国内妊娠期高血压综合征的系统评价及Meta分析文献再评价
|
摘要
目的对国内数据库收录的关于妊娠期高血压综合征的系统评价及Meta分析文献进行质量评价,并讨论其主要研究结果。方法检索中国知网、万方医学网、维普数据库,截止时间至2018年12月,依据纳入及排除标准筛选出妊娠期高血压综合征的相关系统评价及Meta分析文献,采用AMSTAR量表评价并分析文献质量。结果最终纳入的77篇文献中,检索的数据库平均为5.21个,文献AMSTAR评分为5.68分,中等质量文献占75.32%;纳入的文献主要推荐采用sFLT-1/PlGF检测子痫,对高危孕产妇推荐采用低剂量阿司匹林和补钙措施预防子痫,对于血压偏高的孕产妇推荐采用硝苯地平降压治疗。结论国内发表的妊娠期高血压综合征系统评价及Meta分析的质量有待进一步提高,高质量的研究有助于妊娠期高血压综合征的准确早期诊断、干预、治疗。
Objective To evaluate the quality of systematic reviews and Meta-analysis literature on pregnancy-induced hypertension syndrome in domestic database, and to discuss the main study results. Methods The databases of CNKI,Wanfang Medical databases and Weipu databases until December 2018 were retrieved. According to the inclusion and exclusion criteria, the systematic reviews and Meta-analysis literature on pregnancy-induced hypertension syndrome were selected, and literature quality was evaluated and analyzed using the AMSTAR scale. Results Of 77 literatures included,the average number of databases retrieved was 5.21, and the AMSTAR score of literatures was 5.68, medium-quality literature accounted for 75.32%. In literatures, the sFLT-1/PlGF was recommended for the detection of eclampsia, low-dose aspirin and calcium supplementation was recommended for the prevention of eclampsia in high-risk pregnant women, and nifedipine was recommended for the treatment of pregnant patients with high blood pressure. Conclusion The quality of systematic reviews and Meta-analysis in pregnancy-induced hypertension syndrome in China needs to be further strengthened. High-quality research contributes to accurate early diagnosis, intervention and treatment of pregnancy-induced hypertension syndrome.
Objective To evaluate the quality of systematic reviews and Meta-analysis literature on pregnancy-induced hypertension syndrome in domestic database, and to discuss the main study results. Methods The databases of CNKI,Wanfang Medical databases and Weipu databases until December 2018 were retrieved. According to the inclusion and exclusion criteria, the systematic reviews and Meta-analysis literature on pregnancy-induced hypertension syndrome were selected, and literature quality was evaluated and analyzed using the AMSTAR scale. Results Of 77 literatures included,the average number of databases retrieved was 5.21, and the AMSTAR score of literatures was 5.68, medium-quality literature accounted for 75.32%. In literatures, the sFLT-1/PlGF was recommended for the detection of eclampsia, low-dose aspirin and calcium supplementation was recommended for the prevention of eclampsia in high-risk pregnant women, and nifedipine was recommended for the treatment of pregnant patients with high blood pressure. Conclusion The quality of systematic reviews and Meta-analysis in pregnancy-induced hypertension syndrome in China needs to be further strengthened. High-quality research contributes to accurate early diagnosis, intervention and treatment of pregnancy-induced hypertension syndrome.
引文
[1]NGOC N,THI N.Causes of stillbirths and early neonatal deaths:data from 7993 pregnancies in six developing countries[J].Bull World Health Organ,2006,84(9):699-705.
[2]MOODLEY J.Maternal deaths associated with hypertensive disorders of pregnancy:a opulation-based study[J].Hypertens Pregnancy,2004,23(3):247-256.
[3]ROBERTS JM,PEARSON G,CUTLER J,et al.Summary of the NHLBIworking group on research on hypertension during pregnancy[J].Hypertension,2003,41(3):437-445.
[4]韩如雪,刘澳林,陈贤坤,等.血脂康治疗高脂血症系统评价的再评价[J].中药新药与临床药理,2019,30(1):110-116.
[5]熊俊,陈日新.系统评价/Meta分析方法学质量的评价工具AM-STAR[J].中国循证医学杂志,2011,11(9):1084-1089.
[6]DULEY L.The global impact of pre-eclampsia and eclampsia[J].Semin Perinatol,2009,33(3):130-137.
[7]蔡俊英,陈梅娇,林清.联合补充维生素C和E预防先兆子(疒间)发生随机对照试验的Meta分析[J].第二军医大学学报,2010,31(11):1206-1210.
[8]庞国勋,马银玲,邱志宏,等.口服硝苯地平与静脉注射拉贝洛尔治疗重度妊娠期高血压的系统评价与Meta分析[J].中国药物评价,2018,35(5):384-390.
[9]顾宁,胡娅莉.拉贝洛尔治疗妊娠期轻中度高血压对母儿结局影响的meta分析[J].中华围产医学杂志,2014,17(10):682-688.
[10]刘倩倩,余艳红,龚时鹏,等.硝苯地平治疗重度子痫前期患者临床疗效与围产儿结局的荟萃分析[J].中华妇产科杂志,2012,47(8):592-597.
[11]洪音,孟浩,徐俊,等.血清sFlt-1、PLGF水平及比值变化预测孕妇轻度子痫前期发病的Meta分析[J].南京医科大学学报自:然科学版,2016,36(10):1270-1276.
[2]MOODLEY J.Maternal deaths associated with hypertensive disorders of pregnancy:a opulation-based study[J].Hypertens Pregnancy,2004,23(3):247-256.
[3]ROBERTS JM,PEARSON G,CUTLER J,et al.Summary of the NHLBIworking group on research on hypertension during pregnancy[J].Hypertension,2003,41(3):437-445.
[4]韩如雪,刘澳林,陈贤坤,等.血脂康治疗高脂血症系统评价的再评价[J].中药新药与临床药理,2019,30(1):110-116.
[5]熊俊,陈日新.系统评价/Meta分析方法学质量的评价工具AM-STAR[J].中国循证医学杂志,2011,11(9):1084-1089.
[6]DULEY L.The global impact of pre-eclampsia and eclampsia[J].Semin Perinatol,2009,33(3):130-137.
[7]蔡俊英,陈梅娇,林清.联合补充维生素C和E预防先兆子(疒间)发生随机对照试验的Meta分析[J].第二军医大学学报,2010,31(11):1206-1210.
[8]庞国勋,马银玲,邱志宏,等.口服硝苯地平与静脉注射拉贝洛尔治疗重度妊娠期高血压的系统评价与Meta分析[J].中国药物评价,2018,35(5):384-390.
[9]顾宁,胡娅莉.拉贝洛尔治疗妊娠期轻中度高血压对母儿结局影响的meta分析[J].中华围产医学杂志,2014,17(10):682-688.
[10]刘倩倩,余艳红,龚时鹏,等.硝苯地平治疗重度子痫前期患者临床疗效与围产儿结局的荟萃分析[J].中华妇产科杂志,2012,47(8):592-597.
[11]洪音,孟浩,徐俊,等.血清sFlt-1、PLGF水平及比值变化预测孕妇轻度子痫前期发病的Meta分析[J].南京医科大学学报自:然科学版,2016,36(10):1270-1276.