DNA修复基因XPD多态性与HCC发生的关系及其临床意义
摘要
肝细胞肝癌(HCC)是对人类健康、生命威胁较大的恶性肿瘤之一,多与乙肝病毒感染、黄曲霉毒素等因素有关。但是,仅有小部分HCC患者具有上述危险因素暴露史,HCC多与人群或个体的肿瘤易感性有关。而基因的多态性均存在单核苷酸多态性(SNP),且其产物常伴有不同程度的生物学活性。DNA修复系统是机体内重要的防御屏障,能直接参与修复内、外环境引起的DNA损伤。但是,对于修复能力缺陷或低下者,基因突变、细胞癌变的风险将会增加,而对于DNA修复能力低于一般人群的个体HCC发生率更高。DNA修复基因着色性干皮病基因D (XPD)是其常见的修复基因,能直接参与DNA碱基切除修复及核苷酸切除修复,并且两种基因多个位点存在单核苷酸多肽显效,与HCC易感性有关。因此,本文通过分析DNA修复基因XPD多态性与HCC发生的关系,探讨其临床意义,为HCC的治疗、干预提供依据和参考。
引文
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[2]李沭,南月丽,邓宇,等.细胞周期信号通路相关基因单核苷酸多态性与肝细胞癌临床病理特征关系[J].中国公共卫生,2017,33(4):577-583.
[3]张莎,陈自平,杜文军,等.DNA修复基因XPD XPCXRCC4基因多态性与结直肠癌易感性的关联性研究[J].中国肿瘤临床,2017,44(8):365-370.
[4]Miller KD,Siegel RL,Lin CC,et al.Cancer treatment and survivorship statistics,2016[J].CA Cancer J Clin,2016,66(4):271-289.
[5]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[6]Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
[7]Ghosh S,Ghosh S,Bankura B,et al.Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal,India[J].Tumor Biol,2016,37(7):9139-9149.
[8]崔文豪,李成浩,朴熙绪,等.ErbB2基因rs1058808位点多态性与延边地区HBV相关肝细胞肝癌的关系及民族差异[J].山东医药,2017,57(10):5-7.
[9]郑智华,黄爱民,高美钦,等.APEX1单核苷酸多态性与肝癌易感性关系的研究[J].福建医科大学学报,2016,50(2):88-92.
[10]胡洪波,唐超莉,李永标,等.XPD基因多态性与广西壮族人群肝癌家族聚集性的关系[J].山东医药,2016,56(13):33-35.
[11]Schetter AJ,Harris CC.Alterations of microRNAs contribute to colon carcinogenesis[J].Semin Oncol,2011,38(6):734-742.
[12]张路遥,黄辉星,曹立环,等.CDCA8和INCENP mR-NA在肝细胞癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(2):158-167.
[13]Yue AM,Xie ZB,Guo SP,et al.Implication of Polymorphisms in DNA Repair Genes in Prognosis of Hepatocellular Carcinoma[J].Asian Pac J Cancer Prev,2013,14(1):355-358.
[14]Guan Q,Chen Z,Chen Q,et al.XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients[J].Oncol Lett,2017,14(3):2783-2788.
[15]Zheng JF,Li LL,Lu J,et al.XPD Functions as a Tumor Suppressor and Dysregulates Autophagy in Cultured Hep G2 Cells[J].Med Sci Monit,2015,21:1562-1568.
[16]Lye MS,Visuvanathan S,Chong PP,et al.Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population[J].PLo S One,2015,10(6):e0130530.
[17]张清秀,姚云清,李始亮,等.白细胞介素18基因多态性与HBV所致肝细胞肝癌的相关性[J].中华肝脏病杂志,2016,24(5):352-357.
[18]周争光,汪蕊,李玉梅,等.mir-130a-3p及smad 4在肝细胞癌组织中的表达及临床意义[J].安徽医科大学学报,2017,52(3):383-387.
[19]Dasdemir S,Guven M,Pekkoc KC,et al.DNA repair gene XPD Asp312Asn and XRCC4 G-1394T polymorphisms and the risk of autism spectrum disorder[J].Cell mol Biol(Noisy-le-grand),2016,62(3):46-50.
[20]Yang QI,Wei YF,Zhang Y,et al.XPD Lys751Gln and Asp312Asn polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis of 11 case-control studies in an Asian population[J].Exp Ther Med,2015,9(6):2406-2414.
[21]陈宏伟,李宗锋,张红娟,等.Nemo样激酶蛋白在原发性肝细胞癌中的表达及意义[J].实用医学杂志,2016,32(19):3204-3208.
[22]Huang L,Mo Z,Lao X,et al.PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population[J].Tumor Biol,2016,37(5):6599-6606.
[23]盛若凡,曾蒙苏,陈伶俐,等.不同程度肝纤维化背景下小肝癌的磁共振表现比较分析[J].临床放射学杂志,2016,35(3):369-373.
[24]邓雪松,潘红艳,成俊,等.上调miR-449a表达对肝癌细胞生长和侵袭能力的影响[J].中国普通外科杂志,2018,27(1):68-74.
[25]滕雪,关尚为,刘朦朦,等.晚期非小细胞肺癌患者XPD基因多态性与铂类药物化疗临床疗效相关性的Meta分析[J].中国药房,2016,27(24):3380-3384.
[26]Ravegnini G,Nannini M,Simeon V,et al.Polymorphisms in DNA repair genes in gastrointestinal stromal tumours:susceptibility and correlation with tumour characteristics and clinical outcome[J].Tumour Biol,2016,37(10):13413-13423.
[27]Wang XC,Wang F,Quan QQ.Roles of XRCC1/XPD/ERCC1 Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization[J].Genet Test Mol Biomarkers,2016,20(4):176-184.
[28]黄国林,滕翠芳,罗燕妹,等.肝细胞肝癌患者癌组织中Ras相关C3肉毒素底物转化生长因子β1表达变化及其意义[J].山东医药,2018,58(15):58-60.
[29]王凇,郝艳红,杨薇,等.肝癌射频消融后肝脓肿的发生率及危险因素分析[J].中国介入影像与治疗学,2018,15(1):37-41.
[30]褚亚,周石,王黎洲,等.磷脂酶Cβ1上调表达与肝细胞肝癌增殖和预后相关[J].介入放射学杂志,2018,27(1):29-34.
[31]张崇辉,陈莉.肝细胞肝癌间质微环境与TLR3表达的相关性及其对预后的影响[J].肿瘤防治研究,2017,44(4):262-267.
[32]Wang B,Yeh CB,Lein MY,et al.Effects of HMGB1Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma[J].Int J Med Sci,2016,13(4):304-309.
[33]B■nescu C,Iancu M,Trifa AP,et al.Influence of XPC,XPD,XPF,and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population[J].Tumour Biol,2016,37(7):9357-9366.
[34]Zhang L,Xu K,Liu C,et al.Meta-analysis reveals an association between signal transducer and activator of transcription-4 polymorphism and hepatocellular carcinoma risk[J].Hepatol Res,2017,47(4):303-311.
[35]Wang B,Hsu CJ,Lee HL,et al.Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma[J].Int J Med Sci,2018,15(6):653-658.
[36]Huang W,Zhang H,Hao Y,et al.A Non-Synonymous Single Nucleotide Polymorphism in the HJURP Gene Associated with Susceptibility to Hepatocellular Carcinoma among Chinese[J].Plos One,2016,11(2):e0148618.
[2]李沭,南月丽,邓宇,等.细胞周期信号通路相关基因单核苷酸多态性与肝细胞癌临床病理特征关系[J].中国公共卫生,2017,33(4):577-583.
[3]张莎,陈自平,杜文军,等.DNA修复基因XPD XPCXRCC4基因多态性与结直肠癌易感性的关联性研究[J].中国肿瘤临床,2017,44(8):365-370.
[4]Miller KD,Siegel RL,Lin CC,et al.Cancer treatment and survivorship statistics,2016[J].CA Cancer J Clin,2016,66(4):271-289.
[5]Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[6]Ferlay J,Soerjomataram I,Dikshit R,et al.Cancer incidence and mortality worldwide:sources,methods and major patterns in GLOBOCAN 2012[J].Int J Cancer,2015,136(5):E359-E386.
[7]Ghosh S,Ghosh S,Bankura B,et al.Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal,India[J].Tumor Biol,2016,37(7):9139-9149.
[8]崔文豪,李成浩,朴熙绪,等.ErbB2基因rs1058808位点多态性与延边地区HBV相关肝细胞肝癌的关系及民族差异[J].山东医药,2017,57(10):5-7.
[9]郑智华,黄爱民,高美钦,等.APEX1单核苷酸多态性与肝癌易感性关系的研究[J].福建医科大学学报,2016,50(2):88-92.
[10]胡洪波,唐超莉,李永标,等.XPD基因多态性与广西壮族人群肝癌家族聚集性的关系[J].山东医药,2016,56(13):33-35.
[11]Schetter AJ,Harris CC.Alterations of microRNAs contribute to colon carcinogenesis[J].Semin Oncol,2011,38(6):734-742.
[12]张路遥,黄辉星,曹立环,等.CDCA8和INCENP mR-NA在肝细胞癌组织中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(2):158-167.
[13]Yue AM,Xie ZB,Guo SP,et al.Implication of Polymorphisms in DNA Repair Genes in Prognosis of Hepatocellular Carcinoma[J].Asian Pac J Cancer Prev,2013,14(1):355-358.
[14]Guan Q,Chen Z,Chen Q,et al.XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients[J].Oncol Lett,2017,14(3):2783-2788.
[15]Zheng JF,Li LL,Lu J,et al.XPD Functions as a Tumor Suppressor and Dysregulates Autophagy in Cultured Hep G2 Cells[J].Med Sci Monit,2015,21:1562-1568.
[16]Lye MS,Visuvanathan S,Chong PP,et al.Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population[J].PLo S One,2015,10(6):e0130530.
[17]张清秀,姚云清,李始亮,等.白细胞介素18基因多态性与HBV所致肝细胞肝癌的相关性[J].中华肝脏病杂志,2016,24(5):352-357.
[18]周争光,汪蕊,李玉梅,等.mir-130a-3p及smad 4在肝细胞癌组织中的表达及临床意义[J].安徽医科大学学报,2017,52(3):383-387.
[19]Dasdemir S,Guven M,Pekkoc KC,et al.DNA repair gene XPD Asp312Asn and XRCC4 G-1394T polymorphisms and the risk of autism spectrum disorder[J].Cell mol Biol(Noisy-le-grand),2016,62(3):46-50.
[20]Yang QI,Wei YF,Zhang Y,et al.XPD Lys751Gln and Asp312Asn polymorphisms and hepatocellular carcinoma susceptibility:A meta-analysis of 11 case-control studies in an Asian population[J].Exp Ther Med,2015,9(6):2406-2414.
[21]陈宏伟,李宗锋,张红娟,等.Nemo样激酶蛋白在原发性肝细胞癌中的表达及意义[J].实用医学杂志,2016,32(19):3204-3208.
[22]Huang L,Mo Z,Lao X,et al.PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population[J].Tumor Biol,2016,37(5):6599-6606.
[23]盛若凡,曾蒙苏,陈伶俐,等.不同程度肝纤维化背景下小肝癌的磁共振表现比较分析[J].临床放射学杂志,2016,35(3):369-373.
[24]邓雪松,潘红艳,成俊,等.上调miR-449a表达对肝癌细胞生长和侵袭能力的影响[J].中国普通外科杂志,2018,27(1):68-74.
[25]滕雪,关尚为,刘朦朦,等.晚期非小细胞肺癌患者XPD基因多态性与铂类药物化疗临床疗效相关性的Meta分析[J].中国药房,2016,27(24):3380-3384.
[26]Ravegnini G,Nannini M,Simeon V,et al.Polymorphisms in DNA repair genes in gastrointestinal stromal tumours:susceptibility and correlation with tumour characteristics and clinical outcome[J].Tumour Biol,2016,37(10):13413-13423.
[27]Wang XC,Wang F,Quan QQ.Roles of XRCC1/XPD/ERCC1 Polymorphisms in Predicting Prognosis of Hepatocellular Carcinoma in Patients Receiving Transcatheter Arterial Chemoembolization[J].Genet Test Mol Biomarkers,2016,20(4):176-184.
[28]黄国林,滕翠芳,罗燕妹,等.肝细胞肝癌患者癌组织中Ras相关C3肉毒素底物转化生长因子β1表达变化及其意义[J].山东医药,2018,58(15):58-60.
[29]王凇,郝艳红,杨薇,等.肝癌射频消融后肝脓肿的发生率及危险因素分析[J].中国介入影像与治疗学,2018,15(1):37-41.
[30]褚亚,周石,王黎洲,等.磷脂酶Cβ1上调表达与肝细胞肝癌增殖和预后相关[J].介入放射学杂志,2018,27(1):29-34.
[31]张崇辉,陈莉.肝细胞肝癌间质微环境与TLR3表达的相关性及其对预后的影响[J].肿瘤防治研究,2017,44(4):262-267.
[32]Wang B,Yeh CB,Lein MY,et al.Effects of HMGB1Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma[J].Int J Med Sci,2016,13(4):304-309.
[33]B■nescu C,Iancu M,Trifa AP,et al.Influence of XPC,XPD,XPF,and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population[J].Tumour Biol,2016,37(7):9357-9366.
[34]Zhang L,Xu K,Liu C,et al.Meta-analysis reveals an association between signal transducer and activator of transcription-4 polymorphism and hepatocellular carcinoma risk[J].Hepatol Res,2017,47(4):303-311.
[35]Wang B,Hsu CJ,Lee HL,et al.Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma[J].Int J Med Sci,2018,15(6):653-658.
[36]Huang W,Zhang H,Hao Y,et al.A Non-Synonymous Single Nucleotide Polymorphism in the HJURP Gene Associated with Susceptibility to Hepatocellular Carcinoma among Chinese[J].Plos One,2016,11(2):e0148618.