捻转血矛线虫病的研究进展
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摘要
捻转血矛线虫病是由主要寄生于反刍动物皱胃的捻转血矛线虫引起的一种重要的寄生线虫病,在我国草地牧区普遍流行,可引起宿主消瘦、贫血等慢性消耗性症状,严重感染甚至可引起死亡,给我国养殖业带来巨大的经济损失。由于基层养殖人员常常忽视寄生线虫病的危害,缺乏基本的防控常识和驱虫意识,从而错过了预防和治疗该病的最佳时机,最终导致动物大批感染,极大的降低了动物的品质和养殖的经济效益。本文从捻转血矛线虫的形态和生活史着手,介绍了捻转血矛线虫病的危害和症状、诊断和治疗、防控方法及感染和致病的相关分子机制研究进展,希望能为该病的防控提供一定的指导。
Haemonchosis is a parasitic nematode disease caused by Haemonchus contortus. This parasite mainly inhabits in stomachs of infected ruminants and is epidemic in wild grasslands and pastoral areas of China. Clinical signs include anemia, diarrhea or even death in cattle and sheep, resulting in huge economic losses. Ignore of parasitic nematode infection and lack of deworming awareness for grassroots farmers often lead to miss the best opportunity to prevent and control this disease, eventually bring about numerous infected animals with decreased quality and economic losses. In this paper, we introduced the morphology and life cycle of H. contortus, damage and clinical signs, diagnosis and treatment of Haemonchosis, methods for prevention and control as well as progresses on molecular mechanisms of infection and pathogenesis.
Haemonchosis is a parasitic nematode disease caused by Haemonchus contortus. This parasite mainly inhabits in stomachs of infected ruminants and is epidemic in wild grasslands and pastoral areas of China. Clinical signs include anemia, diarrhea or even death in cattle and sheep, resulting in huge economic losses. Ignore of parasitic nematode infection and lack of deworming awareness for grassroots farmers often lead to miss the best opportunity to prevent and control this disease, eventually bring about numerous infected animals with decreased quality and economic losses. In this paper, we introduced the morphology and life cycle of H. contortus, damage and clinical signs, diagnosis and treatment of Haemonchosis, methods for prevention and control as well as progresses on molecular mechanisms of infection and pathogenesis.
引文
[1]徐盾.辽宁绒山羊捻转血矛线虫病的诊治[J].畜牧兽医科技信息,2017(6):88.
[2]李国清.兽医寄生虫学(双语版)[M].北京:中国农业大学出版社,2006:200-203.
[3]宋铭忻,张龙现.兽医寄生虫学[M].北京:科学出版社,2009:160-163.
[4]王宇恒.寄生虫对动物机体的危害[J].山东畜牧兽医,2017,38(7):46.
[5]夏道伦,李淑萍.羊捻转血矛线虫病的危害及防控[J].兽医导刊,2018(7):30-32.
[6]杨文科.春季高潮和消化道线虫感染之间的关系[J].新疆畜牧业,2007(4):50-51.
[7]赵小红.常用动物寄生虫的粪便检查技术[J].中国畜牧兽医文摘,2013(5):47.
[8]林琳,江斌,吴胜会,等.不同药物对放牧山羊捻转血矛线虫驱虫效果比较试验[J].福建畜牧兽医,2016,38(6):1-3.
[9]王喜军,颜酃,何健,等.黑山羊捻转血矛线虫病的诊治[J].湖南畜牧兽医,2008(2):20-21.
[10]冯向阳,瞿涛,付明哲.奶山羊场捻转血矛线虫病诊断与抗药性检测[J].家畜生态学报,2016,37(10):61-64.
[11]额叶勒德格,曹增富,海鹰,等.乌审旗地区绵羊消化道线虫感染情况及耐药性的调查[J].中国兽医科学,2018,48(6):735-742.
[12]李英芳.山羊捻转血矛线虫病的诊断与治疗[J].中国畜牧兽医文摘,2015,31(2):144.
[13]陶正泽,刘保有,李林,等.浅析羊捻转血矛线虫病临床诊断与治疗[J].中国畜禽种业,2017(6):108-109.
[14]巴哈特哈孜.羊消化道线虫病的种类鉴别及防治[J].当代畜牧,2016(14):85-86.
[15]刘绍斌.湖羊捻转血矛线虫病的诊治与预防[J].农技服务,2017,34(5):145.
[16]成钢,王文龙,赵铭,等.湖区波尔山羊常见寄生虫病临床诊断与综合防控[J].江苏农业科学,2014,42(1):170-171.
[17]钟荣珍,周道玮.羊捻转血矛线虫的免疫机理及控制其感染的营养调控措施[J].动物营养学报,2013,25(9):1921-1928.
[18]丁厚辉,王宇恒,王玉,等.羊捻转血矛线虫病的诊断与防治[J].山东畜牧兽医,2016,37(3):64-65.
[19]He L,Gasser R B,Korhonen P K,et al.A TGF-βtype I receptor-like molecule with a key functional role in Haemonchus contortus development[J].Int J Parasitol,2018,48(13):1023-1033.
[20]Yang Y,Ma Y,Chen X,et al.Screening and analysis of Hc-ubq and Hc-gst related to desiccation survival of infective Haemonchus contortus larvae[J].Vet Parasitol,2015,210(3-4):179-185.
[21]Yan B,Guo X,Zhou Q,et al.Hc-fau,a novel gene regulating diapause in the nematode parasite Haemonchus contortus[J].Int J Parasitol,2014,44(11):775-786.
[22]Zhang L,Mou L,Chen X,et al.Identification and preliminary characterization of Hc-clec-160,a novel C-type lectin domain-containing gene of the strongylid nematode Haemonchus contortus[J].Parasit Vectors,2018,11(1):430.
[23]Wang F,Xu L,Song X,et al.Identification of differentially expressed proteins between free-living and activated third-stage larvae of Haemonchus contortus[J].Vet Parasitol,2016,215:72-77.
[24]Li B,Gadahi J A,Gao W,et al.Characterization of a novel aspartyl protease inhibitor from Haemonchus contortus[J].Parasit Vectors,2017,10(1):191.
[25]Ehsan M,Gao W,Gadahi J A,et al.Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro[J].Parasit Vectors,2017,10(1):311.
[26]Ehsan M,Wang W,Gadahi J A,et al.The serine/threonine-protein phosphatase 1 from Haemonchus contortus is actively involved in suppressive regulatory roles on immune functions of goat peripheral blood mononuclear cells[J].Front Immunol,2018,9:1627.
[27]Gadahi J A,Yongqian B,Ehsan M,et al.Haemonchus contortus excretory and secretory proteins(HcESPs)suppress functions of goat PBMCs in vitro[J].Oncotarget,2016,7(24):35670-35679.
[28]Guo X L,Zhang H,Zheng X,et al.Structural and functional characterization of a novel gene,Hc-daf-22,from the strongylid nematode Haemonchus contortus[J].Parasit Vectors,2016,9(1):422.
[29]Ding H,Shi H,Shi Y,et al.Characterization and function analysis of a novel gene,Hc-maoc-1,in the parasitic nematode Haemonochus contortus[J].Parasit Vectors,2017,10(1):67.
[30]El-Ashram S,Li C,Abouhajer F,et al.An ex vivo abomasal ovine model to study the immediate immune response in the context of Haemonchus contortus larvalstage[J].Vet Parasitol,2018,254:105-113.
[2]李国清.兽医寄生虫学(双语版)[M].北京:中国农业大学出版社,2006:200-203.
[3]宋铭忻,张龙现.兽医寄生虫学[M].北京:科学出版社,2009:160-163.
[4]王宇恒.寄生虫对动物机体的危害[J].山东畜牧兽医,2017,38(7):46.
[5]夏道伦,李淑萍.羊捻转血矛线虫病的危害及防控[J].兽医导刊,2018(7):30-32.
[6]杨文科.春季高潮和消化道线虫感染之间的关系[J].新疆畜牧业,2007(4):50-51.
[7]赵小红.常用动物寄生虫的粪便检查技术[J].中国畜牧兽医文摘,2013(5):47.
[8]林琳,江斌,吴胜会,等.不同药物对放牧山羊捻转血矛线虫驱虫效果比较试验[J].福建畜牧兽医,2016,38(6):1-3.
[9]王喜军,颜酃,何健,等.黑山羊捻转血矛线虫病的诊治[J].湖南畜牧兽医,2008(2):20-21.
[10]冯向阳,瞿涛,付明哲.奶山羊场捻转血矛线虫病诊断与抗药性检测[J].家畜生态学报,2016,37(10):61-64.
[11]额叶勒德格,曹增富,海鹰,等.乌审旗地区绵羊消化道线虫感染情况及耐药性的调查[J].中国兽医科学,2018,48(6):735-742.
[12]李英芳.山羊捻转血矛线虫病的诊断与治疗[J].中国畜牧兽医文摘,2015,31(2):144.
[13]陶正泽,刘保有,李林,等.浅析羊捻转血矛线虫病临床诊断与治疗[J].中国畜禽种业,2017(6):108-109.
[14]巴哈特哈孜.羊消化道线虫病的种类鉴别及防治[J].当代畜牧,2016(14):85-86.
[15]刘绍斌.湖羊捻转血矛线虫病的诊治与预防[J].农技服务,2017,34(5):145.
[16]成钢,王文龙,赵铭,等.湖区波尔山羊常见寄生虫病临床诊断与综合防控[J].江苏农业科学,2014,42(1):170-171.
[17]钟荣珍,周道玮.羊捻转血矛线虫的免疫机理及控制其感染的营养调控措施[J].动物营养学报,2013,25(9):1921-1928.
[18]丁厚辉,王宇恒,王玉,等.羊捻转血矛线虫病的诊断与防治[J].山东畜牧兽医,2016,37(3):64-65.
[19]He L,Gasser R B,Korhonen P K,et al.A TGF-βtype I receptor-like molecule with a key functional role in Haemonchus contortus development[J].Int J Parasitol,2018,48(13):1023-1033.
[20]Yang Y,Ma Y,Chen X,et al.Screening and analysis of Hc-ubq and Hc-gst related to desiccation survival of infective Haemonchus contortus larvae[J].Vet Parasitol,2015,210(3-4):179-185.
[21]Yan B,Guo X,Zhou Q,et al.Hc-fau,a novel gene regulating diapause in the nematode parasite Haemonchus contortus[J].Int J Parasitol,2014,44(11):775-786.
[22]Zhang L,Mou L,Chen X,et al.Identification and preliminary characterization of Hc-clec-160,a novel C-type lectin domain-containing gene of the strongylid nematode Haemonchus contortus[J].Parasit Vectors,2018,11(1):430.
[23]Wang F,Xu L,Song X,et al.Identification of differentially expressed proteins between free-living and activated third-stage larvae of Haemonchus contortus[J].Vet Parasitol,2016,215:72-77.
[24]Li B,Gadahi J A,Gao W,et al.Characterization of a novel aspartyl protease inhibitor from Haemonchus contortus[J].Parasit Vectors,2017,10(1):191.
[25]Ehsan M,Gao W,Gadahi J A,et al.Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro[J].Parasit Vectors,2017,10(1):311.
[26]Ehsan M,Wang W,Gadahi J A,et al.The serine/threonine-protein phosphatase 1 from Haemonchus contortus is actively involved in suppressive regulatory roles on immune functions of goat peripheral blood mononuclear cells[J].Front Immunol,2018,9:1627.
[27]Gadahi J A,Yongqian B,Ehsan M,et al.Haemonchus contortus excretory and secretory proteins(HcESPs)suppress functions of goat PBMCs in vitro[J].Oncotarget,2016,7(24):35670-35679.
[28]Guo X L,Zhang H,Zheng X,et al.Structural and functional characterization of a novel gene,Hc-daf-22,from the strongylid nematode Haemonchus contortus[J].Parasit Vectors,2016,9(1):422.
[29]Ding H,Shi H,Shi Y,et al.Characterization and function analysis of a novel gene,Hc-maoc-1,in the parasitic nematode Haemonochus contortus[J].Parasit Vectors,2017,10(1):67.
[30]El-Ashram S,Li C,Abouhajer F,et al.An ex vivo abomasal ovine model to study the immediate immune response in the context of Haemonchus contortus larvalstage[J].Vet Parasitol,2018,254:105-113.