补充谷氨酰胺对运动机体影响研究进展
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摘要
谷氨酰胺作为人体中含量最高的氨基酸,是胃肠道和众多免疫细胞重要的能量来源。补充谷氨酰胺有助于提高运动能力并且促进运动疲劳的恢复。本文针对补充谷氨酰胺对过度运动机体的保护作用,综合了近期相关文献,阐述了补充谷氨酰胺对运动能力、运动恢复及免疫系统的作用机理,以期为谷氨酰胺对运动机体作用途径的相关研究提供参考。
Glutamine,as the highest content of amino acids in human body,is an important source of energy and a number of immune cells. Glutamine supplementation can help improving exercise capacity and promote the recovery of sports fatigue. In this paper,the protective effects of glutamine supplementation on over-exercise organisms are combined,and recent relevant literature is synthesized to describe the mechanism of action of glutamine supplementation on valley exercise capacity,exercise recovery,and immune system.,in order to provide a reference for the study of the role of glutamine in human kinesiology.
Glutamine,as the highest content of amino acids in human body,is an important source of energy and a number of immune cells. Glutamine supplementation can help improving exercise capacity and promote the recovery of sports fatigue. In this paper,the protective effects of glutamine supplementation on over-exercise organisms are combined,and recent relevant literature is synthesized to describe the mechanism of action of glutamine supplementation on valley exercise capacity,exercise recovery,and immune system.,in order to provide a reference for the study of the role of glutamine in human kinesiology.
引文
[1] Petry E R,Cruzat V F,Heck T G,et al. L-glutamine supplementations enhance liver glutamine-glutathione axis and heat shock factor-1 expression in endurance-exercise trained rats[J]. Int J Sport Nutr Exerc Metab,2015,25(2):188-197.
[2] Zuhl M N,Lanphere K R,Kravitz L,et al. Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression[J]. Journal of Applied Physiology,2014,116(2):183-191.
[3] Bunprajun,Tipwadee,Chatsudthipong,et al. Impact of physical activity on age-related insulin resistance:The contribution of posttranscriptional gene silencing[J]. Faseb Journal,2013,27(7):1093-1093.
[4] Newsholme P,Cruzat V,Arfuso F,et al. Nutrient regulation of insulin secretion and action[M]. S. Karger,2014.
[5]景洪江,程义勇,李树田,等.谷氨酸和谷氨酰胺对大鼠学习记忆的影响[J].卫生研究,2000,29(1):40-42.
[6]夏旭. Gln增加T2DM大鼠骨骼肌质量的探究[D]. Place:昆明理工大学,2017.
[7]张蕴琨,王斌,蒋晓玲,等.补充谷氨酰胺对大鼠力竭运动后血、脑游离色氨酸和脑5-羟色胺含量的影响[J].中国运动医学杂志,2004,23(6):634-638.
[8] J P,G W,M H,et al. Changes in neutrophil surface receptor expression,degranulation,and respiratory burst activity after moderateand high-intensity exercise[J]. Journal of applied physiology(Bethesda,Md:1985),2004,97(2):612-618.
[9]卢向阳,乔玉成,朱亮,等.谷氨酰胺与番茄红素抗运动性疲劳效果的比较研究[J].体育研究与教育,2015,6:106-110.
[10] Cruzat V F,Pantale2o L C,Jr D J,et al. Oral supplementations with free and dipeptide forms of L-glutamine in endotoxemic mice:effects on muscle glutamine-glutathione axis and heat shock proteins[J].Journal of Nutritional Biochemistry,2014,25(3):345-352.
[11] Song Q H,Xu R M,Zhang Q H,et al. Glutamine supplementation and immune function during heavy load training[J]. Int J Clin Pharmacol Ther,2015,53(5):372-376.
[12] Xue H,Slavov D,Wischmeyer P E. Glutamine-mediated Dual Regulation of Heat Shock Transcription Factor-1 Activation and Expression[J]. Journal of Biological Chemistry,2012,287(48):40400-40413.
[13] Dokladny K,Moseley P L,Ma T Y. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability[J]. American Journal of Physiology Gastrointestinal&Liver Physiology,2006,290(2):G204-G212.
[14] Wischmeyer P E,Riehm J,Singleton K D,et al. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells[J]. Nutrition,2003,19(1):1-6.
[2] Zuhl M N,Lanphere K R,Kravitz L,et al. Effects of oral glutamine supplementation on exercise-induced gastrointestinal permeability and tight junction protein expression[J]. Journal of Applied Physiology,2014,116(2):183-191.
[3] Bunprajun,Tipwadee,Chatsudthipong,et al. Impact of physical activity on age-related insulin resistance:The contribution of posttranscriptional gene silencing[J]. Faseb Journal,2013,27(7):1093-1093.
[4] Newsholme P,Cruzat V,Arfuso F,et al. Nutrient regulation of insulin secretion and action[M]. S. Karger,2014.
[5]景洪江,程义勇,李树田,等.谷氨酸和谷氨酰胺对大鼠学习记忆的影响[J].卫生研究,2000,29(1):40-42.
[6]夏旭. Gln增加T2DM大鼠骨骼肌质量的探究[D]. Place:昆明理工大学,2017.
[7]张蕴琨,王斌,蒋晓玲,等.补充谷氨酰胺对大鼠力竭运动后血、脑游离色氨酸和脑5-羟色胺含量的影响[J].中国运动医学杂志,2004,23(6):634-638.
[8] J P,G W,M H,et al. Changes in neutrophil surface receptor expression,degranulation,and respiratory burst activity after moderateand high-intensity exercise[J]. Journal of applied physiology(Bethesda,Md:1985),2004,97(2):612-618.
[9]卢向阳,乔玉成,朱亮,等.谷氨酰胺与番茄红素抗运动性疲劳效果的比较研究[J].体育研究与教育,2015,6:106-110.
[10] Cruzat V F,Pantale2o L C,Jr D J,et al. Oral supplementations with free and dipeptide forms of L-glutamine in endotoxemic mice:effects on muscle glutamine-glutathione axis and heat shock proteins[J].Journal of Nutritional Biochemistry,2014,25(3):345-352.
[11] Song Q H,Xu R M,Zhang Q H,et al. Glutamine supplementation and immune function during heavy load training[J]. Int J Clin Pharmacol Ther,2015,53(5):372-376.
[12] Xue H,Slavov D,Wischmeyer P E. Glutamine-mediated Dual Regulation of Heat Shock Transcription Factor-1 Activation and Expression[J]. Journal of Biological Chemistry,2012,287(48):40400-40413.
[13] Dokladny K,Moseley P L,Ma T Y. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability[J]. American Journal of Physiology Gastrointestinal&Liver Physiology,2006,290(2):G204-G212.
[14] Wischmeyer P E,Riehm J,Singleton K D,et al. Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells[J]. Nutrition,2003,19(1):1-6.