利用miRNA表达谱构建PanCancer-miRNA网络
摘要
miRNA与许多肿瘤癌症都有着密切关联,它们可能调控着大量癌症的生物过程,这使得miRNA称为诊断、预防疾病的新型生物学标记。本文通过研究多种癌症的miRNA的表达谱,构建了泛癌症(PanCancer)-miRNA网络,揭示了miRNA合作调控癌症等疾病生物过程的机理特征,有助于进一步了解miRNA与癌症之间的复杂关系。
引文
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[2] Tamborero D, Gonzalezperez A, Perezllamas C, et al. Comprehensive identification of mutational cancer driver genes across12 tumor types[J]. Scientific Reports,2013,3(10):2650.
[3] Katarzyna T, Patrycja C, Maciej W. The Cancer Genome Atlas(TCGA):an immeasurable source of knowledge[J]. Contemporary Oncology, 2015, 19(1A):A68.
[4] Zhaowen Liu;Junying Zhang;Xiguo Yuan;Baobao Liu;Yajun Liu;Aimin Li;Yuanyuan Zhang;XiaohanSun;Shouheng Tuo;.Detecting pan-cancer conserved micro RNA modules from micro RNA expression profiles across multiple cancers[J],2015,11(8):2227-2237.
[5] http://www.cytoscape.org
[6] Xiong G, Wang Y, Ding Q, et al. Hsa-mir-1269 genetic variant contributes to hepatocellular carcinoma susceptibility through affecting SOX6.[J]. American Journal of Translational Research,2015,7(10):2091.
[7] Ma S, Tang K H, Chan Y P, et al. mi R-130b Promotes CD133+Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1[J]. Cell Stem Cell,2010,7(6):694-707.
[8] Asangani I A, Rasheed S A K, Nikolova D A, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer[J]. Oncogene,2008,27(15):2128-2136.
[9] Huang X; Ding L; Bennewith KL; Tong RT; Welford SM; Ang KK; Story M; Le QT; Giaccia AJ. Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation[J]. Molecular Cell,2009, 5(6):856.
[10] Fang L, Deng Z, Shatseva T, et al. MicroRNA miR-93promotes tumor growth and angiogenesis by targeting integrin-β8.[J]. Oncogene,2011,30(7):806-821.