甜槠化学成分研究(Ⅰ)
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摘要
目的:研究甜槠树叶中的化学成分。方法:采用Toyopearl HW-40F、Sephadex LH-20、MCI gel CHP 20P、HP20SS等柱色谱对甜槠树叶乙醇提取物进行分离与纯化,运用MS、~1H-NMR、~(13)C-NMR等波谱学方法对化合物进行结构鉴定。结果:从甜槠树叶中分离得到13个化合物,分别鉴定为:没食子酸(1)、gallic aldehyde(2)、咖啡酸(3)、愈创木基丙三醇(4)、ethyl-β-D-glucopyranoside(5)、6-O-galloylglucose(6)、ethyl-O-β-(6′-galloyl)-glucopyranoside(7)、(3R,1′S)-[1′-(6″-O-galloyl-β-D-glucopyranosyl)oxyethyl]-3-hydroxy-dihydrofuran-2(3H)-one(8)、blumenol A(9)、mallophenol B(10)、4-O-咖啡酰基奎宁酸(11)、5-O-咖啡酰基奎宁酸(12)、icariol A_2(13)。结论:所有化合物均为首次从该植物中分离得到,其中,化合物2、6的核磁数据为首次报道。
Objective:To study the chemical constituents from the leaves of Castanopsis eyrei.Methods:The compounds were isolated and purified by Toyopearl HW-40 F、Sephadex LH-20,MCI gel CHP 20 P and HP20 SS column chromatographies,the structures were identified by mass spectroscopic,~1H-NMR and ~(13)C-NMR analysis.Results:Thirteen compounds were obtianed and identified as gallic acid(1)、gallic aldehyde(2)、caffecic acid(3)、guaiacylglycerol(4)、ethyl-β-D-glucopyranoside(5)、6-O-galloylglucose(6)、ethyl-O-β-(6′-galloyl)-glucopyranoside(7)、(3R,1′S)-[1′-(6″-O-galloyl-β-D-glucopyranosyl)oxyethyl]-3-hydroxy-dihydrofuran-2(3 H)-one(8)、blumenol A(9)、mallophenol B(10)、4-O-caffeoylquinic acid(11)、5-O-caffeoylquinic acid(12)、icariol A_2(13).Conclusion:All the compounds are isolated from this plant for the first time.The compounds 2 and 6 are known compounds,but the NMR datum are reported for the first time.
Objective:To study the chemical constituents from the leaves of Castanopsis eyrei.Methods:The compounds were isolated and purified by Toyopearl HW-40 F、Sephadex LH-20,MCI gel CHP 20 P and HP20 SS column chromatographies,the structures were identified by mass spectroscopic,~1H-NMR and ~(13)C-NMR analysis.Results:Thirteen compounds were obtianed and identified as gallic acid(1)、gallic aldehyde(2)、caffecic acid(3)、guaiacylglycerol(4)、ethyl-β-D-glucopyranoside(5)、6-O-galloylglucose(6)、ethyl-O-β-(6′-galloyl)-glucopyranoside(7)、(3R,1′S)-[1′-(6″-O-galloyl-β-D-glucopyranosyl)oxyethyl]-3-hydroxy-dihydrofuran-2(3 H)-one(8)、blumenol A(9)、mallophenol B(10)、4-O-caffeoylquinic acid(11)、5-O-caffeoylquinic acid(12)、icariol A_2(13).Conclusion:All the compounds are isolated from this plant for the first time.The compounds 2 and 6 are known compounds,but the NMR datum are reported for the first time.
引文
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[10] Huang YL,Wang YF,Liu JL,et al.Phenolic Compounds from the leaves of Castanopsis fargesii[J].Molecules,2017,22(1):E162.
[11] 许小红,阮宝强,蒋山好,等.笔管草中Megastigmane及黄酮苷类化学成分[J].中国天然药物,2015,3(2):93-96.
[12] Wei K,Li W,Koike K,et al.Two new galloylglucosides from the leaves of Malloatus furetianus[J].Chem Pharm Bull,2004,52(6):776-779.
[13] 张婷婷,曹跃,曹佳,等.火绒草的咖啡酰类成分研究[J].中药材,2017,40(1):90-93.
[14] 石钺,石任兵,刘斌,等.银翘散抗流感病毒有效部位群化学成分的分离与鉴定[J].中国中药杂志,2003,28(1):43-47.
[15] 彭伟文,何文生,纪梦颖,等.黑面神药材70%乙醇提取部分的化学成分研究[J].中国药房,2017,28(36):5144-5147.
[2] 王亚凤,黄永林,刘金磊,等.栲树叶多酚类成分的研究(Ⅰ)[J].中成药,2016,38(7):1531-1533.
[3] 沈欣承.亚热带甜槠天然林生物量和碳储量研究[D].株洲:中南林业科技大学,2017.
[4] 杨小凤,付宏征,雷海民,等.栾树的化学成分[J].药学学报,1999,34(6):457-462.
[5] 施树云,周宏灏,张宇平,等.管花蒲公英化学成分研究[J].中国中药杂志,2009,34(8):1002-1004.
[6] 蒋伟,王长虹,王峥涛.当归水溶性成分研究[J].中国药学杂志,2010,45(2):101-103.
[7] Takayanagi T,Ishikawa T,Kitajima J.Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin[J].Phytochemistry,2003,63(4):479-484.
[8] Lampire O,Mila I,Raminosoa M,et al.Polyphenols isolated from the bark of Castanea sativ Mill.chemical structures and auto-association[J].Phytochemistry,1998,49(2):623-631.
[9] Kang QJ,Yang XW,Wu SH,et al.Chemical constituents from the stem bark of Trewia nudiflora L.and their Antioxidant activities[J].Planta Medica,2008,74(4):445-448.
[10] Huang YL,Wang YF,Liu JL,et al.Phenolic Compounds from the leaves of Castanopsis fargesii[J].Molecules,2017,22(1):E162.
[11] 许小红,阮宝强,蒋山好,等.笔管草中Megastigmane及黄酮苷类化学成分[J].中国天然药物,2015,3(2):93-96.
[12] Wei K,Li W,Koike K,et al.Two new galloylglucosides from the leaves of Malloatus furetianus[J].Chem Pharm Bull,2004,52(6):776-779.
[13] 张婷婷,曹跃,曹佳,等.火绒草的咖啡酰类成分研究[J].中药材,2017,40(1):90-93.
[14] 石钺,石任兵,刘斌,等.银翘散抗流感病毒有效部位群化学成分的分离与鉴定[J].中国中药杂志,2003,28(1):43-47.
[15] 彭伟文,何文生,纪梦颖,等.黑面神药材70%乙醇提取部分的化学成分研究[J].中国药房,2017,28(36):5144-5147.