MicroRNA调控胶质瘤替莫唑胺化疗耐药的研究进展
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摘要
microRNA是一类非编码的内源性小分子RNA,对基因表达进行转录后水平的调控。国内外学者对miRNA在胶质瘤耐药中的作用做了积极的探索和研究,发现miRNA在耐药中起十分重要的作用。本文将阐述miRNA与胶质瘤替莫唑胺化疗耐药基因的关系,促进在胶质瘤中针对特定通路的新靶向治疗的进一步发展。
MicroRNAs(miRNA) are small non-codingRNAs of endogenous small molecules,which are important to regulate the post-transcription of gene expression. MiRNAs in glioma drug resistance has been explored and researched, found that the miRNA plays an important role in drug resistance. Currently, we made a systematic review of the miRNA and Glioma for Temozolomide(TMZ)chemotherapy drug resistance gene for promoting specific pathways in Glioma of new targeted therapy of the further development.
MicroRNAs(miRNA) are small non-codingRNAs of endogenous small molecules,which are important to regulate the post-transcription of gene expression. MiRNAs in glioma drug resistance has been explored and researched, found that the miRNA plays an important role in drug resistance. Currently, we made a systematic review of the miRNA and Glioma for Temozolomide(TMZ)chemotherapy drug resistance gene for promoting specific pathways in Glioma of new targeted therapy of the further development.
引文
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[3]Zhou X,Ren Y,Moore L,et al.Downregulation of mi R-21inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status[J].Lab Invest,2010,90(2):144-155.
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[6]Mc Faline-Figueroa JL,Braun CJ,Stanciu M,et al.Minor Changes in Expression of the Mismatch Repair Protein MSH2Exert a Major Impact on Glioblastoma Response to Temozolomide[J].Cancer Res,2015,75(15):3127-3138.
[7]Feng R,Dong L.Knockdown of micro RNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells[J].Int J Clin Exp Pathol,2015,8(6):6107-6116.
[8]Munoz JL,Rodriguez-Cruz V,Ramkissoon SH,et al.Temozolomide resistance in glioblastoma occurs by mi RNA-9-targeted PTCH1,independent of sonic hedgehog level[J].Oncotarget,2015,6(2):1190-1201.
[9]Shi L,Zhang S,Feng K,et al.Micro RNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis[J].Int J Oncol,2012,40(1):119-129.
[10]Wu H,Liu Q,Cai T,et al.Mi R-136 modulates glioma cell sensitivity to temozolomide by targeting astrocyte elevated gene-1[J].Diagn Pathol,2014,9:173.
[11]Li P,Lu X,Wang Y,et al.Mi R-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells[J].J Biomed Res,2010,24(6):436-443.
[12]Quintavalle C,Mangani D,Roscigno G,et al.Mi R-221/222 target the DNA methyltransferase MGMT in glioma cells[J].PLo S One,2013,8(9):e74466.
[13]Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
[14]Mestdagh P,Hartmann N,Baeriswyl L,et al.Evaluation of quantitative mi RNA expression platforms in the micro RNA quality control(mi RQC)study[J].Nat Methods,2014,11(8):809-815.
[15]Stahlhut Espinosa CE,Slack FJ.The role of micro RNAs in cancer[J].Yale J Biol Med,2006,79(3-4):131-140.
[16]Shen J,Hung MC.Signaling-mediated regulation of Micro RNA processing[J].Cancer Res,2015,75(5):783-791.
[17]Khorkova O,Myers AJ,Hsiao J,et al.Natural antisense transcripts[J].Hum Mol Genet,2014,23(R1):R54-R63.
[18]Garajova I,Le Large TY,Giovannetti E,et al.The Role of Micro RNAs in Resistance to Current Pancreatic Cancer Treatment:Translational Studies and Basic Protocols for Extraction and PCR Analysis[J].Methods Mol Biol,2016,1395:163-187.
[19]Esquela-Kerscher A,Slack FJ.Oncomirs-micro RNAs with a role in cancer[J].Nat Rev Cancer,2006,6(4):259-269.
[20]Weber F,Teresi RE,Broelsch CE,et al.A limited set of human Micro RNA is deregulated in follicular thyroid carcinoma[J].J Clin Endocrinol Metab,2006,91(9):3584-3591.
[21]Ling H,Fabbri M,Calin GA.Micro RNAs and other non-coding RNAs as targets for anticancer drug development[J].Nat Rev Drug Discov,2013,12(11):847-865.
[22]Gottesman MM.Mechanisms of cancer drug resistance[J].Annu Rev Med,2002,53:615-627.
[23]Khamisipour G,Jadidi-Niaragh F,Jahromi AS,et al.Mechanisms of tumor cell resistance to the current targeted-therapy agents[J].Tumour Biol,2016.
[24]Rigalli JP,Ciriaci N,Mottino AD,et al.Modulation of expression and activity of ABC transporters by the phytoestrogen genistein.Impact on drug disposition[J].Curr Med Chem,2016,23(13):1370-13789.
[25]Berman M,Mattheolabakis G,Suresh M,et al.Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted micro RNA delivery[J].Expert Opin Drug Deliv,2016,13(7):987-998.
[26]Tomimaru Y,Eguchi H,Nagano H,et al.Micro RNA-21 induces resistance to the anti-tumour effect of interferon-alpha/5-fluorouracil in hepatocellular carcinoma cells[J].Br J Cancer,2010,103(10):1617-1626.
[27]Chan XH,Nama S,Gopal F,et al.Targeting glioma stem cells by functional inhibition of a prosurvival oncomi R-138 in malignant gliomas[J].Cell Rep,2012,2(3):591-602.
[28]Stojcheva N,Schechtmann G,Sass S,et al.Micro RNA-138promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM[J].Oncotarget,2016,7(11):12937-12950.
[29]Calin GA,Dumitru CD,Shimizu M,et al.Frequent deletions and down-regulation of micro-RNA genes mi R15 and mi R16 at13q14 in chronic lymphocytic leukemia[J].Proc Natl Acad Sci USA,2002,99(24):15524-15529.
[30]Aqeilan RI,Calin GA,Croce CM.mi R-15a and mi R-16-1 in cancer:discovery,function and future perspectives[J].Cell Death Differ,2010,17(2):215-220.
[31]Kasar S,Underbayev C,Hassan M,et al.Alterations in the mir-15a/16-1 Loci Impairs Its Processing and Augments B-1Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia(CLL)[J].PLo S One,2016,11(3):e149331.
[32]Porkka KP,Ogg EL,Saramaki OR,et al.The mi R-15a-mi R-16-1locus is homozygously deleted in a subset of prostate cancers[J].Genes Chromosomes Cancer,2011,50(7):499-509.
[33]Lan F,Yue X,Ren G,et al.mi R-15a/16 enhances radiation sensitivity of non-small cell lung cancer cells by targeting the TLR1/NF-kappa B signaling pathway[J].Int J Radiat Oncol Biol Phys,2015,91(1):73-81.
[34]Han J,Chen Q.Mi R-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells[J].Int J Clin Exp Pathol,2015,8(10):12698-12707.
[35]Shi L,Zhang S,Feng K,et al.Micro RNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis[J].Int J Oncol,2012,40(1):119-129.
[36]Cairo S,Wang Y,de Reynies A,et al.Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer[J].Proc Natl Acad Sci USA,2010,107(47):20471-20476.
[37]Shi L,Zhang J,Pan T,et al.Mi R-125b is critical for the suppression of human U251 glioma stem cell proliferation[J].Brain Res,2010,1312:120-126.
[38]Kim JT,Kim JS,Ko KW,et al.Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas[J].Oncol Rep,2006,16(1):33-39.
[39]Chen J,Fu X,Wan Y,et al.mi R-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1[J].Tumour Biol,2014,35(7):6293-6302.
[40]Le MT,Teh C,Shyh-Chang N,et al.Micro RNA-125b is a novel negative regulator of p53[J].Genes Dev,2009,23(7):862-876.
[41]Zhang Z,Zhang B,Li W,et al.Epigenetic Silencing of mi R-203Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells[J].Genes Cancer,2011,2(8):782-791.
[42]Li Y,Yuan Y,Tao K,et al.Inhibition of BCR/ABL protein expression by mi R-203 sensitizes for imatinib mesylate[J].PLo S One,2013,8(4):e61858.
[43]Tang G,Wu J,Xiao G,et al.Mi R-203 sensitizes glioma cells to temozolomide and inhibits glioma cell invasion by targeting E2F3[J].Mol Med Rep,2015,11(4):2838-2844.
[2]Desjardins A,Vlahovic G,Friedman HS.Vaccine Therapy,Oncolytic Viruses,and Gliomas[J].Oncology(Williston Park),2016,30(3):211-218.
[3]Zhou X,Ren Y,Moore L,et al.Downregulation of mi R-21inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status[J].Lab Invest,2010,90(2):144-155.
[4]Miglierini P,Bouchekoua M,Rousseau B,et al.Impact of the per-operatory application of GLIADEL wafers(BCNU,carmustine)in combination with temozolomide and radiotherapy in patients with glioblastoma multiforme:efficacy and toxicity[J].Clin Neurol Neurosurg,2012,114(9):1222-1225.
[5]Plowman J,Waud WR,Koutsoukos AD,et al.Preclinical antitumor activity of temozolomide in mice:efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea[J].Cancer Res,1994,54(14):3793-3799.
[6]Mc Faline-Figueroa JL,Braun CJ,Stanciu M,et al.Minor Changes in Expression of the Mismatch Repair Protein MSH2Exert a Major Impact on Glioblastoma Response to Temozolomide[J].Cancer Res,2015,75(15):3127-3138.
[7]Feng R,Dong L.Knockdown of micro RNA-127 reverses adriamycin resistance via cell cycle arrest and apoptosis sensitization in adriamycin-resistant human glioma cells[J].Int J Clin Exp Pathol,2015,8(6):6107-6116.
[8]Munoz JL,Rodriguez-Cruz V,Ramkissoon SH,et al.Temozolomide resistance in glioblastoma occurs by mi RNA-9-targeted PTCH1,independent of sonic hedgehog level[J].Oncotarget,2015,6(2):1190-1201.
[9]Shi L,Zhang S,Feng K,et al.Micro RNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis[J].Int J Oncol,2012,40(1):119-129.
[10]Wu H,Liu Q,Cai T,et al.Mi R-136 modulates glioma cell sensitivity to temozolomide by targeting astrocyte elevated gene-1[J].Diagn Pathol,2014,9:173.
[11]Li P,Lu X,Wang Y,et al.Mi R-181b suppresses proliferation of and reduces chemoresistance to temozolomide in U87 glioma stem cells[J].J Biomed Res,2010,24(6):436-443.
[12]Quintavalle C,Mangani D,Roscigno G,et al.Mi R-221/222 target the DNA methyltransferase MGMT in glioma cells[J].PLo S One,2013,8(9):e74466.
[13]Lee RC,Feinbaum RL,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
[14]Mestdagh P,Hartmann N,Baeriswyl L,et al.Evaluation of quantitative mi RNA expression platforms in the micro RNA quality control(mi RQC)study[J].Nat Methods,2014,11(8):809-815.
[15]Stahlhut Espinosa CE,Slack FJ.The role of micro RNAs in cancer[J].Yale J Biol Med,2006,79(3-4):131-140.
[16]Shen J,Hung MC.Signaling-mediated regulation of Micro RNA processing[J].Cancer Res,2015,75(5):783-791.
[17]Khorkova O,Myers AJ,Hsiao J,et al.Natural antisense transcripts[J].Hum Mol Genet,2014,23(R1):R54-R63.
[18]Garajova I,Le Large TY,Giovannetti E,et al.The Role of Micro RNAs in Resistance to Current Pancreatic Cancer Treatment:Translational Studies and Basic Protocols for Extraction and PCR Analysis[J].Methods Mol Biol,2016,1395:163-187.
[19]Esquela-Kerscher A,Slack FJ.Oncomirs-micro RNAs with a role in cancer[J].Nat Rev Cancer,2006,6(4):259-269.
[20]Weber F,Teresi RE,Broelsch CE,et al.A limited set of human Micro RNA is deregulated in follicular thyroid carcinoma[J].J Clin Endocrinol Metab,2006,91(9):3584-3591.
[21]Ling H,Fabbri M,Calin GA.Micro RNAs and other non-coding RNAs as targets for anticancer drug development[J].Nat Rev Drug Discov,2013,12(11):847-865.
[22]Gottesman MM.Mechanisms of cancer drug resistance[J].Annu Rev Med,2002,53:615-627.
[23]Khamisipour G,Jadidi-Niaragh F,Jahromi AS,et al.Mechanisms of tumor cell resistance to the current targeted-therapy agents[J].Tumour Biol,2016.
[24]Rigalli JP,Ciriaci N,Mottino AD,et al.Modulation of expression and activity of ABC transporters by the phytoestrogen genistein.Impact on drug disposition[J].Curr Med Chem,2016,23(13):1370-13789.
[25]Berman M,Mattheolabakis G,Suresh M,et al.Reversing epigenetic mechanisms of drug resistance in solid tumors using targeted micro RNA delivery[J].Expert Opin Drug Deliv,2016,13(7):987-998.
[26]Tomimaru Y,Eguchi H,Nagano H,et al.Micro RNA-21 induces resistance to the anti-tumour effect of interferon-alpha/5-fluorouracil in hepatocellular carcinoma cells[J].Br J Cancer,2010,103(10):1617-1626.
[27]Chan XH,Nama S,Gopal F,et al.Targeting glioma stem cells by functional inhibition of a prosurvival oncomi R-138 in malignant gliomas[J].Cell Rep,2012,2(3):591-602.
[28]Stojcheva N,Schechtmann G,Sass S,et al.Micro RNA-138promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM[J].Oncotarget,2016,7(11):12937-12950.
[29]Calin GA,Dumitru CD,Shimizu M,et al.Frequent deletions and down-regulation of micro-RNA genes mi R15 and mi R16 at13q14 in chronic lymphocytic leukemia[J].Proc Natl Acad Sci USA,2002,99(24):15524-15529.
[30]Aqeilan RI,Calin GA,Croce CM.mi R-15a and mi R-16-1 in cancer:discovery,function and future perspectives[J].Cell Death Differ,2010,17(2):215-220.
[31]Kasar S,Underbayev C,Hassan M,et al.Alterations in the mir-15a/16-1 Loci Impairs Its Processing and Augments B-1Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia(CLL)[J].PLo S One,2016,11(3):e149331.
[32]Porkka KP,Ogg EL,Saramaki OR,et al.The mi R-15a-mi R-16-1locus is homozygously deleted in a subset of prostate cancers[J].Genes Chromosomes Cancer,2011,50(7):499-509.
[33]Lan F,Yue X,Ren G,et al.mi R-15a/16 enhances radiation sensitivity of non-small cell lung cancer cells by targeting the TLR1/NF-kappa B signaling pathway[J].Int J Radiat Oncol Biol Phys,2015,91(1):73-81.
[34]Han J,Chen Q.Mi R-16 modulate temozolomide resistance by regulating BCL-2 in human glioma cells[J].Int J Clin Exp Pathol,2015,8(10):12698-12707.
[35]Shi L,Zhang S,Feng K,et al.Micro RNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis[J].Int J Oncol,2012,40(1):119-129.
[36]Cairo S,Wang Y,de Reynies A,et al.Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer[J].Proc Natl Acad Sci USA,2010,107(47):20471-20476.
[37]Shi L,Zhang J,Pan T,et al.Mi R-125b is critical for the suppression of human U251 glioma stem cell proliferation[J].Brain Res,2010,1312:120-126.
[38]Kim JT,Kim JS,Ko KW,et al.Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas[J].Oncol Rep,2006,16(1):33-39.
[39]Chen J,Fu X,Wan Y,et al.mi R-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1[J].Tumour Biol,2014,35(7):6293-6302.
[40]Le MT,Teh C,Shyh-Chang N,et al.Micro RNA-125b is a novel negative regulator of p53[J].Genes Dev,2009,23(7):862-876.
[41]Zhang Z,Zhang B,Li W,et al.Epigenetic Silencing of mi R-203Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells[J].Genes Cancer,2011,2(8):782-791.
[42]Li Y,Yuan Y,Tao K,et al.Inhibition of BCR/ABL protein expression by mi R-203 sensitizes for imatinib mesylate[J].PLo S One,2013,8(4):e61858.
[43]Tang G,Wu J,Xiao G,et al.Mi R-203 sensitizes glioma cells to temozolomide and inhibits glioma cell invasion by targeting E2F3[J].Mol Med Rep,2015,11(4):2838-2844.