当归饮子治疗特应性皮炎的疗效分析及对患者免疫功能调节作用研究
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摘要
目的探讨当归饮子治疗特应性皮炎的疗效分析及对患者免疫功能调节作用研究。方法采用病例对照研究的方法对我院收治的100例特应性皮炎患者进行临床观察。将患者病例按随机数字表分为观察组与对照组,各50例。对照组进行常规西医治疗,观察组在对照组的基础上运用当归饮子进行治疗。治疗结束后,计算并比较2组临床总有效率,观察2组患者的皮肤干燥程度、皮损程度及皮肤瘙痒程度,并对其进行症状评分,对2组细胞因子水平变化及生活质量评分。结果 2组患者经过治疗后,观察组临床总有效率为82.00%,优于对照组的70.00%(P <0.05);2组患者皮肤干燥程度、皮损程度及皮肤瘙痒程度治疗后均有所改善(P <0.05),观察组改善程度更为明显(P <0.05);2组患者经过治疗后细胞因子水平IL-6及TNF-α水平指标均有所变化,IL-6降低,TNF-α升高,且观察组效果更加明显(P <0.05);与对照组患者生活质量评分比较,观察组增加明显(P <0.05)。结论当归饮子具有养血润燥、祛风止痒的作用,对特应性皮炎患者疗效显著,可以有效调节患者的免疫功能。
Objective To investigate the efficacy of Danggui Yinzi in the treatment of atopic dermatitis and its role in the regulation of immune function. Methods A case-control study was performed on 100 patients with atopic dermatitis in our hospital. The patients were allocated according to a random number table. There were 50 patients in the experimental group and 50 in the control group. The control group received conventional western medicineand the experimental group was treated with Danggui Yinzi on the basis of the treatment of the control group. After treatment, the total effective rate was calculated and compared between the two groups. The degree of skin dryness, skin lesionsand pruritus were observed in the two groups. The symptoms and the cytokine levels and quality of life were scored in both groups. Results After treatment, the total effective rate(82.00%) in the experimental group was better than that(70.00%) in the control group(P < 0.05). The degree of skin dryness, skin lesions and pruritus were improved in both groups(P < 0.05), especially in the experimental group. The levels of cytokines IL-6 and TNF-α were changed after treatment in both groups. The decrease of IL-6 and the increase of INF-r were more significant in the experimental group than in the experimental group(P < 0.05). The quality of life score in the treatment group was significantly higher than that in the control group(P < 0.05). Conclusion Danggui Yinzi has a significant effect on patients with atopic dermatitis and can effectively regulate the immune function of patients.
Objective To investigate the efficacy of Danggui Yinzi in the treatment of atopic dermatitis and its role in the regulation of immune function. Methods A case-control study was performed on 100 patients with atopic dermatitis in our hospital. The patients were allocated according to a random number table. There were 50 patients in the experimental group and 50 in the control group. The control group received conventional western medicineand the experimental group was treated with Danggui Yinzi on the basis of the treatment of the control group. After treatment, the total effective rate was calculated and compared between the two groups. The degree of skin dryness, skin lesionsand pruritus were observed in the two groups. The symptoms and the cytokine levels and quality of life were scored in both groups. Results After treatment, the total effective rate(82.00%) in the experimental group was better than that(70.00%) in the control group(P < 0.05). The degree of skin dryness, skin lesions and pruritus were improved in both groups(P < 0.05), especially in the experimental group. The levels of cytokines IL-6 and TNF-α were changed after treatment in both groups. The decrease of IL-6 and the increase of INF-r were more significant in the experimental group than in the experimental group(P < 0.05). The quality of life score in the treatment group was significantly higher than that in the control group(P < 0.05). Conclusion Danggui Yinzi has a significant effect on patients with atopic dermatitis and can effectively regulate the immune function of patients.
引文
[1]沈跃莉.复方甘草酸苷片与他克莫司软膏在湿疹和特应性皮炎治疗中的应用[J].中国医药导刊,2016,18(8):826-827,829.
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[3]杨扬,宋瑜,蔡希,等.运脾化湿清肺汤对脾虚型特应性皮炎血清IL-2、sIL-2R影响的临床研究[J].山西中医学院学报,2015,16(5):32-34.
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[10]郑义辉.复方甘草酸苷片联合氯雷他定分散片治疗特应性皮炎的疗效分析[J].当代医学,2014,20(17):126-127.
[11]谭彦.卡介菌多糖核酸联合他克莫司、复方甘草酸苷治疗特应性皮炎的疗效观察[J].医学理论与实践,2014,27(21):2819-2821.
[12]陈梦娇,丁佩军,张慧敏.中医药对特应性皮炎免疫调节作用的研究进展[J].现代中西医结合杂志,2016,25(24):2734-2736.
[13]谢艳飞,孙占林.复方中药治疗特应性皮炎疗效及对免疫功能调节作用研究[J].中国医药指南,2013,11(12):688-689.
[14]王杰彪,祁素仪.神经免疫调节因子对特应性皮炎患者的影响研究[J].中国医学工程,2014,22(6):42-43.
[15]周雅逊,刘晓光,李覃,等.免疫制剂在特应性皮炎中的应用[J].武警后勤学院学报(医学版),2013,22(4):341-344.
[16]任发亮,顾恒.中外特应性皮炎诊疗指南比较[J].中国皮肤性病学杂志,2013,27(2):210-213.
[17]梁源,刘玲玲.外用钙调神经磷酸酶抑制剂在特应性皮炎中的应用[J].中国医学文摘(皮肤科学),2016,33(2):189-194.
[18]中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组.规范外用糖皮质激素类药物专家共识[J].中华皮肤科杂志,2015,48(2):73-75.
[19]林丽丽,汪受传.汪受传消风化湿解毒法治疗异位性皮炎[J].中国中医基础医学杂志,2015,17(8):1027-1028.
[20]孙源梅,刁庆春.中医药治疗特应性皮炎研究概况[J].四川中医,2013,31(8):189-190.
[21]廖勇梅,陈达灿,陈德宇.培土清心方对特应性皮炎患者血清总IgE、ECP影响的研究[J].江西中医药,2013,44(8):14-16.
[22]王磊,陈力.湿疹的病因研究及中西医治疗[J].长春中医药大学学报,2011,27(2):220-221.
[23]喻桃,陈保疆,王萍,等.健脾补肾疗法对特应性皮炎患者血清总IgE水平的影响[J].吉林中医药,2006,26(9):15-17.
[24]李冬香.健脾祛风汤治疗特应性皮炎的临床效果[J].中国当代医药,2017,24(31):155-157.
[25]冯小兰,曾宪玉,徐宜厚.徐宜厚教授治疗特异性皮炎经验[J].中国中西医结合皮肤性病学杂志,2017,16(3):266-268.
[26]薛素琴,谭金华.十皮汤对特应性皮炎患者皮肤屏障功能影响[J].中国实验方剂学杂志,2011,17(14):282-283.
[27]王海波,刘海春,王振清.健脾安神中药治疗特应性皮炎[J].吉林中医药,2014,34(12):1255-1257.
[28]景涛,赵振宇,李振化,等.黄芩苷滴丸治疗特应性皮炎的临床研究[J].中国中西医结合皮肤性病学杂志,2017,16(3):238-240.
[29]黄时燕,聂巧峰,张毅.当归饮子联合火针治疗血虚肤燥型神经性皮炎32例[J].四川中医,2014,32(9):121-122.
[2]徐皓,马玉宏,史洁.他克莫司联合复方甘草酸苷治疗特应性皮炎疗效观察[J].人民军医,2013,56(2):185-186.
[3]杨扬,宋瑜,蔡希,等.运脾化湿清肺汤对脾虚型特应性皮炎血清IL-2、sIL-2R影响的临床研究[J].山西中医学院学报,2015,16(5):32-34.
[4]马雁南,孙令,张策,等.中西医结合治疗特应性皮炎的Meta分析[J].医学与哲学(B),2017,38(11):49-53.
[5]郭静,杜艾嫒,左小红,等.当归饮子治疗皮肤病的溯源及现代研究进展[J].辽宁中医杂志,2016,43(5):1097-1100.
[6]LIU P,ZHAO Y,MU Z L,et al.Clinical features of adult/adolescent atopic dermatitis and Chinese criteria for atopic dermatitis[J].Chinese Medical Journal,2016,129(7):757-762.
[7]陈达灿.特应性皮炎中医诊疗方案专家共识[J].中国中西医结合皮肤性病学杂志,2013,12(1):60-61.
[8]韩琼,王梦,吴艳,等.黄蜀运用温阳法治疗异位性皮炎经验[J].四川中医,2015,33(2):1-2.
[9]王华.特应性皮炎临床特点与诊断标准探讨[J].长春中医药大学学报,2015,31(6):1279-1281.
[10]郑义辉.复方甘草酸苷片联合氯雷他定分散片治疗特应性皮炎的疗效分析[J].当代医学,2014,20(17):126-127.
[11]谭彦.卡介菌多糖核酸联合他克莫司、复方甘草酸苷治疗特应性皮炎的疗效观察[J].医学理论与实践,2014,27(21):2819-2821.
[12]陈梦娇,丁佩军,张慧敏.中医药对特应性皮炎免疫调节作用的研究进展[J].现代中西医结合杂志,2016,25(24):2734-2736.
[13]谢艳飞,孙占林.复方中药治疗特应性皮炎疗效及对免疫功能调节作用研究[J].中国医药指南,2013,11(12):688-689.
[14]王杰彪,祁素仪.神经免疫调节因子对特应性皮炎患者的影响研究[J].中国医学工程,2014,22(6):42-43.
[15]周雅逊,刘晓光,李覃,等.免疫制剂在特应性皮炎中的应用[J].武警后勤学院学报(医学版),2013,22(4):341-344.
[16]任发亮,顾恒.中外特应性皮炎诊疗指南比较[J].中国皮肤性病学杂志,2013,27(2):210-213.
[17]梁源,刘玲玲.外用钙调神经磷酸酶抑制剂在特应性皮炎中的应用[J].中国医学文摘(皮肤科学),2016,33(2):189-194.
[18]中国中西医结合学会皮肤性病专业委员会环境与职业性皮肤病学组.规范外用糖皮质激素类药物专家共识[J].中华皮肤科杂志,2015,48(2):73-75.
[19]林丽丽,汪受传.汪受传消风化湿解毒法治疗异位性皮炎[J].中国中医基础医学杂志,2015,17(8):1027-1028.
[20]孙源梅,刁庆春.中医药治疗特应性皮炎研究概况[J].四川中医,2013,31(8):189-190.
[21]廖勇梅,陈达灿,陈德宇.培土清心方对特应性皮炎患者血清总IgE、ECP影响的研究[J].江西中医药,2013,44(8):14-16.
[22]王磊,陈力.湿疹的病因研究及中西医治疗[J].长春中医药大学学报,2011,27(2):220-221.
[23]喻桃,陈保疆,王萍,等.健脾补肾疗法对特应性皮炎患者血清总IgE水平的影响[J].吉林中医药,2006,26(9):15-17.
[24]李冬香.健脾祛风汤治疗特应性皮炎的临床效果[J].中国当代医药,2017,24(31):155-157.
[25]冯小兰,曾宪玉,徐宜厚.徐宜厚教授治疗特异性皮炎经验[J].中国中西医结合皮肤性病学杂志,2017,16(3):266-268.
[26]薛素琴,谭金华.十皮汤对特应性皮炎患者皮肤屏障功能影响[J].中国实验方剂学杂志,2011,17(14):282-283.
[27]王海波,刘海春,王振清.健脾安神中药治疗特应性皮炎[J].吉林中医药,2014,34(12):1255-1257.
[28]景涛,赵振宇,李振化,等.黄芩苷滴丸治疗特应性皮炎的临床研究[J].中国中西医结合皮肤性病学杂志,2017,16(3):238-240.
[29]黄时燕,聂巧峰,张毅.当归饮子联合火针治疗血虚肤燥型神经性皮炎32例[J].四川中医,2014,32(9):121-122.