黄芩汤传统汤剂与配方颗粒中3种有效成分的比较研究
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摘要
目的:比较黄芩汤传统汤剂与配方颗粒中3种有效成分的含量差异。方法:采用HPLC法测定黄芩汤配方颗粒与传统汤剂中黄芩苷、芍药苷、甘草酸的含量,并对含量测定方法进行考察。结果:传统汤剂与10个不同厂家不同批号配方颗粒综合评分分别为618.50、250.47、351.41、522.70、485.31、423.52、463.30、404.42、261.64、202.24、250.88,传统汤剂综合评分明显高于不同厂家生产的配方颗粒。结论:传统汤剂有效成分含量高于配方颗粒。
Objective: To compare the content of three effective components of Huangqin Tang traditional decoction and formula granules. Methods: HPLC method was used to determine the content of baicalin, paeoniflorin and glycyrrhizic acid of Huangqin Tang granules and traditional decoctions, and the content determination method was investigated. Results: The traditional decoction with different manufacturers of different batch number formula particle comprehensive score were 618.50, 250.47, 351.41, 522.70, 485.31, 423.52, 463.30, 404.42,261.64, 202.24 and 250.88; the traditional decoction comprehensive score was significantly higher than that of different manufacturers Formula particles. Conclusion: The traditional decoction has more active ingredients than formula granules.
Objective: To compare the content of three effective components of Huangqin Tang traditional decoction and formula granules. Methods: HPLC method was used to determine the content of baicalin, paeoniflorin and glycyrrhizic acid of Huangqin Tang granules and traditional decoctions, and the content determination method was investigated. Results: The traditional decoction with different manufacturers of different batch number formula particle comprehensive score were 618.50, 250.47, 351.41, 522.70, 485.31, 423.52, 463.30, 404.42,261.64, 202.24 and 250.88; the traditional decoction comprehensive score was significantly higher than that of different manufacturers Formula particles. Conclusion: The traditional decoction has more active ingredients than formula granules.
引文
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[3]张立山,李超.浅议黄芩汤[J].中华中医药杂志,2016,31(12):5107-5109.
[4]吴英魁.黄芩汤颗粒剂治疗大肠湿热型溃疡性结肠炎[J].中国医药指南,2016,14(21):187-188.
[5]杨梅,吴东.黄芩汤颗粒剂联合美沙拉秦对溃疡性结肠炎的临床疗效研究[J].中国中西医结合消化杂志,2016,24(3):221-223.
[6]陈敏妃,李华峰,许志良.黄芩汤病机初探[J].浙江中医药大学学报,2016,40(12):926-927,931.
[7]陈丽,颜春鲁,朱俊燚,等.黄芩汤对溃疡性结肠炎大鼠的治疗作用及机制研究[J].中药材,2016,39(3):652-655.
[8]赵坤,宋攀,张其奇,等.黄芩汤治疗溃疡性结肠炎疗效的Meta分析[J].中国实验方剂学杂志,2016,22(4):213-217.
[9]罗云,张婧,赵海平,等.高效液相色谱法同时测定银翘散中绿原酸、连翘苷、牛蒡苷、甘草苷、甘草酸的含量[J].中国药学杂志,2013,48(6):473-476.
[10]林伟雄,乐智勇,车海燕,等.吴茱萸汤颗粒剂、配方颗粒剂及传统汤剂中指标成分的含量比较[J].中国实验方剂学杂志,2017,23(13):30-34.
[11]刘效栓,李喜香,焦正花,等.正交试验法优选防风感冒颗粒制备工艺[J].中国中医药信息杂志,2012,19(1):64-66.
[12]李俊杰,文学平,徐凌云.黄芩苷新剂型及其药理学研究进展[J].中国新药杂志,2017,26(17):2046-2051.
[13]金英善,陈曼丽,陶俊.芍药化学成分和药理作用研究进展[J].中国药理学与毒理学杂志,2013,27(4):745-750.
[14]韩瑶聃,王彬,王政雨,等.甘草酸药理作用的研究进展[J].中国新药杂志,2012,21(21):2499-2505.
[15]马鸿雁,李霞,李楠,等.甘草及其活性成分的表面活性比较研究[J].现代药物与临床,2011,26(3):227-229.