不同地区0～14岁儿童幽门螺杆菌及其细胞毒素相关基因蛋白A阳性菌株感染状况
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摘要
目的调查广西北海市及黑龙江大庆市儿童幽门螺杆菌(HP)及其细胞毒素相关基因蛋白A阳性(CagA~+)菌株的感染状况。方法选择分别在北海市人民医院儿科及大庆市油田总医院儿科就诊的儿童281名和284名为研究对象。检测并对比两地区儿童HP及CagA~+菌株感染情况,分析各地区不同人口学特征儿童的HP及CagA~+菌株感染情况。结果北海市儿童HP及CagA~+菌株的感染率均高于大庆市儿童(均P <0. 05);北海市7～<11岁组和11～14岁组儿童HP及CagA~+菌株的感染率均高于1～<7岁组儿童(均P <0. 05)。大庆市不同人口学特征儿童HP及CagA~+菌株的感染率比较,差异无统计学意义(P> 0. 05)。结论儿童HP和CagA~+菌株感染率存在地区差异。
Objective To investigate the prevalence of Helicobacter pylori( HP) and cytotoxin-associated gene protein A positive( CagA~+) strains infection among children from Beihai City of Guangxi Province and Daqing City of Heilongjiang Province. Methods Totally281 children from the Department of Pediatrics of Beihai People's Hospital and 284 from the Department of Pediatrics of Daqing Oilfield General Hospital were enrolled as the subjects. The prevalence of HP and CagA~+strains infection in children was detected and was compared between the two regions. The prevalence of HP and CagA~+strains infection was analyzed among children with various demographic characteristics in different regions. Results The infection rates of HP and CagA~+strains in children from Beihai City were higher than those in children from Daqing City( all P < 0. 05); in Beihai City,the infection rates of HP and CagA~+strains in children aged 7 to < 11 years and 11 to 14 years were higher than those in children aged 1 to < 7 years( all P < 0. 05). No statistically significant difference was observed in the infection rate of HP or CagA~+strains among Daqing children with various demographic characteristics( P > 0. 05). Conclusion Regional differences are found in the children's infection rates of HP and CagA~+strains.
Objective To investigate the prevalence of Helicobacter pylori( HP) and cytotoxin-associated gene protein A positive( CagA~+) strains infection among children from Beihai City of Guangxi Province and Daqing City of Heilongjiang Province. Methods Totally281 children from the Department of Pediatrics of Beihai People's Hospital and 284 from the Department of Pediatrics of Daqing Oilfield General Hospital were enrolled as the subjects. The prevalence of HP and CagA~+strains infection in children was detected and was compared between the two regions. The prevalence of HP and CagA~+strains infection was analyzed among children with various demographic characteristics in different regions. Results The infection rates of HP and CagA~+strains in children from Beihai City were higher than those in children from Daqing City( all P < 0. 05); in Beihai City,the infection rates of HP and CagA~+strains in children aged 7 to < 11 years and 11 to 14 years were higher than those in children aged 1 to < 7 years( all P < 0. 05). No statistically significant difference was observed in the infection rate of HP or CagA~+strains among Daqing children with various demographic characteristics( P > 0. 05). Conclusion Regional differences are found in the children's infection rates of HP and CagA~+strains.
引文
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[10]冯作化,药立波,周春燕,等.医学分子生物学[M].武汉:武汉出版社,1998:97-102.
[11] Frenck RW Jr,Clemens J. Helicobacter in the developing World[J]. Microbes Infect,2003,5(8):705-713.
[2] Pacifico L,Osborn JF,Tromba V,et al. Helicobacter pylori infection and extragastric disorders in children:a critical update[J]. World J Gastroenterol,2014,20(6):1 379-1 401.
[3] Testerman TL,Morris J. Beyond the stomach:an updated view of Helicobacter pylori pathogenesis,diagnosis,and treatment[J]. World J Gastroenterol,2014,20(36):12 781-12 808.
[4]李增烈,廖宁逊.幽门螺杆菌易感的若干社会经济因素[J].中华内科杂志,1998,37(8):566-567.
[5] Bridge DR,Merrell DS. Polymorphism in the Helicobacter pylori CagA and VacA toxins and disease[J]. Gut Microbes,2013,4(2):101-117.
[6]黄超全,张映红,刘丽.长沙市儿童幽门螺旋杆菌感染的调查及相关因素分析[J].中国现代医学杂志,2002,12(10):80,82.
[7]卢乐声,徐智芳,白星,等.嘉兴地区学龄儿童幽门螺杆菌感染状况和危险因素及耐药性分析[J].中国妇幼保健,2018,33(2):338-340.
[8]丁召路,徐樨巍,李在玲,等.中国三地区无症状儿童幽门螺杆菌现症感染率的流行病学调查[C].第十届全国儿童消化系统疾病学术会议论文集,2014:109-110.
[9]刘伟,许春娣,奚容平,等.上海地区不同家庭环境中儿童幽门螺杆菌感染的流行病学[J].中国实用儿科杂志,2006,21(1):19-21.
[10]冯作化,药立波,周春燕,等.医学分子生物学[M].武汉:武汉出版社,1998:97-102.
[11] Frenck RW Jr,Clemens J. Helicobacter in the developing World[J]. Microbes Infect,2003,5(8):705-713.