摘要
采用混合载体制备姜黄素固体分散体以提高姜黄素的溶解度和溶出度.实验采用溶剂法制备姜黄素固体分散体,以体外溶出度和饱和溶解度为评价指标,结合傅里叶红外光谱和差示扫描量热法,单因素试验筛选载体种类、单一载体与混合载体以及载药量,优化处方.最终处方为以尤特奇?聚丙烯酸树脂和羟丙基甲基纤维素为混合载体,姜黄素和两种载体的质量比例为1∶2∶2,此时姜黄素的溶出效果最佳.姜黄素以无定形态分散在载体中,姜黄素与载体间形成较强的相互作用,15 min的溶出度可到90%以上,饱和溶解度是原料药的9.7倍.实验结果表明,姜黄素三元固体分散体可提高姜黄素的溶解度和溶出度,为姜黄素制剂的研究提供了有效的实验参考.
In this study,mixed carriers were used to prepare a solid dispersion of curcumin(CUR)to improve the solubility and dissolution of CUR. The solid dispersions were prepared by solvent method. Taking the in vitro dissolution and saturation solubility as evaluation indicators,combined with Fourier transform infrared spectroscopy(FTIR) and differential scanning calorimetry analysis(DSC),the single-factor test was used to select carrier types,single carrier or mixed carriers,and drug loading for optimizing prescriptions. The final prescription was to use Eudragit? EPO(EPO)and hydroxypropyl methyl cellulose(HPMC)as mixed carriers and the weight ratio of CUR,EPO and HPMC was 1∶2∶2. The CUR was dispersed in the carrier in an amorphous state,and the CUR formed stronger molecular interactions with carriers. The dissolution rate of CUR can be more than 90% in 15 minutes,and the saturation solubility was 9.7 times in the bulk drug. The results indicate that the ternary solid dispersion can greatly improve the solubility and dissolution of CUR,which provides efficient experimental reference for the study of CUR preparations.
引文
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