早孕因子及其临床应用研究进展
摘要
早孕因子是一种与妊娠相关的微量蛋白,已广泛应用于动物的早期妊娠诊断中。目前,国内外学者通过动物体内的血液对早孕因子的生理生化特点及检测方法进行了大量的研究。随着养殖业的不断发展,通过早孕因子可以尽早地鉴定出妊娠母畜,以便降低空怀率,节约饲养成本,由此可见,早孕因子的检测对生产实践具有重大意义。文章主要阐述了早孕因子的理化性质、作用机制及临床应用,并对其在家畜早孕诊断方面的应用前景进行了展望。
引文
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[13] 练玉银, 吴晓亮, 王家骥,等. 鼠抗早孕因子单克隆抗体的制备及鉴定[J]. 中国热带医学, 2012, 12(5):532-534.
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[15] SOHEILA A, IMAN M, AZADEH A, et al. Ovarian malignant mixed germ cell tumor: a case of unusual presentation as molar pregnancy[J]. J Reprod Infertil,2016, 17(2):133-136.
[16] THIEL S, LANGERGOULD A, ROCKHOFF M, et al. Interferon-beta exposure during first trimester is safe in women with multiple sclerosis-a prospective cohort study from the german multiple sclerosis and pregnancy registry[J]. Mult Scler, 2016, 22(6):12.
[17] 刘静静, 王思伟, 董世伟,等. 绵羊早孕因子重组蛋白在大肠杆菌中的高效表达[J]. 中国草食动物科学, 2014(s1):199-200.
[18] CHILL H H, MALYANKER N, KARAVANI G, et al. Association between uterine position and transvaginal misoprostol treatment for early pregnancy failure[J]. J Obstet Gynaecol Res, 2018,44(2):248-252.
[19] 刘云. 基于早孕因子检测的奶牛早孕诊断ELISA方法的建立[D]. 石河子:石河子大学, 2015.
[2] CHENG S J, ZHENG Z Q. Early pregnancy factor in cervical mucus of pregnant women[J]. Am J Reprod Immunol, 2015, 51(2):102-105.
[3] OHNUMA K, YOKOO M, ITO K, et al. Study of early pregnancy factor (EPF) in Equine (Equus caballus)[J]. Am J Reprod Immunol, 2015, 43(3):174-179.
[4] GAO Q, HE G, ZHANG L, et al. Activity and distribution of plasma platelet-activating factor acetylhydrolase in women with gestational diabetes mellitus and their neonates[J]. Diabetes Metab Res Rev, 2016, 32(6):634-642.
[5] ZHANG L Y, MI H, YAN J K, et al. Pregnancy-associated changes in expression of progesterone receptor and progesterone-induced blocking factor genes in bone marrow of ewes[J]. Anim Reprod Sci,2017,186:77-84.
[6] KAWAMURA K, FUKUDA J, KUMAGAI J, et al. Chaperonin 10 in the rat oocytes and early embryos: its expression and activity for early pregnancy factor[J]. Am J Reprod Immunol, 2015, 44(4):242-248.
[7] SPENCER T E, FORDE N, LONERGAN P. The role of progesterone and conceptus-derived factors in uterine biology during early pregnancy in ruminants [J]. J Dairy Sci, 2016, 99(7):5941-5950.
[8] QU L M, WANG S H, YANG K, et al. CD4+ Foxp3+ CD25+/- Tregs characterize liver tissue specimens of patients suffering from drug-induced autoimmune hepatitis: a clinical-pathological study[J]. Hepatobiliary Pancreat Dis Int, 2018,17(2):133-139.
[9] WANG W J, LIU F J, ZHANG X, et al. Periodic elevation of regulatory T cells on the day of embryo transfer is associated with better in vitro fertilization outcome[J]. J Reprod Immunol, 2017, 119:49-53.
[10] YU L L, ZHANG Y H, ZHAO F X. Expression of indoleamine 2,3-dioxygenase in pregnant mice correlates with CD4+ CD25+ Foxp3+ T regulatory cells[J]. Eur Rev Med Pharmacol Sci, 2017, 21(8):1722.
[11] QIAN J, ZHANG N, LIN J, et al. Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion[J]. Biosci Trends, 2018,12(2):157-167.
[12] 林燕棉. 恶性生殖系统肿瘤组织中EPF的表达及EPF-McAb对生殖肿瘤细胞增殖的影响[D]. 广州:广州医科大学, 2015.
[13] 练玉银, 吴晓亮, 王家骥,等. 鼠抗早孕因子单克隆抗体的制备及鉴定[J]. 中国热带医学, 2012, 12(5):532-534.
[14] GUPTA M, SAINI V. Germ cell tumors and their association with pregnancy[M].Ger Cell,2018,6:124-146.
[15] SOHEILA A, IMAN M, AZADEH A, et al. Ovarian malignant mixed germ cell tumor: a case of unusual presentation as molar pregnancy[J]. J Reprod Infertil,2016, 17(2):133-136.
[16] THIEL S, LANGERGOULD A, ROCKHOFF M, et al. Interferon-beta exposure during first trimester is safe in women with multiple sclerosis-a prospective cohort study from the german multiple sclerosis and pregnancy registry[J]. Mult Scler, 2016, 22(6):12.
[17] 刘静静, 王思伟, 董世伟,等. 绵羊早孕因子重组蛋白在大肠杆菌中的高效表达[J]. 中国草食动物科学, 2014(s1):199-200.
[18] CHILL H H, MALYANKER N, KARAVANI G, et al. Association between uterine position and transvaginal misoprostol treatment for early pregnancy failure[J]. J Obstet Gynaecol Res, 2018,44(2):248-252.
[19] 刘云. 基于早孕因子检测的奶牛早孕诊断ELISA方法的建立[D]. 石河子:石河子大学, 2015.