胰岛素对心肌离子通道的调控
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摘要
胰岛素除调节糖脂代谢、血压、血管收缩反应,还显著影响着心肌细胞电生理。胰岛素可调控心肌细胞膜上的离子通道,调节途径包括细胞骨架、氧化还原系统、蛋白磷酸酶;缩短心肌细胞动作电位时程的原因为:增强L型钙离子电流、非选择性阳离子电流、瞬时外向钾电流等。
引文
[1]Brownsey RW,Boone AN,Allard MF.Actions of insulin on themammalian heart:metabolism,pathology and biochemical mech-anisms[J].Cardiovasc Res,1997,34(1):3-24.
[2]Hiraoka M.A novel action of insulin on cardiac membrane[J].Circ Res,2003,92(7):707-709.
[3]Watanabe T,Ashikaga T,Nishizaki M,et al.Association of in-sulin with QTc dispersion[J].The Lancet,1997,350:1821.
[4]Jourdon P,Feuvray D.Calcium and potassium currents in ven-tricular myocytes isolated from diabetic rats[J].J Physiol,1993,470:411-429.
[5]Wang DW,Kiyosue T,Shigematsu S.Abnormalities of K+andCa2+currents in ventricular myocytes from rats with chronic di-abetes[J].Am J Physiol,1995,269(4Pt2):H1288-H1296.
[6]Aulbach F,Simm A,Maier S,et al.Insulin stimulates the L-type Ca2+current in rat cardiac myocytes[J].Cardiovas Res,1999,42(1):113-120.
[7]Shimoni Y.Hormonal control of cardiac ion channels and trans-porters[J].Prog Biophys Mol Biol,1999,72(1):67-108.
[8]Norby FL,Wold LE,Duan J,et al.IGF-1attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes[J].Am J Physiol Endocrinol Metab,2002,283(4):E658-E666.
[9]Liu Z.Insulin at physiological concentrations increases microvas-cular perfusion in human myocardium[J].Am J Physiol Endo-crinol Metab,2007,293(5):E1250-E1255.
[10]Cabou C,Cani PD,Campistron G,et al.Central insulin regu-lates heart rate and arterial blood flow:an endethelial nitric oxidesynthase-dependent mechanism altered during diabetes[J].Dia-betes,2007,56(12):2872-2877.
[11]Villa-Abrille MC,Sidor A,O′Rourke B.Insulin effects on car-diac Na+/Ca2+exchanger activity:role of the eytoplasmic regu-latory loop[J].J Biol Chem,2008,283(24):16505-16513.
[12]王如兴,宋建平,杨向军,等.正常大鼠心室肌细胞动作电位和瞬时外向钾离子电流的特点[J].中国心脏起搏与心电生理杂志,2007,21(5):441-444.
[13]万军,黄从新,王腾.家兔心室肌各层细胞的动作电位及瞬间外向钾电流特性[J].中国心脏起搏与心电生理杂志,2001,15(1):25-27.
[14]Smimoni Y,Ewart HS,Severson D.TypeⅠandⅡmodels ofdiabetes produce different modifications of K+currents in ratheart:role of insulin[J].J Physiol,1998,507(Pt2):485-496.
[15]谢强,张紫冠,李卫华,等.胰岛素对家兔右室心肌各层细胞动作电位的影响[J].中国心脏起搏与心生理杂志,2010,24(5):442-445.
[16]O′Brien RM,Granner DK.Regulation of gene expression by in-sulin[J].Biochem J,1991,278(Pt3):609-619.
[17]Samson SL,Wong NC.Role of Sp1in insulin regulation of geneexpression[J].J Mol Endocrinol,2002,29(3):265-279.
[18]Shimoni Y,Ewart HS,Severson D.Insulin stimulation of ratventricular K+currents depends on the integrity of the cytoskele-tion[J].J Physiol,1999,514(Pt3):735-745.
[19]李勋,杨向军,蒋文平.糖尿病大鼠心室肌细胞钾通道的改变[J].中华高血压杂志,2006,14(8):647-650.
[20]Xu Z,Patel KP,Lou MF,et al.Up-regulation of K+channelsin diabetic rat ventricular myocytes by insulin and glutathione[J].Cardiovasc Res,2002,53(1):80-88.
[21]Sweeney G,Klip A.Regulation of the Na+/K+-ATPase byinsulin:why and how[J].Mol Cell Biochem,1998,182(1-2):121-133.
[22]Ragolia L,Cherpalis B,Srinivasan M,et al.Role of serine/threonine protein phosphatases in insulin regulation of Na+/K+-ATPase activity in cultured rat skeletal muscle cells[J].J Bi-ol Chem,1997,272(38):23653-23658.
[23]Zhang YH,Hancox JC.A novel,voltage-dependent nonselec-tive cation current activated by insulin in guinea pig isolated ven-tricular myocytes[J].Circ Res,2003,92(7):765-768.
[24]Shimoni Y,Rattner JB.Type 1diabetes leads to cytoskeletonchanges that are reflected in insulin action on rat cardiac K+cur-rents[J].Am J Physiol Endocrinol Metab,2001,281(3):E575-E585.
[25]Galli A,DeFelice LJ.Inactivation of L-type Ca channels in em-bryonic chick ventricle cells:dependence on the cytoskeletal a-gents colchicine and taxol[J].Biophy J,1994,67(6):2296-2304.
[26]Shimoni Y,Hunt D,Chuang M,et al.Modulation of potassiumcurrents by angiotensin and oxidative stress in cardiac cells fromthe diabetic rat[J].J Physiol,2005,567(Pt1):177-190.
[27]Li X,Tang K,Xie B,et al.Regulation of Kv4channel expres-sion in failing rat heart by the thioredoxin system[J].Am JPhysiol Heart Circ Physiol,2008,295(1):H416-H424.
[28]Li X,Xu Z,Li S,et al.Redox regulation of Ito remodeling indiabetic rat heart[J].Am J Physiol Heart Circ Physiol,2005,288(3):H1417-H1424.
[29]Maier S,Aulbach F,Simm A,et al.Stimulation of L-type Ca2+ current in human atrial myocytes by insulin[J].Cardio-vasc Res,1999,44(2):390-397.
[2]Hiraoka M.A novel action of insulin on cardiac membrane[J].Circ Res,2003,92(7):707-709.
[3]Watanabe T,Ashikaga T,Nishizaki M,et al.Association of in-sulin with QTc dispersion[J].The Lancet,1997,350:1821.
[4]Jourdon P,Feuvray D.Calcium and potassium currents in ven-tricular myocytes isolated from diabetic rats[J].J Physiol,1993,470:411-429.
[5]Wang DW,Kiyosue T,Shigematsu S.Abnormalities of K+andCa2+currents in ventricular myocytes from rats with chronic di-abetes[J].Am J Physiol,1995,269(4Pt2):H1288-H1296.
[6]Aulbach F,Simm A,Maier S,et al.Insulin stimulates the L-type Ca2+current in rat cardiac myocytes[J].Cardiovas Res,1999,42(1):113-120.
[7]Shimoni Y.Hormonal control of cardiac ion channels and trans-porters[J].Prog Biophys Mol Biol,1999,72(1):67-108.
[8]Norby FL,Wold LE,Duan J,et al.IGF-1attenuates diabetes-induced cardiac contractile dysfunction in ventricular myocytes[J].Am J Physiol Endocrinol Metab,2002,283(4):E658-E666.
[9]Liu Z.Insulin at physiological concentrations increases microvas-cular perfusion in human myocardium[J].Am J Physiol Endo-crinol Metab,2007,293(5):E1250-E1255.
[10]Cabou C,Cani PD,Campistron G,et al.Central insulin regu-lates heart rate and arterial blood flow:an endethelial nitric oxidesynthase-dependent mechanism altered during diabetes[J].Dia-betes,2007,56(12):2872-2877.
[11]Villa-Abrille MC,Sidor A,O′Rourke B.Insulin effects on car-diac Na+/Ca2+exchanger activity:role of the eytoplasmic regu-latory loop[J].J Biol Chem,2008,283(24):16505-16513.
[12]王如兴,宋建平,杨向军,等.正常大鼠心室肌细胞动作电位和瞬时外向钾离子电流的特点[J].中国心脏起搏与心电生理杂志,2007,21(5):441-444.
[13]万军,黄从新,王腾.家兔心室肌各层细胞的动作电位及瞬间外向钾电流特性[J].中国心脏起搏与心电生理杂志,2001,15(1):25-27.
[14]Smimoni Y,Ewart HS,Severson D.TypeⅠandⅡmodels ofdiabetes produce different modifications of K+currents in ratheart:role of insulin[J].J Physiol,1998,507(Pt2):485-496.
[15]谢强,张紫冠,李卫华,等.胰岛素对家兔右室心肌各层细胞动作电位的影响[J].中国心脏起搏与心生理杂志,2010,24(5):442-445.
[16]O′Brien RM,Granner DK.Regulation of gene expression by in-sulin[J].Biochem J,1991,278(Pt3):609-619.
[17]Samson SL,Wong NC.Role of Sp1in insulin regulation of geneexpression[J].J Mol Endocrinol,2002,29(3):265-279.
[18]Shimoni Y,Ewart HS,Severson D.Insulin stimulation of ratventricular K+currents depends on the integrity of the cytoskele-tion[J].J Physiol,1999,514(Pt3):735-745.
[19]李勋,杨向军,蒋文平.糖尿病大鼠心室肌细胞钾通道的改变[J].中华高血压杂志,2006,14(8):647-650.
[20]Xu Z,Patel KP,Lou MF,et al.Up-regulation of K+channelsin diabetic rat ventricular myocytes by insulin and glutathione[J].Cardiovasc Res,2002,53(1):80-88.
[21]Sweeney G,Klip A.Regulation of the Na+/K+-ATPase byinsulin:why and how[J].Mol Cell Biochem,1998,182(1-2):121-133.
[22]Ragolia L,Cherpalis B,Srinivasan M,et al.Role of serine/threonine protein phosphatases in insulin regulation of Na+/K+-ATPase activity in cultured rat skeletal muscle cells[J].J Bi-ol Chem,1997,272(38):23653-23658.
[23]Zhang YH,Hancox JC.A novel,voltage-dependent nonselec-tive cation current activated by insulin in guinea pig isolated ven-tricular myocytes[J].Circ Res,2003,92(7):765-768.
[24]Shimoni Y,Rattner JB.Type 1diabetes leads to cytoskeletonchanges that are reflected in insulin action on rat cardiac K+cur-rents[J].Am J Physiol Endocrinol Metab,2001,281(3):E575-E585.
[25]Galli A,DeFelice LJ.Inactivation of L-type Ca channels in em-bryonic chick ventricle cells:dependence on the cytoskeletal a-gents colchicine and taxol[J].Biophy J,1994,67(6):2296-2304.
[26]Shimoni Y,Hunt D,Chuang M,et al.Modulation of potassiumcurrents by angiotensin and oxidative stress in cardiac cells fromthe diabetic rat[J].J Physiol,2005,567(Pt1):177-190.
[27]Li X,Tang K,Xie B,et al.Regulation of Kv4channel expres-sion in failing rat heart by the thioredoxin system[J].Am JPhysiol Heart Circ Physiol,2008,295(1):H416-H424.
[28]Li X,Xu Z,Li S,et al.Redox regulation of Ito remodeling indiabetic rat heart[J].Am J Physiol Heart Circ Physiol,2005,288(3):H1417-H1424.
[29]Maier S,Aulbach F,Simm A,et al.Stimulation of L-type Ca2+ current in human atrial myocytes by insulin[J].Cardio-vasc Res,1999,44(2):390-397.