成都市体检人群连续8年血尿酸水平变化及高尿酸血症患病率分析
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摘要
目的:分析成都地区健康体检者2009-2016年连续8年血清尿酸(SUA)水平及高尿酸血症(HUA)患病率动态变化,进一步为HUA的防治提供依据。方法:连续8年检测822例健康体检者SUA水平及肝功、肾功、血清酶类生化指标及2009年和2016年两年总体检人群SUA水平。结果:连续8年体检人群SUA水平与性别相关,并且在女性各年龄段存在显著差异(P <0.001)。经年龄、性别矫正后,体检人群第8年时SUA水平显著高于第1年(P <0.001),HUA的患病率逐年增加,男性HUA患病率明显高于女性(P <0.05)。体检人群在40岁左右时,HUA的发病风险最低,78岁时发病风险达到最大。高脂血症会显著增加HUA的患病风险。结论:成都市体检人群SUA水平及HUA患病率随体检时间增加有增高的趋势,应引起医务人员高度重视,加强该地区人群健康宣教。
Objective: To analyze serum uric acid(SUA) levels and prevalence of hyperuricemia(HUA) of health examination population in Chengdu from 2009 to 2016 consecutively, and to provide further evidence for the prevention and treatment of HUA. Methods: SUA, serum liver and renal function, and serum enzymes of 822 health examination cases in consecutive 8 years were evaluated;average SUA of total health examination cases in 2009 and 2016 were compared. Results: In 8 consecutive years, the SUA level is related to the gender of population, and is statistically different in different age group of female(P<0.001). After correction for gender and age,SUA levels in the eighth year were higher than that in the first year(P<0.001), and HUA incidence tended to increase over time(P<0.05). Risk of HUA was the lowest in 40 years old, and the highest in 78 years old. Hyperlipidemia could significantly increase risk of HUA. Conclusion: SUA and HUA incidence of health examination cases in Chengdu showed a severe increasing trend. We should pay high attention, strengthen propaganda and education in this area.
Objective: To analyze serum uric acid(SUA) levels and prevalence of hyperuricemia(HUA) of health examination population in Chengdu from 2009 to 2016 consecutively, and to provide further evidence for the prevention and treatment of HUA. Methods: SUA, serum liver and renal function, and serum enzymes of 822 health examination cases in consecutive 8 years were evaluated;average SUA of total health examination cases in 2009 and 2016 were compared. Results: In 8 consecutive years, the SUA level is related to the gender of population, and is statistically different in different age group of female(P<0.001). After correction for gender and age,SUA levels in the eighth year were higher than that in the first year(P<0.001), and HUA incidence tended to increase over time(P<0.05). Risk of HUA was the lowest in 40 years old, and the highest in 78 years old. Hyperlipidemia could significantly increase risk of HUA. Conclusion: SUA and HUA incidence of health examination cases in Chengdu showed a severe increasing trend. We should pay high attention, strengthen propaganda and education in this area.
引文
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[11]Xiang D,Chao Z,Jie W,et al.The associations of serum uric acid level and hyperuricemia with knee osteoarthritis[J].Rheumatology International,2016,20(5):1-7.
[12]Li Q,Zhou Y,Dong K,et al.The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque:A Cross-sectional Study[J].Scientific Reports,2015(5):10003.
[2]Tian Y,Kang C,Xie Z,et al.The association between serum uric acid levels,metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese:results from the DYSlipidemia International Study[J].Bmc Cardiovascular Disorders,2015,15(1):1-10.
[3]李晓敏,陈泽娜,古洁若.高尿酸血症的现状不容忽视[J].新医学,2016,47(3):137-141.
[4]中国成人血脂异常防治指南制订联合委员会.中国成人血脂异常防治指南[M].北京:人民卫生出版社,2007:390-409.
[5]陈涛,李卫,王杨,等.高尿酸血症的患病情况及相关因素分析[J/CD].中华临床医师杂志:电子版,2012,6(13):49-52.
[6]张清涛.某市住建系统职工体检人群高尿酸血症及相关因素[J].公共卫生与预防医学,2016,27(1):111-113.
[7]刘健,何影仪,郑敏玲,等.健康体检人群血清尿酸水平6年动态变化分析[J].检验医学与临床,2012,9(5):526-527.
[8]张立新,刘春晖.白银市健康体检人群高尿酸血症流行特征分析[J].疾病预防控制通报,2015(1):41-42.
[9]吴子瑜,陈仕智,万建新.福州市健康体检成人高尿酸血症发生率调查及相关危险因素分析[J].中华高血压杂志,2012,20(10):952-955.
[10]刘晶茹,张秀梅,谭丽,等.长春市体检人群高尿酸血症患病率调查及相关危险因素分析[J].中国临床研究,2014,27(6):763-765.
[11]Xiang D,Chao Z,Jie W,et al.The associations of serum uric acid level and hyperuricemia with knee osteoarthritis[J].Rheumatology International,2016,20(5):1-7.
[12]Li Q,Zhou Y,Dong K,et al.The Association between Serum Uric Acid Levels and the Prevalence of Vulnerable Atherosclerotic Carotid Plaque:A Cross-sectional Study[J].Scientific Reports,2015(5):10003.