,1981,24(1):65.
[22]肖凯,王莉,刘玉清,等.草乌的体外胚胎发育毒性研究[J].毒理学杂志,2007,21(4):317.
[23]韩佳寅,易艳,梁爱华,等.千里光对小鼠体外培养胚胎的胚胎毒性研究[J].药学学报,2014(09):1267.
[24]Daston G,Baines D,Yonker JE.Chick embryo retinal cellcultures as a screen for developmental toxicity[J].ToxicolAppliedPharma col,1991,109(2):352.
[25]Wilk ZasadnaI,Minta M.Developmental toxicity of ochratoxinain rat embryo midbrain micromass cultures[J].Int J Mol Sci,2009,10(1):37.
[26]Tahereh TAL,AEI-KHOZANI,Zahra VOJDANI,et al.Toxic Effectsof Elaeagnusangustifolia Fruit Extract on Chondrogenesis and Osteo-genesis in Mouse Limb Buds[J].Tokai J ExpClin Med,2011,36(3):63.
[27]Evans MJ,Kaufman MH.Establishment in culture of pluripotentialcells from mouse embryos[J].Nature,1981,292(5819):154.
[28]Seiler A E,Spielmann H.The validated embryonic stem cell test to pre-dictembryotoxicity in vitro[J].Nat Protoc,2011,6(7):961.
[29]鲁娣,张崴.胚胎干细胞及诱导多能干细胞在胚胎毒性研究中的应用[J].国际生殖健康/计划生育杂志,2017,36(2):130.
[30]岳苹.生半夏及干姜人参半夏方对小鼠胚胎发育及mESC分化的影响[D].南京中医药大学,2017.
[31]王键.中药黄芩苷通过下调miR-294抑制小鼠D3胚胎干细胞增殖能力[D].华中科技大学生理学,2013.
[32]Sipes N S,Padilla S,Knudsen T B.Zebrafish:as an integrative model for twenty-first century toxicity testing[J].Birth Defects Res C Embryo Today,2011,93(3):256.
[33]Organization for Economic Co-operation and Development.Short guidance on the threshold approach for acute fish toxicity[EB/OL].(2010-05-31[2016-05-31]).
[34]彭蕴茹,韦英杰,丁永芳,等.基于斑马鱼模型的药物毒性研究进展与中药毒性研究新策略[J].中草药,2017(01):17.
[35]孙冰,许慧慧,黄超,等.环境毒理学研究的重要模式生物-斑马鱼[J].环境与职业医学,2016(06):610.
[36]赵崇军,田敬欢,王金凤,等.斑马鱼在中药研究中的应用进展[J].中草药,2015(17):2635.
[37]严丽锋,顾爱华.斑马鱼在再生医学研究中的应用及进展[J].遗传,2013(07):856.
[38]辛胜昌,赵艳秋,李松,等.斑马鱼模型在药物筛选中的应用[J].遗传,2012(09):1144.
[39]许冰洁,张立将,李春启,等.斑马鱼胚胎评价5种药物的发育毒性与模型验证[J].中国药理学通报,2016,32(1):74.
[40]何育霖,杨雨婷,何贝轩,等.紫草素对斑马鱼胚胎毒性和血管抑制作用[J].中成药,2016,38(2):241.
[41]何贝轩,杨雨婷,何育霖,等.木香挥发油对斑马鱼胚胎发育毒性的初步研究[J].中华中医药杂志,2016(11):4714.
[42]谢辉辉,徐建亚,单进军,等.妊娠相关中药的生殖毒性研究进展[J].中华中医药杂志,2015(07):2428.
[2]王心如.毒理学基础[M].北京:人民卫生出版社,2013.
[3]岳苹,王明明,徐建亚.中药胚胎毒性在体外实验中的研究进展[J].辽宁中医杂志,2017,44(2):416.
[4]孟欣,张树峰,吴金洋,等.中药生殖毒性的研究概况[J].承德医学院学报,2016(01):35.
[5]韩佳寅,易艳,梁爱华,等.中药生殖毒性研究思路和方法[J].药学学报,2014(11):1498.
[6]Wu.C.Overview.of.developmental.and.reproductive.toxicity.research.in.China:history,funding mechanisms,and frontiers of the research[J].Birth Def(Part B),2010,89(1):9.
[7]陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1993.
[8]俞超芹.中药胚胎毒性及生殖毒性的再认识:全国中西医结合妊娠期疾患专题学术会议,银川,2011[C].
[9]林娜,胡建平.中药胚胎毒性的研究现状和展望[J].中国中药杂志,2005(17):1317.
[10]ICH.Detection of toxicity to reproduction for medicinal products&toxicity to male fertility(S5(R2)[M].ICH,2005:1.
[11]周会芳,王丽,张艳军,等.胚胎干细胞的代谢组学方法在毒理学中的应用进展[J].中国药理学通报,2011,27(2):149.
[12]GenschowE,SpielmannH,Scholz G,et al.The ECVAM international validation Study on in vitro embryotoxicitytests:esults of the definitive phase and evaluation of prediction models Altern Lab Anim,2002,30(2):151.
[13]韩佳寅,梁爱华.全胚胎培养技术及其应用研究进展[J].中国中药杂志,2010,35(5):549.
[14]赵丽颖.中药生殖发育及胚胎毒性试验研究进展[J].时珍国医国药,2015(03):697.
[15]周莉,崇立明,何强,等.藏药红花如意丸对大鼠胚胎-胎仔发育的影响[J].中国新药杂志,2017(01):77.
[16]岳苹,张衎,单进军,等.生半夏汤与干姜人参半夏汤对小鼠一般毒性和胚胎发育的影响[J].中国实验方剂学杂志,2016(19):105.
[17]宋翼升,张立将,周国亮,等.云南白药对大鼠的胚胎-胎仔发育毒性的影响[J].中华中医药学刊,2014(07):1609.
[18]周国亮,张立将,宋翼升,等.云南白药对大鼠生育力与早期胚胎发育毒性的影响[J].中华中医药学刊,2014(08):1886.
[19]陈蓉芳,朱玉平,马玺里,等.雷公藤提取物对大鼠致畸敏感期毒性试验研究[J].中国新药杂志,2004(S1):1334.
[20]王海凤,郭兵,马旭平,等.大黄水提取物对妊娠早期孕鼠生殖毒性作用及其机理的初步研究[J].中国免疫学杂志,2016(02):184.
[21]Brown NA,Fabro S.Quantitation of rat embryonic development invitro:A morphological scoring system[J].Teratology,1981,24(1):65.
[22]肖凯,王莉,刘玉清,等.草乌的体外胚胎发育毒性研究[J].毒理学杂志,2007,21(4):317.
[23]韩佳寅,易艳,梁爱华,等.千里光对小鼠体外培养胚胎的胚胎毒性研究[J].药学学报,2014(09):1267.
[24]Daston G,Baines D,Yonker JE.Chick embryo retinal cellcultures as a screen for developmental toxicity[J].ToxicolAppliedPharma col,1991,109(2):352.
[25]Wilk ZasadnaI,Minta M.Developmental toxicity of ochratoxinain rat embryo midbrain micromass cultures[J].Int J Mol Sci,2009,10(1):37.
[26]Tahereh TAL,AEI-KHOZANI,Zahra VOJDANI,et al.Toxic Effectsof Elaeagnusangustifolia Fruit Extract on Chondrogenesis and Osteo-genesis in Mouse Limb Buds[J].Tokai J ExpClin Med,2011,36(3):63.
[27]Evans MJ,Kaufman MH.Establishment in culture of pluripotentialcells from mouse embryos[J].Nature,1981,292(5819):154.
[28]Seiler A E,Spielmann H.The validated embryonic stem cell test to pre-dictembryotoxicity in vitro[J].Nat Protoc,2011,6(7):961.
[29]鲁娣,张崴.胚胎干细胞及诱导多能干细胞在胚胎毒性研究中的应用[J].国际生殖健康/计划生育杂志,2017,36(2):130.
[30]岳苹.生半夏及干姜人参半夏方对小鼠胚胎发育及mESC分化的影响[D].南京中医药大学,2017.
[31]王键.中药黄芩苷通过下调miR-294抑制小鼠D3胚胎干细胞增殖能力[D].华中科技大学生理学,2013.
[32]Sipes N S,Padilla S,Knudsen T B.Zebrafish:as an integrative model for twenty-first century toxicity testing[J].Birth Defects Res C Embryo Today,2011,93(3):256.
[33]Organization for Economic Co-operation and Development.Short guidance on the threshold approach for acute fish toxicity[EB/OL].(2010-05-31[2016-05-31]).
[34]彭蕴茹,韦英杰,丁永芳,等.基于斑马鱼模型的药物毒性研究进展与中药毒性研究新策略[J].中草药,2017(01):17.
[35]孙冰,许慧慧,黄超,等.环境毒理学研究的重要模式生物-斑马鱼[J].环境与职业医学,2016(06):610.
[36]赵崇军,田敬欢,王金凤,等.斑马鱼在中药研究中的应用进展[J].中草药,2015(17):2635.
[37]严丽锋,顾爱华.斑马鱼在再生医学研究中的应用及进展[J].遗传,2013(07):856.
[38]辛胜昌,赵艳秋,李松,等.斑马鱼模型在药物筛选中的应用[J].遗传,2012(09):1144.
[39]许冰洁,张立将,李春启,等.斑马鱼胚胎评价5种药物的发育毒性与模型验证[J].中国药理学通报,2016,32(1):74.
[40]何育霖,杨雨婷,何贝轩,等.紫草素对斑马鱼胚胎毒性和血管抑制作用[J].中成药,2016,38(2):241.
[41]何贝轩,杨雨婷,何育霖,等.木香挥发油对斑马鱼胚胎发育毒性的初步研究[J].中华中医药杂志,2016(11):4714.
[42]谢辉辉,徐建亚,单进军,等.妊娠相关中药的生殖毒性研究进展[J].中华中医药杂志,2015(07):2428.