儿童紫癜性肾炎病因及免疫机制研究进展
摘要
目的过敏性紫癜是儿童时期常见的一种白细胞破裂性小血管炎,主要累及皮肤、胃肠道、关节、肾脏。当肾脏受损时发展为紫癜性肾炎,其中有2.2%的紫癜性肾炎患儿最终进展为终末期肾病。紫癜性肾炎的发病机制并不完全明确,现就该病的病因、发病机制研究新进展进行综述。
引文
[1] SaulsburyFT.Clinical update.Henoch-Schonlein purpura.Lan-cet,2007,369(9566):976-978.
[2] Brogan PA,Dillon MJ.Vasculitis from the pediatric perspective[J].CurrRheumatol Rep,2000,2:411-416.
[3] Lau KK,Suzuki H,Nowak J,et al.Pathogenesis of Henoch-Schonlein purpura nephritis[J].Pediatr Nephrol,2010,25(1):19-26.
[4] 陈艳霞,曹莉萍, 房向东,等 .幽门螺杆菌感染与肾脏相关性疾病[J].基础医学与临床 ,2014,34(8):1150-1153.
[5] 张鹏、何晓东、陈望.幽门螺杆菌与紫癜性肾炎的相关性研究[J].中国现代药物应用,2016,10(14):172-173.
[6] 黎文静、徐萌,等.儿童过敏性紫癜患者肺炎支原体抗体的检测及其临床意义[J].吉林大学学报,2017.43(1):155-158.
[7] 吴春蕾,樊忠民,夏正坤,等.血管紧张素原基因多态性与儿童过敏性紫癜及紫癜性肾炎的关系[J].临床儿科杂志,2009,27(4):314-316.
[8] 赵培伟,李瑛,何学莲,等.血管紧张素转换酶基因插入/缺失多态性与过敏性紫癜及紫癜性肾炎相关性研究Meta分析[J].中国实用儿科杂志,2011,26:767-769.
[9] 侯红红、黄燕萍,等.CTLA-4基因多态性与过敏性紫癜的相关性研究[J].中国当代儿科杂志,2017,19(3):296-302.
[10] 王宝香,梅红,等.纤溶酶原激活物抑制因子1基因多态性与过敏性紫癜胃肠道出血的相关性[J].临床儿科杂志,2016,34(3):197-200.
[11] Stoilova-McPhie S,Villoutreix BO,Mertens K,et al.3-Dimensional structure of membrane-bound coagulation factor VIII:modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography[J].Blood,2002,99:1215-23.
[12] Elmas AT,Tabel Y.Platelet counts in children with henoch-schonlein purpura-relationship to renal involvement.J Clin Lab Anal.2014.doi:10.1002/jcla.21817.
[13] Tabel Y,Inanc FC,Dogan DG,et al.Clinical features of children with Henoch-Schonlein purpura:risk factors associated with renal involvement.Iran J Kidney Dis,2012,6(4):269-274.
[14] Elmas AT,Tabel Y.Platelet counts in children with henoch-schonlein purpura-relationship to renal involvement[J].J Clin Lab Anal.2014.doi:10.1002/jcla.21817.
[15] Imke Hennies,Charlotte Gimpel,et al.Presentation of pediatric Henoch-Sch?nlein purpura nephritis changes with age and renal histology depends on biopsy timing.Pediatr Nephrol.2017.DOI 10.1007/s00467-017-3794-1.
[16] Gharavi AG,Moldoveanu Z,Wyatt RJ,Barker CV,Woodford SY,Lifton RP,et al.Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy.J Am Soc Nephrol,2008,19:1008-1014.
[17] Coppo R,Amore A.Aberrantly glycosylated IgA nephropathy(IgAN)[J].Kidney Int,2004,65(5):1544-1547.
[18] Jun-Yi Chen,Jian-Hua Mao.Henoch-Sch?nlein purpura nephritis in children:incidence,pathogenesis and management[J].World Journal of Pediatrics,2015,11(1):29-34.
[19] 徐达良,王云,杨巧芝,等.儿童过敏性紫癜性肾炎病理特点与临床表现相关性[J].中华实用儿科临床杂志,2015,30(21):1622-1625.
[20] 焦宏,张辉,佟月娟,等.过敏性紫癜肾炎患儿外周血淋巴细胞的变化特点[J].中华实验和临床感染病杂志(电子版),2015,9(5):661-664.
[21] 张红,王强,房俊,等.儿童过敏性紫癜急性期T细胞亚群及B细胞的变化及意义[J].实用医院临床杂志,2017,14(2):75-77.
[22] 王战胜,刘雨露,等.纠正Th1/Th2迁移在小儿过敏性紫癜早期肾损伤急救中的临床意义[J].中国损伤与修复杂志(电子版),2016,11(2):113-116.
[23] 邵晓珊,江超,李宇红,等.儿童紫癜性肾炎CD4+CD25+调节性T细胞的功能研究[J].中华儿科杂志,2014,52(7):516-520.
[24] 杨帆,伍伟锋.IL-23/Th17轴与自身免疫性疾病[J].国际免疫学杂志,2012,35(1):61-63.
[25] Baohui Y,Xiongjun T,et al.Effect of CD40/CD40L signaling on IL-10-producing regulatory B cells in Chinese children with Henoch-Sch?nlein purpura nephritis[J].Immunol Res,2017,65:592-604.
[26] 谭雄俊,杨宝辉,等.IL-10+B细胞对儿童过敏性紫癜Th17/Treg免疫平衡紊乱的影响[J].免疫学杂志,2017,33(2):133-140.
[27] 邢静,李文斌,等.儿童过敏性紫癜患者血清IL-21、TGF-β、TNF-α和IgA1的变化及其意义[J].海南医学,2017,28(3):394-396.
[28] 张远达,董青伟,等.过敏性紫癜患儿25-羟基维生素D3水平变化及意义[J].中国当代儿科杂志,2017,19(3):292-295.
[29] 李涛,邓芳,等.血管紧张素原在儿童过敏性紫癜肾炎发生发展中的作用[J].中国现代医学杂志,2017,27(16):53-57.
[2] Brogan PA,Dillon MJ.Vasculitis from the pediatric perspective[J].CurrRheumatol Rep,2000,2:411-416.
[3] Lau KK,Suzuki H,Nowak J,et al.Pathogenesis of Henoch-Schonlein purpura nephritis[J].Pediatr Nephrol,2010,25(1):19-26.
[4] 陈艳霞,曹莉萍, 房向东,等 .幽门螺杆菌感染与肾脏相关性疾病[J].基础医学与临床 ,2014,34(8):1150-1153.
[5] 张鹏、何晓东、陈望.幽门螺杆菌与紫癜性肾炎的相关性研究[J].中国现代药物应用,2016,10(14):172-173.
[6] 黎文静、徐萌,等.儿童过敏性紫癜患者肺炎支原体抗体的检测及其临床意义[J].吉林大学学报,2017.43(1):155-158.
[7] 吴春蕾,樊忠民,夏正坤,等.血管紧张素原基因多态性与儿童过敏性紫癜及紫癜性肾炎的关系[J].临床儿科杂志,2009,27(4):314-316.
[8] 赵培伟,李瑛,何学莲,等.血管紧张素转换酶基因插入/缺失多态性与过敏性紫癜及紫癜性肾炎相关性研究Meta分析[J].中国实用儿科杂志,2011,26:767-769.
[9] 侯红红、黄燕萍,等.CTLA-4基因多态性与过敏性紫癜的相关性研究[J].中国当代儿科杂志,2017,19(3):296-302.
[10] 王宝香,梅红,等.纤溶酶原激活物抑制因子1基因多态性与过敏性紫癜胃肠道出血的相关性[J].临床儿科杂志,2016,34(3):197-200.
[11] Stoilova-McPhie S,Villoutreix BO,Mertens K,et al.3-Dimensional structure of membrane-bound coagulation factor VIII:modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography[J].Blood,2002,99:1215-23.
[12] Elmas AT,Tabel Y.Platelet counts in children with henoch-schonlein purpura-relationship to renal involvement.J Clin Lab Anal.2014.doi:10.1002/jcla.21817.
[13] Tabel Y,Inanc FC,Dogan DG,et al.Clinical features of children with Henoch-Schonlein purpura:risk factors associated with renal involvement.Iran J Kidney Dis,2012,6(4):269-274.
[14] Elmas AT,Tabel Y.Platelet counts in children with henoch-schonlein purpura-relationship to renal involvement[J].J Clin Lab Anal.2014.doi:10.1002/jcla.21817.
[15] Imke Hennies,Charlotte Gimpel,et al.Presentation of pediatric Henoch-Sch?nlein purpura nephritis changes with age and renal histology depends on biopsy timing.Pediatr Nephrol.2017.DOI 10.1007/s00467-017-3794-1.
[16] Gharavi AG,Moldoveanu Z,Wyatt RJ,Barker CV,Woodford SY,Lifton RP,et al.Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy.J Am Soc Nephrol,2008,19:1008-1014.
[17] Coppo R,Amore A.Aberrantly glycosylated IgA nephropathy(IgAN)[J].Kidney Int,2004,65(5):1544-1547.
[18] Jun-Yi Chen,Jian-Hua Mao.Henoch-Sch?nlein purpura nephritis in children:incidence,pathogenesis and management[J].World Journal of Pediatrics,2015,11(1):29-34.
[19] 徐达良,王云,杨巧芝,等.儿童过敏性紫癜性肾炎病理特点与临床表现相关性[J].中华实用儿科临床杂志,2015,30(21):1622-1625.
[20] 焦宏,张辉,佟月娟,等.过敏性紫癜肾炎患儿外周血淋巴细胞的变化特点[J].中华实验和临床感染病杂志(电子版),2015,9(5):661-664.
[21] 张红,王强,房俊,等.儿童过敏性紫癜急性期T细胞亚群及B细胞的变化及意义[J].实用医院临床杂志,2017,14(2):75-77.
[22] 王战胜,刘雨露,等.纠正Th1/Th2迁移在小儿过敏性紫癜早期肾损伤急救中的临床意义[J].中国损伤与修复杂志(电子版),2016,11(2):113-116.
[23] 邵晓珊,江超,李宇红,等.儿童紫癜性肾炎CD4+CD25+调节性T细胞的功能研究[J].中华儿科杂志,2014,52(7):516-520.
[24] 杨帆,伍伟锋.IL-23/Th17轴与自身免疫性疾病[J].国际免疫学杂志,2012,35(1):61-63.
[25] Baohui Y,Xiongjun T,et al.Effect of CD40/CD40L signaling on IL-10-producing regulatory B cells in Chinese children with Henoch-Sch?nlein purpura nephritis[J].Immunol Res,2017,65:592-604.
[26] 谭雄俊,杨宝辉,等.IL-10+B细胞对儿童过敏性紫癜Th17/Treg免疫平衡紊乱的影响[J].免疫学杂志,2017,33(2):133-140.
[27] 邢静,李文斌,等.儿童过敏性紫癜患者血清IL-21、TGF-β、TNF-α和IgA1的变化及其意义[J].海南医学,2017,28(3):394-396.
[28] 张远达,董青伟,等.过敏性紫癜患儿25-羟基维生素D3水平变化及意义[J].中国当代儿科杂志,2017,19(3):292-295.
[29] 李涛,邓芳,等.血管紧张素原在儿童过敏性紫癜肾炎发生发展中的作用[J].中国现代医学杂志,2017,27(16):53-57.