丹参酮注射液联合乌司他汀对颅脑损伤认知功能及炎症反应的影响
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摘要
目的:探讨丹参酮注射液联合乌司他汀对颅脑损伤患者炎症因子和认知功能的影响。方法:分析2016年3月—2017年3月在医院接受治疗的颅脑损伤患者的临床资料,根据其用药分为对照组和观察组,对照组给予乌司他汀治疗,观察组在此基础上给予丹参酮注射液治疗。比较两组患者治疗前后脑血流、NIHSS评分、炎症因子和认知功能的差异。结果:两组患者治疗前脑血流指标无差别,治疗后,观察组患者Qmean高于对照组(t=-12.077,P<0.001),Zc和DR水平低于对照组(t=7.745、8.961,P<0.001);两组患者治疗前NIHSS评分无差别,治疗后,观察组患者的NIHSS评分低于对照组(t=14.373,P<0.001);两组患者治疗前炎症因子水平无差别,治疗后,观察组患者的IL-18、IL-6和hs-CRP水平低于对照组(t=9.810、7.575、7.983,P<0.001);两组患者治疗前认知功能无差别,治疗后,观察组认知功能恢复优于对照组。结论:丹参酮注射液联合乌司他汀对颅脑损伤患者有较好的治疗效果,可明显改善患者的认知功能,降低炎症因子水平。
Objective: To investigate the effect of Tanshinone Injection combined with ulinastatin on inflammatory factors and cognitive function in patients with craniocerebral injury. Methods: The clinical data of craniocerebral trauma patients who received treatment in our hospital from March 2016 to March 2017 were retrospectively analyzed. The patients were divided into control group and observation group according to their medication. The control group was treated with ulinastatin,and the observation group was treated with Tanshinone Injection. Results: There was no difference between the two groups in the treatment of forebrain blood flow. After treatment,the Q mean in the observation group was higher than that in the control group( t =-12. 077,P < 0. 001),and the levels of Zc and DR were lower than those of the control group( t = 7. 745,8. 961,P < 0. 001). There was no difference in NIHSS score between the two groups before treatment. After treatment,the NIHSS score of the observation group was lower than that of the control group( t = 14. 373,P< 0. 001). Two groups had no difference between the levels of proinflammatory cytokines. After treatment,the observation group's IL-18,IL-6 and hs-CRP levels were lower than those of the control group( t = 9. 810,7. 575,7. 983,P< 0. 001). There was no difference in cognitive function between the two groups before treatment. After treatment,the cognitive function of the observation group was better than that of the control group. Conclusion: Tanshinone Injection combined with ulinastatin can improve the cognitive function and reduce the level of inflammatory factors in patients with craniocerebral injury.
Objective: To investigate the effect of Tanshinone Injection combined with ulinastatin on inflammatory factors and cognitive function in patients with craniocerebral injury. Methods: The clinical data of craniocerebral trauma patients who received treatment in our hospital from March 2016 to March 2017 were retrospectively analyzed. The patients were divided into control group and observation group according to their medication. The control group was treated with ulinastatin,and the observation group was treated with Tanshinone Injection. Results: There was no difference between the two groups in the treatment of forebrain blood flow. After treatment,the Q mean in the observation group was higher than that in the control group( t =-12. 077,P < 0. 001),and the levels of Zc and DR were lower than those of the control group( t = 7. 745,8. 961,P < 0. 001). There was no difference in NIHSS score between the two groups before treatment. After treatment,the NIHSS score of the observation group was lower than that of the control group( t = 14. 373,P< 0. 001). Two groups had no difference between the levels of proinflammatory cytokines. After treatment,the observation group's IL-18,IL-6 and hs-CRP levels were lower than those of the control group( t = 9. 810,7. 575,7. 983,P< 0. 001). There was no difference in cognitive function between the two groups before treatment. After treatment,the cognitive function of the observation group was better than that of the control group. Conclusion: Tanshinone Injection combined with ulinastatin can improve the cognitive function and reduce the level of inflammatory factors in patients with craniocerebral injury.
引文
[1]李侠,张磊,陈燕伟,等.852例开放性颅脑损伤的临床救治经验[J].中华神经医学杂志,2014,13(5):451-455.
[2]王雷平,吴崇光,姚军,等.颅脑损伤去骨瓣减压术后并发创伤后脑积水的危险因素[J].中华创伤杂志,2014,30(4):307-310.
[3]路顺利.丹参酮注射液联合乌司他汀对颅脑损伤病人脑保护及炎症反应的影响[J].中西医结合心脑血管病杂志,2017,15(9):1147-1149.
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[5]Bao P T,Zhao W G,Li Y,et al.Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy:a randomized,placebo-controlled study[J].Medical oncology,2015,32(1):111-116.
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[7]叶琦,王华.丹参注射液联合乌司他丁对重型颅脑损伤患者的脑保护作用及对炎症反应的影响[J].中国生化药物杂志,2017,4(4):115-118.
[8]张建军,柴成国,李敬,等.乌司他丁对重型颅脑损伤合并早期呼吸机相关性肺炎的临床观察[J].河北医药,2015,3(3):376-377.
[9]江皓波,马明远,张云海,等.血必净注射液在重型颅脑损伤伴凝血功能异常患者中的应用[J].中华神经医学杂志,2015,14(9):937-940.
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[11]原晓玲,杨发明,姚爱娜,等.大剂量乌司他丁对重症颅脑损伤后肺部感染的疗效及安全性研究[J].实用医技杂志,2016,23(8):870-872.
[12]崔波,吴健.颅脑损伤患者急性期白细胞介素-1β及细胞间黏附分子-1水平的变化[J].中国实用神经疾病杂志,2015,12(24):13-14.
[13]袁春儿,吴坚敏,王伟群,等.高压氧治疗对重型颅脑损伤合并肺部感染患者降钙素原和C反应蛋白的影响[J].中华航海医学与高气压医学杂志,2016,23(1):6-8.
[14]李明.神经节苷酯钠辅助治疗对急性重症颅脑损伤患者神经损伤程度及细胞因子、体液免疫的影响[J].海南医学院学报,2017,23(1):48-51.
[15]王冰,李兵,胡世颉,等.乌司他丁对重型颅脑损伤患者神经保护作用[J].贵阳医学院学报,2014,39(5):660-663.
[2]王雷平,吴崇光,姚军,等.颅脑损伤去骨瓣减压术后并发创伤后脑积水的危险因素[J].中华创伤杂志,2014,30(4):307-310.
[3]路顺利.丹参酮注射液联合乌司他汀对颅脑损伤病人脑保护及炎症反应的影响[J].中西医结合心脑血管病杂志,2017,15(9):1147-1149.
[4]蔡春雨,訾东燕,郑奕,等.乌司他丁对颅脑损伤手术患者围术期脑保护及炎性反应的影响[J].海南医学院学报,2016,22(20):2437-2439.
[5]Bao P T,Zhao W G,Li Y,et al.Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy:a randomized,placebo-controlled study[J].Medical oncology,2015,32(1):111-116.
[6]李兵,胡世颉,王冰,等.重度颅脑损伤合并多器官功能衰竭应用乌司他丁治疗效果的临床研究[J].陕西医学杂志,2015,5(12):1650-1652.
[7]叶琦,王华.丹参注射液联合乌司他丁对重型颅脑损伤患者的脑保护作用及对炎症反应的影响[J].中国生化药物杂志,2017,4(4):115-118.
[8]张建军,柴成国,李敬,等.乌司他丁对重型颅脑损伤合并早期呼吸机相关性肺炎的临床观察[J].河北医药,2015,3(3):376-377.
[9]江皓波,马明远,张云海,等.血必净注射液在重型颅脑损伤伴凝血功能异常患者中的应用[J].中华神经医学杂志,2015,14(9):937-940.
[10]Cullen A,Terris M,Ford R,et al.Spinal clearance in unconscious children following traumatic brain injury[J].Paediatric anaesthesia,2014,24(7):711-716.
[11]原晓玲,杨发明,姚爱娜,等.大剂量乌司他丁对重症颅脑损伤后肺部感染的疗效及安全性研究[J].实用医技杂志,2016,23(8):870-872.
[12]崔波,吴健.颅脑损伤患者急性期白细胞介素-1β及细胞间黏附分子-1水平的变化[J].中国实用神经疾病杂志,2015,12(24):13-14.
[13]袁春儿,吴坚敏,王伟群,等.高压氧治疗对重型颅脑损伤合并肺部感染患者降钙素原和C反应蛋白的影响[J].中华航海医学与高气压医学杂志,2016,23(1):6-8.
[14]李明.神经节苷酯钠辅助治疗对急性重症颅脑损伤患者神经损伤程度及细胞因子、体液免疫的影响[J].海南医学院学报,2017,23(1):48-51.
[15]王冰,李兵,胡世颉,等.乌司他丁对重型颅脑损伤患者神经保护作用[J].贵阳医学院学报,2014,39(5):660-663.