附子理中丸联合当归生姜羊肉汤治疗脾肾阳虚证腹泻型肠易激综合征临床观察
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摘要
[目的]观察附子理中丸联合当归生姜羊肉汤治疗脾肾阳虚证腹泻型肠易激综合征(IBS-D)临床疗效。[方法]将120例患者按随机数字表法分为治疗组(50例)和对照组(70例),治疗组予附子理中丸联合当归生姜羊肉汤治疗,对照组予附子理中丸,2组均治疗4周,观察治疗前后中医症状积分变化、复发率及评价临床疗效。[结果]与本组治疗前比较,2组中医证候积分差异有统计学意义(P<0.05);2组治疗中医证候积分差、临床疗效比较,差异有统计学意义(P<0.05);与对照组比较,治疗组在治疗后3、4、5个月复发率显著优于对照组(P<0.05);而2组治疗6个月后复发率比较差异无统计学意义(P>0.05)。[结论]附子理中丸联合当归生姜羊肉汤治疗脾肾阳虚证IBS-D疗效确切,值得推广应用。
[Objective]To observe the clinical efficacy of Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup in treating diarrhea-type irritable bowel syndrome(IBS-D) with spleen and kidney yang deficiency syndrome. [Methods]120 patients were divided into treatment group(50 cases) and control group(70 cases) according to random number table. The treatment group was treated with Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup. The control group was treated with Fuzi Lizhong Pill only. After 4 weeks of treatment, the change of TCM symptom scores, recurrence rates and clinical efficacies were evaluated before and after treatment. [Results]The difference of TCM syndrome scores in both groups was statistically significant(P<0.05) after treatment, compared with that before treatment. The difference between the groups in the treatment of TCM syndromes and clinical efficacy was statistically significant(P<0.05). The recurrence rate of the treatment group was significantly better than that of the control group at 3, 4, and 5 months(P<0.05). There was no significantly difference between the groups after 6 months of treatment(P>0.05). [Conclusion]Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup for the treatment of spleen and kidney yang deficiency syndrome IBS-D is effective and worthy of further clinical application.
[Objective]To observe the clinical efficacy of Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup in treating diarrhea-type irritable bowel syndrome(IBS-D) with spleen and kidney yang deficiency syndrome. [Methods]120 patients were divided into treatment group(50 cases) and control group(70 cases) according to random number table. The treatment group was treated with Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup. The control group was treated with Fuzi Lizhong Pill only. After 4 weeks of treatment, the change of TCM symptom scores, recurrence rates and clinical efficacies were evaluated before and after treatment. [Results]The difference of TCM syndrome scores in both groups was statistically significant(P<0.05) after treatment, compared with that before treatment. The difference between the groups in the treatment of TCM syndromes and clinical efficacy was statistically significant(P<0.05). The recurrence rate of the treatment group was significantly better than that of the control group at 3, 4, and 5 months(P<0.05). There was no significantly difference between the groups after 6 months of treatment(P>0.05). [Conclusion]Fuzi Lizhong Pill combined with Angelica Ginger Mutton Soup for the treatment of spleen and kidney yang deficiency syndrome IBS-D is effective and worthy of further clinical application.
引文
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[2] Zhao JM,Li L,Chen L,et al.Comparison of the analgesic effects between electro-acupuncture and moxibustion with visceral hypersensitivity rats in irritable bowel syndrome[J].World J Gastroenterol,2017,23(16):2928-2939.
[3] Celebi S,Acik Y,Deveci SE,et al.Epidemiological features of irritable bowel syndrome in a Turkish urban society[J].J Gastroenterol Hepatol,2004,19(7):738-743.
[4] 中国中西医结合学会消化系统疾病专业委员会.肠易激综合征中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(3):227-232.
[5] 陈灏珠.实用内科学[M].北京:人民卫生出版社,2005:1948-1951.
[6] Brian EA,Fermin M,Lin C,et al.Bowel Disodrers[J].Gastroenterology,2016,150(5):1393-1407.
[7] 李乾构,周学文,单兆伟.中医消化病诊疗指南[M].北京:中医药出版社,2006:90-94.
[8] 郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:143-143.
[9] 李子君,肖冰.肠易激综合征发病机制的研究进展[J].现代消化及介入诊疗,2018,23(1):121-123.
[10] 张正利,蔡淦.肠易激综合征中医论治溯源[J].中国中医基础医学杂志,2001,7(7):48-50.