妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎C反应蛋白、氧化应激产物的影响及其疗效
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摘要
目的探究妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎患者血清C反应蛋白(CRP)、氧化应激产物及临床疗效的影响。方法选取2014年10月~2015年12月在湖州市南浔区中西医结合医院妇产科确诊老年霉菌性阴道炎患者66例,随机分成2组,各33例。对照组予硝呋太尔制霉素阴道软胶囊,联合组在对照组的基础上给予妇科消炎方,6 d为1个疗程,共2个疗程,检测治疗前后血清炎性因子及氧化应激产物水平,并观察临床疗效。结果与治疗前比较,2组血清肿瘤坏死因子α(TNF-α)、CRP、白介素-6(IL-6)、IL-8水平降低(P<0.05),超氧化物歧化酶(SOD)、一氧化氮(NO)升高(P<0.05),丙二醛(MDA)、内皮素-1(ET-1)降低(P<0.05);与对照组比较,联合组血清TNF-α、CRP、IL-6、IL-8水平较低(P<0.05),SOD、NO较高(P<0.05),MDA、ET-1较低(P<0.05)。联合组临床疗效显著优于对照组(Z=-2.902,P=0.004)。结论妇科消炎方联合硝呋太尔制霉素对老年霉菌性阴道炎有较好的临床疗效,可有效降低血清炎性因子及氧化应激产物水平,且安全性高。
Objective To explore the effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on serum levels of CRP,oxidative stress products and its efficacy in the treatment of senile colpomycosis. Methods 66 elderly patients of colpomycosis from October 2014 to December 2015 in department of obstetrics and gynecology of Nanxun Integrative Medicine Hospital were selected and randomly divided into two groups,33 cases in each group. Patients in control group received nifuratel and nysfungin soft capsule,the experimental group received Gynopathic antiphlogistic formula on the basis of control group,with two courses,6 days for one course. The serum inflammatory factors,oxidative stress products and clinical curative effect were compared. Results Compared with pre-treatment,the serum TNF α,CRP,IL-6,IL-8 levels decreased( P < 0. 05),SOD,NO increased( P < 0. 05),MDA,ET-1 decreased( P < 0. 05); compared with control group,the serum TNF α,CRP,IL-6,IL-8 level were lower( P <0. 05),SOD,NO were higher( P < 0. 05),and MDA,ET-1 were lower( P < 0. 05). The clinical efficacy of experimental group was better than that of control group( Z =-2. 902,P = 0. 004). Conclusion The Gynopathic antiphlogistic formula combined with nifuratel and nysfungin has a better efficacy in the treatment of senile colpomycosis,which could effectively reduce the serum levels of inflammatory factors,oxidative stress products with high safety.
Objective To explore the effect of Gynopathic antiphlogistic formula combined with nifuratel and nysfungin on serum levels of CRP,oxidative stress products and its efficacy in the treatment of senile colpomycosis. Methods 66 elderly patients of colpomycosis from October 2014 to December 2015 in department of obstetrics and gynecology of Nanxun Integrative Medicine Hospital were selected and randomly divided into two groups,33 cases in each group. Patients in control group received nifuratel and nysfungin soft capsule,the experimental group received Gynopathic antiphlogistic formula on the basis of control group,with two courses,6 days for one course. The serum inflammatory factors,oxidative stress products and clinical curative effect were compared. Results Compared with pre-treatment,the serum TNF α,CRP,IL-6,IL-8 levels decreased( P < 0. 05),SOD,NO increased( P < 0. 05),MDA,ET-1 decreased( P < 0. 05); compared with control group,the serum TNF α,CRP,IL-6,IL-8 level were lower( P <0. 05),SOD,NO were higher( P < 0. 05),and MDA,ET-1 were lower( P < 0. 05). The clinical efficacy of experimental group was better than that of control group( Z =-2. 902,P = 0. 004). Conclusion The Gynopathic antiphlogistic formula combined with nifuratel and nysfungin has a better efficacy in the treatment of senile colpomycosis,which could effectively reduce the serum levels of inflammatory factors,oxidative stress products with high safety.
引文
[1]王娜梅,崔琳,马春芬,等.苦参凝胶联合氟康唑胶囊治疗霉菌性阴道炎的临床观察[J].中国中药杂志,2015,40(5):978-980.
[2]彭仁菊.中西药外洗相结合治疗霉菌性阴道炎50例[J].中医药临床杂志,2013,25(6):485.
[3]宁艳萍.口服联合外用药物治疗念珠菌性外阴阴道炎患者的临床效果[J].中国药物与临床,2014,14(5):649-650.
[4]胡静,徐婷婷.中药治疗霉菌性阴道炎的疗效观察[J].临床合理用药杂志,2013,6(11):86.
[5]何义萍.霉菌性阴道炎的危险因素分析[J].中国医药指南,2013,11(10):605-606.
[6]樊尚荣,张慧萍.2010年美国疾病控制中心阴道炎治疗指南[J].中国全科医学,2011,14(8):821-822.
[7]韦思清.霉菌性阴道炎的诊断及治疗现状[J].临床合理用药杂志,2015,8(1):180-181.
[8]严清霜,汤万权.中西医结合治疗复发性霉菌性阴道炎64例临床观察[J].中国民族民间医药,2015,24(24):108-109.
[9]旦慧文,卜艳丽.硝呋太尔不良反应文献概述[J].中国药物滥用防治杂志,2015,21(3):172-186.
[10]侯齐书,叶继锋,戴伟伟,等.制霉菌素黏膜给药系统的确定[J].中国药物与临床,2013,13(5):613-615.
[11]毛荣华.硝呋太尔制霉素阴道软胶囊治疗霉菌性阴道炎的临床观察[J].中国医药指南,2013,11(35):59-60.
[12]王波兰.CRP与白细胞检测在孕妇自然分娩前后的应用[J].长江大学学报:自科版,2013,10(33):130.
[13]吕银凤,李姝汶,胡雪梅,等.细菌性阴道病阴道内环境氧化应激状况[J].中国生育健康杂志,2013,19(4):273-277.
[14]马伟荣,童军茂,单春会.超氧化物歧化酶(SOD)的特征及在植物抗逆性方面的研究进展[J].食品工业,2013,34(9):154-158.
[15]宣志强,娄域峰,叶安方,等.介入放射工作人员血清中抗氧化能力的检测与分析[J].中华放射医学与防护杂志,2013,33(4):415-417.
[2]彭仁菊.中西药外洗相结合治疗霉菌性阴道炎50例[J].中医药临床杂志,2013,25(6):485.
[3]宁艳萍.口服联合外用药物治疗念珠菌性外阴阴道炎患者的临床效果[J].中国药物与临床,2014,14(5):649-650.
[4]胡静,徐婷婷.中药治疗霉菌性阴道炎的疗效观察[J].临床合理用药杂志,2013,6(11):86.
[5]何义萍.霉菌性阴道炎的危险因素分析[J].中国医药指南,2013,11(10):605-606.
[6]樊尚荣,张慧萍.2010年美国疾病控制中心阴道炎治疗指南[J].中国全科医学,2011,14(8):821-822.
[7]韦思清.霉菌性阴道炎的诊断及治疗现状[J].临床合理用药杂志,2015,8(1):180-181.
[8]严清霜,汤万权.中西医结合治疗复发性霉菌性阴道炎64例临床观察[J].中国民族民间医药,2015,24(24):108-109.
[9]旦慧文,卜艳丽.硝呋太尔不良反应文献概述[J].中国药物滥用防治杂志,2015,21(3):172-186.
[10]侯齐书,叶继锋,戴伟伟,等.制霉菌素黏膜给药系统的确定[J].中国药物与临床,2013,13(5):613-615.
[11]毛荣华.硝呋太尔制霉素阴道软胶囊治疗霉菌性阴道炎的临床观察[J].中国医药指南,2013,11(35):59-60.
[12]王波兰.CRP与白细胞检测在孕妇自然分娩前后的应用[J].长江大学学报:自科版,2013,10(33):130.
[13]吕银凤,李姝汶,胡雪梅,等.细菌性阴道病阴道内环境氧化应激状况[J].中国生育健康杂志,2013,19(4):273-277.
[14]马伟荣,童军茂,单春会.超氧化物歧化酶(SOD)的特征及在植物抗逆性方面的研究进展[J].食品工业,2013,34(9):154-158.
[15]宣志强,娄域峰,叶安方,等.介入放射工作人员血清中抗氧化能力的检测与分析[J].中华放射医学与防护杂志,2013,33(4):415-417.