胃癌组织中癌胚抗原检测及应用的研究进展
摘要
癌胚抗原(CEA)作为肿瘤标志物已被广泛应用于胃癌研究中,CEA在胃癌患者的血清、胃液、腹水、腹腔冲洗液中的表达国内外有较多的研究,本文对CEA在胃良性组织及胃癌不同部位癌组织中表达及应用的研究进展做一综述。
引文
[1]Gold P,Freedman SO.Demonstration of tumor-specific antigens in human colonic carcinoma by immunological tolerance and absorption techniques[J].J Exp Med,1965,121:439-462.
[2]Gonda G,Bajtai A,Nagy P,et al.Quantitative analysis of p53 expression and cell proliferation in gastric carcinomas.An immunohistochemical study[J].Hepatogastroenterology,2004,51(55):273-276.
[3]吴继锋,杨光霖.胃痛癌胚抗原与其组织发生关系的研究[J].中华肿瘤杂志,1992,14(1):13.
[4]王竹君,李玲,孙宝信,等.良、恶性胃病变组织表达CEA mRNA的差别[J].中国医药导报,2007,24(8):16-17.
[5]卢艺涛,张钢峰,高静,等.早期胃癌与胃组织匀浆中癌胚抗原及胃癌单克隆抗体的关系探讨[J].中国中西医结合消化杂志.2002,10(6):358.
[6]吕新生.实用临床普通外科学[M].长沙:中南大学出版社,2006:944.
[7]吴在德.外科学[M].第6版.北京:人民卫生出版社,2004:305-315.
[8]Yokota T,Ishiyama S,Saito T,et al.Lymph node metastasis as a significant prognostic factor in gastric cancer:a multiple logistic regression analysis[J].Scand J Gastroenterol,2004,39(4):380-384.
[9]崔锐.肿瘤标志物的临床应用[J].医师进修杂志,1999,22(2):60.
[10]胡东升.CEA的免疫组化染色对判断胃癌侵袭范围的价值[J].河南肿瘤学杂志,1997,10(1):16-17.
[11]Hockey MS,Strokes HJ,Thompson H,et al.Carcinoembryonic antigen(CEA)expression and heterogeneity in primary and autologous metastatic gastric tumors demonstrated by a monoclonal antibody[J].Br J Cancer,1984,49(2):129-133.
[12]王海燕,姚桂芹,高佩增,等.CA242,CEA,CA19-9在胃癌及癌前病变组织中表达的相关研究[J].临床消化病杂志,2005,17(6):279-281.
[13]Miyazono F,Takao S,Natsugoe S,et al.Molecular detection of circulating cancer cells during surgery in patients with billiard-pancreatic cancer[J].Am J Surg,1999,177(6):475-479.
[14]Kijima F,Natsugos S,Takao S,et al.Detection and clinical significance of lymph node micrometastasis determined by reverse transcription-polymerase chain reation in patients with esophageal carcinoma[J].Oncology,2000,58(1):38-44.
[15]Gerhard M,Juhl H,Kalthoff H,et al.Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction[J].J Clin Oncol,1994,12(4):725-729.
[16]薛承岩,梁岩,李桂洁.癌胚抗原mRNA在消化系统肿瘤时表达情况的观察[J].世界华人消化杂志,2000,8(9):59.
[17]薛承岩,梁岩,孙宝信,等.消化道恶性肿瘤组织癌胚抗原mRNA表达情况的检测[J].中国癌症杂志,2001,11(3):259-261.
[18]赵德清.检测大肠癌患者血CEA mRNA和CK19 mRNA的临床意义[D].杭州:浙江大学,2002.
[19]Cerhard M,Juhi H,Kalthoff H,et al.Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction[J].J Clin Oncol,1994,12(4):725-729.
[20]Oki E,Maehara Y,Tokunaga E,et al.Detection of disseminated cancer cells in bone marrow of gastric cancer using real time quantitative reverse transcriptase polymerase chain reaction[J].Cancer Lett,2002,188(1-2):191-198.
[21]Kwon SJ,Kim GS.Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach[J].Br J Surg,1996,83(11):1 600-1 603.
[22]Baba H,Maehara Y,Takeuchi H,et al.Effect of lymph node dissection on the prognosis in patients with node-negative early gastric cancer[J].Surgery,1995,117(2):165-169.
[23]Mori M,Mimori K,Ueo H,et al.Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas[J].J Clin Oncol,1998,16(1):128.
[24]Kubota K,Nakanishi H,Hiki N,et al.Quantitative detection of micrometastasis in the lymph nodes of gastric cancer patients with real-time RT-PCR:a comparative study with immunohistochemistry[J].Int J Cancer,2003,105(1):136-143.
[25]Ajisaka H,Miwa K.Micrometastases in sentinel nodes of gastric cancer[J].Br J Cancer,2003,89(4):676-680.
[26]Carlini M,Carboni F,Petric M,et al.Sentinel node in gastric cancer surgery[J].J Exp Clin Cancer Res,2002,21(4):469-473.
[27]Okada Y,Fujiwara Y,Yamamoto H,et al.Genetic detection of lymph node micrometastasis in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay[J].Cancer,2001,92(8):2 056-2 064.
[28]Tsujitani S,Oka S,Suzuki K,et al.Prognostic factors in patients with advanced gastric cancer treated by noncurative resection:a multivariate analysis[J].Hepatogastroenterology,2001,48(41):1 504-1 508.
[29]Yoo CH,Noh SH,Shin DW,et al.Recurrence following curative resection for gastric carcinoma[J].Br J Surg,2000,87(2):236-242.
[30]Kodera Y,Nakanishi H,Ito S,et al.Quantitative detection of disseminated cancer cells in the greater omentum of gastric carcinoma patients with real-time RT-PCR:a comparison with peritoneal lavage cytology[J].Gastric Cancer,2002,5(2):69-76.
[31]Ueno H,Yoshida K,Hirai T,et al.Quantitative detection of carcinoembryonic antigen messenger RNA in the peritoneal cavity of gastric cancer patients by real-time quantitative reverse transcription polymerase chain reaction[J].Anticancer Res,2003,23(2C):1 701-1 708.
[32]Sakakura C,Hagiwara A,Shirasu M,et al.Polymerase chain reaction for detection of carcinoembryonic antigen-expressing tumor cells on milky spots of the greater omentum in gastric cancer patients:a pilot study[J].Int J Cancer,2001,95(5):286-289.
[33]李海林,李永春,王维,等.胃癌胰腺被膜微转移的研究[J].中国普通外科杂志,2011,20(9):963-966.
[2]Gonda G,Bajtai A,Nagy P,et al.Quantitative analysis of p53 expression and cell proliferation in gastric carcinomas.An immunohistochemical study[J].Hepatogastroenterology,2004,51(55):273-276.
[3]吴继锋,杨光霖.胃痛癌胚抗原与其组织发生关系的研究[J].中华肿瘤杂志,1992,14(1):13.
[4]王竹君,李玲,孙宝信,等.良、恶性胃病变组织表达CEA mRNA的差别[J].中国医药导报,2007,24(8):16-17.
[5]卢艺涛,张钢峰,高静,等.早期胃癌与胃组织匀浆中癌胚抗原及胃癌单克隆抗体的关系探讨[J].中国中西医结合消化杂志.2002,10(6):358.
[6]吕新生.实用临床普通外科学[M].长沙:中南大学出版社,2006:944.
[7]吴在德.外科学[M].第6版.北京:人民卫生出版社,2004:305-315.
[8]Yokota T,Ishiyama S,Saito T,et al.Lymph node metastasis as a significant prognostic factor in gastric cancer:a multiple logistic regression analysis[J].Scand J Gastroenterol,2004,39(4):380-384.
[9]崔锐.肿瘤标志物的临床应用[J].医师进修杂志,1999,22(2):60.
[10]胡东升.CEA的免疫组化染色对判断胃癌侵袭范围的价值[J].河南肿瘤学杂志,1997,10(1):16-17.
[11]Hockey MS,Strokes HJ,Thompson H,et al.Carcinoembryonic antigen(CEA)expression and heterogeneity in primary and autologous metastatic gastric tumors demonstrated by a monoclonal antibody[J].Br J Cancer,1984,49(2):129-133.
[12]王海燕,姚桂芹,高佩增,等.CA242,CEA,CA19-9在胃癌及癌前病变组织中表达的相关研究[J].临床消化病杂志,2005,17(6):279-281.
[13]Miyazono F,Takao S,Natsugoe S,et al.Molecular detection of circulating cancer cells during surgery in patients with billiard-pancreatic cancer[J].Am J Surg,1999,177(6):475-479.
[14]Kijima F,Natsugos S,Takao S,et al.Detection and clinical significance of lymph node micrometastasis determined by reverse transcription-polymerase chain reation in patients with esophageal carcinoma[J].Oncology,2000,58(1):38-44.
[15]Gerhard M,Juhl H,Kalthoff H,et al.Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction[J].J Clin Oncol,1994,12(4):725-729.
[16]薛承岩,梁岩,李桂洁.癌胚抗原mRNA在消化系统肿瘤时表达情况的观察[J].世界华人消化杂志,2000,8(9):59.
[17]薛承岩,梁岩,孙宝信,等.消化道恶性肿瘤组织癌胚抗原mRNA表达情况的检测[J].中国癌症杂志,2001,11(3):259-261.
[18]赵德清.检测大肠癌患者血CEA mRNA和CK19 mRNA的临床意义[D].杭州:浙江大学,2002.
[19]Cerhard M,Juhi H,Kalthoff H,et al.Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction[J].J Clin Oncol,1994,12(4):725-729.
[20]Oki E,Maehara Y,Tokunaga E,et al.Detection of disseminated cancer cells in bone marrow of gastric cancer using real time quantitative reverse transcriptase polymerase chain reaction[J].Cancer Lett,2002,188(1-2):191-198.
[21]Kwon SJ,Kim GS.Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach[J].Br J Surg,1996,83(11):1 600-1 603.
[22]Baba H,Maehara Y,Takeuchi H,et al.Effect of lymph node dissection on the prognosis in patients with node-negative early gastric cancer[J].Surgery,1995,117(2):165-169.
[23]Mori M,Mimori K,Ueo H,et al.Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas[J].J Clin Oncol,1998,16(1):128.
[24]Kubota K,Nakanishi H,Hiki N,et al.Quantitative detection of micrometastasis in the lymph nodes of gastric cancer patients with real-time RT-PCR:a comparative study with immunohistochemistry[J].Int J Cancer,2003,105(1):136-143.
[25]Ajisaka H,Miwa K.Micrometastases in sentinel nodes of gastric cancer[J].Br J Cancer,2003,89(4):676-680.
[26]Carlini M,Carboni F,Petric M,et al.Sentinel node in gastric cancer surgery[J].J Exp Clin Cancer Res,2002,21(4):469-473.
[27]Okada Y,Fujiwara Y,Yamamoto H,et al.Genetic detection of lymph node micrometastasis in patients with gastric carcinoma by multiple-marker reverse transcriptase-polymerase chain reaction assay[J].Cancer,2001,92(8):2 056-2 064.
[28]Tsujitani S,Oka S,Suzuki K,et al.Prognostic factors in patients with advanced gastric cancer treated by noncurative resection:a multivariate analysis[J].Hepatogastroenterology,2001,48(41):1 504-1 508.
[29]Yoo CH,Noh SH,Shin DW,et al.Recurrence following curative resection for gastric carcinoma[J].Br J Surg,2000,87(2):236-242.
[30]Kodera Y,Nakanishi H,Ito S,et al.Quantitative detection of disseminated cancer cells in the greater omentum of gastric carcinoma patients with real-time RT-PCR:a comparison with peritoneal lavage cytology[J].Gastric Cancer,2002,5(2):69-76.
[31]Ueno H,Yoshida K,Hirai T,et al.Quantitative detection of carcinoembryonic antigen messenger RNA in the peritoneal cavity of gastric cancer patients by real-time quantitative reverse transcription polymerase chain reaction[J].Anticancer Res,2003,23(2C):1 701-1 708.
[32]Sakakura C,Hagiwara A,Shirasu M,et al.Polymerase chain reaction for detection of carcinoembryonic antigen-expressing tumor cells on milky spots of the greater omentum in gastric cancer patients:a pilot study[J].Int J Cancer,2001,95(5):286-289.
[33]李海林,李永春,王维,等.胃癌胰腺被膜微转移的研究[J].中国普通外科杂志,2011,20(9):963-966.