血清ApoA-1浓度在食管鳞状上皮细胞癌预后的价值
摘要
目的探讨血清ApoA-1浓度与食管鳞状上皮细胞癌的相关性及其预后价值。方法对我院2010年1月—2012年10月收治的食管鳞状上皮细胞癌患者的血清ApoA-1浓度进行回顾性调查分析,与我院体检中心2009年1月—2009年4月219例正常人群的血清ApoA-1浓度作为对照组进行统计学处理分析。结果 210例食管鳞状上皮细胞癌患者组和219例健康对照组在性别和年龄比较均无统计学差异(P>0.05)。血清ApoA-1浓度在ESCC组的pTNM和临床分期均有统计学差异(P<0.05)。与ApoA-1水平高的患者相比,ApoA-1水平低的患者的总体生存率更低(P=0.002)。结论血清ApoA-1水平是食管鳞状上皮细胞癌食管癌的一个重要的预后因素。
引文
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[2] 王凤龙蒋仲敏.环氧合酶-2在食管鳞癌组织中的表达及意义[J]. 广州医药, 2009, 40(6):12-13
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[4] ZHANG X, ZHAO X W, LIU D B, et al. Lipid levels in serum and cancerous tissues of colorectal cancer patients[J]. World J Gastroenterol.,2014, 20(26):8646-8652.
[5] WU Q,CHEN G,WU W M,et al.Metabolic syndrome components and risk factors for pancreatic adenocarcinoma:a case-control study in China [J].Digestion,2012,86(4):294-301.
[6] TUNG C L,LIN S T,CHOU H C,et al.Proteomics-based identification of plasma biomarkers in oral squamous cell carcinoma [J].J Pharm Biomed Anal,2013,75(1):7-17.
[7] OCHOA M C,FIORAVANTI J,RODRIGUEZ I,et al.Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein[J].Cancer Res,2013,73(1):139-149.
[8] CHETTY P S, NGUYEN D, NICKEL M, et al. Comparison of apoA-I helical structure and stability in discoidal and spherical HDL particles by HX and mass spectrometry[J]. J Lipid Res, 2013, 54(6):1589-1597.
[9] GOURIN C G, ZHI W, ADAM B L. Proteomic identification of serum biomarkers for head and neck cancer surveillance[J]. Laryngoscope, 2009,119(7):1291-1302.
[10] EHMANN M, FELIX K, HARTMANN D, et al. Identification of potential markers for the detection of pancreatic cancer through comparative serum protein expression profiling[J]. Pancreas, 2007,34(2):205-214.
[11] DIEPLINGER H, ANKERST D P, BURGES A, et al. Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer[J]. Cancer Epidemiol Biomarkers Prev, 2009,18(4):1127-1133.
[12] TUFT S H, NYMOEN D A, HETLAND F T, et al. APOA1 mRNA expression in ovarian serous carcinoma effusions is a marker of longer survival[J]. Am J Clin Pathol, 2014,142(1):51-57.
[13] CHANG S J, HOU M F, TSAI S M, et al. The association between lipid profiles and breast cancer among Taiwanese women[J]. Clin Chem Lab Med, 2007,45(9):1219-1223.