天然产物与microRNA调控代谢综合征的研究进展
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摘要
代谢综合征已成为全球性的健康问题。microRNA(miRNA)是一类能够调节基因表达的短单链內源非编码RNA(约22 nt),在转录后水平调节基因表达。miRNA在代谢综合征中发挥重要作用,药食同源的天然产物可以通过调控miRNA的活性和功能,改善糖脂代谢紊乱。本文主要综述miRNA在糖尿病、肥胖等代谢综合征的致病机制中的研究进展,深入分析了药食同源的天然产物对miRNA的调控机制,可为发掘miRNA在代谢综合征预防、诊断、治疗中的潜在价值提供理论依据。
The metabolic syndrome has become a global health problem. microRNA(miRNA), a short single-stranded endogenously expressedRNA(approximately 22 nt), regulates gene expression at the post-transcriptional level. A lot of researches have shown that miRNA plays an important role in metabolic syndromes. Additionally, natural products which can be used as both food and medicine can modulate the activities and functions of miRNA to improve glucose and lipid metabolism disorders. Recent evidence described in this review highlights the significant role of miRNA in metabolic syndromes and how dietary factors may influence metabolic syndromes by modulating the activities and functions of miRNA.
The metabolic syndrome has become a global health problem. microRNA(miRNA), a short single-stranded endogenously expressedRNA(approximately 22 nt), regulates gene expression at the post-transcriptional level. A lot of researches have shown that miRNA plays an important role in metabolic syndromes. Additionally, natural products which can be used as both food and medicine can modulate the activities and functions of miRNA to improve glucose and lipid metabolism disorders. Recent evidence described in this review highlights the significant role of miRNA in metabolic syndromes and how dietary factors may influence metabolic syndromes by modulating the activities and functions of miRNA.
引文
[1]董英,钱希文,白娟,等.苦瓜改善胰岛素抵抗功能与作用机制研究进展[J].食品科学,2013,34(21):369-374.DOI:10.7506/spkx1002-6630-201321073.
[2]HALCOX J,MISRA A.Type 2 diabetes mellitus,metabolic syndrome,and mixed dyslipidemia:how similar,how different,and how to treat?[J].Metabolic Syndrome&Related Disorders,2015,13(1):1-21.DOI:10.1089/met.2014.0049.
[3]黄建权,王观春,由凯.肥胖和代谢综合征的药物治疗与研究进展[J].药品评价,2013(9):25-32.
[4]EVA V R.The art of micro RNA research[J].Circulation Research,2011,108(2):219-234.DOI:10.1161/CIRCRESAHA.110.227496.
[5]虞桂,王阶.mi RNA及其调控网络与中医治病求本机制研究[J].中华中医药杂志,2012(11):2789-2791.
[6]HARVEY A L.Plant natural products in anti-diabetic drug discovery[J].Current Organic Chemistry,2010,14(16):1670-1677.DOI:10.2174/138527210792927681.
[7]ROSS S A,DAVIS C D.The emerging role of micro RNA and nutrition in modulating health and disease[J].Annual Review of Nutrition,2014,34:305-336.DOI:10.1146/annurev-nutr-071813-105729.
[8]HERRERA B M,LOCKSTONE H E,TAYLOR J M,et al.Global micro RNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes[J].Diabetologia,2010,53(6):1099-1109.DOI:10.1007/s00125-010-1667-2.
[9]LI X L.Mi R-375,a micro RNA related to diabetes[J].Gene,2013,533(1):1-4.DOI:10.1016/j.gene.2013.09.105.
[10]ZHU L,CHEN L,SHI C M,et al.Mi R-335,an adipogenesis-related micro RNA,is involved in adipose tissue inflammation[J].Cell Biochemistry&Biophysics,2014,68(2):283-290.DOI:10.1007/s12013-013-9708-3.
[11]KILIC I D,DODURGA Y,ULUDAG B,et al.Micro RNA-143 and-223 in obesity[J].Gene,2015,560(2):140-142.DOI:10.1016/j.gene.2015.01.048.
[12]GAO Song,WASSLER M,ZHANG Lulu,et al.Micro RNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis[J].Atherosclerosis,2014,232(1):171-179.DOI:10.1016/j.atherosclerosis.2013.11.029.
[13]KULLMANN A,WEBER P S,BISHOP J B,et al.Equine insulin receptor and insulin-like growth factor-1 receptor expression in digital lamellar tissue and insulin target tissues[J].Equine Veterinary Journal,2015,48(5):626-632.DOI:10.1111/evj.12474.
[14]SUN C Z,HUANG F Z,LIU X Y,et al.Mi R-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR[J].International Journal of Molecular Medicine,2015,35(3):847-853.DOI:10.3892/ijmm.2015.2076.
[15]ESGUERRA J L S,CAROLINE B,CILIO C M,et al.Differential glucose-regulation of micro RNA in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat[J].PLo S ONE,2011,6(4):e18613.DOI:10.1371/journal.pone.0018613.
[16]ARNER E,MEJHERT N,KULYTéA,et al.Adipose tissue micro RNA as regulators of CCL2 production in human obesity[J].Diabetes,2012,61(8):1986-93.DOI:10.2337/db11-1508.
[17]CAPOBIANCO V,NARDELLI C,FERRIGNO M,et al.mi RNA and protein expression profiles of visceral adipose tissue reveal mi R-141/YWHAG and mi R-520e/RAB11A as two potential mi RNA/protein target pairs associated with severe obesity[J].Journal of Proteome Research,2012,11(6):3358-3369.DOI:10.1021/pr300152z.
[18]DIAWARA M R,HUE C,WILDER S P,et al.Adaptive expression of micro RNA-125a in adipose tissue in response to obesity in mice and men[J].PLo S ONE,2014,9(3):e91375-e91375.DOI:10.1371/journal.pone.0091375.
[19]CHEN Ling,DAI Yongmei,JI Chenbo,et al.Mi R-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity[J].Molecular and Cellular Endocrinology,2014,393(1/2):65-74.
[20]刁雪红,申锷,胡兵,等.糖尿病小鼠心肌组织micro RNA表达谱分析[J].上海交通大学学报(医学版),2010,30(10):1194-1198.
[21]TALI A S,LIA K,SHARON K R,et al.The promoter of the primi R-375 gene directs expression selectively to the endocrine pancreas[J].PLo S ONE,2009,4(4):5033.DOI:10.1371/journal.pone.0005033.
[22]El OUAAMARI A,BAROUKH N,MARTENS G A,et al.mi R-375targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells[J].Diabetes,2008,57(10):2708-2717.DOI:10.2337/db07-1614.
[23]POY M N,LENA E,JAN K,et al.A pancreatic islet-specific micro RNA regulates insulin secretion[J].Nature,2004,432:226-230.DOI:10.1038/nature03076.
[24]MEERSON A,TRAURIG M,OSSOWSKI V,et al.Human adipose micro RNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α[J].Diabetologia,2013,56(9):1971-1979.DOI:10.1007/s00125-013-2950-9.
[25]CHOU W W,WANG W T,LIAO Y C,et al.Decreased micro RNA-221 is associated with high levels of TNF-αin human adipose tissue-derived mesenchymal stem cells from obese woman[J].Cellular Physiology&Biochemistry,2013,32(1):127-137.DOI:10.1159/000350131.
[26]MENG Shu,CAO Jiatian,ZHANG B,et al.Downregulation of micro RNA-126 in endothelial progenitor cells from diabetes patients,impairs their functional properties,via target gene Spred-1[J].Journal of Molecular&Cellular Cardiology,2012,53(1):64-72.DOI:10.1016/j.yjmcc.2012.04.003.
[27]ZHANG Tao,LüChunfang,LI Liling,et al.Plasma mi R-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals[J].Biomed Research International,2013(4):761617.DOI:10.1155/2013/761617.
[28]YANIV L,EHUD B,REUT A F,et al.RNA-binding protein PTB and micro RNA-221 coregulate Adipo R1 translation and adiponectin signaling[J].Diabetes,2013,63(2):433-445.DOI:10.2337/db13-1032.
[29]BAROUKH N,RAVIER M A,LODER M K,et al.Micro RNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines[J].Journal of Biological Chemistry,2007,282(27):19575-19588.
[30]LOVIS P,GATTESCO S R.Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by micro RNA[J].Biological Chemistry,2008,389(3):305-312.DOI:10.1515/BC.2008.026.
[31]VALéRIE P,AMAR A,VéRONIQUE P M,et al.Micro RNA-9controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells[J].Journal of Biological Chemistry,2006,281(37):26932-26942.DOI:10.1074/jbc.M601225200.
[32]HE Aibin,ZHU Liuluan,GUPTA N,et al.Overexpression of micro ribonucleic acid 29,highly up-regulated in diabetic rats,leads to insulin resistance in 3T3-L1 adipocytes[J].Molecular Endocrinology,2007,21(11):2785-2794.DOI:10.1210/me.2007-0167.
[33]MIRKO T,JEAN H,JüRGEN S,et al.Micro RNA 103 and107 regulate insulin sensitivity[J].Nature,2011,474:649-653.DOI:10.1038/nature10112.
[34]CHEN Lin,HOU Jia,YE Lanfeng,et al.Micro RNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling[J].Scientific Reports,2014,4(1):3819-3819.DOI:10.1038/srep03819.
[35]LORENTE-CEBR IáNS,MEJHERT N,KULY TéA,et al.Micro RNA regulate human adipocyte lipolysis:effects of mi R-145are linked to TNF-α[J].PLo S ONE,2014,9(1):e86800.DOI:10.1371/journal.pone.0086800.
[36]史春梅,徐广峰,季晨博,等.mi R-26b过表达对不同时间点人脂肪细胞分泌脂因子的影响[J].临床儿科杂志,2013(10):914-916.DOI:10.3969/j.issn.1000-3606.2013.10.004.
[37]BALASUBRAMANYAM M,ARAVIND S,GOKULAKRISHNAN K,et al.Impaired mi R-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes[J].Molecular and Cellular Biochemistry,2011,351(1/2):197-205.DOI:10.1007/s11010-011-0727-3.
[38]SALAS-PéREZ F,CODNER E,VALENCIA E,et al.Micro RNA mi R-21a and mi R-93 are down regulated in peripheral blood mononuclear cells(PBMCs)from patients with type 1 diabetes[J].Immune biology,2013,218(5):733-737.DOI:10.1016/j.imbio.2012.08.276.
[39]ZHONG X,CHUNG A C K,CHEN H Y,et al.mi R-21 is a key therapeutic target for renal injury in a mouse model of type 2diabetes[J].Diabetologia,2013,56(3):663-674.DOI:10.1007/s00125-012-2804-x.
[40]FENG Biao,CAO Yanan,CHEN Shali,et al.Mi RNA-1 regulates endothelin-1 in diabetes[J].Life Sciences,2014,118(2):18-23.DOI:10.1016/j.lfs.2013.12.199.
[41]KATO M,ZHANG J,WANG M,et al.Micro RNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors[J].Proceedings of the National Academy of Sciences,2007,104(9):3432-3437.DOI:10.1073/pnas.0611192104.
[42]CHEN Shali,PUTHANVEETIL P,FENG Biao,et al.Cardiac mi R-133a overexpression prevents early cardiac fibrosis in diabetes[J].Journal of Cellular&Molecular Medicine.2014,18(3):415-421.DOI:10.1111/jcmm.12218.
[43]COLLARES C V,EVANGELISTA A F,XAVIER D J,et al.Identifying common and specific micro RNA expressed in peripheral blood mononuclear cell of type 1,type 2,and gestational diabetes mellitus patients[J].BMC Research Notes,2013,6(1):1-15.DOI:10.1186/1756-0500-6-491.
[44]KONG Lei,ZHU Junjie,HAN Wenxia,et al.Significance of serum micro RNA in pre-diabetes and newly diagnosed type 2diabetes:a clinical study[J].Acta Diabetologica,2011,48(1):61-69.DOI:10.1007/s00592-010-0226-0.
[45]WANG X,SUNDQUIST J,Z?LLER B,et al.Determination of 14circulating micro RNA in Swedes and Iraqis with and without diabetes mellitus type 2[J].PLo S ONE,2014,9(1):e86792.DOI:10.1371/journal.pone.0086792.
[46]叶青.脂代谢相关mi RNA靶基因结合区域多态性与代谢综合征及其组分的分子流行病学研究[D].南京:南京医科大学,2013:39-56.
[47]MARTINELLI R,NARDELLI C,PILONE V,et al.mi R-519d Overexpression is associated with human obesity[J].Obesity,2010,18(11):2170-2176.DOI:10.1038/oby.2009.474.
[48]HENEGHAN H M,MILLER N,MCANENA O J,et al.Differential mi RNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers[J].Journal of Clinical Endocrinology&Metabolism,2011,96(5):846-850.DOI:10.1210/jc.2010-2701.
[49]KELLER P,GBURCIK V,PETROVIC N,et al.Gene-chip studies of adipogenesis-regulated micro RNA in mouse primary adipocytes and human obesity[J].BMC Endocrine Disorders,2011,11(1):1-11.DOI:10.1186/1472-6823-11-7.
[50]ORTEGA F J,MORENO-NAVARRETE J M,GERARD P,et al.Mi RNA expression profile of human subcutaneous adipose and during adipocyte differentiation[J].PLo S ONE,2010,5(2):e9022.DOI:10.1371/journal.pone.0009022.
[51]ZHUANG Guoqing,MENG Cong,GUO Xin,et al.A novel regulator of macrophage activation:mi R-223 in obesity-associated adipose tissue inflammation[J].Circulation,2012,125(23):2892-2903.DOI:10.1161/CIRCULATIONAHA.111.087817.
[52]FU Ting,CHOI S E,KIM D H,et al.Aberrantly elevated micro RNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptorβ-Klotho[J].Proceedings of the National Academy of Sciences,2012,109(40):16137-16142.DOI:10.1073/pnas.1205951109.
[53]PAN Shifeng,ZHENG Yating,ZHAO Ruqian,et al.Micro RNA-130b and micro RNA-374b mediate the effect of maternal dietary protein on offspring lipid metabolism in Meishan pigs[J].British Journal of Nutrition,2013,109(10):1-8.DOI:10.1017/S0007114512003728.
[54]WANG Yucheng,LI Yuying,WANG Xinyi,et al.Circulating mi R-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity[J].Diabetologia,2013,56(10):2275-2285.DOI:10.1007/s00125-013-2996-8.
[55]HULSMANS M,van DOOREN E,MATHIEU C,et al.Decrease of mi R-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin[J].PLo S ONE,2012,7(2):e32794.DOI:10.1371/journal.pone.0032794.
[56]CHOI S E,FU T,SEOK S,et al.Elevated micro RNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT[J].Aging Cell,2013,12(6):1062-1072.DOI:10.1111/acel.12135.
[57]BENATTI R O,MELO A M,BORGES F O,et al.Maternal highfat diet consumption modulates hepatic lipid metabolism and micro RNA-122(mi R-122)and micro RNA-370(mi R-370)expression in offspring[J].British Journal of Nutrition,2014,111(12):2112-2122.DOI:10.1017/S0007114514000579.
[58]FOLEY N H,O'NEILL L A.Mi R-107:a toll-like receptor-regulated mi RNA dysregulated in obesity and typeⅡdiabetes[J].Journal of Leukocyte Biology,2012,92(3):521-527.DOI:10.1189/jlb.0312160.
[59]NAKANISHI N,NAKAGAWA Y,TOKUSHIGE N.The up-regulation of micro RNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice[J].Biochemical&Biophysical Research Communications,2009,385(4):492-496.DOI:10.1016/j.bbrc.2009.05.058.
[60]KORNFELD J W,BAITZEL C,K?NNER A C,et al.Obesity-induced overexpression of mi R-802 impairs glucose metabolism through silencing of Hnf1b[J].Nature,2013,494:111-115.DOI:10.1038/nature11793.
[61]JORDAN S D,MARKUS K,WILLMES D M,et al.Obesity-induced overexpression of mi RNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism[J].Nature Cell Biology,2011,13(4):434-446.DOI:10.1038/ncb2211.
[62]KIM C,LEE H,CHO Y M,et al.TNFα-induced mi R-130 resulted in adipocyte dysfunction during obesity-related inflammation[J].Febs Letters,2013,587(23):3853-3858.DOI:10.1016/j.febslet.2013.10.018.
[63]ORTEGA F J,MERCADER J M,JOSéMARíA M N,et al.Profiling of circulating micro RNA reveals common micro RNA linked to type 2diabetes that change with insulin sensitization[J].Diabetes Care,2014,37(5):1375-1383.DOI:10.2337/dc13-1847.
[64]ORTEGA F J,MERCADER J M,CATALáN V,et al.Targeting the circulating micro RNA signature of obesity[J].Clinical Chemistry,2013,59(5):781-792.DOI:10.1373/clinchem.2012.195776.
[65]ANNA P P,ORTEGA F J,MERCADER J M,et al.Changes in circulating micro RNA are associated with childhood obesity[J].Journal of Clinical Endocrinology and Metabolism,2013,98(10):1655-1660.DOI:10.1210/jc.2013-1496.
[66]CARRER M,LIU N,GRUETER C E,et al.Control of mitochondrial metabolism and systemic energy homeostasis by micro RNA 378 and378*[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(38):15330-15335.DOI:10.1073/pnas.1207605109.
[67]张政,罗勇军,彭惠民,等.早期糖尿病肾病相关微小RNA在小鼠肾脏的表达变化[J].第三军医大学学报,2010,32(13):1383-1386.
[68]ZHANG Z,PENG H M,CHEN J X,et al.Micro RNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice[J].Febs Letters,2009,583(12):2009-2014.DOI:10.1016/j.febslet.2009.05.021.
[69]CHENG Y H,LIU X J,YANG J,et al.Micro RNA-145,a novel smooth muscle cell phenotypic marker and modulator,controls vascular neointimal lesion formation[J].Circulation Research,2009,105(2):158-166.DOI:10.1161/CIRCRESAHA.109.197517.
[70]ANDREA C,MARCO M,CHRISTINE V,et al.Deregulation of micro RNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia[J].Circulation,2011,123(3):282-291.DOI:10.1161/CIRCULATIONAHA.110.952325.
[71]FERREIRAL R P,AMANDAF F,SANTOSRH B,et al.Micro RNA mi R-1,mi R-133a,mi R-133b,mi R-208a and mi R-208b are dysregulated in Chronic Chagas disease Cardiomyopathy[J].International Journal of Cardiology,2014,175(3):409-417.DOI:10.1016/j.ijcard.2014.05.019.
[72]TURCHINOVICH A,WEIZ L,BURWINKEL B.Extracellular mi RNAs:the mystery of their origin and function[J].Trends in Biochemical Sciences,2012,37(11):460-465.DOI:10.1016/j.tibs.2012.08.003.
[73]ZHANG Lin,HOU Dongxia,CHEN Xi,et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1:evidence of cross-kingdom regulation by micro RNA[J].Cell Research,2012,22(1):107-126.DOI:10.1038/cr.2011.158.
[74]WANG K,LI H,YUAN Y,et al.The complex exogenous RNA spectra in human plasma:an interface with human gut biota?[J].PLo S ONE,2012,7(12):1354-1357.DOI:10.1371/journal.pone.0051009.
[75]KOSAKA N,IZUMI H,SEKINE K,et al.Micro RNA as a new immune-regulatory agent in breast milk[J].Silence,2010,1(1):7.DOI:10.1186/1758-907X-1-7.
[76]TITLE A C,DENZLER R,STOFFEL M.Uptake and function studies of maternal milk-derived micro RNAs*[J].Journal of Biological Chemistry,2015,290(39):23680-23691.DOI:10.1074/jbc.M115.676734.
[77]DRAGAN M,CHRISTIANE D,ERWAN G,et al.Modulation of mi RNA expression by dietary polyphenols in apo E deficient mice:a new mechanism of the action of polyphenols[J].PLo S ONE,2012,7(1):156-167.DOI:10.1371/journal.pone.0029837.
[78]NOLTE H E N M,van ROOIJ E,BUSHELL M,et al.The role of micro RNA in nutritional control[J].Journal of Internal Medicine,2015,278(2):99-109.DOI:10.1111/joim.12372.
[79]WEN X Y,WU S Y,LI Z Q,et al.Ellagitannin(BJA3121),an antiproliferative natural polyphenol compound,can regulate the expression of Mi RNAs in Hep G 2 cancer cells[J].Phytotherapy Research,2009,23(6):778-784.DOI:10.1002/ptr.2616.
[80]AROLA-ARNAL A,BLADéC.Proanthocyanidins modulate micro RNA expression in human Hep G2 cells[J].PLo S ONE,2011,6(10):148.DOI:10.1371/journal.pone.0025982.
[81]BASELGA-ESCUDERO L,BLADéC,RIBAS-LATRE A,et al.Grape seed proanthocyanidins repress the hepatic lipid regulators mi R-33and mi R-122 in rats[J].Molecular Nutrition&Food Research,2012,56(11):1636-1646.DOI:10.1002/mnfr.201200237.
[82]YANG Y M,SEO S Y,KIM T H,et al.Decrease of micro RNA-122causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B,which is reversed by licorice flavonoid[J].Hepatology,2012,56(6):2209-2220.DOI:10.1002/hep.25912.
[83]KUTAY H,BAI S,DATTA J,et al.Downregulation of mi R-122 in the rodent and human hepatocellular carcinomas[J].Journal of Cellular Biochemistry,2006,99(3):671-678.DOI:10.1002/jcb.20982.
[84]JOVEN J,ESPINEL E,RULL A,et al.Plant-derived polyphenols regulate expression of mi RNA paralogs mi R-103/107 and mi R-122and prevent diet-induced fatty liver disease in hyperlipidemic mice[J].Biochimica et Biophysica Acta,2012,1820(7):894-899.DOI:10.1016/j.bbagen.2012.03.020.
[85]BOESCH-SAADATMANDI C,WAGNER A E,WOLFFRAM S,et al.Effect of quercetin on inflammatory gene expression in mice liver in vivo-role of redox factor 1,mi RNA-122 and mi RNA-125b[J].Pharmacological Research the Official Journal of the Italian Pharmacological Society,2012,65(5):523-530.DOI:10.1016/j.phrs.2012.02.007.
[86]GAEDICKE S,ZHANG X,SCHMELZER C,et al.Vitamin E dependent micro RNA regulation in rat liver[J].Febs Letters,2008,582(23/24):3542-3546.DOI:10.1016/j.febslet.2008.09.032.
[87]NORATTOG D,GABRIELAA M,TALCOTT S T,et al.Polyphenolics from ac?ai?(Euterpe oleracea Mart.)and red muscadine grape(Vitis rotundifolia)protect human umbilical vascular endothelial cells(HUVEC)from glucose-and lipopolysaccharide(LPS)-induced inflammation and target micro RNA-126[J].Journal of Agricultural and Food Chemistry,2011,59(14):7999-8012.DOI:10.1021/jf201056x.
[88]NORATTO G D,YOUNGMOK K,TALCOTT S T,et al.Flavonol-rich fractions of yaupon holly leaves(Ilex vomitoria,Aquifoliaceae)induce micro RNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofibroblast CCD-18Co cells[J].Fitoterapia,2011,82(4):557-569.DOI:10.1016/j.fitote.2011.01.013.
[89]WAGNER A E,BOESCH-SAADATMANDI C,DOSE J,et al.Antiinflammatory potential of allyl-isothiocyanate-role of Nrf2,NF-κB and micro RNA-155[J].Journal of Cellular and Molecular Medicine,2012,16(4):836-843.DOI:10.1111/j.1582-4934.2011.01367.x.
[90]TOMé-CARNEIRO J,LARROSA M,Yá?EZ-GASCóN M J,et al.One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related micro RNA and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease[J].Pharmacological Research,2013,72(3):69-82.DOI:10.1016/j.phrs.2013.03.011.
[91]BOESCH-SAADATMANDI C,LOBODA A,WAGNER A E,et al.Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression:role of mi R-155[J].Journal of Nutritional Biochemistry,2011,22(3):293-299.DOI:10.1016/j.jnutbio.2010.02.008.
[92]NIVEDITA B,STEPHEN T,STEPHEN S,et al.Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo:potential role of mi RNA-27a and mi RNA-155 in cell survival and inflammation[J].Breast Cancer Research&Treatment,2012,136(1):21-34.DOI:10.1007/s10549-012-2224-0.
[93]TILI E,MICHAILLE J B,ALDER H,et al.Resveratrol decreases the levels of mi R-155 by upregulating mi R-663,a micro RNA targeting Jun B and Jun D[J].Carcinogenesis,2010,31(9):1561-1566.DOI:10.1093/carcin/bgq143.
[94]CHEN Y Z,LIU W C,SUN T,et al.1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting micro RNA-155-SOCS1 in macrophages[J].Journal of Immunology,2013,190(7):3687-3695.DOI:10.4049/jimmunol.1203273.
[95]PILAR P,FRANCISCA S,ANDREU P.Expression of adipose micro RNA is sensitive to dietary conjugated linoleic acid treatment in mice[J].PLo S ONE,2010,5(9):e13005.DOI:10.1371/journal.pone.0013005.
[96]ZITMAN-GAL T,GREEN J,PASMANIK-CHOR M,et al.Vitamin D manipulates mi R-181c,mi R-20b and mi R-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment[J].Cardiovascular Diabetology,2014,13(1):8.DOI:10.1186/1475-2840-13-8.
[97]HASSAN Z K,Al-OLAYAN E M.Curcumin reorganizes mi RNA expression in a mouse model of liver fibrosis[J].Asian Pacific Journal of Cancer Prevention Apjcp,2012,13(13):5405-5408.DOI:10.7314/APJCP.2012.13.11.5405.
[98]LAM T K,STEPHANIE S,YINGDONG Z,et al.Influence of quercetin-rich food intake on micro RNA expression in lung cancer tissues[J].Cancer Epidemiology Biomarkers&Prevention,2012,21(12):2176-2184.DOI:10.1158/1055-9965.EPI-12-0745.
[99]TSANG W P,KWOK T T.Epigallocatechin gallate up-regulation of mi R-16 and induction of apoptosis in human cancer cells[J].Journal of Nutritional Biochemistry,2010,21(2):140-146.DOI:10.1016/j.jnutbio.2008.12.003.
[100]AHN J,LEE H,CHANG H J,et al.Lycopene inhibits hepatic steatosis via micro RNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet[J].Molecular Nutrition&Food Research,2012,56(11):1665-1674.DOI:10.1002/mnfr.201200182.
[101]VINCIGUERRA M,SGROI A,VEVRAT-DUREBEX C,et al.Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog(PTEN)via micro RNA-21 upregulation in hepatocytes[J].Hepatology,2009,49(4):1176-1184.DOI:10.1002/hep.22737.
[102]TEROAO M,FRATELLIM,KUROSAKI M,et al.Induction of mi R-21by retinoic acid in estrogen receptor-positive breast carcinoma cells[J].Journal of Biological Chemistry,2011,286(5):4027-4042.DOI:10.1074/jbc.M110.184994.
[103]张雪.雷公藤红素通过抑制NF-κB上调mi R-223,纠正软脂酸导致的Hep G2细胞糖吸收下降[D].银川:宁夏医科大学,2014:12-41.
[104]袁绪胜.Micro RNA-126对ox-LDL诱导血管内皮细胞黏附功能的调控及丹皮酚干预机制[D].合肥:安徽中医药大学,2013:54-79.
[105]郑征.Omega-3多不饱和脂肪酸通过影响mi R:146b的表达实现对炎症的调节[D].青岛:青岛大学,2013:24-42.
[106]张茜.天麦消渴片通过micro RNA和m RNA调控网络改善糖代谢机制研究[D].北京:北京协和医学院,2014:74-135.
[107]贾蓉.mi RNA-21在UUO幼年大鼠肾组织中的表达趋势及药物干预的效果[D].太原:山西医科大学,2014:12-32.
[108]谢凤燕.丹酚酸B阻止TGF-β1诱导的HK-2细胞转分化以及相关micro RNA的变化[D].南京:南京医科大学,2012:16-46.
[2]HALCOX J,MISRA A.Type 2 diabetes mellitus,metabolic syndrome,and mixed dyslipidemia:how similar,how different,and how to treat?[J].Metabolic Syndrome&Related Disorders,2015,13(1):1-21.DOI:10.1089/met.2014.0049.
[3]黄建权,王观春,由凯.肥胖和代谢综合征的药物治疗与研究进展[J].药品评价,2013(9):25-32.
[4]EVA V R.The art of micro RNA research[J].Circulation Research,2011,108(2):219-234.DOI:10.1161/CIRCRESAHA.110.227496.
[5]虞桂,王阶.mi RNA及其调控网络与中医治病求本机制研究[J].中华中医药杂志,2012(11):2789-2791.
[6]HARVEY A L.Plant natural products in anti-diabetic drug discovery[J].Current Organic Chemistry,2010,14(16):1670-1677.DOI:10.2174/138527210792927681.
[7]ROSS S A,DAVIS C D.The emerging role of micro RNA and nutrition in modulating health and disease[J].Annual Review of Nutrition,2014,34:305-336.DOI:10.1146/annurev-nutr-071813-105729.
[8]HERRERA B M,LOCKSTONE H E,TAYLOR J M,et al.Global micro RNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes[J].Diabetologia,2010,53(6):1099-1109.DOI:10.1007/s00125-010-1667-2.
[9]LI X L.Mi R-375,a micro RNA related to diabetes[J].Gene,2013,533(1):1-4.DOI:10.1016/j.gene.2013.09.105.
[10]ZHU L,CHEN L,SHI C M,et al.Mi R-335,an adipogenesis-related micro RNA,is involved in adipose tissue inflammation[J].Cell Biochemistry&Biophysics,2014,68(2):283-290.DOI:10.1007/s12013-013-9708-3.
[11]KILIC I D,DODURGA Y,ULUDAG B,et al.Micro RNA-143 and-223 in obesity[J].Gene,2015,560(2):140-142.DOI:10.1016/j.gene.2015.01.048.
[12]GAO Song,WASSLER M,ZHANG Lulu,et al.Micro RNA-133a regulates insulin-like growth factor-1 receptor expression and vascular smooth muscle cell proliferation in murine atherosclerosis[J].Atherosclerosis,2014,232(1):171-179.DOI:10.1016/j.atherosclerosis.2013.11.029.
[13]KULLMANN A,WEBER P S,BISHOP J B,et al.Equine insulin receptor and insulin-like growth factor-1 receptor expression in digital lamellar tissue and insulin target tissues[J].Equine Veterinary Journal,2015,48(5):626-632.DOI:10.1111/evj.12474.
[14]SUN C Z,HUANG F Z,LIU X Y,et al.Mi R-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR[J].International Journal of Molecular Medicine,2015,35(3):847-853.DOI:10.3892/ijmm.2015.2076.
[15]ESGUERRA J L S,CAROLINE B,CILIO C M,et al.Differential glucose-regulation of micro RNA in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat[J].PLo S ONE,2011,6(4):e18613.DOI:10.1371/journal.pone.0018613.
[16]ARNER E,MEJHERT N,KULYTéA,et al.Adipose tissue micro RNA as regulators of CCL2 production in human obesity[J].Diabetes,2012,61(8):1986-93.DOI:10.2337/db11-1508.
[17]CAPOBIANCO V,NARDELLI C,FERRIGNO M,et al.mi RNA and protein expression profiles of visceral adipose tissue reveal mi R-141/YWHAG and mi R-520e/RAB11A as two potential mi RNA/protein target pairs associated with severe obesity[J].Journal of Proteome Research,2012,11(6):3358-3369.DOI:10.1021/pr300152z.
[18]DIAWARA M R,HUE C,WILDER S P,et al.Adaptive expression of micro RNA-125a in adipose tissue in response to obesity in mice and men[J].PLo S ONE,2014,9(3):e91375-e91375.DOI:10.1371/journal.pone.0091375.
[19]CHEN Ling,DAI Yongmei,JI Chenbo,et al.Mi R-146b is a regulator of human visceral preadipocyte proliferation and differentiation and its expression is altered in human obesity[J].Molecular and Cellular Endocrinology,2014,393(1/2):65-74.
[20]刁雪红,申锷,胡兵,等.糖尿病小鼠心肌组织micro RNA表达谱分析[J].上海交通大学学报(医学版),2010,30(10):1194-1198.
[21]TALI A S,LIA K,SHARON K R,et al.The promoter of the primi R-375 gene directs expression selectively to the endocrine pancreas[J].PLo S ONE,2009,4(4):5033.DOI:10.1371/journal.pone.0005033.
[22]El OUAAMARI A,BAROUKH N,MARTENS G A,et al.mi R-375targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells[J].Diabetes,2008,57(10):2708-2717.DOI:10.2337/db07-1614.
[23]POY M N,LENA E,JAN K,et al.A pancreatic islet-specific micro RNA regulates insulin secretion[J].Nature,2004,432:226-230.DOI:10.1038/nature03076.
[24]MEERSON A,TRAURIG M,OSSOWSKI V,et al.Human adipose micro RNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α[J].Diabetologia,2013,56(9):1971-1979.DOI:10.1007/s00125-013-2950-9.
[25]CHOU W W,WANG W T,LIAO Y C,et al.Decreased micro RNA-221 is associated with high levels of TNF-αin human adipose tissue-derived mesenchymal stem cells from obese woman[J].Cellular Physiology&Biochemistry,2013,32(1):127-137.DOI:10.1159/000350131.
[26]MENG Shu,CAO Jiatian,ZHANG B,et al.Downregulation of micro RNA-126 in endothelial progenitor cells from diabetes patients,impairs their functional properties,via target gene Spred-1[J].Journal of Molecular&Cellular Cardiology,2012,53(1):64-72.DOI:10.1016/j.yjmcc.2012.04.003.
[27]ZHANG Tao,LüChunfang,LI Liling,et al.Plasma mi R-126 is a potential biomarker for early prediction of type 2 diabetes mellitus in susceptible individuals[J].Biomed Research International,2013(4):761617.DOI:10.1155/2013/761617.
[28]YANIV L,EHUD B,REUT A F,et al.RNA-binding protein PTB and micro RNA-221 coregulate Adipo R1 translation and adiponectin signaling[J].Diabetes,2013,63(2):433-445.DOI:10.2337/db13-1032.
[29]BAROUKH N,RAVIER M A,LODER M K,et al.Micro RNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines[J].Journal of Biological Chemistry,2007,282(27):19575-19588.
[30]LOVIS P,GATTESCO S R.Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by micro RNA[J].Biological Chemistry,2008,389(3):305-312.DOI:10.1515/BC.2008.026.
[31]VALéRIE P,AMAR A,VéRONIQUE P M,et al.Micro RNA-9controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells[J].Journal of Biological Chemistry,2006,281(37):26932-26942.DOI:10.1074/jbc.M601225200.
[32]HE Aibin,ZHU Liuluan,GUPTA N,et al.Overexpression of micro ribonucleic acid 29,highly up-regulated in diabetic rats,leads to insulin resistance in 3T3-L1 adipocytes[J].Molecular Endocrinology,2007,21(11):2785-2794.DOI:10.1210/me.2007-0167.
[33]MIRKO T,JEAN H,JüRGEN S,et al.Micro RNA 103 and107 regulate insulin sensitivity[J].Nature,2011,474:649-653.DOI:10.1038/nature10112.
[34]CHEN Lin,HOU Jia,YE Lanfeng,et al.Micro RNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling[J].Scientific Reports,2014,4(1):3819-3819.DOI:10.1038/srep03819.
[35]LORENTE-CEBR IáNS,MEJHERT N,KULY TéA,et al.Micro RNA regulate human adipocyte lipolysis:effects of mi R-145are linked to TNF-α[J].PLo S ONE,2014,9(1):e86800.DOI:10.1371/journal.pone.0086800.
[36]史春梅,徐广峰,季晨博,等.mi R-26b过表达对不同时间点人脂肪细胞分泌脂因子的影响[J].临床儿科杂志,2013(10):914-916.DOI:10.3969/j.issn.1000-3606.2013.10.004.
[37]BALASUBRAMANYAM M,ARAVIND S,GOKULAKRISHNAN K,et al.Impaired mi R-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes[J].Molecular and Cellular Biochemistry,2011,351(1/2):197-205.DOI:10.1007/s11010-011-0727-3.
[38]SALAS-PéREZ F,CODNER E,VALENCIA E,et al.Micro RNA mi R-21a and mi R-93 are down regulated in peripheral blood mononuclear cells(PBMCs)from patients with type 1 diabetes[J].Immune biology,2013,218(5):733-737.DOI:10.1016/j.imbio.2012.08.276.
[39]ZHONG X,CHUNG A C K,CHEN H Y,et al.mi R-21 is a key therapeutic target for renal injury in a mouse model of type 2diabetes[J].Diabetologia,2013,56(3):663-674.DOI:10.1007/s00125-012-2804-x.
[40]FENG Biao,CAO Yanan,CHEN Shali,et al.Mi RNA-1 regulates endothelin-1 in diabetes[J].Life Sciences,2014,118(2):18-23.DOI:10.1016/j.lfs.2013.12.199.
[41]KATO M,ZHANG J,WANG M,et al.Micro RNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors[J].Proceedings of the National Academy of Sciences,2007,104(9):3432-3437.DOI:10.1073/pnas.0611192104.
[42]CHEN Shali,PUTHANVEETIL P,FENG Biao,et al.Cardiac mi R-133a overexpression prevents early cardiac fibrosis in diabetes[J].Journal of Cellular&Molecular Medicine.2014,18(3):415-421.DOI:10.1111/jcmm.12218.
[43]COLLARES C V,EVANGELISTA A F,XAVIER D J,et al.Identifying common and specific micro RNA expressed in peripheral blood mononuclear cell of type 1,type 2,and gestational diabetes mellitus patients[J].BMC Research Notes,2013,6(1):1-15.DOI:10.1186/1756-0500-6-491.
[44]KONG Lei,ZHU Junjie,HAN Wenxia,et al.Significance of serum micro RNA in pre-diabetes and newly diagnosed type 2diabetes:a clinical study[J].Acta Diabetologica,2011,48(1):61-69.DOI:10.1007/s00592-010-0226-0.
[45]WANG X,SUNDQUIST J,Z?LLER B,et al.Determination of 14circulating micro RNA in Swedes and Iraqis with and without diabetes mellitus type 2[J].PLo S ONE,2014,9(1):e86792.DOI:10.1371/journal.pone.0086792.
[46]叶青.脂代谢相关mi RNA靶基因结合区域多态性与代谢综合征及其组分的分子流行病学研究[D].南京:南京医科大学,2013:39-56.
[47]MARTINELLI R,NARDELLI C,PILONE V,et al.mi R-519d Overexpression is associated with human obesity[J].Obesity,2010,18(11):2170-2176.DOI:10.1038/oby.2009.474.
[48]HENEGHAN H M,MILLER N,MCANENA O J,et al.Differential mi RNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers[J].Journal of Clinical Endocrinology&Metabolism,2011,96(5):846-850.DOI:10.1210/jc.2010-2701.
[49]KELLER P,GBURCIK V,PETROVIC N,et al.Gene-chip studies of adipogenesis-regulated micro RNA in mouse primary adipocytes and human obesity[J].BMC Endocrine Disorders,2011,11(1):1-11.DOI:10.1186/1472-6823-11-7.
[50]ORTEGA F J,MORENO-NAVARRETE J M,GERARD P,et al.Mi RNA expression profile of human subcutaneous adipose and during adipocyte differentiation[J].PLo S ONE,2010,5(2):e9022.DOI:10.1371/journal.pone.0009022.
[51]ZHUANG Guoqing,MENG Cong,GUO Xin,et al.A novel regulator of macrophage activation:mi R-223 in obesity-associated adipose tissue inflammation[J].Circulation,2012,125(23):2892-2903.DOI:10.1161/CIRCULATIONAHA.111.087817.
[52]FU Ting,CHOI S E,KIM D H,et al.Aberrantly elevated micro RNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptorβ-Klotho[J].Proceedings of the National Academy of Sciences,2012,109(40):16137-16142.DOI:10.1073/pnas.1205951109.
[53]PAN Shifeng,ZHENG Yating,ZHAO Ruqian,et al.Micro RNA-130b and micro RNA-374b mediate the effect of maternal dietary protein on offspring lipid metabolism in Meishan pigs[J].British Journal of Nutrition,2013,109(10):1-8.DOI:10.1017/S0007114512003728.
[54]WANG Yucheng,LI Yuying,WANG Xinyi,et al.Circulating mi R-130b mediates metabolic crosstalk between fat and muscle in overweight/obesity[J].Diabetologia,2013,56(10):2275-2285.DOI:10.1007/s00125-013-2996-8.
[55]HULSMANS M,van DOOREN E,MATHIEU C,et al.Decrease of mi R-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin[J].PLo S ONE,2012,7(2):e32794.DOI:10.1371/journal.pone.0032794.
[56]CHOI S E,FU T,SEOK S,et al.Elevated micro RNA-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT[J].Aging Cell,2013,12(6):1062-1072.DOI:10.1111/acel.12135.
[57]BENATTI R O,MELO A M,BORGES F O,et al.Maternal highfat diet consumption modulates hepatic lipid metabolism and micro RNA-122(mi R-122)and micro RNA-370(mi R-370)expression in offspring[J].British Journal of Nutrition,2014,111(12):2112-2122.DOI:10.1017/S0007114514000579.
[58]FOLEY N H,O'NEILL L A.Mi R-107:a toll-like receptor-regulated mi RNA dysregulated in obesity and typeⅡdiabetes[J].Journal of Leukocyte Biology,2012,92(3):521-527.DOI:10.1189/jlb.0312160.
[59]NAKANISHI N,NAKAGAWA Y,TOKUSHIGE N.The up-regulation of micro RNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice[J].Biochemical&Biophysical Research Communications,2009,385(4):492-496.DOI:10.1016/j.bbrc.2009.05.058.
[60]KORNFELD J W,BAITZEL C,K?NNER A C,et al.Obesity-induced overexpression of mi R-802 impairs glucose metabolism through silencing of Hnf1b[J].Nature,2013,494:111-115.DOI:10.1038/nature11793.
[61]JORDAN S D,MARKUS K,WILLMES D M,et al.Obesity-induced overexpression of mi RNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism[J].Nature Cell Biology,2011,13(4):434-446.DOI:10.1038/ncb2211.
[62]KIM C,LEE H,CHO Y M,et al.TNFα-induced mi R-130 resulted in adipocyte dysfunction during obesity-related inflammation[J].Febs Letters,2013,587(23):3853-3858.DOI:10.1016/j.febslet.2013.10.018.
[63]ORTEGA F J,MERCADER J M,JOSéMARíA M N,et al.Profiling of circulating micro RNA reveals common micro RNA linked to type 2diabetes that change with insulin sensitization[J].Diabetes Care,2014,37(5):1375-1383.DOI:10.2337/dc13-1847.
[64]ORTEGA F J,MERCADER J M,CATALáN V,et al.Targeting the circulating micro RNA signature of obesity[J].Clinical Chemistry,2013,59(5):781-792.DOI:10.1373/clinchem.2012.195776.
[65]ANNA P P,ORTEGA F J,MERCADER J M,et al.Changes in circulating micro RNA are associated with childhood obesity[J].Journal of Clinical Endocrinology and Metabolism,2013,98(10):1655-1660.DOI:10.1210/jc.2013-1496.
[66]CARRER M,LIU N,GRUETER C E,et al.Control of mitochondrial metabolism and systemic energy homeostasis by micro RNA 378 and378*[J].Proceedings of the National Academy of Sciences of the United States of America,2012,109(38):15330-15335.DOI:10.1073/pnas.1207605109.
[67]张政,罗勇军,彭惠民,等.早期糖尿病肾病相关微小RNA在小鼠肾脏的表达变化[J].第三军医大学学报,2010,32(13):1383-1386.
[68]ZHANG Z,PENG H M,CHEN J X,et al.Micro RNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice[J].Febs Letters,2009,583(12):2009-2014.DOI:10.1016/j.febslet.2009.05.021.
[69]CHENG Y H,LIU X J,YANG J,et al.Micro RNA-145,a novel smooth muscle cell phenotypic marker and modulator,controls vascular neointimal lesion formation[J].Circulation Research,2009,105(2):158-166.DOI:10.1161/CIRCRESAHA.109.197517.
[70]ANDREA C,MARCO M,CHRISTINE V,et al.Deregulation of micro RNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia[J].Circulation,2011,123(3):282-291.DOI:10.1161/CIRCULATIONAHA.110.952325.
[71]FERREIRAL R P,AMANDAF F,SANTOSRH B,et al.Micro RNA mi R-1,mi R-133a,mi R-133b,mi R-208a and mi R-208b are dysregulated in Chronic Chagas disease Cardiomyopathy[J].International Journal of Cardiology,2014,175(3):409-417.DOI:10.1016/j.ijcard.2014.05.019.
[72]TURCHINOVICH A,WEIZ L,BURWINKEL B.Extracellular mi RNAs:the mystery of their origin and function[J].Trends in Biochemical Sciences,2012,37(11):460-465.DOI:10.1016/j.tibs.2012.08.003.
[73]ZHANG Lin,HOU Dongxia,CHEN Xi,et al.Exogenous plant MIR168a specifically targets mammalian LDLRAP1:evidence of cross-kingdom regulation by micro RNA[J].Cell Research,2012,22(1):107-126.DOI:10.1038/cr.2011.158.
[74]WANG K,LI H,YUAN Y,et al.The complex exogenous RNA spectra in human plasma:an interface with human gut biota?[J].PLo S ONE,2012,7(12):1354-1357.DOI:10.1371/journal.pone.0051009.
[75]KOSAKA N,IZUMI H,SEKINE K,et al.Micro RNA as a new immune-regulatory agent in breast milk[J].Silence,2010,1(1):7.DOI:10.1186/1758-907X-1-7.
[76]TITLE A C,DENZLER R,STOFFEL M.Uptake and function studies of maternal milk-derived micro RNAs*[J].Journal of Biological Chemistry,2015,290(39):23680-23691.DOI:10.1074/jbc.M115.676734.
[77]DRAGAN M,CHRISTIANE D,ERWAN G,et al.Modulation of mi RNA expression by dietary polyphenols in apo E deficient mice:a new mechanism of the action of polyphenols[J].PLo S ONE,2012,7(1):156-167.DOI:10.1371/journal.pone.0029837.
[78]NOLTE H E N M,van ROOIJ E,BUSHELL M,et al.The role of micro RNA in nutritional control[J].Journal of Internal Medicine,2015,278(2):99-109.DOI:10.1111/joim.12372.
[79]WEN X Y,WU S Y,LI Z Q,et al.Ellagitannin(BJA3121),an antiproliferative natural polyphenol compound,can regulate the expression of Mi RNAs in Hep G 2 cancer cells[J].Phytotherapy Research,2009,23(6):778-784.DOI:10.1002/ptr.2616.
[80]AROLA-ARNAL A,BLADéC.Proanthocyanidins modulate micro RNA expression in human Hep G2 cells[J].PLo S ONE,2011,6(10):148.DOI:10.1371/journal.pone.0025982.
[81]BASELGA-ESCUDERO L,BLADéC,RIBAS-LATRE A,et al.Grape seed proanthocyanidins repress the hepatic lipid regulators mi R-33and mi R-122 in rats[J].Molecular Nutrition&Food Research,2012,56(11):1636-1646.DOI:10.1002/mnfr.201200237.
[82]YANG Y M,SEO S Y,KIM T H,et al.Decrease of micro RNA-122causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B,which is reversed by licorice flavonoid[J].Hepatology,2012,56(6):2209-2220.DOI:10.1002/hep.25912.
[83]KUTAY H,BAI S,DATTA J,et al.Downregulation of mi R-122 in the rodent and human hepatocellular carcinomas[J].Journal of Cellular Biochemistry,2006,99(3):671-678.DOI:10.1002/jcb.20982.
[84]JOVEN J,ESPINEL E,RULL A,et al.Plant-derived polyphenols regulate expression of mi RNA paralogs mi R-103/107 and mi R-122and prevent diet-induced fatty liver disease in hyperlipidemic mice[J].Biochimica et Biophysica Acta,2012,1820(7):894-899.DOI:10.1016/j.bbagen.2012.03.020.
[85]BOESCH-SAADATMANDI C,WAGNER A E,WOLFFRAM S,et al.Effect of quercetin on inflammatory gene expression in mice liver in vivo-role of redox factor 1,mi RNA-122 and mi RNA-125b[J].Pharmacological Research the Official Journal of the Italian Pharmacological Society,2012,65(5):523-530.DOI:10.1016/j.phrs.2012.02.007.
[86]GAEDICKE S,ZHANG X,SCHMELZER C,et al.Vitamin E dependent micro RNA regulation in rat liver[J].Febs Letters,2008,582(23/24):3542-3546.DOI:10.1016/j.febslet.2008.09.032.
[87]NORATTOG D,GABRIELAA M,TALCOTT S T,et al.Polyphenolics from ac?ai?(Euterpe oleracea Mart.)and red muscadine grape(Vitis rotundifolia)protect human umbilical vascular endothelial cells(HUVEC)from glucose-and lipopolysaccharide(LPS)-induced inflammation and target micro RNA-126[J].Journal of Agricultural and Food Chemistry,2011,59(14):7999-8012.DOI:10.1021/jf201056x.
[88]NORATTO G D,YOUNGMOK K,TALCOTT S T,et al.Flavonol-rich fractions of yaupon holly leaves(Ilex vomitoria,Aquifoliaceae)induce micro RNA-146a and have anti-inflammatory and chemopreventive effects in intestinal myofibroblast CCD-18Co cells[J].Fitoterapia,2011,82(4):557-569.DOI:10.1016/j.fitote.2011.01.013.
[89]WAGNER A E,BOESCH-SAADATMANDI C,DOSE J,et al.Antiinflammatory potential of allyl-isothiocyanate-role of Nrf2,NF-κB and micro RNA-155[J].Journal of Cellular and Molecular Medicine,2012,16(4):836-843.DOI:10.1111/j.1582-4934.2011.01367.x.
[90]TOMé-CARNEIRO J,LARROSA M,Yá?EZ-GASCóN M J,et al.One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related micro RNA and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease[J].Pharmacological Research,2013,72(3):69-82.DOI:10.1016/j.phrs.2013.03.011.
[91]BOESCH-SAADATMANDI C,LOBODA A,WAGNER A E,et al.Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression:role of mi R-155[J].Journal of Nutritional Biochemistry,2011,22(3):293-299.DOI:10.1016/j.jnutbio.2010.02.008.
[92]NIVEDITA B,STEPHEN T,STEPHEN S,et al.Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo:potential role of mi RNA-27a and mi RNA-155 in cell survival and inflammation[J].Breast Cancer Research&Treatment,2012,136(1):21-34.DOI:10.1007/s10549-012-2224-0.
[93]TILI E,MICHAILLE J B,ALDER H,et al.Resveratrol decreases the levels of mi R-155 by upregulating mi R-663,a micro RNA targeting Jun B and Jun D[J].Carcinogenesis,2010,31(9):1561-1566.DOI:10.1093/carcin/bgq143.
[94]CHEN Y Z,LIU W C,SUN T,et al.1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting micro RNA-155-SOCS1 in macrophages[J].Journal of Immunology,2013,190(7):3687-3695.DOI:10.4049/jimmunol.1203273.
[95]PILAR P,FRANCISCA S,ANDREU P.Expression of adipose micro RNA is sensitive to dietary conjugated linoleic acid treatment in mice[J].PLo S ONE,2010,5(9):e13005.DOI:10.1371/journal.pone.0013005.
[96]ZITMAN-GAL T,GREEN J,PASMANIK-CHOR M,et al.Vitamin D manipulates mi R-181c,mi R-20b and mi R-15a in human umbilical vein endothelial cells exposed to a diabetic-like environment[J].Cardiovascular Diabetology,2014,13(1):8.DOI:10.1186/1475-2840-13-8.
[97]HASSAN Z K,Al-OLAYAN E M.Curcumin reorganizes mi RNA expression in a mouse model of liver fibrosis[J].Asian Pacific Journal of Cancer Prevention Apjcp,2012,13(13):5405-5408.DOI:10.7314/APJCP.2012.13.11.5405.
[98]LAM T K,STEPHANIE S,YINGDONG Z,et al.Influence of quercetin-rich food intake on micro RNA expression in lung cancer tissues[J].Cancer Epidemiology Biomarkers&Prevention,2012,21(12):2176-2184.DOI:10.1158/1055-9965.EPI-12-0745.
[99]TSANG W P,KWOK T T.Epigallocatechin gallate up-regulation of mi R-16 and induction of apoptosis in human cancer cells[J].Journal of Nutritional Biochemistry,2010,21(2):140-146.DOI:10.1016/j.jnutbio.2008.12.003.
[100]AHN J,LEE H,CHANG H J,et al.Lycopene inhibits hepatic steatosis via micro RNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet[J].Molecular Nutrition&Food Research,2012,56(11):1665-1674.DOI:10.1002/mnfr.201200182.
[101]VINCIGUERRA M,SGROI A,VEVRAT-DUREBEX C,et al.Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog(PTEN)via micro RNA-21 upregulation in hepatocytes[J].Hepatology,2009,49(4):1176-1184.DOI:10.1002/hep.22737.
[102]TEROAO M,FRATELLIM,KUROSAKI M,et al.Induction of mi R-21by retinoic acid in estrogen receptor-positive breast carcinoma cells[J].Journal of Biological Chemistry,2011,286(5):4027-4042.DOI:10.1074/jbc.M110.184994.
[103]张雪.雷公藤红素通过抑制NF-κB上调mi R-223,纠正软脂酸导致的Hep G2细胞糖吸收下降[D].银川:宁夏医科大学,2014:12-41.
[104]袁绪胜.Micro RNA-126对ox-LDL诱导血管内皮细胞黏附功能的调控及丹皮酚干预机制[D].合肥:安徽中医药大学,2013:54-79.
[105]郑征.Omega-3多不饱和脂肪酸通过影响mi R:146b的表达实现对炎症的调节[D].青岛:青岛大学,2013:24-42.
[106]张茜.天麦消渴片通过micro RNA和m RNA调控网络改善糖代谢机制研究[D].北京:北京协和医学院,2014:74-135.
[107]贾蓉.mi RNA-21在UUO幼年大鼠肾组织中的表达趋势及药物干预的效果[D].太原:山西医科大学,2014:12-32.
[108]谢凤燕.丹酚酸B阻止TGF-β1诱导的HK-2细胞转分化以及相关micro RNA的变化[D].南京:南京医科大学,2012:16-46.