葛根芩连汤对小儿慢性牙周炎患者牙周组织IL-1β水平及药理学研究
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摘要
目的:观察葛根芩连汤对小儿慢性牙周炎患者牙周组织IL-1β水平的影响。方法:选取2014年12月至2016年12在本院接受治疗的慢性牙周炎患者70例,将70例慢性牙周炎患者分为两组,对照组35例,观察组35例。对照组里的患者给予牙周基础治疗,观察组在对照组基础上给予葛根芩连汤,对比两组患者治疗前后附着水平、菌斑指数的水平和探诊深度;检测患者的龈沟液中IL-1β、IL-6水平和患者的血清。结果:观察组总有效率为94.29%,对照组的总有效率71.43%,观察组显著高于对照组的,差异有统计学意义(χ~2=6.437,P<0.05);两组患者治疗后的附着水平、探诊深度、菌斑指数明显下降(P<0.05),治疗后的探诊深度、附着水平、菌斑指数,对照组明显高于观察组,差异有统计学意义(P<0.05);两组患者治疗后龈沟液中IL-1β、IL-6水平和血清显著降低(P<0.05),治疗后的龈沟液中IL-1β、IL-6水平和血清,对照组明显高于观察组,差异有统计学意义(P<0.05)。结论:慢性牙周炎患者的IL-1β水平能通过葛根芩连汤显著降低,从而减轻炎性反应,提高患者的治疗效果。
Objective: To investigate the effect of Gegen Qianlian Decoction on periodontal tissue IL-1β in children with chronic periodontitis. Methods: 70 patients with chronic periodontitis treated in our hospital from December 2014 to December2016 were divided into two groups: controlled group( 35 cases) and observation group( 35 cases). The patients in the controlled group were treated with periodontal basis. The observation group was given Gegen Qinlian Decoction on the basis of the controlled group,and the levels of plaque and plaque index were compared before and after treatment. The gingival crevicular fluid IL-1β,IL-6 levels and serum of patients was detected. Results: The total effective rate was 94. 29% in the observation group and71. 43% in the controlled group. The difference was statistically significant( χ~2= 6. 437,P<0. 05) in the observation group and the observation group( P<0. 05). The depth of treatment,the level of attachment,the plaque index and the controlled group were significantly higher than those of the observation group( P< 0. 05). The difference between the two groups was statistically significant( P<0. 05). The levels of IL-1β and IL-6 in the gingival crevicular fluid after treatment were significantly higher than those in the controlled group( P<0. 05),and the levels of IL-1β and IL-6 in the gingival crevicular fluid were significantly lower than those in the controlled group,the difference was statistically significant( P< 0. 05). Conclusion: IL-1β levels in patients with chronic periodontitis can be significantly reduced by Gegen Qinlian Decoction,thereby can reduce the inflammatory response and improve the treatment of patients.
Objective: To investigate the effect of Gegen Qianlian Decoction on periodontal tissue IL-1β in children with chronic periodontitis. Methods: 70 patients with chronic periodontitis treated in our hospital from December 2014 to December2016 were divided into two groups: controlled group( 35 cases) and observation group( 35 cases). The patients in the controlled group were treated with periodontal basis. The observation group was given Gegen Qinlian Decoction on the basis of the controlled group,and the levels of plaque and plaque index were compared before and after treatment. The gingival crevicular fluid IL-1β,IL-6 levels and serum of patients was detected. Results: The total effective rate was 94. 29% in the observation group and71. 43% in the controlled group. The difference was statistically significant( χ~2= 6. 437,P<0. 05) in the observation group and the observation group( P<0. 05). The depth of treatment,the level of attachment,the plaque index and the controlled group were significantly higher than those of the observation group( P< 0. 05). The difference between the two groups was statistically significant( P<0. 05). The levels of IL-1β and IL-6 in the gingival crevicular fluid after treatment were significantly higher than those in the controlled group( P<0. 05),and the levels of IL-1β and IL-6 in the gingival crevicular fluid were significantly lower than those in the controlled group,the difference was statistically significant( P< 0. 05). Conclusion: IL-1β levels in patients with chronic periodontitis can be significantly reduced by Gegen Qinlian Decoction,thereby can reduce the inflammatory response and improve the treatment of patients.
引文
[1]李文娟,彭伟,王丹,等.葛根芩连汤对慢性牙周炎合并动脉粥样硬化大鼠TNF-α水平的影响[J].郑州大学学报(医学版),2015,8(1):23~26
[2]邓莉.肿痛安胶囊对慢性牙周炎患者临床疗效及炎症因子IL-1β和IL-6影响的研究[J].临床和实验医学杂志,2016,15(16):1628~1630
[3]杨宇,孙敬涛.肿痛安胶囊对慢性牙周炎患者临床疗效及炎症因子IL-1β和IL-6的影响研究[J].辽宁中医药大学学报,2015,39(7):186~188
[4]罗欣,王丹,彭伟,等.葛根芩连汤对牙周炎大鼠血清hsCRP、IL-6表达的影响[J].实用口腔医学杂志,2015,31(6):780~783
[5]刘自华,安叡,张艺竹,等.基于AMI-MS法的印刷背面粘脏测试方法研究[J].中国中药杂志,2015,40(15):3072~3080
[6]杨佳,杨建军.慢性牙周炎种植修复后短期疗效及与IL-1水平的相关性研究[J].中国疗养医学,2015,24(5):457~460
[7]崔占琴,李文静,刘焕.自锁托槽矫治器对慢性广泛型牙周炎正畸治疗患者龈沟液中IL-1β和TNF-α表达的影响[J].河北医药,2016,38(10):1445~1449
[8]宋碧连,李磊,孙少平.牙周干预治疗对慢性心力衰竭患者BNP、IL-1β指标的影响[J].现代医院,2015,46(7):52~53
[9]张大风,黄盛斌,张友婷,等.盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性研究[J].中国临床药理学杂志,2015,65(8):590~591
[10]赵益,赖小东,叶争荣,等.葛根芩连汤对溃疡性结肠炎模型大鼠抗氧化及抗炎的作用机制[J].中华中医药杂志,2016,27(5):1741~1745
[11]Wenjuan L I,Peng W,Wang D,et al.Gegenqinlian decoction decreases serum TNF-αlevel in rats with chronic periodontitis and atherosclerosis[J].Journal of Practical Stomatology,2015,1(2):361~363
[12]Wenjuan L I,Peng W,Wang D,et al.Effects of Gegenqinlian decoction on TNF-αlevel in rats with chronic periodontitis and atherosclerosis[J].Journal of Zhengzhou University,2015,59(7):315~320
[13]Xu B L,Zhang G J,Ji Y B.Active components alignment of Gegenqinlian decoction protects ulcerative colitis by attenuating inflammatory and oxidative stress.[J].Journal of Ethnopharmacology,2015,162(9):253~259
[14]Wang Y L,Liu L J,Zhao W H,et al.Intervening TNF-αvia PPARγwith Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease[J].Evidence-based Complementary and Alternative Medicine,2015,15(7):715~722
[15]Liu X M,Yang G Y,Guang-Zhi H E,et al.Influence of Gegenqinlian Decoction on Intestinal Lactobacillusin Antibiotic Associated Diarrhea Model Treatment[J].Journal of Domestic Animal Ecology,2016,35(6):735~729
[2]邓莉.肿痛安胶囊对慢性牙周炎患者临床疗效及炎症因子IL-1β和IL-6影响的研究[J].临床和实验医学杂志,2016,15(16):1628~1630
[3]杨宇,孙敬涛.肿痛安胶囊对慢性牙周炎患者临床疗效及炎症因子IL-1β和IL-6的影响研究[J].辽宁中医药大学学报,2015,39(7):186~188
[4]罗欣,王丹,彭伟,等.葛根芩连汤对牙周炎大鼠血清hsCRP、IL-6表达的影响[J].实用口腔医学杂志,2015,31(6):780~783
[5]刘自华,安叡,张艺竹,等.基于AMI-MS法的印刷背面粘脏测试方法研究[J].中国中药杂志,2015,40(15):3072~3080
[6]杨佳,杨建军.慢性牙周炎种植修复后短期疗效及与IL-1水平的相关性研究[J].中国疗养医学,2015,24(5):457~460
[7]崔占琴,李文静,刘焕.自锁托槽矫治器对慢性广泛型牙周炎正畸治疗患者龈沟液中IL-1β和TNF-α表达的影响[J].河北医药,2016,38(10):1445~1449
[8]宋碧连,李磊,孙少平.牙周干预治疗对慢性心力衰竭患者BNP、IL-1β指标的影响[J].现代医院,2015,46(7):52~53
[9]张大风,黄盛斌,张友婷,等.盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎的临床疗效及安全性研究[J].中国临床药理学杂志,2015,65(8):590~591
[10]赵益,赖小东,叶争荣,等.葛根芩连汤对溃疡性结肠炎模型大鼠抗氧化及抗炎的作用机制[J].中华中医药杂志,2016,27(5):1741~1745
[11]Wenjuan L I,Peng W,Wang D,et al.Gegenqinlian decoction decreases serum TNF-αlevel in rats with chronic periodontitis and atherosclerosis[J].Journal of Practical Stomatology,2015,1(2):361~363
[12]Wenjuan L I,Peng W,Wang D,et al.Effects of Gegenqinlian decoction on TNF-αlevel in rats with chronic periodontitis and atherosclerosis[J].Journal of Zhengzhou University,2015,59(7):315~320
[13]Xu B L,Zhang G J,Ji Y B.Active components alignment of Gegenqinlian decoction protects ulcerative colitis by attenuating inflammatory and oxidative stress.[J].Journal of Ethnopharmacology,2015,162(9):253~259
[14]Wang Y L,Liu L J,Zhao W H,et al.Intervening TNF-αvia PPARγwith Gegenqinlian Decoction in Experimental Nonalcoholic Fatty Liver Disease[J].Evidence-based Complementary and Alternative Medicine,2015,15(7):715~722
[15]Liu X M,Yang G Y,Guang-Zhi H E,et al.Influence of Gegenqinlian Decoction on Intestinal Lactobacillusin Antibiotic Associated Diarrhea Model Treatment[J].Journal of Domestic Animal Ecology,2016,35(6):735~729