原发性肝癌中西医结合治疗及危险因素研究现状
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摘要
原发性肝癌是我国常见的恶性肿瘤之一,具有发病率高、病情进展快、易反复发作、病灶易转移等特点,且病死率较高。诱发原发性肝癌发病的因素较多,如遗传因素、环境污染、病毒性肝炎、肝硬化等。手术是治疗原发性肝癌的有效方法,但大多患者确诊时已属肝癌晚期,失去手术治疗的最佳时机,因此需要联合其他方法治疗。中医认为原发性肝癌属"积聚"范畴,中医在治疗方面有良好优势,同时联合西医治疗,效果显著。本文针对近年原发性肝癌的危险因素调查情况及中西医治疗情况作一综述。
Primary liver cancer is one of the most common malignant tumors in China,which is characterized by high incidence,rapid progression,easy recurrence,easy metastasis and high mortality. There are many factors inducing the incidence of primary liver cancer,such as genetic factors,environmental pollution,viral hepatitis,cirrhosis and so on. Surgery is an effective method for the treatment of primary liver cancer,but when most of the patients are diagnosed with advanced liver cancer,they have lost the best opportunity for surgical treatment. Therefore,it is necessary to combine the treatment western medicine with traditional Chinese medicine.Traditional Chinese medicine believes that primary liver cancer belongs to the category of "accumulation",and traditional Chinese medicine has good advantages in the treatment. When Traditional Chinese medicine is combined with western medicine treatment,the effect is remarkable. This article reviews the investigation of risk factors of primary liver cancer and the treatment of traditional Chinese and western medicine in recent years.
Primary liver cancer is one of the most common malignant tumors in China,which is characterized by high incidence,rapid progression,easy recurrence,easy metastasis and high mortality. There are many factors inducing the incidence of primary liver cancer,such as genetic factors,environmental pollution,viral hepatitis,cirrhosis and so on. Surgery is an effective method for the treatment of primary liver cancer,but when most of the patients are diagnosed with advanced liver cancer,they have lost the best opportunity for surgical treatment. Therefore,it is necessary to combine the treatment western medicine with traditional Chinese medicine.Traditional Chinese medicine believes that primary liver cancer belongs to the category of "accumulation",and traditional Chinese medicine has good advantages in the treatment. When Traditional Chinese medicine is combined with western medicine treatment,the effect is remarkable. This article reviews the investigation of risk factors of primary liver cancer and the treatment of traditional Chinese and western medicine in recent years.
引文
[1]张俊雅,温晓斐,闫鹏,等.原发性肝癌的介入治疗现状与进展[J].现代生物医学进展,2016,16(29):5797-5800.
[2] Xi SY,Minuk GY. Role of traditional Chinese medicine in the management of patients with hepatocellular carcinoma[J].World J Hepatol,2018,10(11):799-806.
[3] Qiao DD,Yang J,Lei XF,et al. Expression of microRNA-122and microRNA-22 in HBV-related liver cancer and the correlation with clinical features[J]. Eur Rev Med Pharmacol Sci,2017,21(4):742-747.
[4]赵荣荣,邓永东,袁宏. 236例原发性肝癌患者流行病学及临床特点分析[J].临床肝胆病杂志,2016,32(8):1538-1542.
[5]鲁笑欣,张春燕,黄天壬,等. 2004~2013年广西6201例原发性肝癌患者乙肝和丙肝病毒感染情况分析[J].山东医药,2015,55(14):35-37.
[6]张明媛,牛俊奇.东方国家原发性肝癌发病趋势及影响因素[J].临床肝胆病杂志,2018,34(7):1399-1402.
[7]黄新,许觉彬,陈玲玲,等. 2型糖尿病及胰岛素抵抗与HBV相关性肝癌的关系[J].临床医药文献电子杂志,2018,5(79):29-30.
[8]刘海行,王健松,张慧英,等.糖尿病与肝癌发生关系的前瞻性研究荟萃分析[J].中国冶金工业医学杂志,2014,31(6):621-623.
[9]王星,顾明君,马俊花. 2型糖尿病患者血糖控制水平与原发性肝癌发生的相关性研究[J].实用癌症杂志,2016,1(12):1967-1969.
[10]方孔雄,农秋峰,陆雪明,等.广西隆安县2006-2014年原发性肝癌回顾性调查研究[J].中华疾病控制杂志,2016,20(9):932-935.
[11]薛常镐,钟文玲,陈铁晖,等.同安区居民饮用水污染与原发性肝癌关系的调查[J].海峡预防医学杂志,1998,9(4):14.
[12]陈璐,王文萍.中西医结合治疗原发性肝癌概况[J].实用中医内科杂志,2016,30(9):119-121.
[13]钟文洲,陈正义,王齐全.原发性肝癌发病危险因素的病例对照分析[J].安徽医药,2014,18(2):275-277.
[14] Ajmera VH,Terrault NA,Harrison SA. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review[J]. Hepatology,2017,65(6):2090-2099.
[15]何娜娜,王冬梅,张新军.补肾健脾方联合扶正抑瘤方治疗原发性肝癌术后疗效及对血清免疫因子水平的影响[J].现代中西医结合杂志,2017,26(21):2309-2311.
[16]何玲玲,赵亚林,杜林林,等.益气养阴扶正法治疗原发性肝癌[J].中医学报,2015,30(7):931-933.
[17]骆红霞,李进,李月翠,等.白虎汤对原发性肝癌TACE术后患者MMP-1、MMP-3、MMP-9蛋白酶的影响及其临床意义[J].中华中医药学刊,2016,34(2):380-383.
[18]曾玉丹.中医膏方调理原发性肝癌射波刀治疗术后临床观察及护理体会[J].河北中医,2016,38(2):278-280.
[19]赵增虎,王明贤,李海,等.益气活血中药对原发性肝癌三维适形放疗肝脏微循环影响的研究[J].中国中西医结合消化杂志,2014,22(7):381-383.
[20]张杨,孙立哲,刘宝刚,等.中西医联合放化疗对原发性肝癌患者疗效及转移相关因子的影响[J].湖南中医药大学学报,2017,37(2):188-191.
[21]蒋满红.常规化疗联合中医药疏肝化瘀方案对原发性肝癌的临床效果[J].实用癌症杂志,2016,31(8):1329-1331.
[22]林宝琪,林丽珠.舒尼替尼联合中药治疗肝细胞癌术后复发并多发转移1例[J].中国中西医结合杂志,2016,36(10):1271-1274.
[23]吴越,杨本强,刘文源,等.中药联合索拉非尼治疗中晚期原发性肝癌的疗效评价[J].中国临床实用医学,2016,7(2):3-5.
[2] Xi SY,Minuk GY. Role of traditional Chinese medicine in the management of patients with hepatocellular carcinoma[J].World J Hepatol,2018,10(11):799-806.
[3] Qiao DD,Yang J,Lei XF,et al. Expression of microRNA-122and microRNA-22 in HBV-related liver cancer and the correlation with clinical features[J]. Eur Rev Med Pharmacol Sci,2017,21(4):742-747.
[4]赵荣荣,邓永东,袁宏. 236例原发性肝癌患者流行病学及临床特点分析[J].临床肝胆病杂志,2016,32(8):1538-1542.
[5]鲁笑欣,张春燕,黄天壬,等. 2004~2013年广西6201例原发性肝癌患者乙肝和丙肝病毒感染情况分析[J].山东医药,2015,55(14):35-37.
[6]张明媛,牛俊奇.东方国家原发性肝癌发病趋势及影响因素[J].临床肝胆病杂志,2018,34(7):1399-1402.
[7]黄新,许觉彬,陈玲玲,等. 2型糖尿病及胰岛素抵抗与HBV相关性肝癌的关系[J].临床医药文献电子杂志,2018,5(79):29-30.
[8]刘海行,王健松,张慧英,等.糖尿病与肝癌发生关系的前瞻性研究荟萃分析[J].中国冶金工业医学杂志,2014,31(6):621-623.
[9]王星,顾明君,马俊花. 2型糖尿病患者血糖控制水平与原发性肝癌发生的相关性研究[J].实用癌症杂志,2016,1(12):1967-1969.
[10]方孔雄,农秋峰,陆雪明,等.广西隆安县2006-2014年原发性肝癌回顾性调查研究[J].中华疾病控制杂志,2016,20(9):932-935.
[11]薛常镐,钟文玲,陈铁晖,等.同安区居民饮用水污染与原发性肝癌关系的调查[J].海峡预防医学杂志,1998,9(4):14.
[12]陈璐,王文萍.中西医结合治疗原发性肝癌概况[J].实用中医内科杂志,2016,30(9):119-121.
[13]钟文洲,陈正义,王齐全.原发性肝癌发病危险因素的病例对照分析[J].安徽医药,2014,18(2):275-277.
[14] Ajmera VH,Terrault NA,Harrison SA. Is moderate alcohol use in nonalcoholic fatty liver disease good or bad? A critical review[J]. Hepatology,2017,65(6):2090-2099.
[15]何娜娜,王冬梅,张新军.补肾健脾方联合扶正抑瘤方治疗原发性肝癌术后疗效及对血清免疫因子水平的影响[J].现代中西医结合杂志,2017,26(21):2309-2311.
[16]何玲玲,赵亚林,杜林林,等.益气养阴扶正法治疗原发性肝癌[J].中医学报,2015,30(7):931-933.
[17]骆红霞,李进,李月翠,等.白虎汤对原发性肝癌TACE术后患者MMP-1、MMP-3、MMP-9蛋白酶的影响及其临床意义[J].中华中医药学刊,2016,34(2):380-383.
[18]曾玉丹.中医膏方调理原发性肝癌射波刀治疗术后临床观察及护理体会[J].河北中医,2016,38(2):278-280.
[19]赵增虎,王明贤,李海,等.益气活血中药对原发性肝癌三维适形放疗肝脏微循环影响的研究[J].中国中西医结合消化杂志,2014,22(7):381-383.
[20]张杨,孙立哲,刘宝刚,等.中西医联合放化疗对原发性肝癌患者疗效及转移相关因子的影响[J].湖南中医药大学学报,2017,37(2):188-191.
[21]蒋满红.常规化疗联合中医药疏肝化瘀方案对原发性肝癌的临床效果[J].实用癌症杂志,2016,31(8):1329-1331.
[22]林宝琪,林丽珠.舒尼替尼联合中药治疗肝细胞癌术后复发并多发转移1例[J].中国中西医结合杂志,2016,36(10):1271-1274.
[23]吴越,杨本强,刘文源,等.中药联合索拉非尼治疗中晚期原发性肝癌的疗效评价[J].中国临床实用医学,2016,7(2):3-5.