免疫1号方治疗气阴两虚证干燥综合征临床研究
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摘要
目的:观察免疫1号方治疗气阴两虚证干燥综合征的临床疗效。方法:将60例气阴两虚证干燥综合征患者随机分为中医组和对照组,各30例;对照组采用硫酸羟氯喹片治疗,中医组在对照组治疗的基础上加用免疫1号方治疗;2组疗程均为3个月,观察比较2组临床疗效、中医证候积分、口干津少及目干涩的视觉模拟评分法(VAS)评分、泪液分泌试验情况。结果:总有效率中医组为93.33%,对照组为70.00%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组眼干、口干、乏力、鼻干、关节疼痛、皮肤干等中医证候积分均较治疗前降低(P <0.05);且中医组上述各项积分均低于对照组(P <0.05)。治疗后,2组主症口干津少、目干涩的VAS评分均较治疗前降低(P <0.05);且中医组两项评分均低于对照组(P <0.05)。治疗后,泪液分泌试验阳性率中医组为6.67%,对照组为26.67%,2组比较,差异有统计学意义(P <0.05)。结论:免疫1号方治疗气阴两虚证干燥综合征疗效显著,可明显改善患者临床症状,恢复泪腺分泌功能。
Objective: To observe the clinical effect of immunity No.1 prescription on sjogren syndrome with dual deficiency of qi and yin syndrome. Methods:A total of 60 cases of patients with sjogren syndrome with dual deficiency of qi and yin syndrome were randomly divided into the Chinese medicine group and the control group,30 cases in each group. The control group was treated with hydroxychloroquine sulfate tablets,and the Chinese medicine group was additionally treated with immunity No.1 prescription based on the treatment of the control group. Both groups were treated for three months. The clinical effect,Chinese medicine syndrome scores,the scores of dry mouth,little fluid and dry eyes in Visual Analogue Scale(VAS) and the results of Schirmer's test in the two groups were observed and compared. Results:The total effective rate was93.33% in the Chinese medicine group and 70.00% in the control group, the difference being significant(P < 0.05). After treatment,Chinese syndrome scores including dry eyes,dry mouth,hypodynamia,dry nose,joint pain and dry skin in the two groups were decreased when compared with those before treatment(P < 0.05); the above scores in the Chinese medicine group were lower than those in the control group(P < 0.05). After treatment,the scores of main symptoms of dry mouth,little fluid and dry eyes in VAS in the two groups were decreased when compared with those before treatment(P <0.05);the above scores in the Chinese medicine group were lower than those in the control group(P < 0.05). After treatment,the positive rate of Schirmer's test was 6.67% in the Chinese medicine group and 26.67% in the control group,the difference being significant(P < 0.05). Conclusion:Immunity No.1 prescription has significant curative effect in treating sjogren syndrome with dual deficiency of qi and yin syndrome,which can significantly alleviate the symptoms and restore the secretory function of lacrimal gland.
Objective: To observe the clinical effect of immunity No.1 prescription on sjogren syndrome with dual deficiency of qi and yin syndrome. Methods:A total of 60 cases of patients with sjogren syndrome with dual deficiency of qi and yin syndrome were randomly divided into the Chinese medicine group and the control group,30 cases in each group. The control group was treated with hydroxychloroquine sulfate tablets,and the Chinese medicine group was additionally treated with immunity No.1 prescription based on the treatment of the control group. Both groups were treated for three months. The clinical effect,Chinese medicine syndrome scores,the scores of dry mouth,little fluid and dry eyes in Visual Analogue Scale(VAS) and the results of Schirmer's test in the two groups were observed and compared. Results:The total effective rate was93.33% in the Chinese medicine group and 70.00% in the control group, the difference being significant(P < 0.05). After treatment,Chinese syndrome scores including dry eyes,dry mouth,hypodynamia,dry nose,joint pain and dry skin in the two groups were decreased when compared with those before treatment(P < 0.05); the above scores in the Chinese medicine group were lower than those in the control group(P < 0.05). After treatment,the scores of main symptoms of dry mouth,little fluid and dry eyes in VAS in the two groups were decreased when compared with those before treatment(P <0.05);the above scores in the Chinese medicine group were lower than those in the control group(P < 0.05). After treatment,the positive rate of Schirmer's test was 6.67% in the Chinese medicine group and 26.67% in the control group,the difference being significant(P < 0.05). Conclusion:Immunity No.1 prescription has significant curative effect in treating sjogren syndrome with dual deficiency of qi and yin syndrome,which can significantly alleviate the symptoms and restore the secretory function of lacrimal gland.
引文
[1]王小琪,刘东舟,刘翠莲,等.原发性干燥综合征发病机制的研究进展[J].临床医学研究与实践,2017,2(3):189-191.
[2]张昊泽,张奉春.深入探究干燥综合征的发病机制[J].浙江医学,2016,38(3):157-158,162.
[3]方妍妍,刘健,董文哲,等.刘健运用健脾益气法辨治干燥综合征的经验[J].中国临床保健杂志,2017,20(5):604-606.
[4]中华医学会风湿病学分会.干燥综合征诊断及治疗指南[J].中华风湿病学杂志,2010,14(11):766-768.
[5]娄玉钤.中国风湿病学[M].北京:人民卫生出版社,2001:1641-1642.
[6]国家技术监督局.中医临床诊疗术语证候部分[M].北京:中国标准出版社,1997:1-2.
[7]国家中医药管理局医政司.22个专业95个病种中医诊疗方案[M].北京:国家中医药管理局医政司,2010:280-284.
[8]董庆,徐旭娟.干燥综合征疲乏症状研究进展[J].重庆医学,2017,46(2):264-266.
[9]郭丽,李志军.感染与干燥综合征关系的研究进展[J].医学综述,2017,23(8):1633-1637.
[10]姜泉,张华东,陈祎,等.路志正治疗干燥综合征经验[J].中医杂志,2016,57(6):463-465.
[11]陆韵薇,于顾然,符布清.生地黄水煎剂对H2O2诱导的PC12细胞凋亡的保护作用研究[J].江苏中医药,2016,48(10):103-105.
[2]张昊泽,张奉春.深入探究干燥综合征的发病机制[J].浙江医学,2016,38(3):157-158,162.
[3]方妍妍,刘健,董文哲,等.刘健运用健脾益气法辨治干燥综合征的经验[J].中国临床保健杂志,2017,20(5):604-606.
[4]中华医学会风湿病学分会.干燥综合征诊断及治疗指南[J].中华风湿病学杂志,2010,14(11):766-768.
[5]娄玉钤.中国风湿病学[M].北京:人民卫生出版社,2001:1641-1642.
[6]国家技术监督局.中医临床诊疗术语证候部分[M].北京:中国标准出版社,1997:1-2.
[7]国家中医药管理局医政司.22个专业95个病种中医诊疗方案[M].北京:国家中医药管理局医政司,2010:280-284.
[8]董庆,徐旭娟.干燥综合征疲乏症状研究进展[J].重庆医学,2017,46(2):264-266.
[9]郭丽,李志军.感染与干燥综合征关系的研究进展[J].医学综述,2017,23(8):1633-1637.
[10]姜泉,张华东,陈祎,等.路志正治疗干燥综合征经验[J].中医杂志,2016,57(6):463-465.
[11]陆韵薇,于顾然,符布清.生地黄水煎剂对H2O2诱导的PC12细胞凋亡的保护作用研究[J].江苏中医药,2016,48(10):103-105.