摘要
阿尔茨海默病(Alzheimer's disease)是一种以认知功能障碍为主要病症的神经退行性疾病,病理特征以老年斑(senile plaques,SP)的形成、神经纤维缠结(neurofibrillary tangles,NFT)和神经元的丢失为主,其发病机制复杂,且目前尚无有效治疗手段。黄芩活性成分以黄酮类化合物为主,除具有广泛的如抗炎、抗氧化、抗肿瘤和免疫调节等多种药理作用外,还可以用于神经系统疾病,因而被纳入抗阿尔茨海默病研究。研究表明黄芩有效活性成分可对抗阿尔茨海默病相关炎症、氧化应激、神经毒性并保护神经元,从而改善阿尔茨海默病模型动物病况,逆转其行为认知功能,为阿尔茨海默病的治疗提供新思路。本文就阿尔茨海默病相关发病机制,阐述黄芩抗阿尔茨海默病作用机制。
Alzheimer's disease( AD) is a neurodegenerative disease with cognitive dysfunction. The main pathological features of the disease are the SP,the NFT and the loss of neurons.The mechanism of the disease is complex,and there is no effective treatment.The main active ingredient of Scutellaria baicalensis Georgi is flavonoids,which has good effect on inflammation,oxidation,tumor and immune regulation,and it can be used as an anti-AD drug.Many study show that the active ingredient of Scutellaria baicalensis Georgi can resist AD related inflammation,oxidative stress,neurotoxicity and protect the neurons,thus improving the pathological condition of AD model,reversing their cognitive dysfunction,and providing new idea for the treatment of AD.In this paper,the mechanism of Scutellaria baicalensis Georgi resisting AD was discussed on the pathogenesis of AD.
引文
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