脑靶向性鼻腔给药的研究进展
摘要
目的:介绍近年鼻腔给药的研究进展,以及对国内外脑靶向性鼻腔给药文献的整理和分析。方法:结合鼻腔的生理特点,查阅国内外近年的相关文献资料,分析与综述应用鼻腔给药的方法治疗脑部疾病。结果:鼻腔给药具有使用方便,起效快和能避过胃肠道肝脏首过效应等特点。鼻腔给药能绕过血脑屏障,靶向于脑部,成为治疗脑部疾病的一个研究热点。结论:脑靶向性鼻腔给药具有许多优于其他给药途径治疗脑部疾病的优点,该类制剂在未来有巨大的发展潜力。
引文
[1]曾萍萍,付文洋.鼻腔给药的中药制剂最新研究进展[J].中国医药指南,2013,11(14):65-66.
[2]Landis M S,Boyder T,Pegg S.Nasal-to-CNS drug delivery:where are we now and where are we heading?An industrial perspective[J].Therapeutic Delivery,2012,3(2):195-208.
[3]Illum L.Transport of drugs from the nasal cavity to the central nervous system[J].European Journal of Pharmaceutical Sciences,2000,11(1):1-18.
[4]Thorne R G,Pronk G J,Padmanabhan V,et al.Delivery of insulin-likegrowthfactor-I to the rat brain and spinal cord alongol factory and trigeminal pathways following intranasal administration[J].Neuroscience,2004,127(2):481-496.
[5]Ruigrok M J,de Lange E C.Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies:Towards prediction of Nose-to-Brain Transport in Humans[J].Aaps Jonrnal,2015,17(3):493-505.
[6]Misra A,Kher G.Drug delivery systems from nose to brain[J].Curr Pharm Biotechnol,2012,13(12):2355-2379.
[7]张龙开,许日鑫,蒋梅,等.β-细辛醚微乳鼻腔给药脑内靶向性评价[J].中草药,2014,45(1):86-89.
[8]徐雄波,潘育方,黄志军,等.鼻腔给药尼莫地平纳米乳的制备及脑组织靶向性初步评价[J].中国药学杂志,2012,47(8):594-598.
[9]Abhilash P Appu,Peethambaran Arun,Jishnu KS.Krishnan.Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS[J].Journal of Neuroscience Methods,2016(259):129-134.
[10]王光明,潘艳,孔秋玲,等.细辛脑羟丙基-β-环糊精溶液剂鼻腔给药脑内释药的可行性[J].中国实验方剂学杂志,2012,18(3):16-18.
[11]樊新颖,李芸,马敏,等.神经生长因子鼻腔给药对有机磷酸酯类化合物中毒大鼠纹状体损伤的影响[J].中华医学杂志,2012,92(33):2366-2369.
[12]Nithin D.Nasalirrigation with or without drugs:the evidence[J].Curr Opin Otolaryngol Head Neck Surg,2012,20(1):53-57.
[13]姜涛,蒋剑平,周水晶,等.芳香开窍药嗅吸剂对急性颅脑创伤患者脑组织血供情况的影响及预后[J].浙江中医药大学学报,2013(12):1400-1402.
[14]陈新梅.剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响[J].中国实验方剂学杂志,2011,17(14):43-46.
[15]黄世杰.舒马曲坦鼻吸粉获FDA批准用于治疗偏头痛[J].国际药学研究杂志,2016,43(3):480-480.
[16]Sunita Yadav,Srujan K,Gandham,Riccardo Panicucc,et al.Intranasal Brain Delivery of Cationic NanoemulsionEncapsulated TNFααsiRNA in Prevention of Experimental Neuroinflammation[J].Nanomedicine Nanotechnology Biology&Medicine,2016,12(4):987-1002.
[17]李丽霞,陈楚云.脑清喷鼻微乳对急性脑出血患者自由基水平及疗效的影响[J].山西中医学院学报,2015(1):34-36.
[18]Chi Zhang,Jie Chen,Chengcheng Feng,et al.Intranasal nanoparticles of basic fibroblast growth factor for braindelivery to treat Alzheimer’s disease[J].International Journal of Pharmaceutics,2014,461(1-2):192-202.
[19]王丛瑶,郑杭生,谷满仓,等.盐酸阿霉素壳聚糖纳米粒大鼠鼻腔给药的脑内药动学研究[J].中国药理学通报,2012:994-999.
[20]李萍,王化芬,史卫峰,等.固相萃取与液质联用法分析东莨菪碱经鼻腔给药的脑靶向性[J].重庆医学,2013(36):4405-4407.
[2]Landis M S,Boyder T,Pegg S.Nasal-to-CNS drug delivery:where are we now and where are we heading?An industrial perspective[J].Therapeutic Delivery,2012,3(2):195-208.
[3]Illum L.Transport of drugs from the nasal cavity to the central nervous system[J].European Journal of Pharmaceutical Sciences,2000,11(1):1-18.
[4]Thorne R G,Pronk G J,Padmanabhan V,et al.Delivery of insulin-likegrowthfactor-I to the rat brain and spinal cord alongol factory and trigeminal pathways following intranasal administration[J].Neuroscience,2004,127(2):481-496.
[5]Ruigrok M J,de Lange E C.Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies:Towards prediction of Nose-to-Brain Transport in Humans[J].Aaps Jonrnal,2015,17(3):493-505.
[6]Misra A,Kher G.Drug delivery systems from nose to brain[J].Curr Pharm Biotechnol,2012,13(12):2355-2379.
[7]张龙开,许日鑫,蒋梅,等.β-细辛醚微乳鼻腔给药脑内靶向性评价[J].中草药,2014,45(1):86-89.
[8]徐雄波,潘育方,黄志军,等.鼻腔给药尼莫地平纳米乳的制备及脑组织靶向性初步评价[J].中国药学杂志,2012,47(8):594-598.
[9]Abhilash P Appu,Peethambaran Arun,Jishnu KS.Krishnan.Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS[J].Journal of Neuroscience Methods,2016(259):129-134.
[10]王光明,潘艳,孔秋玲,等.细辛脑羟丙基-β-环糊精溶液剂鼻腔给药脑内释药的可行性[J].中国实验方剂学杂志,2012,18(3):16-18.
[11]樊新颖,李芸,马敏,等.神经生长因子鼻腔给药对有机磷酸酯类化合物中毒大鼠纹状体损伤的影响[J].中华医学杂志,2012,92(33):2366-2369.
[12]Nithin D.Nasalirrigation with or without drugs:the evidence[J].Curr Opin Otolaryngol Head Neck Surg,2012,20(1):53-57.
[13]姜涛,蒋剑平,周水晶,等.芳香开窍药嗅吸剂对急性颅脑创伤患者脑组织血供情况的影响及预后[J].浙江中医药大学学报,2013(12):1400-1402.
[14]陈新梅.剂型因素和给药途径对人参皂苷Rg1在大鼠血清和脑组织中分布的影响[J].中国实验方剂学杂志,2011,17(14):43-46.
[15]黄世杰.舒马曲坦鼻吸粉获FDA批准用于治疗偏头痛[J].国际药学研究杂志,2016,43(3):480-480.
[16]Sunita Yadav,Srujan K,Gandham,Riccardo Panicucc,et al.Intranasal Brain Delivery of Cationic NanoemulsionEncapsulated TNFααsiRNA in Prevention of Experimental Neuroinflammation[J].Nanomedicine Nanotechnology Biology&Medicine,2016,12(4):987-1002.
[17]李丽霞,陈楚云.脑清喷鼻微乳对急性脑出血患者自由基水平及疗效的影响[J].山西中医学院学报,2015(1):34-36.
[18]Chi Zhang,Jie Chen,Chengcheng Feng,et al.Intranasal nanoparticles of basic fibroblast growth factor for braindelivery to treat Alzheimer’s disease[J].International Journal of Pharmaceutics,2014,461(1-2):192-202.
[19]王丛瑶,郑杭生,谷满仓,等.盐酸阿霉素壳聚糖纳米粒大鼠鼻腔给药的脑内药动学研究[J].中国药理学通报,2012:994-999.
[20]李萍,王化芬,史卫峰,等.固相萃取与液质联用法分析东莨菪碱经鼻腔给药的脑靶向性[J].重庆医学,2013(36):4405-4407.