血塞通和激素静脉滴注联合高压氧治疗突发性感音神经性聋的临床效果
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摘要
目的探讨血塞通和激素静脉滴注联合高压氧治疗突发性感音神经性聋的临床效果。方法选取2015年1月～2018年7月我院收治的127例突发性感音神经性聋患者作为研究对象。根据不同的治疗方式,将患者分为常规组(63例)和试验组(64例)。常规组患者采用糖皮质激素静脉滴注治疗,试验组在常规组治疗的基础上使用血塞通联合高压氧治疗。比较两组患者的纯音听阈、混合静脉血氧饱和度(SvO2)和治疗效果。结果试验组患者治疗后的纯音听阈为(42.02±11.35)dB HL,低于常规组的(51.05±10.89)dB HL,差异有统计学意义(P<0.05);试验组患者治疗后的SvO2水平为(98.61±1.62)%,高于常规组的(95.34±1.27)%,差异有统计学意义(P<0.05);试验组患者治疗后的总有效率为95.31%,高于常规组的84.13%,差异有统计学意义(P<0.05)。结论突发性感音神经性聋患者在激素静脉滴注治疗的基础上采用注射用血塞通联合高压氧治疗,临床效果效显著,值得推广和使用。
Objective To investigate the clinical effect of Xuesaitong and hormone intravenous drip combined with hyperbaric oxygen in the treatment of sudden sensorineural hearing loss. Methods A total of 127 patients with sudden sensorineural deafness treated in our hospital from January 2015 to July 2018 were selected as study objects. According to different treatment methods, the patients were divided into routine group(63 cases) and experimental group(64 cases). The patients in the routine group were treated with glucocorticoid intravenous drip, while the patients in the experimental group were treated with Xuesaitong combined with hyperbaric oxygen on the basis of routine treatment. The pure tone hearing threshold, mixed venous oxygen saturation(SvO_2) and treatment effect were compared between the two groups. Results The pure tone hearing threshold after treatment in the experimental group was(42.02±11.35) dB HL, which was lower than that in the routine group for(51.05±10.89) dB HL, and the difference was statistically significant(P<0.05). The level of SvO_2 after treatment in the experimental group was(98.61±1.62)%, which was higher than that in the routine group for(95.34±1.27)%, and the difference was statistically significant(P<0.05). The total effective rate after treatment in the experimental group was 95.31%, which was higher than that in the routine group for 84.13%,and the difference was statistically significant(P<0.05). Conclusion Patients with sudden sensorineural hearing loss treated with Xuesaitong combined with hyperbaric oxygen on the basis of hormone intravenous drip, has significant clinical effect, which is worth popularizing and using.
Objective To investigate the clinical effect of Xuesaitong and hormone intravenous drip combined with hyperbaric oxygen in the treatment of sudden sensorineural hearing loss. Methods A total of 127 patients with sudden sensorineural deafness treated in our hospital from January 2015 to July 2018 were selected as study objects. According to different treatment methods, the patients were divided into routine group(63 cases) and experimental group(64 cases). The patients in the routine group were treated with glucocorticoid intravenous drip, while the patients in the experimental group were treated with Xuesaitong combined with hyperbaric oxygen on the basis of routine treatment. The pure tone hearing threshold, mixed venous oxygen saturation(SvO_2) and treatment effect were compared between the two groups. Results The pure tone hearing threshold after treatment in the experimental group was(42.02±11.35) dB HL, which was lower than that in the routine group for(51.05±10.89) dB HL, and the difference was statistically significant(P<0.05). The level of SvO_2 after treatment in the experimental group was(98.61±1.62)%, which was higher than that in the routine group for(95.34±1.27)%, and the difference was statistically significant(P<0.05). The total effective rate after treatment in the experimental group was 95.31%, which was higher than that in the routine group for 84.13%,and the difference was statistically significant(P<0.05). Conclusion Patients with sudden sensorineural hearing loss treated with Xuesaitong combined with hyperbaric oxygen on the basis of hormone intravenous drip, has significant clinical effect, which is worth popularizing and using.
引文
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[10]Kim TS,Yoo MH,Lee HS,et al.Short-term changes in tinnitus pitch related to audiometric shape in sudden sensorineural hearing loss[J].Auris Nasus Larynx,2016,43(3):281-286.
[11]迟放鲁,赵晖.突发性聋的高压氧治疗[J].中国眼耳鼻喉科杂志,2017,17(1):3-6.
[12]张明,李云霞,杨志远.高压氧辅助前列地尔联合鼓室注射地塞米松对突发性耳聋患者听力恢复和血流变学的影响[J].中国临床医生杂志,2017,45(11):75-77.
[13]Eftekharian A,Amizadeh M.Pulse steroid therapy in idiopathic sudden sensorineural hearing loss:a randomized controlled clinical trial[J].Laryngoscope,2016,126(1):150-155.
[14]李希平.突发性聋的治疗困惑与思考[J].中国耳鼻咽喉头颈外科,2016,23(2):63-65.
[15]Lee JW,Park YA,Park SM,et al.Clinical features and prognosis of sudden sensorineural hearing loss secondary to intralabyrinthine hemorrhage[J].J Audiol Otol,2016,20(1):31-35.
[2]杨莉,干强,方红雁,等.糖皮质激素与高压氧治疗高频下降型突发性耳聋的临床疗效观察[J].重庆医学,2017,46(14):1910-1911.
[3]徐桂丽,林道冠,林青.糖皮质激素联合高压氧治疗突发性聋的临床观察[J].中国听力语言康复科学杂志,2018,16(1):22-25.
[4]王冰.高压氧辅助治疗糖尿病合并突发性耳聋患者的疗效观察[J].中国听力语言康复科学杂志,2016,14(5):371-373.
[5]Hou J,She W,Du X,et al.Histone deacetylase 2 in sudden sensorineural hearing loss patients in response to intratympanic methylprednisolone perfusion[J].Otolaryngol Head Neck Surg,2016,154(1):164.
[6]王丽平,李中明,徐沙丽.高压氧联合法舒地尔注射液治疗突发性耳聋的疗效观察[J].神经损伤与功能重建,2016,11(5):451-453.
[7]孙饶奚,赵宇,刘军.布地奈德鼓室内注射治疗难治性突发性聋[J].临床耳鼻咽喉头颈外科杂志,2016,(12):972-977.
[8]Nakagawa T,Yamamoto M,Kumakawa K,et al.Prognostic impact of salvage treatment on hearing recovery in patients with sudden sensorineural hearing loss refractory to systemic corticosteroids:a retrospective observational study[J].Auris Nasus Larynx,2016,43(5):489-494.
[9]周景慧.高压氧联合银杏达莫治疗突发性聋的疗效观察[J].临床耳鼻咽喉头颈外科杂志,2016,(19):1559-1560.
[10]Kim TS,Yoo MH,Lee HS,et al.Short-term changes in tinnitus pitch related to audiometric shape in sudden sensorineural hearing loss[J].Auris Nasus Larynx,2016,43(3):281-286.
[11]迟放鲁,赵晖.突发性聋的高压氧治疗[J].中国眼耳鼻喉科杂志,2017,17(1):3-6.
[12]张明,李云霞,杨志远.高压氧辅助前列地尔联合鼓室注射地塞米松对突发性耳聋患者听力恢复和血流变学的影响[J].中国临床医生杂志,2017,45(11):75-77.
[13]Eftekharian A,Amizadeh M.Pulse steroid therapy in idiopathic sudden sensorineural hearing loss:a randomized controlled clinical trial[J].Laryngoscope,2016,126(1):150-155.
[14]李希平.突发性聋的治疗困惑与思考[J].中国耳鼻咽喉头颈外科,2016,23(2):63-65.
[15]Lee JW,Park YA,Park SM,et al.Clinical features and prognosis of sudden sensorineural hearing loss secondary to intralabyrinthine hemorrhage[J].J Audiol Otol,2016,20(1):31-35.