FBW7与Cullin7在耐紫杉醇三阴乳腺癌组织中的表达及临床意义
摘要
目的探讨FBW7与Cullin7在耐紫杉醇三阴乳腺癌组织中的表达。方法免疫组化SP法检测29例耐紫杉醇三阴乳腺癌组织及20例紫杉醇敏感三阴乳腺癌组织中FBW7和Cullin7的表达,分析二者相关性。结果 FBW7在耐紫杉醇三阴乳腺癌组织中阳性表达10例,少于紫杉醇敏感三阴乳腺癌组织的13例(P=0.035)。Cullin7在耐紫杉醇三阴乳腺癌组织中阳性表达18例,多于紫杉醇敏感三阴乳腺癌组织的6例(P=0.047)。FBW7与Cullin7表达在耐紫杉醇三阴乳腺癌中呈正相关(r=0.432,P=0.017)。结论在耐紫杉醇三阴乳腺癌中,FBW7与Cullin7均参与耐药机制发生过程。
引文
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