摘要
以廉价易得的苯-D6为起始原料,经硝化、还原、重氮化、偶合生成苏丹红Ⅰ-D5。以消耗的苯-D6计算,苏丹红Ⅰ-D5的总收率可达82.2%。采用1HNMR和ESI-MS等确定产品结构信息,产品的同位素丰度为99.1 atom%D,纯度为99.5%。该化合物可作为食品安全检测领域非法添加物质苏丹红Ⅰ检测的稳定同位素内标试剂。
This work presents an efficient and convenient synthesis method of sudan Ⅰ-D5 with benzene-D6 as the common substrate,which is mainly obtained via nitration,reduction,diazotization and a coupling reaction.The yields of sudan Ⅰ-D5 was 82. 2%based on benzene-D6 consumed.The product's structures were confirmed by1 HNMR and ESI-MS.The chemical purity of this product is 99. 5% and deuterium isotopic enrichment of this product is 99. 1 atom% D. The compound could be used in the field of food safety testing as stable isotope internal standard reagent.
引文
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