当归饮子治疗寻常型银屑病的研究进展
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摘要
银屑病是一种常见的慢性复发性炎症性皮肤病,中医称之为"白疕",该病易复发难治愈。历代中医医家认为银屑病的病因病机主要与血热、血燥、血瘀有关。当归饮子方为寻常型银屑病的代表方,在临床已广泛应用。文章对当归饮子治疗寻常型银屑病的临床应用进行了总结,包括联合中药外治法及西医疗法,发现当归饮子治疗寻常型银屑病的临床效果值得肯定,能够有效减小皮损面积,降低临床复发率,且具有不良反应低、能改善患者的抑郁状态、提高患者生活质量的优势;同时对当归饮子方中的单味药至整方的药理研究进行了归纳,发现其主要通过控制炎症反应、调节免疫、抑制银屑病角质形成细胞过度增殖、改善和修复银屑病患者皮肤屏障功能以达到治疗效果,进而阐明当归饮子治疗寻常型银屑病的有效性。
Psoriasis is a common chronic relapsing inflammatory disease of the skin,which is called "Baibi"in traditional Chinese medicine. It is not only easy to relapse,but also difficult to be cured. The doctors of traditional Chinese medicine considers that the etiology and pathogenesis of psoriasis is related to blood heat,blood dryness and blood stasis. Chinese Angelica Drink is the representative prescription of psoriasis vulgaris and has been widely used in clinic. In this paper,the clinical application of Chinese Angelica Drink in treatment of psoriasis vulgaris are summarized,which includes the therapeutic method about combining with the external treatment of traditional Chinese medicine and the western medicine therapy. It was found that the clinical effect of Chinese Angelica Drink in treating psoriasis was remarkable. It can not only effectively reduce the lesion area and the recurrence rate,but also has low adverse reaction,which can improve the depressive state and the life quality of patients. At the same time,the pharmacological researches of Chinese Angelica Drink in treatment of psoriasis vulgaris are summarized,including the single medicine of Chinese Angelica Drink and the compound. It showed that Chinese Angelica Drink treats the psoriasis vulgaris by controlling the inflammatory response and immune regulation,inhibiting the keratinocyte of psoriasis reproducing,improving and repairing the skin function in patients with psoriasis to achieve the therapeutic effect and to clarify Chinese Angelica Drink in treatment of psoriasis vulgaris is effective.
Psoriasis is a common chronic relapsing inflammatory disease of the skin,which is called "Baibi"in traditional Chinese medicine. It is not only easy to relapse,but also difficult to be cured. The doctors of traditional Chinese medicine considers that the etiology and pathogenesis of psoriasis is related to blood heat,blood dryness and blood stasis. Chinese Angelica Drink is the representative prescription of psoriasis vulgaris and has been widely used in clinic. In this paper,the clinical application of Chinese Angelica Drink in treatment of psoriasis vulgaris are summarized,which includes the therapeutic method about combining with the external treatment of traditional Chinese medicine and the western medicine therapy. It was found that the clinical effect of Chinese Angelica Drink in treating psoriasis was remarkable. It can not only effectively reduce the lesion area and the recurrence rate,but also has low adverse reaction,which can improve the depressive state and the life quality of patients. At the same time,the pharmacological researches of Chinese Angelica Drink in treatment of psoriasis vulgaris are summarized,including the single medicine of Chinese Angelica Drink and the compound. It showed that Chinese Angelica Drink treats the psoriasis vulgaris by controlling the inflammatory response and immune regulation,inhibiting the keratinocyte of psoriasis reproducing,improving and repairing the skin function in patients with psoriasis to achieve the therapeutic effect and to clarify Chinese Angelica Drink in treatment of psoriasis vulgaris is effective.
引文
[1]张建中.银屑病的流行病学与危险因素[J].实用医院临床杂志,2013,10(1):4-6.
[2]Fry L.Psoriasis[J].Br J Dermatol,1988,119(4):445-461.
[3]赵炳南,张志礼.简明中医皮肤病学[M].北京:中国展望出版社,1983:200-203.
[4]宋坪,李博鉴.从血论治诸法合用----朱仁康研究员治疗银屑病经验[J].中国中西医结合皮肤性病学杂志,2004,3(1):1-2.
[5]周德瑛.名医经验集[M].北京:中国医药科技出版社,1996:295.
[6]赵炳南.赵炳南临床经验集[M].北京:人民卫生出版社1975:226-227.
[7]金起凤.消银解毒汤治疗银屑病58例疗效观察[J].辽宁中医志,1983,7(6):29-30.
[8]张志礼,黄敬彦,姚玉珍,等.200例银屑病中医辨证论治体会[J].中华医学杂志,1974,54(4):05-206.
[9]周渐云,姚守恩.许铣教授治疗斑块状银屑病经验介绍[J].新中医,2005,37(10):14-15.
[10]郭静,杜艾嫒,左小红,等.当归饮子治疗皮肤病的溯源及现代研究进展[J].辽宁中医杂志,2016,43(5):1097-1100.
[11]闵三旭,李岳林,陈吉兵,等.当归饮子加减结合自制银屑灵霜治疗寻常型银屑病6例[J].甘肃中医,2010,23(5):44.
[12]汪耕郭.当归饮子内服与羊雄散外搽治疗银屑病10例[J].安徽中医学院学报,1990,9(3):42.
[13]魏巍.当归饮子加减联合中药药浴治疗静止期银屑病的临床观察[D].哈尔滨:黑龙江中医药大学,2016.
[14]汪海珍,黄盼,杨志波.当归饮子配方颗粒对血虚风燥型银屑病患者皮肤屏障功能的影响[J].湖南中医药大学学报,2015,35(4):41-43.
[15]李芳梅,杨志波,曾宪玉.当归饮子对寻常型银屑病患者皮肤屏障功能的影响[J].中医药导报,2014,20(7):11-13.
[16]付涛.当归饮子联合窄谱中波紫外线治疗银屑病的临床疗效观察[D].哈尔滨:黑龙江中医药大学,2015.
[17]吴科佳.加减当归饮子治疗银屑病血虚风燥证的临床研究[D].南京:南京中医药大学,2014.
[18]侯春雨,刘彤.当归的免疫药理作用研究[J].黑龙江科技信息,2013(6):11.
[19]周强,栗占国.白芍总苷的药理作用及其在自身免疫性疾病中的应用[J].中国新药与临床杂志,2003,22(11):687-691.
[20]张文海.川芎的药理作用及临床应用[J].中国卫生标准管理,2015,6(26):117-118.
[21]刘双利,姜程曦,赵岩,等.防风化学成分及其药理作用研究进展[J].中草药,2017,48(10):2146-2152.
[22]高学敏.中药学[M].北京:中国中医药出版社,2007:433.
[23]景海霞,盛晚香.当归多糖对豚鼠银屑病样皮损中角质形成细胞凋亡的影响[J].武汉大学学报,2006,27(3):377-380.
[24]Kovacs D,Falchi M,Cardinali G,et al.Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis[J].Exp Dermatol,2005,14:130-137.
[25]于春水,牟韵竹,苏江维,等.当归多糖对Ha CaT细胞中成纤维细胞生长因子10影响的研究[J].中国中西医结合皮肤性病学杂志,2010,9(2):87-89.
[26]张苑.白芍总苷对BALB/c银屑病小鼠皮肤组织及外周血VEGFmRNA表达的影响[D].广州:南方医科大学,2014.
[27]张宇虹,郭在培,焦晓燕,等.白芍总苷对轻、中度寻常性银屑病患者血清中IL-17和IL-23的影响[J].中国皮肤性病学杂志,2012,26(5):391-392,398.
[28]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,28(2):135-137.
[29]王小艳,陈星宇,朱玲玲,等.白芍总苷对急性期寻常性银屑病患者外周血白细胞介素12、白细胞介素35表达的影响[J].中国中西医结合皮肤性病学杂志,2015,14(4):222-224.
[30]闫小溪.银屑病经典方剂含药血清对白介素22诱导Ha CaT细胞增殖的影响[D].北京:北京中医药大学,2014.
[31]文谦,黄刚,李芳梅,等.当归饮子对银屑病模型豚鼠皮肤Filaggrin和Caspase-14基因及蛋白表达的影响[J].新疆医科大学学报,2016,39(4):418-421.
[32]文谦,李芳梅,杨志波.当归饮子对银屑病模型豚鼠神经酰胺含量、AQP-3基因及蛋白表达的干预研究[J].环球中医药,2016,9(8):914-917.
[2]Fry L.Psoriasis[J].Br J Dermatol,1988,119(4):445-461.
[3]赵炳南,张志礼.简明中医皮肤病学[M].北京:中国展望出版社,1983:200-203.
[4]宋坪,李博鉴.从血论治诸法合用----朱仁康研究员治疗银屑病经验[J].中国中西医结合皮肤性病学杂志,2004,3(1):1-2.
[5]周德瑛.名医经验集[M].北京:中国医药科技出版社,1996:295.
[6]赵炳南.赵炳南临床经验集[M].北京:人民卫生出版社1975:226-227.
[7]金起凤.消银解毒汤治疗银屑病58例疗效观察[J].辽宁中医志,1983,7(6):29-30.
[8]张志礼,黄敬彦,姚玉珍,等.200例银屑病中医辨证论治体会[J].中华医学杂志,1974,54(4):05-206.
[9]周渐云,姚守恩.许铣教授治疗斑块状银屑病经验介绍[J].新中医,2005,37(10):14-15.
[10]郭静,杜艾嫒,左小红,等.当归饮子治疗皮肤病的溯源及现代研究进展[J].辽宁中医杂志,2016,43(5):1097-1100.
[11]闵三旭,李岳林,陈吉兵,等.当归饮子加减结合自制银屑灵霜治疗寻常型银屑病6例[J].甘肃中医,2010,23(5):44.
[12]汪耕郭.当归饮子内服与羊雄散外搽治疗银屑病10例[J].安徽中医学院学报,1990,9(3):42.
[13]魏巍.当归饮子加减联合中药药浴治疗静止期银屑病的临床观察[D].哈尔滨:黑龙江中医药大学,2016.
[14]汪海珍,黄盼,杨志波.当归饮子配方颗粒对血虚风燥型银屑病患者皮肤屏障功能的影响[J].湖南中医药大学学报,2015,35(4):41-43.
[15]李芳梅,杨志波,曾宪玉.当归饮子对寻常型银屑病患者皮肤屏障功能的影响[J].中医药导报,2014,20(7):11-13.
[16]付涛.当归饮子联合窄谱中波紫外线治疗银屑病的临床疗效观察[D].哈尔滨:黑龙江中医药大学,2015.
[17]吴科佳.加减当归饮子治疗银屑病血虚风燥证的临床研究[D].南京:南京中医药大学,2014.
[18]侯春雨,刘彤.当归的免疫药理作用研究[J].黑龙江科技信息,2013(6):11.
[19]周强,栗占国.白芍总苷的药理作用及其在自身免疫性疾病中的应用[J].中国新药与临床杂志,2003,22(11):687-691.
[20]张文海.川芎的药理作用及临床应用[J].中国卫生标准管理,2015,6(26):117-118.
[21]刘双利,姜程曦,赵岩,等.防风化学成分及其药理作用研究进展[J].中草药,2017,48(10):2146-2152.
[22]高学敏.中药学[M].北京:中国中医药出版社,2007:433.
[23]景海霞,盛晚香.当归多糖对豚鼠银屑病样皮损中角质形成细胞凋亡的影响[J].武汉大学学报,2006,27(3):377-380.
[24]Kovacs D,Falchi M,Cardinali G,et al.Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis[J].Exp Dermatol,2005,14:130-137.
[25]于春水,牟韵竹,苏江维,等.当归多糖对Ha CaT细胞中成纤维细胞生长因子10影响的研究[J].中国中西医结合皮肤性病学杂志,2010,9(2):87-89.
[26]张苑.白芍总苷对BALB/c银屑病小鼠皮肤组织及外周血VEGFmRNA表达的影响[D].广州:南方医科大学,2014.
[27]张宇虹,郭在培,焦晓燕,等.白芍总苷对轻、中度寻常性银屑病患者血清中IL-17和IL-23的影响[J].中国皮肤性病学杂志,2012,26(5):391-392,398.
[28]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,28(2):135-137.
[29]王小艳,陈星宇,朱玲玲,等.白芍总苷对急性期寻常性银屑病患者外周血白细胞介素12、白细胞介素35表达的影响[J].中国中西医结合皮肤性病学杂志,2015,14(4):222-224.
[30]闫小溪.银屑病经典方剂含药血清对白介素22诱导Ha CaT细胞增殖的影响[D].北京:北京中医药大学,2014.
[31]文谦,黄刚,李芳梅,等.当归饮子对银屑病模型豚鼠皮肤Filaggrin和Caspase-14基因及蛋白表达的影响[J].新疆医科大学学报,2016,39(4):418-421.
[32]文谦,李芳梅,杨志波.当归饮子对银屑病模型豚鼠神经酰胺含量、AQP-3基因及蛋白表达的干预研究[J].环球中医药,2016,9(8):914-917.