唑吡坦不良反应文献分析
|
摘要
目的分析唑吡坦不良反应的发生情况及特点,为临床安全用药提供参考。方法检索中国生物医学文献数据库、中国科学引文数据库、中文科技期刊全文数据库(维普)、中国学术期刊(网络版)、万方数字化期刊全文库、PubMed数据库有关唑吡坦不良反应个案报道,进行回顾性分析。结果共纳入文献病例55例,男女比例1∶1.12,年龄≥65岁者24人,构成比为43.64%;不良反应多发生于服药后1 d内,共34例,构成比为61.82%;累及系统/器官主要以中枢神经系统为主,表现为睡行症、精神异常、幻觉、睡眠饮食障碍等,其次为泌尿生殖系统。结论临床应高度重视唑吡坦的不良反应,加强用药监护,确保用药安全。
Objective To analyze the occurrence and characteristics of adverse reactions induced by zolpidem in order to provide reference for clinical safe medication. Methods China Biology Medicine disc, Chinese Science Citation Database, Chinese Science and Technology Journal Full-text Database(VIP), Chinese Academic Journal(online), Wangfang Database, and PubMed Database were searched for adverse drug reactions induced by zolpidem, and were made a retrospective analysis. Results Totally 55 cases were included in the literature, and the ratio of male to female was 1∶1.12. Patients older than 65 years accounted for 43.64%. Patients(34 cases) had adverse reactions within 1 d after taking the medicine, constituting 61.28%. The system/organs involved were mainly the central nervous system, which was mainly for somnambulism, mental disorders, hallucinations, sleep and eating disorders, etc, followed by the urogenital system. Conclusion Adverse reactions induced by zolpidem should be highly valued to strengthen medication custody and ensure drug safety.
Objective To analyze the occurrence and characteristics of adverse reactions induced by zolpidem in order to provide reference for clinical safe medication. Methods China Biology Medicine disc, Chinese Science Citation Database, Chinese Science and Technology Journal Full-text Database(VIP), Chinese Academic Journal(online), Wangfang Database, and PubMed Database were searched for adverse drug reactions induced by zolpidem, and were made a retrospective analysis. Results Totally 55 cases were included in the literature, and the ratio of male to female was 1∶1.12. Patients older than 65 years accounted for 43.64%. Patients(34 cases) had adverse reactions within 1 d after taking the medicine, constituting 61.28%. The system/organs involved were mainly the central nervous system, which was mainly for somnambulism, mental disorders, hallucinations, sleep and eating disorders, etc, followed by the urogenital system. Conclusion Adverse reactions induced by zolpidem should be highly valued to strengthen medication custody and ensure drug safety.
引文
[1]American Academy of Sleep Medicine.International Classification of Sleep Disorders[M].3rd ed.Darien,Illinois:American Academy of Sleep Medicine,2014.
[2]Janson C,Lindberg E,Gislason T,et al.Insomnia in men-a 10-year prospective population based study.[J].Sleep,2001,24(4):425.
[3]李振洲,张耀芬,曹燕滔,等.唑吡坦诱发夜游症一例[J].中华老年心脑血管病杂志,2008,10(1):60.
[4]吴虹,史祥平.唑吡坦引起一过性定向障碍[J].药物不良反应杂志,2005,7(2):130-131.
[5]曹燕滔,李振洲,张昕,等.唑吡坦引起睡行症[J].药物不良反应杂志,2007,9(4):279-280.
[6]张辉,姜景丽,张淑英.唑吡旦致顺行性遗忘2例[J].临床荟萃,2008,23(6):409-409.
[7]郭庆棠.思诺思致精神症状3例[J].青岛大学医学院学报,2001,37(4):314-314.
[8]黄国军,阮云军.思诺思致精神症状2例[J].第一军医大学分校学报,2002,25(1):77-78.
[9]费叶,余艳芳.唑吡坦引起精神症状不良反应1例[J].药物流行病学杂志,2004,13(5):278-279.
[10]付英,田亚云,敦昌平,等.酒石酸唑吡坦导致不宁腿综合征1例[J].临床荟萃,2017,32(3):259-260.
[11]龙飞隆.唑吡坦致癫痫样发作1例[J].实用医学杂志,2004,20(11):35.
[12]吴小和.唑吡坦致精神症状1例[J].中国新药与临床杂志,2004,23(4):256-256.
[13]周斌,辛苏萍,张磊,等.唑吡坦致晕厥1例[J].临床荟萃,2012,27(13):1136-1136.
[14]刘志勇,叶文胜.唑吡坦致精神错乱一例[J].中华老年医学杂志,2004,23(4):224-224.
[15]孙爱军,徐丽婷.酒石酸唑吡坦致精神障碍1例[J].中国药物应用与监测,2008,5(6):52-52.
[16]过斌,屈英.唑吡坦所致幻视1例[J].临床精神医学杂志,2008,18(6):383-383.
[17]王志强,张春红,张秀华.酒石酸唑吡坦片致精神症状1例[J].中国临床药理学杂志,2005,21(4):21.
[18]纪晓芳,何忠芳.酒石酸唑吡坦致尿失禁1例[J].医药导报,2013,32(1):126-127.
[19]孙向菊,吴玉波,蒋爱华.唑吡坦致尿失禁[J].药物不良反应杂志,2010,12(6):409-418.
[20]戴慧卿,张文悦,李全志.喹硫平与唑吡坦联用致抗精神病药恶性综合征[J].药物不良反应杂志,2010,12(3):211-212.
[21]臧若虹,于冉.酒石酸唑吡坦与文拉法辛合用致幻觉[J].药物不良反应杂志,2010,12(2):143-144.
[22]聂鑫,张亚同.酒石酸唑吡坦片致精神错乱[J].药物不良反应杂志,2010,12(3):212-213.
[23]孙云川,李荔,赵环宇,等.唑吡坦致高龄男性患者性欲异常1例[J].药物流行病学杂志,2016,25(11):741-742.
[24]曹晶晶,王虎军.唑吡坦致老年患者睡行症[J].药物不良反应杂志,2008,10(2):139-140.
[25]邱畅,江帆,邝如意.唑吡坦致睡眠行为障碍3例[J].药物不良反应杂志,2010,12(4):286-288.
[26]钟晗,刘晓琰,赵旭霁.唑吡坦致患者昏迷1例分析[J].药物流行病学杂志,2013,22(11):626-627.
[27]王怡苹,邓晓辉,范鲁雁.唑吡坦致精神症状2例[J].中国医院药学杂志,2016,36(2):157-158.
[28]牛慧艳,栾松,张占强.酒石酸唑吡坦片致梦驾症1例[J].中国健康月刊,2011,30(9):5-6.
[29]铁常乐,毛佩贤.酒石酸唑吡坦诱发睡行症一例[J].中华精神科杂志,2010,43(1):7.
[30]张庆玉,王训强,季蕴辛.唑吡坦引起幻视1例[J].中国药物依赖性杂志,2015,24(1):78.
[31]章斌,解莹馨.酒石酸唑吡坦致精神症状2例[J].医药导报,2017,36(s1):151-152.
[32]Huang C L,Chang C J,Hung C F,et al.Zolpideminduced distortion in visual perception[J].Ann Pharmacother,2003,37(5):683-686.
[33]Doane J A,Dalpiaz A S.Zolpidem-induced sleep-driving[J].Am J Med,2008,121(11):e5.
[34]Dang A,Garg G,Rataboli P V.Zolpidem induced nocturnal sleep-related eating disorder(NSRED)in a male patient[J].Int J Eat Disord,2010,42(4):385-386.
[35]Morgenthaler T I,Silber M H.Amnestic sleep-related eating disorder associated with zolpidem[J].Sleep Med,2002,3(4):323-327.
[36]Kinnan S,Petty F,Wilson D R.Zolpidem-induced mania in a patient with schizoaffective disorder[J].Psychosomatics,2011,52(5):493-494.
[37]Tripodianakis J,Potagas C,Papageorgiou P,et al.Zolpidemrelated epileptic seizures:a case report[J].Eur Psychiatry,2003,18(3):140-141.
[38]Sattar S P,Ramaswamy S,Bhatia S C,et al.Somnambulism due to probable interaction of valproic acid and zolpidem[J].Ann Pharmacother,2003,37(10):1429.
[39]Martín-Clavo S,Maciá-Botejara E,Liso-Rubio F J,et al.Erythrodermia induced by zolpidem:case description[J].Farm Hosp,2009,33(33):53-54.
[40]Brodeur M R,Stirling A L.Delirium associated with zolpidem[J].Ann Pharmacother,2001,35(12):1562.
[41]Young-Min P,Hyun-Woo S.Zolpidem induced sleeprelated eating and complex behaviors in a patient with obstructive sleep apnea and restless legs syndrome[J].Clin Psychopharmacol Neurosci,2016,14(3):299-301.
[42]Sharma A,Dewan V K.A Case report of zolpideminduced somnambulism[J].Prim Care Companion J Clin Psychiatry,2005,7(2):74.
[43]Nzwalo H,Ferreira L,Peralta R,et al.Sleep-related eating disorder secondary to zolpidem[J].BMJ Case Rep,2013,doi:10.1136/bcr-2012-008003.
[44]Skourides D,Samartzis L.Initiation of illusions after combination of zolpidem and paroxetine in a young woman:a case report.[J].Prim Care Companion Cns Disord,2012,14(4):e121-e122.
[45]da Silva V C,Bittencourt P L,Pinho S,et al.Delayedonset hepatic encephalopathy induced by zolpidem:a case report[J].Clinics(Sao Paulo),2008,63(4):565-566.
[46]Yang W,Dollear M,Muthukrishnan S R.One rare side effect of zolpidem-sleepwalking:a case report[J].Arch Phys Med Rehabil,2005,86(6):1265-1266.
[47]Pal S G,Neeraj L.Zolpidem-induced hallucinations:a brief case report from the Indian subcontinent[J].Indian J Psychol Med,2013,35(2):212-213.
[48]Mortaz H S,Faizi M,Babaeian M.Zolpidem-induced suicide attempt:a case report[J].Daru,2013,21(1):77.
[49]Priya S S,Dl B,T S.Zolpidem induced hyponatremia:a case report[J].J Clin Diagn Res,2014,8(9):HD03.
[50]Freudenreich O,Menza M.Zolpidem-related delirium:a case report[J].J Clin Psychiatry,2000,61(6):449-450.
[51]Toner L C,Tsambiras B M,Catalano G,et al.Central nervous system side effects associated with zolpidem treatment[J].Clin Neuropharmacol,1999,23(1):54-58.
[52]Inagaki T,Miyaoka T,Tsuji S,et al.Adverse reactions to zolpidem:case reports and a review of the literature[J].Prim Care Companion J Clin Psychiatry,2010,12(6):733-739.
[2]Janson C,Lindberg E,Gislason T,et al.Insomnia in men-a 10-year prospective population based study.[J].Sleep,2001,24(4):425.
[3]李振洲,张耀芬,曹燕滔,等.唑吡坦诱发夜游症一例[J].中华老年心脑血管病杂志,2008,10(1):60.
[4]吴虹,史祥平.唑吡坦引起一过性定向障碍[J].药物不良反应杂志,2005,7(2):130-131.
[5]曹燕滔,李振洲,张昕,等.唑吡坦引起睡行症[J].药物不良反应杂志,2007,9(4):279-280.
[6]张辉,姜景丽,张淑英.唑吡旦致顺行性遗忘2例[J].临床荟萃,2008,23(6):409-409.
[7]郭庆棠.思诺思致精神症状3例[J].青岛大学医学院学报,2001,37(4):314-314.
[8]黄国军,阮云军.思诺思致精神症状2例[J].第一军医大学分校学报,2002,25(1):77-78.
[9]费叶,余艳芳.唑吡坦引起精神症状不良反应1例[J].药物流行病学杂志,2004,13(5):278-279.
[10]付英,田亚云,敦昌平,等.酒石酸唑吡坦导致不宁腿综合征1例[J].临床荟萃,2017,32(3):259-260.
[11]龙飞隆.唑吡坦致癫痫样发作1例[J].实用医学杂志,2004,20(11):35.
[12]吴小和.唑吡坦致精神症状1例[J].中国新药与临床杂志,2004,23(4):256-256.
[13]周斌,辛苏萍,张磊,等.唑吡坦致晕厥1例[J].临床荟萃,2012,27(13):1136-1136.
[14]刘志勇,叶文胜.唑吡坦致精神错乱一例[J].中华老年医学杂志,2004,23(4):224-224.
[15]孙爱军,徐丽婷.酒石酸唑吡坦致精神障碍1例[J].中国药物应用与监测,2008,5(6):52-52.
[16]过斌,屈英.唑吡坦所致幻视1例[J].临床精神医学杂志,2008,18(6):383-383.
[17]王志强,张春红,张秀华.酒石酸唑吡坦片致精神症状1例[J].中国临床药理学杂志,2005,21(4):21.
[18]纪晓芳,何忠芳.酒石酸唑吡坦致尿失禁1例[J].医药导报,2013,32(1):126-127.
[19]孙向菊,吴玉波,蒋爱华.唑吡坦致尿失禁[J].药物不良反应杂志,2010,12(6):409-418.
[20]戴慧卿,张文悦,李全志.喹硫平与唑吡坦联用致抗精神病药恶性综合征[J].药物不良反应杂志,2010,12(3):211-212.
[21]臧若虹,于冉.酒石酸唑吡坦与文拉法辛合用致幻觉[J].药物不良反应杂志,2010,12(2):143-144.
[22]聂鑫,张亚同.酒石酸唑吡坦片致精神错乱[J].药物不良反应杂志,2010,12(3):212-213.
[23]孙云川,李荔,赵环宇,等.唑吡坦致高龄男性患者性欲异常1例[J].药物流行病学杂志,2016,25(11):741-742.
[24]曹晶晶,王虎军.唑吡坦致老年患者睡行症[J].药物不良反应杂志,2008,10(2):139-140.
[25]邱畅,江帆,邝如意.唑吡坦致睡眠行为障碍3例[J].药物不良反应杂志,2010,12(4):286-288.
[26]钟晗,刘晓琰,赵旭霁.唑吡坦致患者昏迷1例分析[J].药物流行病学杂志,2013,22(11):626-627.
[27]王怡苹,邓晓辉,范鲁雁.唑吡坦致精神症状2例[J].中国医院药学杂志,2016,36(2):157-158.
[28]牛慧艳,栾松,张占强.酒石酸唑吡坦片致梦驾症1例[J].中国健康月刊,2011,30(9):5-6.
[29]铁常乐,毛佩贤.酒石酸唑吡坦诱发睡行症一例[J].中华精神科杂志,2010,43(1):7.
[30]张庆玉,王训强,季蕴辛.唑吡坦引起幻视1例[J].中国药物依赖性杂志,2015,24(1):78.
[31]章斌,解莹馨.酒石酸唑吡坦致精神症状2例[J].医药导报,2017,36(s1):151-152.
[32]Huang C L,Chang C J,Hung C F,et al.Zolpideminduced distortion in visual perception[J].Ann Pharmacother,2003,37(5):683-686.
[33]Doane J A,Dalpiaz A S.Zolpidem-induced sleep-driving[J].Am J Med,2008,121(11):e5.
[34]Dang A,Garg G,Rataboli P V.Zolpidem induced nocturnal sleep-related eating disorder(NSRED)in a male patient[J].Int J Eat Disord,2010,42(4):385-386.
[35]Morgenthaler T I,Silber M H.Amnestic sleep-related eating disorder associated with zolpidem[J].Sleep Med,2002,3(4):323-327.
[36]Kinnan S,Petty F,Wilson D R.Zolpidem-induced mania in a patient with schizoaffective disorder[J].Psychosomatics,2011,52(5):493-494.
[37]Tripodianakis J,Potagas C,Papageorgiou P,et al.Zolpidemrelated epileptic seizures:a case report[J].Eur Psychiatry,2003,18(3):140-141.
[38]Sattar S P,Ramaswamy S,Bhatia S C,et al.Somnambulism due to probable interaction of valproic acid and zolpidem[J].Ann Pharmacother,2003,37(10):1429.
[39]Martín-Clavo S,Maciá-Botejara E,Liso-Rubio F J,et al.Erythrodermia induced by zolpidem:case description[J].Farm Hosp,2009,33(33):53-54.
[40]Brodeur M R,Stirling A L.Delirium associated with zolpidem[J].Ann Pharmacother,2001,35(12):1562.
[41]Young-Min P,Hyun-Woo S.Zolpidem induced sleeprelated eating and complex behaviors in a patient with obstructive sleep apnea and restless legs syndrome[J].Clin Psychopharmacol Neurosci,2016,14(3):299-301.
[42]Sharma A,Dewan V K.A Case report of zolpideminduced somnambulism[J].Prim Care Companion J Clin Psychiatry,2005,7(2):74.
[43]Nzwalo H,Ferreira L,Peralta R,et al.Sleep-related eating disorder secondary to zolpidem[J].BMJ Case Rep,2013,doi:10.1136/bcr-2012-008003.
[44]Skourides D,Samartzis L.Initiation of illusions after combination of zolpidem and paroxetine in a young woman:a case report.[J].Prim Care Companion Cns Disord,2012,14(4):e121-e122.
[45]da Silva V C,Bittencourt P L,Pinho S,et al.Delayedonset hepatic encephalopathy induced by zolpidem:a case report[J].Clinics(Sao Paulo),2008,63(4):565-566.
[46]Yang W,Dollear M,Muthukrishnan S R.One rare side effect of zolpidem-sleepwalking:a case report[J].Arch Phys Med Rehabil,2005,86(6):1265-1266.
[47]Pal S G,Neeraj L.Zolpidem-induced hallucinations:a brief case report from the Indian subcontinent[J].Indian J Psychol Med,2013,35(2):212-213.
[48]Mortaz H S,Faizi M,Babaeian M.Zolpidem-induced suicide attempt:a case report[J].Daru,2013,21(1):77.
[49]Priya S S,Dl B,T S.Zolpidem induced hyponatremia:a case report[J].J Clin Diagn Res,2014,8(9):HD03.
[50]Freudenreich O,Menza M.Zolpidem-related delirium:a case report[J].J Clin Psychiatry,2000,61(6):449-450.
[51]Toner L C,Tsambiras B M,Catalano G,et al.Central nervous system side effects associated with zolpidem treatment[J].Clin Neuropharmacol,1999,23(1):54-58.
[52]Inagaki T,Miyaoka T,Tsuji S,et al.Adverse reactions to zolpidem:case reports and a review of the literature[J].Prim Care Companion J Clin Psychiatry,2010,12(6):733-739.