柔肝和胃消痞汤治疗功能性消化不良上腹痛综合征59例临床研究
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摘要
目的:观察柔肝和胃消痞汤治疗功能性消化不良(FD)上腹痛综合征的临床疗效。方法:将120例FD上腹痛综合征患者随机分为2组。治疗组予柔肝和胃消痞汤治疗,对照组口服奥美拉唑肠溶胶囊,2组疗程均为4周。观察2组临床症状、胃感觉功能、生活质量的改善情况,评估治疗效果,统计2组停药12周时的复发情况。结果:治疗后,2组餐后饱胀不适、早饱感、中上腹痛、中上腹烧灼感均较治疗前改善(P <0.05);治疗组各项症状改善情况均优于对照组(P <0.05)。治疗后,2组胃感知阈值及胃不适阈值均较治疗前升高(P <0.05);治疗组胃感知阈值与胃不适阈值均比对照组升高更明显(P <0.05)。治疗后,对照组总体健康和活力评分均较治疗前改善(P <0.05);治疗组除生理功能评分外,余各项评分均较治疗前改善(P <0.05);组间比较,治疗组除生理功能及活力评分外,余各项评分改善情况均优于对照组(P <0.05)。治疗组总有效率88.14%,对照组总有效率71.93%,2组比较,差异有统计学意义(P <0.05)。对照组复发率41.18%(7/17),治疗组复发率13.33%(4/30),2组比较,差异有统计学意义(P <0.05)。结论:柔肝和胃消痞汤能有效缓解FD上腹痛综合征患者的临床症状,改善胃感觉功能和生活质量,降低复发率。
Objective:To observe the clinical effect of Rougan Hewei Xiaopi tang for functional dyspepsia(FD) with epigastric pain syndrome. Methods:A total of 120 patients with FD with epigastric pain syndrome were randomly divided into two groups. The treatment group was treated with Rougan Hewei Xiaopi tang and the control group was given oral administration of omeprazole enteric-coated capsules. The course of treatment in both groups lasted for four weeks. The improvement of the clinical symptoms,sensory function of the stomach and the quality of life in the two groups were observed. The curative effect was evaluated and the recurrences after twelve weeks of drug withdrawal in the two groups were observed. Results:After treatment,the symptoms of postprandial fullness and discomfort,early satiety,upper middle abdominal pain and burning sensation in upper middle abdomen in the two groups were improved when compared with those before treatment(P < 0.05);the improvement of each symptom in the treatment group was better than that in the control group(P < 0.05). After treatment,the gastric perception threshold and gastric discomfort threshold in the two groups were increased when compared with those before treatment(P < 0.05),and the gastric perception threshold and gastric discomfort threshold in the treatment group were increased more significantly than those in the control group(P < 0.05). After treatment,the scores of general health and vitality in the control group were improved when compared with those before treatment(P <0.05),and each score except the score of physiological function in the treatment group was improved when compared with that before treatment(P < 0.05);the improvement of each score except the score of physiological function and the score of vitality in the treatment group was better than that in the control group(P < 0.05). The total effective rate was 88.14% in the treatment group and 71.93% in the control group,the difference being significant(P < 0.05). The recurrence rate was 41.18%(7/17) in the control group and 13.33%(4/30) in the treatment group,the difference being significant(P < 0.05). Conclusion:Rougan Hewei Xiaopi tang can effectively relief the clinical symptoms of patients with FD with epigastric pain syndrome,improving the sensory function of the stomach and the quality of life as well as decreasing the recurrence rate.
Objective:To observe the clinical effect of Rougan Hewei Xiaopi tang for functional dyspepsia(FD) with epigastric pain syndrome. Methods:A total of 120 patients with FD with epigastric pain syndrome were randomly divided into two groups. The treatment group was treated with Rougan Hewei Xiaopi tang and the control group was given oral administration of omeprazole enteric-coated capsules. The course of treatment in both groups lasted for four weeks. The improvement of the clinical symptoms,sensory function of the stomach and the quality of life in the two groups were observed. The curative effect was evaluated and the recurrences after twelve weeks of drug withdrawal in the two groups were observed. Results:After treatment,the symptoms of postprandial fullness and discomfort,early satiety,upper middle abdominal pain and burning sensation in upper middle abdomen in the two groups were improved when compared with those before treatment(P < 0.05);the improvement of each symptom in the treatment group was better than that in the control group(P < 0.05). After treatment,the gastric perception threshold and gastric discomfort threshold in the two groups were increased when compared with those before treatment(P < 0.05),and the gastric perception threshold and gastric discomfort threshold in the treatment group were increased more significantly than those in the control group(P < 0.05). After treatment,the scores of general health and vitality in the control group were improved when compared with those before treatment(P <0.05),and each score except the score of physiological function in the treatment group was improved when compared with that before treatment(P < 0.05);the improvement of each score except the score of physiological function and the score of vitality in the treatment group was better than that in the control group(P < 0.05). The total effective rate was 88.14% in the treatment group and 71.93% in the control group,the difference being significant(P < 0.05). The recurrence rate was 41.18%(7/17) in the control group and 13.33%(4/30) in the treatment group,the difference being significant(P < 0.05). Conclusion:Rougan Hewei Xiaopi tang can effectively relief the clinical symptoms of patients with FD with epigastric pain syndrome,improving the sensory function of the stomach and the quality of life as well as decreasing the recurrence rate.
引文
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[5]李启祥,朱良知,侯晓华,等.饮水负荷试验测定胃感觉的临床研究[J].中华内科杂志,2004,43(6):436-438.
[6]李鲁,王红妹,沈毅.SF-36健康调查量表中文版的研制及其性能测试[J].中华预防医学杂志,2002,36(2):38-42.
[7]仝甲钊,曲波,王蓓蓓,等.功能性消化不良的发病机制[J].世界华人消化杂志,2013,21(9):785-790.
[8]雒芳,刘纯伦.功能性消化不良发病机制研究进展[J].现代医药卫生,2014,30(11):1662-1665.
[9]周福生,祝淑贞.功能性消化不良发病机制的研究进展[J].中华中医药学刊,2005,23(7):1177-1179.
[10]陈月红,马良,陈鉴.中西医结合治疗功能性消化不良临床效果评价[J].中华中医药学刊,2015,33(12):2981-2983.
[2]李军祥,陈誩,李岩.功能性消化不良中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2017,25(12):889-894.
[3] Halder SL, Talley NJ.Functional Dyspepsia:A New RomeⅢParadigm[J].Curr Treat Options Gastroenterol,2007,10(4):259-272.
[4]中华中医药学会脾胃病分会.消化不良中医诊疗共识意见(2009)[J].中国中西医结合杂志,2010,30(5):533-537.
[5]李启祥,朱良知,侯晓华,等.饮水负荷试验测定胃感觉的临床研究[J].中华内科杂志,2004,43(6):436-438.
[6]李鲁,王红妹,沈毅.SF-36健康调查量表中文版的研制及其性能测试[J].中华预防医学杂志,2002,36(2):38-42.
[7]仝甲钊,曲波,王蓓蓓,等.功能性消化不良的发病机制[J].世界华人消化杂志,2013,21(9):785-790.
[8]雒芳,刘纯伦.功能性消化不良发病机制研究进展[J].现代医药卫生,2014,30(11):1662-1665.
[9]周福生,祝淑贞.功能性消化不良发病机制的研究进展[J].中华中医药学刊,2005,23(7):1177-1179.
[10]陈月红,马良,陈鉴.中西医结合治疗功能性消化不良临床效果评价[J].中华中医药学刊,2015,33(12):2981-2983.