无机纳米药物载体在肿瘤诊疗中的研究进展
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摘要
纳米药物作为一种新兴技术,为肿瘤的精确定位和早期诊断、靶向、长效和联合治疗提供了重要的研发平台,为克服传统药物非特异性靶向和非选择性损伤机体组织的瓶颈问题提供了可能。近年来研究者基于量子点、纳米金、纳米介孔硅等无机纳米药物载体设计合成了大量可用于肿瘤诊疗的纳米药物,主要通过"核-壳"结构设计、表面修饰等方法提高纳米药物性能。综述了无机纳米材料作为纳米药物载体在肿瘤诊疗中的应用,详细介绍了纳米药物的设计策略和肿瘤诊疗作用机制,并对未来进行无机纳米药物在肿瘤诊疗中的临床应用进行了展望。
Nanomedicine, as an integrated platform, has the potential to accurately monitor tumor for early diagnosis and dramatically improve the targeted, long-lasting and combinational therapy. Compared with traditional therapeutics, nanomedicine would effectively improve the drug accumulationand controlled release in the tumor sites to improve the therapeutic effect. Recently, all kinds of nanomedicines are designed and synthesized for tumor diagnosis and treatment based on inorganic nanocarriers, such as quantum dots, gold nanoparticles, silicon nanoparticles and so on. They might be adjusted and promoted their properties by core-shell structure, surface modification and other strategies. In this review, the inorganic nanometer materials as nano drug carriers applied in tumor diagnosis and treatment were summarized; nano drug design strategies and mechanisms of tumor diagnosis and treatment were introduced in detail, and the future of inorganic nano drugs in tumor diagnosis and treatment of clinical application was prospected.
Nanomedicine, as an integrated platform, has the potential to accurately monitor tumor for early diagnosis and dramatically improve the targeted, long-lasting and combinational therapy. Compared with traditional therapeutics, nanomedicine would effectively improve the drug accumulationand controlled release in the tumor sites to improve the therapeutic effect. Recently, all kinds of nanomedicines are designed and synthesized for tumor diagnosis and treatment based on inorganic nanocarriers, such as quantum dots, gold nanoparticles, silicon nanoparticles and so on. They might be adjusted and promoted their properties by core-shell structure, surface modification and other strategies. In this review, the inorganic nanometer materials as nano drug carriers applied in tumor diagnosis and treatment were summarized; nano drug design strategies and mechanisms of tumor diagnosis and treatment were introduced in detail, and the future of inorganic nano drugs in tumor diagnosis and treatment of clinical application was prospected.
引文
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[13]FAN J L,GUO S G,WANG S,et al.Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363enzyme-targeting[J].Chemical Communications,2017,53(35):4857-4860.
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[25]ZHOU W,GAO X,LIU D,et al.Gold nanoparticles for in vitro diagnostics[J].Chemical Reviews,2015,115(19):10575-10636.
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[37]LIANG C,DIAO S,WANG C,et al.Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes[J].Advanced Materials,2014,26(32):5646-5652.
[38]LIU J,WANG C,WANG X,et al.Mesoporous silica coated single-walled carbon nanotubes as a multifunctional light‐responsive platform for cancer combination therapy[J].Advanced Functional Materials,2015,25(3):384-392.
[39]XIE L S,WANG G H,ZHOU H,et al.Functional long circulating single walled carbon nanotubes for fluorescent/photoacoustic imaging-guided enhanced phototherapy[J].Biomaterials,2016,103:219-228.
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[41]KANG S,LEE J,RYU S,et al.Gold nanoparticle graphene oxide hybrid sheets attached on mesenchymal stem cells for effective photothermal cancer therapy[J].Chemistry of Materials,2017,29(8):3461-3476.
[42]WANG S,LIN Q J,CHEN J T,et al.Biocompatible polydopamine-encapsulated gadolinium-loaded carbon nanotubes for MRI and color mapping guided photothermal dissection of tumor metastasis[J].Carbon,2017,112:53-62.
[43]罗运晖,乐恺,赵凌云,等.交变磁场中Fe3O4磁流体对肿瘤组织加热作用的理论研究[J].化工学报,2009,60(4):833-839.LUO Y H,YUE K,ZHAO L Y,et al.Theoretical study on heating effect of Fe3O4 magnetic fluid on tumor tissues in alternating magnetic field[J].CIESC Journal,2009,60(4):833-839.
[44]胡平,常恬,陈震宇,等.纳米Fe3O4磁性颗粒表面改性及其在医学和环保领域的应用[J].化工学报,2017,68(7):2641-2652.HU P,CHANG T,CHEN Z Y,et al.Surface modification and application in biomedicine and environmental protection of magnetic Fe3O4 nanoparticles[J].CIESC Journal,2017,68(7):2641-2652.
[45]LAURENT S,FORGE D,PORT M,et al.Magnetic iron oxide nanoparticles:synthesis,stabilization,vectorization,physicochemical characterizations,and biological applications[J].Chemical Reviews,2008,108(6):2064-2110.
[46]LEE N,YOO D,LING D,et al.Iron oxide based nanoparticles for multimodal imaging and magneto responsive therapy[J].Chemical Reviews,2015,115(19):10637-10689.
[47]LI J C,ZHENG L F,CAI H D,et al.Polyethylene imine-mediated synthesis of folic acid-targeted iron oxide nanoparticles for in vivo tumor MR imaging[J].Biomaterials,2013,34(33):8382-8392.
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