2017年山西省大骨节病治疗效果分析
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摘要
目的改善大骨节病患者的关节功能障碍,缓解临床症状,为科学防治积累经验。方法依据国家《成人大骨节病治疗指导意见》,在山西省历史重病区选取10个县,每个县选取Ⅰ度或Ⅱ、Ⅲ度大骨节病患者30人进行药物治疗,疗程3个月,药物以软骨营养素为主,各县自行采购。结果共选取298名大骨节病患者,药物均以硫酸软骨素为主,V-E及抗炎镇痛等药物辅助治疗。治疗总有效率为63.76%;其中,Ⅰ度55.56%,Ⅱ度79.05%,Ⅲ度53.77%。不同分度的大骨节病患者之间疗效经χ~2检验,具有统计学意义(χ~2=26.656,P<0.01);Ⅱ度病例治疗有效率高于Ⅰ度和Ⅲ度。结论以硫酸软骨素为主,V-E及抗炎镇痛等药物为辅助的药物联合对症治疗,对成人大骨节病治疗效果较好。
Objective To improve joint dysfunction in patients with Kaschin-Beck disease(KBD) and relieve clinical symptoms,and accumulate experience for scientific prevention and treatment.Method In accordance with "the National Guidelines for the Treatment of Adult Kaschin-Beck Disease",10 counties were selected in the historically seriously ill areas of Shanxi Province.Thirty patients with KBD of degree Ⅰ or Ⅱ or Ⅲ were selected for drug treatment in each county.The drugs were mainly chondronutrients,which were purchased by the counties themselves,and the course of treatment lasted three months.Results The total effective rate was 63.76%,of which 55.56% was in degree Ⅰ,79.05% in degree Ⅱ and 53.77% in degree Ⅲ.The effective rates between different degrees of KSD were analyzed with χ~2 test,and all of the differences were statistically significant(χ~2 =26.656,P<0.01).Among them,the treatment effective rate of degreeⅡcases was higher than those of degreesⅠand Ⅲ. Conclusion Chondroitin sulfate as the main drug,combined with vitamin E and anti-inflammatory and analgesic drugs treat adult KBD,the curative effect is positive.
Objective To improve joint dysfunction in patients with Kaschin-Beck disease(KBD) and relieve clinical symptoms,and accumulate experience for scientific prevention and treatment.Method In accordance with "the National Guidelines for the Treatment of Adult Kaschin-Beck Disease",10 counties were selected in the historically seriously ill areas of Shanxi Province.Thirty patients with KBD of degree Ⅰ or Ⅱ or Ⅲ were selected for drug treatment in each county.The drugs were mainly chondronutrients,which were purchased by the counties themselves,and the course of treatment lasted three months.Results The total effective rate was 63.76%,of which 55.56% was in degree Ⅰ,79.05% in degree Ⅱ and 53.77% in degree Ⅲ.The effective rates between different degrees of KSD were analyzed with χ~2 test,and all of the differences were statistically significant(χ~2 =26.656,P<0.01).Among them,the treatment effective rate of degreeⅡcases was higher than those of degreesⅠand Ⅲ. Conclusion Chondroitin sulfate as the main drug,combined with vitamin E and anti-inflammatory and analgesic drugs treat adult KBD,the curative effect is positive.
引文
[1] 王正辉,王三祥,吴赵明,等.山西省儿童大骨节病控制和消除评价[J].疾病预防控制通报,2017,32(6):28-30.
[2] 中华人民共和国卫生部.WS/T207-2010 大骨节病诊断[S].北京:中国标准出版社,2010.
[3] 中华人民共和国卫生部.WS/T79-2011 大骨节病治疗效果判定[S].北京:中国标准出版社,2012.
[4] 郭雄.关注大骨节病疾病模型的建立及其应用研究[J].中华地方病学杂志,2017,36(7)469-471.
[5] 曹小刚,吕晓亚,徐刚要,等.3种药物治疗大骨节病的临床疗效观察[J].中国地方病学杂志,2004,23(6):592.
[6] 许鹏,郭雄,靳卫章,等.关节腔内注射透明质酸钠治疗大骨节病的疗效观察[J].中华地方病学杂志,2004,23(6):589-590.
[2] 中华人民共和国卫生部.WS/T207-2010 大骨节病诊断[S].北京:中国标准出版社,2010.
[3] 中华人民共和国卫生部.WS/T79-2011 大骨节病治疗效果判定[S].北京:中国标准出版社,2012.
[4] 郭雄.关注大骨节病疾病模型的建立及其应用研究[J].中华地方病学杂志,2017,36(7)469-471.
[5] 曹小刚,吕晓亚,徐刚要,等.3种药物治疗大骨节病的临床疗效观察[J].中国地方病学杂志,2004,23(6):592.
[6] 许鹏,郭雄,靳卫章,等.关节腔内注射透明质酸钠治疗大骨节病的疗效观察[J].中华地方病学杂志,2004,23(6):589-590.