呋喃酰腙及其镍、锰配合物的合成与晶体结构及抑菌活性
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摘要
通过2-呋喃甲醛与4-甲氧基苯甲酰肼缩合,得到一种新型的希夫碱配体2-呋喃甲醛缩-4-甲氧基苯甲酰腙(HL),将HL与Ni(NO3)2·6H2O、MnCl2·4H2O分别在乙醇与丙酮的混合溶剂中反应,采用溶剂挥发获得配体单晶、不同构型的新型配合物NiL2和Mn(HL)2Cl2单晶。采用元素分析、红外光谱、核磁共振、X-射线单晶衍射对HL、NiL2和Mn(HL)2Cl2进行表征,结构分析表明HL属于三方晶系,空间群R3,晶胞参数a=2.442(2)nm,b=2.442(2)nm,c=1.135 4(10)nm,γ=120°,Z=18。NiL2和Mn(HL)2Cl2均属于单斜晶系,空间群P21/n和P21/c。NiL2属于近似平面四方构型,晶胞参数a=1.206 7(8)nm,b=0.577 4(4)nm,c=1.841 8(13)nm,β=107.122(11)°,Z=2;Mn(HL)2Cl2属于扭曲八面体构型,晶胞参数a=0.915 5(4)nm,b=0.721 7(4)nm,c=2.033 6(9)nm,β=96.047(9)°,Z=2。用琼脂扩散法测定了配体和配合物对大肠杆菌、金黄色葡萄球菌、绿脓杆菌的抑制活性,结果显示NiL2对金色葡萄球菌有显著的抑制作用。
A novel Schiff base ligand which called 2-furancarbaldehyde-4-methoxy-benzoylhydrazone(HL) has been synthesized from 2-furancarbaldehyde and 4-methoxybenzoylhydrazine. Two different configurations metal complexes of the ligand which named NiL2and Mn(HL)2Cl2were also synthesized in mixed solvent of ethanol and acetone with Ni(NO3)2·6H2O and MnCl2·4H2O. The single crystal of HL, NiL2and Mn(HL)2Cl2were obtained through solvent evaporation method. Complex NiL2and Mn(HL)2Cl2were characterized by using X-ray, EA, FT-IR and 1H NMR methods. Structure analysis shows the ligand HL crystallizes in the trigonal system, space group R3 with a= 2.442(2) nm, b=2.442(2) nm, c=1.135 4(10) nm parameters, γ=120°, Z=18. Complex NiL2and Mn(HL)2Cl2crystallizes both in the monoclinic system. Complex NiL2has square planar configuration in space group P21/n with a = 1.206 7(8) nm, b=0.577 4(4) nm, c=1.841 8(13) nm parameters, β=107.122(11)°, Z=2; Complex Mn(HL)2Cl2has distorted octahedral configuration in space group P21/c with a=0.915 5(4) nm, b=0.721 7(4) nm, c=2.033 6(9) nm parameters, β=96.047(9)°, Z=2. The ligand and its metal complexes have been screened for their antibacterial activities by agar diffusion method. The result shows that complex NiL2has very significant antibacterial activity to Staphylococcus aureus. CCDC: 926194, HL; 926193, NiL2; 926195, Mn(HL)2Cl2.
A novel Schiff base ligand which called 2-furancarbaldehyde-4-methoxy-benzoylhydrazone(HL) has been synthesized from 2-furancarbaldehyde and 4-methoxybenzoylhydrazine. Two different configurations metal complexes of the ligand which named NiL2and Mn(HL)2Cl2were also synthesized in mixed solvent of ethanol and acetone with Ni(NO3)2·6H2O and MnCl2·4H2O. The single crystal of HL, NiL2and Mn(HL)2Cl2were obtained through solvent evaporation method. Complex NiL2and Mn(HL)2Cl2were characterized by using X-ray, EA, FT-IR and 1H NMR methods. Structure analysis shows the ligand HL crystallizes in the trigonal system, space group R3 with a= 2.442(2) nm, b=2.442(2) nm, c=1.135 4(10) nm parameters, γ=120°, Z=18. Complex NiL2and Mn(HL)2Cl2crystallizes both in the monoclinic system. Complex NiL2has square planar configuration in space group P21/n with a = 1.206 7(8) nm, b=0.577 4(4) nm, c=1.841 8(13) nm parameters, β=107.122(11)°, Z=2; Complex Mn(HL)2Cl2has distorted octahedral configuration in space group P21/c with a=0.915 5(4) nm, b=0.721 7(4) nm, c=2.033 6(9) nm parameters, β=96.047(9)°, Z=2. The ligand and its metal complexes have been screened for their antibacterial activities by agar diffusion method. The result shows that complex NiL2has very significant antibacterial activity to Staphylococcus aureus. CCDC: 926194, HL; 926193, NiL2; 926195, Mn(HL)2Cl2.
引文
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[4]REN Hai-Xian(任海仙),TANG Jing(唐静),WEI Tai-Bao(魏太保),et al.Chinese J.Inorg.Chem.(无机化学学报),2007,23(11):1907-1911
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[7]ZHU Shan-Shan(朱姗姗),LU Jun-Rui(卢俊瑞),XIN ChunWei(辛春伟),et al.Chinese J.Org.Chem.(有机化学),2010,30(12):1914-1920
[8]CHEN Qiong(陈琼),LONG De-Qing(龙德清),CHENG Jing(程靖),et al.Chem.J.Chinese Universities(高等学校化学学报),2006,27(3):454-459
[9]LIU Jing-Gang(刘劲刚),JI Liang-Nian(计亮年).Chinese J.Inorg.Chem.(无机化学学报),2000,16(2):195-203
[10]Abbas A,Hassan K,Farzad K,et al.J.Chem.Eng.Data,2010,55(11):4725-4731
[11]Punam B,Sujeetkumar J,Imran A.J.Agric.Food Chem.,2009,57(20):9780-9786
[12]HE Shui-Yang(何水样),CHEN Jun-Li(陈军利),YANG Rui(杨锐),et al.Chinese J.Org.Chem.(有机化学),2003,23(12):1387-1392
[13]Jose R P,Cristina S,Suely L,et al.J.Med.Chem.,2001,44(22):3673-3681
[14]CHENG Wei-Hua(程卫华),SI Zong-Xing(司宗兴).Chinese J.Applied Chem.(应用化学),2000,17(4):444-446
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[19]LU Wen-Guan(卢文贯),PENG Cui-Hong(彭翠红),LIU Hong-Wen(刘宏文),et al.Chinese J.Inorg.Chem.(无机化学学报),2003,19(11):1222-1226
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