银屑胶囊联合阿维A治疗寻常型银屑病临床效果及对外周血T淋巴细胞免疫功能影响
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摘要
目的探讨银屑胶囊联合阿维A治疗寻常型银屑病的临床效果及对外周血T淋巴细胞免疫功能的影响。方法选取符合纳入及排除标准的寻常型银屑病88例,采用随机数字表法随机将其分为观察组及对照组两组各44例。观察组采用银屑胶囊联合阿维A治疗,对照组采用阿维A治疗。观察比较两组治疗前和治疗8周后银屑病皮肤损伤面积和银屑病严重程度指数(PASI)及外周血T淋巴细胞变化情况,治疗8周后临床效果,以及治疗过程中不良反应发生情况。结果治疗前,两组PASI及外周血T淋巴细胞比较差异均无统计学意义(P>0.05)。治疗8周后,两组PASI和CD8+均较治疗前降低,CD3+、CD4+及CD4+/CD8+均较治疗前升高,差异具有统计学意义(P<0.05)。治疗8周后,观察组PASI和CD8+低于对照组,CD3+、CD4+及CD4+/CD8+高于对照组,差异具有统计学意义(P<0.05)。治疗8周后,观察组总有效率为93.18%,对照组总有效率为72.27%,观察组明显高于对照组,差异具有统计学意义(P<0.05)。治疗过程中观察组出现恶心1例;对照组出现头痛1例,恶心2例。结论银屑胶囊联合阿维A治疗寻常型银屑病临床效果显著,可能通过改变外周血T淋巴细胞免疫功能失衡状态而发挥相关作用。
Objective To investigate clinical effect of Yinxie capsule combined with Acitretin in treatment of patients with psoriasis vulgaris and its effect on immune function of T lymphocytes in peripheral blood. Methods A total of 88 patients with psoriasis vulgaris,who had met in the admittance and exclusion criteria,were divided into control group( n = 44) and observation group( n = 44) by random number method. Observation group was treated with Yinxie capsule combined with Acitretin,while control group was treated with Acitretin. Psoriasis area and severity index( PASI) scores and T lymphocyte subsets in peripheral blood before and in 8 weeks after treatment,clinical efficacy in 8 weeks after treatment and incidence conditions of adverse reactions during course of treatment were observed and compared in two groups. Results There were no significant differences in PASI scores and T cell subsets in peripheral blood before treatment in two groups( P > 0.05). In 8 weeks after treatment,PASI scores and CD8+were significantly lower,while CD3 +,CD4 + and CD4 +/CD8 + levels were significantly higher than those before treatment in two groups( P < 0. 05); in observation group,PASI scores and CD8 + were significantly lower,while CD3+,CD4+ and CD4+/CD8+ levels were significantly higher than those in control group( P<0.05). The total effective rate in observation group( 93.18%) was significantly higher than 72.27% in control group( P<0.05). During the course of treatment,1 patient had nausea in observation group,while 1 patient with headache and 2 patients with nausea were found in control group. Conclusion Yinxie capsule combined with Acitretin in treatment of patients with psoriasis vulgaris may achieve well clinical effect,and it may play role by changing disequilibrium condition of T lymphocytes immune function in peripheral blood.
Objective To investigate clinical effect of Yinxie capsule combined with Acitretin in treatment of patients with psoriasis vulgaris and its effect on immune function of T lymphocytes in peripheral blood. Methods A total of 88 patients with psoriasis vulgaris,who had met in the admittance and exclusion criteria,were divided into control group( n = 44) and observation group( n = 44) by random number method. Observation group was treated with Yinxie capsule combined with Acitretin,while control group was treated with Acitretin. Psoriasis area and severity index( PASI) scores and T lymphocyte subsets in peripheral blood before and in 8 weeks after treatment,clinical efficacy in 8 weeks after treatment and incidence conditions of adverse reactions during course of treatment were observed and compared in two groups. Results There were no significant differences in PASI scores and T cell subsets in peripheral blood before treatment in two groups( P > 0.05). In 8 weeks after treatment,PASI scores and CD8+were significantly lower,while CD3 +,CD4 + and CD4 +/CD8 + levels were significantly higher than those before treatment in two groups( P < 0. 05); in observation group,PASI scores and CD8 + were significantly lower,while CD3+,CD4+ and CD4+/CD8+ levels were significantly higher than those in control group( P<0.05). The total effective rate in observation group( 93.18%) was significantly higher than 72.27% in control group( P<0.05). During the course of treatment,1 patient had nausea in observation group,while 1 patient with headache and 2 patients with nausea were found in control group. Conclusion Yinxie capsule combined with Acitretin in treatment of patients with psoriasis vulgaris may achieve well clinical effect,and it may play role by changing disequilibrium condition of T lymphocytes immune function in peripheral blood.
引文
[1]沈跃莉,叶俊儒.阿维A胶囊联合复方甘草酸苷片对寻常型银屑病患者症状的改善及安全性[J].医学综述,2016,22(17):3491-3493.
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[9]祁战涛.凉血解毒汤治疗寻常型银屑病的疗效观察[J].陕西中医,2016,37(8):1033-1034.
[10]贾宝珍,郭书萍,刘宏业.阿维A胶囊联合喜炎平治疗斑块型银屑病的临床观察及血清肿瘤坏死因子-α检测[J].中国药物与临床,2016,16(2):181-183.
[11]韩雪松,岳致丰,田坤,等.阿维A联合窄谱中波紫外线对寻常型银屑病疗效研究[J].海南医学院学报,2016,22(5):516-517,520.
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[13]王维宁,方栩,黄琼.注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合阿维A治疗中重度斑块状银屑病的疗效和安全性观察[J].中华皮肤科杂志,2016,49(4):292-293.
[14]韦斌,蒋祖玲.阿维A联合舒肤散熏洗治疗寻常型银屑病临床观察[J].中国中西医结合皮肤性病学杂志,2015,14(1):45-47.
[15]刘云贞,李春鸟.清热消肿洗剂熏蒸联合中医辨证论治口服中药治疗寻常型银屑病的疗效分析[J].陕西中医,2016,37(7):897-898.
[16]李鑫,刘丽娟,于亮.阿维A对寻常型银屑病树突状细胞活性的影响[J].中国麻风皮肤病杂志,2015,31(2):74-76.
[17]徐平,丁佩军,张慧敏.狼毒方熏洗联合复方青黛胶囊口服治疗寻常型银屑病血热证31例临床观察[J].中医杂志,2016,57(22):1943-1945.
[18]初金玉,刘丽英,鄂佳,等.银屑胶囊联合复方氟米松软膏治疗寻常型银屑病的临床观察[J].中国药房,2016,27(26):3665-3667.
[19]刘春平,陈强,赵淑肖.复方甘草甜素和紫丹银屑胶囊联合治疗银屑病[J].中华皮肤科杂志,2005,38(3):180.
[20]周艳,韩丹,牟宽厚,等.阿维A联合雷公藤及他卡西醇软膏治疗中重度银屑病的临床疗效[J].山西医科大学学报,2015,46(6):579-582.
[21]何梅芳,张衍波,刘博武,等.温泉泥疗及中药蒸汽浴结合阿维A治疗银屑病患者疗效观察与护理[J].中华保健医学杂志,2013,15(4):332-334.
[22]解翠林,付曼妮.消银颗粒联合阿维A治疗寻常型银屑病的临床研究[J].现代药物与临床,2016,31(11):1834-1837.
[2]祁战涛,杨靖,王少博,等.凉血活血汤联合阿维A胶囊治疗银屑病的临床疗效及其机制研究[J].现代生物医学进展,2016,16(27):5283-5286.
[3]彭丹,席建元,祁林,等.银屑平丸联合阿维A胶囊治疗寻常型银屑病的疗效观察[J].中国中西医结合皮肤性病学杂志,2015,14(1):41-42.
[4]范瑞,多克·多丽娜,王峰.银屑胶囊致严重肝损害1例[J].中国医院药学杂志,2017,37(7):671-672.
[5]李月梅,冯育洁.银屑胶囊联合复方氨肽素片治疗寻常型银屑病临床观察[J].中华皮肤科杂志,2011,44(8):602.
[6]王俊伟,张斌,高丽,等.银屑胶囊联合阿维A治疗寻常型银屑病患者的疗效及对血清IL-4、IL-10和INF-γ的影响[J].中国中西医结合皮肤性病学杂志,2017,16(2):116-118.
[7]房慧媚,詹庆霞,王红梅,等.中药治疗寻常型银屑病的Meta分析[J].中国中西医结合皮肤性病学杂志,2016,15(2):83-88.
[8]周素荣,邵娟,夏秀娟,等.不同季节就诊的寻常型银屑病患者病情严重程度及危险因素分析[J].国际皮肤性病学杂志,2015,41(3):147-148.
[9]祁战涛.凉血解毒汤治疗寻常型银屑病的疗效观察[J].陕西中医,2016,37(8):1033-1034.
[10]贾宝珍,郭书萍,刘宏业.阿维A胶囊联合喜炎平治疗斑块型银屑病的临床观察及血清肿瘤坏死因子-α检测[J].中国药物与临床,2016,16(2):181-183.
[11]韩雪松,岳致丰,田坤,等.阿维A联合窄谱中波紫外线对寻常型银屑病疗效研究[J].海南医学院学报,2016,22(5):516-517,520.
[12]吴超,晋红中.寻常型银屑病合并手指Bowen病一例[J].中国医学科学院学报,2015,37(5):631-632.
[13]王维宁,方栩,黄琼.注射用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白联合阿维A治疗中重度斑块状银屑病的疗效和安全性观察[J].中华皮肤科杂志,2016,49(4):292-293.
[14]韦斌,蒋祖玲.阿维A联合舒肤散熏洗治疗寻常型银屑病临床观察[J].中国中西医结合皮肤性病学杂志,2015,14(1):45-47.
[15]刘云贞,李春鸟.清热消肿洗剂熏蒸联合中医辨证论治口服中药治疗寻常型银屑病的疗效分析[J].陕西中医,2016,37(7):897-898.
[16]李鑫,刘丽娟,于亮.阿维A对寻常型银屑病树突状细胞活性的影响[J].中国麻风皮肤病杂志,2015,31(2):74-76.
[17]徐平,丁佩军,张慧敏.狼毒方熏洗联合复方青黛胶囊口服治疗寻常型银屑病血热证31例临床观察[J].中医杂志,2016,57(22):1943-1945.
[18]初金玉,刘丽英,鄂佳,等.银屑胶囊联合复方氟米松软膏治疗寻常型银屑病的临床观察[J].中国药房,2016,27(26):3665-3667.
[19]刘春平,陈强,赵淑肖.复方甘草甜素和紫丹银屑胶囊联合治疗银屑病[J].中华皮肤科杂志,2005,38(3):180.
[20]周艳,韩丹,牟宽厚,等.阿维A联合雷公藤及他卡西醇软膏治疗中重度银屑病的临床疗效[J].山西医科大学学报,2015,46(6):579-582.
[21]何梅芳,张衍波,刘博武,等.温泉泥疗及中药蒸汽浴结合阿维A治疗银屑病患者疗效观察与护理[J].中华保健医学杂志,2013,15(4):332-334.
[22]解翠林,付曼妮.消银颗粒联合阿维A治疗寻常型银屑病的临床研究[J].现代药物与临床,2016,31(11):1834-1837.