老年2型糖尿病患者基础胰岛素门诊治疗的临床观察
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摘要
目的观察老年2型糖尿病患者基础胰岛素门诊治疗的临床疗效。方法选取本院糖尿病门诊口服降糖药治疗不佳的90例老年2型糖尿病患者作为观察对象,均分为观察组和对照组,两组均服用格列美脲,观察组皮下注射甘精胰岛素,对照组皮下注射地特胰岛素,治疗周期为6个月。结果治疗后,两组组内比较FBG、2hPBG、HbA1c均明显低于治疗前(P<0.05);治疗后,对照组FBG明显的低于观察组(P<0.05),两组2hPBG、HbA1c比较均无显著性差异(P>0.05);两组低血糖发生率无显著性差异(P>0.05),对照组胰岛素用量明显的低于观察组(P<0.05)。结论口服降糖药控制不佳的老年2型糖尿病患者,采用格列美脲联合甘精胰岛素或地特胰岛素治疗均能有效控制血糖,安全性好,后者胰岛素用量更少。
Objective Observation of elderly patients with type 2 diabetes mellitus insulin outpatient treatment clinical curative effect. Methods Choose our poor oral medications to treat 90 cases of diabetes clinics in elderly patients with type 2 diabetes as research object, were divided into observation group and control group, Two groups are taking Glenn beauty urea, observation group of subcutaneous insulin injection, the control group in subcutaneous injection of insulin, treatment period is 6 months. Results After treatment, the comparison of FBG, 2 HPBG, HbA1 c within two way were significantly lower than before treatment(P < 0.05); After treatment, the control of FBG obviously is lower than the observation group(P < 0.05), two groups of 2 HPBG, HbA1 c comparison there was no significant difference(P > 0.05); Two groups the incidence of hypoglycaemia there was no significant difference(P > 0.05),obviously lower than control group insulin group(P < 0.05). Conclusion Oral medications poorly controlled in elderly patients with type 2 diabetes, Glenn beauty urea joint insulin or to insulin treatment can effectively control blood sugar, good security, the latter less dosage of insulin.
Objective Observation of elderly patients with type 2 diabetes mellitus insulin outpatient treatment clinical curative effect. Methods Choose our poor oral medications to treat 90 cases of diabetes clinics in elderly patients with type 2 diabetes as research object, were divided into observation group and control group, Two groups are taking Glenn beauty urea, observation group of subcutaneous insulin injection, the control group in subcutaneous injection of insulin, treatment period is 6 months. Results After treatment, the comparison of FBG, 2 HPBG, HbA1 c within two way were significantly lower than before treatment(P < 0.05); After treatment, the control of FBG obviously is lower than the observation group(P < 0.05), two groups of 2 HPBG, HbA1 c comparison there was no significant difference(P > 0.05); Two groups the incidence of hypoglycaemia there was no significant difference(P > 0.05),obviously lower than control group insulin group(P < 0.05). Conclusion Oral medications poorly controlled in elderly patients with type 2 diabetes, Glenn beauty urea joint insulin or to insulin treatment can effectively control blood sugar, good security, the latter less dosage of insulin.
引文
[1]杨咏梅,陶丽珍.地特胰岛素联合阿卡波糖治疗初诊老年2型糖尿病效果观察[J].山东医药,2016,56(22):72-73.
[2]徐文博,孙晓晶.老年2型糖尿病病人自我护理能力及社会支持与生存质量的相关性[J].中国老年学杂志,2013,33(10):2342-2344.
[3]李伟芳,李华,董捷,等.老年2型糖尿病慢性并发症发病时间及危险因素分析[J].中国全科医学,2015,18(14):1632-1636.
[4]胡军,许腾,高啸,等.西格列汀联合地特胰岛素治疗老年2型糖尿病的疗效及安全性观察[J].中国医院药学杂志,2015,35(10):949-951.
[5]钟雯,李又空,曾姣娥,等.沙格列汀联合阿卡波糖治疗初诊老年2型糖尿病的疗效[J].实用医学杂志,2015,31(4):649-651.
[6]Caporale JE,Pichón-Riviere A,Beratarrechea AG,et al.A Comparison of 1-Year Treatment Costs in Patients with Type2 Diabetes Following Initiation of Insulin Glargine or Insulin Detemir in Argentina[J].Value in Health Regional Issues,2014,14(5):14-19.
[7]周泽华,肖蓉,何煦,等.胰岛素类似物联合口服降糖药治疗2型糖尿病[J].重庆医科大学学报,2013,38(8):953-956.
[2]徐文博,孙晓晶.老年2型糖尿病病人自我护理能力及社会支持与生存质量的相关性[J].中国老年学杂志,2013,33(10):2342-2344.
[3]李伟芳,李华,董捷,等.老年2型糖尿病慢性并发症发病时间及危险因素分析[J].中国全科医学,2015,18(14):1632-1636.
[4]胡军,许腾,高啸,等.西格列汀联合地特胰岛素治疗老年2型糖尿病的疗效及安全性观察[J].中国医院药学杂志,2015,35(10):949-951.
[5]钟雯,李又空,曾姣娥,等.沙格列汀联合阿卡波糖治疗初诊老年2型糖尿病的疗效[J].实用医学杂志,2015,31(4):649-651.
[6]Caporale JE,Pichón-Riviere A,Beratarrechea AG,et al.A Comparison of 1-Year Treatment Costs in Patients with Type2 Diabetes Following Initiation of Insulin Glargine or Insulin Detemir in Argentina[J].Value in Health Regional Issues,2014,14(5):14-19.
[7]周泽华,肖蓉,何煦,等.胰岛素类似物联合口服降糖药治疗2型糖尿病[J].重庆医科大学学报,2013,38(8):953-956.