2510株鲍曼不动杆菌分布特征及耐药性
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摘要
目的分析鲍曼不动杆菌(ABA)分布特征及耐药性,为临床提供治疗依据。方法回顾性分析医院2013年1月至2016年12月分离的2 510株ABA的检出率、临床感染分布、药敏结果及多重ABA菌株分离率。结果 4年来,该院ABA占所有检出病原菌的比例呈上升趋势;在痰标本及咽拭子的检出率最高(90.92%);药敏试验结果显示,ABA对常见14种抗菌药的耐药率整体呈上升趋势;4年间多重耐药ABA的分离率由12.50%上升到15.62%。结论 ABA的检出率和耐药性不断上升,应动态监测该菌的分布及耐药情况变迁,分析药敏试验结果,合理使用抗菌药物,以提高疗效并减缓耐药菌株的产生。
Objective To investigate the distribution features and drug resistance of Acinetobacter baumnnii(ABA), to provide references for the clinical therapeutics. Methods The detection rates, clinical infection distributions, drug sensitivity test results and multiple ABA strain isolation rates of 2 510 strains ABA isolated from January 2013 to December 2016 were retrospective analyzed. Results The study found that the proportion of ABA in all pathogenic bacteria increased during the four years in the hospital. The detection rate of ABA was the highest in sputum samples and oropharyngeal swabs(90.92%).The drug sensitivity test results showed that the drug resistance rate of ABA had an upward trend for the 14 kinds of common antibiotics on the whole, and the separation rate of ABA increased from 12.50% to 15.62% in the four years.Conclusion The detection rate and resistance rate of ABA showed increasing trend. It should dynamiclly monitor the ABA distribution and resistance changes, and analyze the drug sensitivity test results to guide the rational use of antibiotics so as to increase the positive effect and reduce drug resistance rate.
Objective To investigate the distribution features and drug resistance of Acinetobacter baumnnii(ABA), to provide references for the clinical therapeutics. Methods The detection rates, clinical infection distributions, drug sensitivity test results and multiple ABA strain isolation rates of 2 510 strains ABA isolated from January 2013 to December 2016 were retrospective analyzed. Results The study found that the proportion of ABA in all pathogenic bacteria increased during the four years in the hospital. The detection rate of ABA was the highest in sputum samples and oropharyngeal swabs(90.92%).The drug sensitivity test results showed that the drug resistance rate of ABA had an upward trend for the 14 kinds of common antibiotics on the whole, and the separation rate of ABA increased from 12.50% to 15.62% in the four years.Conclusion The detection rate and resistance rate of ABA showed increasing trend. It should dynamiclly monitor the ABA distribution and resistance changes, and analyze the drug sensitivity test results to guide the rational use of antibiotics so as to increase the positive effect and reduce drug resistance rate.
引文
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[2]卫生计划生育委员会.抗菌药物临床应用指导原则:2015年版[S].2015-07-24.
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[4]郑卫东,陈娟,郭亮,等.鲍曼不动杆菌耐药性分析及治疗应对策略[J].国际检验医学杂志,2014,35(12):1597-1599.
[5]罗湘蓉,李红凌,何平,等.鲍曼不动杆菌的感染分布及耐药性分析[J].检验医学与临床,2012,9(10):1248-1249.
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[7]姜凤丽,董亚琳,刘冬,等.ICU耐碳青霉烯类抗菌药物鲍曼不动杆菌肺部感染危险因素分析[J].中国药房,2015,26(29):4077-4079.
[8]尤玉红,王冬梅,姜月红,等.1146株鲍曼不动杆菌临床分布及耐药性变迁分析[J].检验与临床,2012,50(8):111-112.
[9]陈佰义,何礼贤,胡必杰,等.中国鲍曼不动杆菌感染诊治与防控专家共识[J].中华医学杂志,2012,92(2):76-85.
[10]COYNE S,ROSENFELD N,LAMBERT T,et al.Overexpression of resistance-nodulation-cell division pump Ade FGH confers multidrug resistance in Acinetobacter baumannii[J].Antimicrob Agents Chemother,2010,54(10):4389-4393.
[11]张功武,钱惠.我院抗菌药物临床应用与细菌耐药情况分析[J].安徽卫生职业技术学院学报,2017,19(4):35-38.
[12]何艳春,林伟雄,覃军.2005—2008年我院抗菌药物使用与细菌耐药性分析[J].中国医院用药评价与析,2010,10(2):123-125.
[13]凌保东.鲍曼不动杆菌抗生素多重耐药性:耐药机制与感染治疗对策[J].中国抗生素杂志,2010,35(4):241-254.
[14]黄婷婷,周志健,杨英为,等.耐碳青霉烯类鲍曼不动杆菌耐药机制及同源性分析[J].中国消毒学杂志,2016,33(5):499-501.
[2]卫生计划生育委员会.抗菌药物临床应用指导原则:2015年版[S].2015-07-24.
[3]许根友.学习《全国临床检验操作规程》(第3版)第一篇对检验工作的实际意义[J].临床血液学杂志(输血与检验),2010,23(6):759-760.
[4]郑卫东,陈娟,郭亮,等.鲍曼不动杆菌耐药性分析及治疗应对策略[J].国际检验医学杂志,2014,35(12):1597-1599.
[5]罗湘蓉,李红凌,何平,等.鲍曼不动杆菌的感染分布及耐药性分析[J].检验医学与临床,2012,9(10):1248-1249.
[6]HASSAN KA,LIU Q,HENDERSON PJF,et al.Homologs of the Acinetobacter baumannii Ace I transporter represent a new family of bacterial multidrug efflux systems[J].MBio,2015,6(1):e01982-14.
[7]姜凤丽,董亚琳,刘冬,等.ICU耐碳青霉烯类抗菌药物鲍曼不动杆菌肺部感染危险因素分析[J].中国药房,2015,26(29):4077-4079.
[8]尤玉红,王冬梅,姜月红,等.1146株鲍曼不动杆菌临床分布及耐药性变迁分析[J].检验与临床,2012,50(8):111-112.
[9]陈佰义,何礼贤,胡必杰,等.中国鲍曼不动杆菌感染诊治与防控专家共识[J].中华医学杂志,2012,92(2):76-85.
[10]COYNE S,ROSENFELD N,LAMBERT T,et al.Overexpression of resistance-nodulation-cell division pump Ade FGH confers multidrug resistance in Acinetobacter baumannii[J].Antimicrob Agents Chemother,2010,54(10):4389-4393.
[11]张功武,钱惠.我院抗菌药物临床应用与细菌耐药情况分析[J].安徽卫生职业技术学院学报,2017,19(4):35-38.
[12]何艳春,林伟雄,覃军.2005—2008年我院抗菌药物使用与细菌耐药性分析[J].中国医院用药评价与析,2010,10(2):123-125.
[13]凌保东.鲍曼不动杆菌抗生素多重耐药性:耐药机制与感染治疗对策[J].中国抗生素杂志,2010,35(4):241-254.
[14]黄婷婷,周志健,杨英为,等.耐碳青霉烯类鲍曼不动杆菌耐药机制及同源性分析[J].中国消毒学杂志,2016,33(5):499-501.