凝血酶原时间测定和活化部分凝血活酶时间测定的应用意义
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摘要
目的研究分析凝血酶原时间(PT)测定以及活化部分凝血活酶时间(APTT)测定在临床中的应用价值。方法择取109例各种疾病患者,并择取同时段到我院进行体检的62名健康人员,共同作为研究对象。观察血液凝血酶原、部分凝血活酶情况,并进行评价与对比分析。结果经过全自动血凝仪检测之后,就凝血酶原时间情况而言,其中血液病延长所占比重最高,由高到低排序为血液病、肝癌、脑出血、弥散性血管内凝血、急慢性感染等。就活化部分凝血活酶时间情况而言,其中脑出血、弥散性血管内凝血所占比重最高,由高到低排序为血液病、其他肝病、高血压以及肝癌等。结论在临床中,对于血液病、肝癌、脑出血、肝病、弥散性血管内凝血等疾病而言,选择对凝血酶原时间以及活化部分凝血活酶时间进行测定的价值理想,敏感性较高。
Objective To study the application of prothrombin time(PT) and activated partial thromboplastin time(APTT) in clinical application. Methods 110 patients with various diseases were selected, and 62 healthy people who were admitted to our hospital for physical examination at the same time were selected as the research object. Blood prothrombin and partial thromboplastin were observed and evaluated and compared. Results After the automatic blood coagulation test, in terms of prothrombin time, the proportion of prolonged blood diseases was the highest, and the order from high to low was blood disease, liver cancer, cerebral hemorrhage, disseminated intravascular coagulation, and urgency. Chronic infections, etc. In terms of the time of activation of partial thromboplastin, cerebral hemorrhage and disseminated intravascular coagulation accounted for the highest proportion, ranking from high to low into blood diseases, other liver diseases, hypertension, and liver cancer. Conclusion In clinical practice, for blood diseases, liver cancer, cerebral hemorrhage, liver disease, disseminated intravascular coagulation and other diseases, the value of measuring prothrombin time and activated partial thromboplastin time is ideal, and the sensitivity is high.
Objective To study the application of prothrombin time(PT) and activated partial thromboplastin time(APTT) in clinical application. Methods 110 patients with various diseases were selected, and 62 healthy people who were admitted to our hospital for physical examination at the same time were selected as the research object. Blood prothrombin and partial thromboplastin were observed and evaluated and compared. Results After the automatic blood coagulation test, in terms of prothrombin time, the proportion of prolonged blood diseases was the highest, and the order from high to low was blood disease, liver cancer, cerebral hemorrhage, disseminated intravascular coagulation, and urgency. Chronic infections, etc. In terms of the time of activation of partial thromboplastin, cerebral hemorrhage and disseminated intravascular coagulation accounted for the highest proportion, ranking from high to low into blood diseases, other liver diseases, hypertension, and liver cancer. Conclusion In clinical practice, for blood diseases, liver cancer, cerebral hemorrhage, liver disease, disseminated intravascular coagulation and other diseases, the value of measuring prothrombin time and activated partial thromboplastin time is ideal, and the sensitivity is high.
引文
[1]梁文彬,王明丽,温林锋.贫血对凝血酶原时间和活化部分凝血活酶时间检测结果的影响研究[J].国际检验医学杂志,2017,38(5):674-675.
[2]商树坤.临产孕妇凝血四项指标的临床检测分析及意义[J].中国继续医学教育,2016,8(10):23-24.
[3]彭传梅,高辉,王杨.稀释回归法在脂血标本凝血检测中的应用探讨[J].国际检验医学杂志,2016,37(4):494-495.
[4]张锋,李晓丹,胡艳君.凝血、抗凝和纤溶实验室指标在子痫前期中的应用[J].中国妇幼保健,2016,31(6):1160-1163.
[5]刘爱胜,林丽云,刘小君.凝血标本离心不全对凝血酶时间测定的影响因素研究[J].医疗卫生装备,2017,38(2):101-103.
[6]林彬.滤白冷沉淀在改善肿瘤患者凝血功能异常中的应用价值[J].中国药物经济学,2016,11(12):124-126.
[7]叶智良,邝绍钧,杨晓明.妊娠高血压疾病妇女D-二聚体及凝血指标检测的临床意义[J].医学综述,2016,22(11):2215-2217.
[8]叶智宾,陈章强.疏血通注射液治疗急性下肢深静脉血栓的疗效及对血小板活化因子的影响[J].赣南医学院学报,2016,36(3):414-416.
[9]李娟.肝硬化患者凝血四项指标检查结果及临床意义[J].临床医学研究与实践,2016,1(3):18.
[10]钟宏文,刘江梅,朱丽康.2型糖尿病血小板参数、凝血功能及血液流变学相关性研究[J].实验与检验医学,2016,34(3):354-357.
[11]刘根斌,陈端英,何孙本.评价温度和时间对血凝四项PT、FIB、APTT和TT结果的影响研究[J].现代预防医学,2016,43(5):887-890.
[12]宋予娟,祝传贵,耿岚.血凝四项与D-二聚体联合检测对临产孕妇的临床意义[J].中国实用医药,2016,11(27):44-45.
[13]成厚丕,兰军.原发性肝癌介入治疗前后患者凝血、纤溶功能和血小板变化的临床意义[J].血栓与止血学,2017,23(4):656-658.
[14]徐兰娟,李保林,沈景桂.血管内降温对重度颅脑损伤早期凝血功能的影响[J].中国实用神经疾病杂志,2017,20(11):55-57.
[15]司丽,程喜富.降纤酶在脑梗死急性期治疗过程中对活化部分凝血活酶时间、血浆凝血酶原时间及血液流变学的影响[J].中国实用医药,2016,11(15):138-139.
[16]于广名.不同凝血分析仪检测系统测定凝血指标的差异性分析[J].中国现代药物应用,2017,11(20):193-194.
[2]商树坤.临产孕妇凝血四项指标的临床检测分析及意义[J].中国继续医学教育,2016,8(10):23-24.
[3]彭传梅,高辉,王杨.稀释回归法在脂血标本凝血检测中的应用探讨[J].国际检验医学杂志,2016,37(4):494-495.
[4]张锋,李晓丹,胡艳君.凝血、抗凝和纤溶实验室指标在子痫前期中的应用[J].中国妇幼保健,2016,31(6):1160-1163.
[5]刘爱胜,林丽云,刘小君.凝血标本离心不全对凝血酶时间测定的影响因素研究[J].医疗卫生装备,2017,38(2):101-103.
[6]林彬.滤白冷沉淀在改善肿瘤患者凝血功能异常中的应用价值[J].中国药物经济学,2016,11(12):124-126.
[7]叶智良,邝绍钧,杨晓明.妊娠高血压疾病妇女D-二聚体及凝血指标检测的临床意义[J].医学综述,2016,22(11):2215-2217.
[8]叶智宾,陈章强.疏血通注射液治疗急性下肢深静脉血栓的疗效及对血小板活化因子的影响[J].赣南医学院学报,2016,36(3):414-416.
[9]李娟.肝硬化患者凝血四项指标检查结果及临床意义[J].临床医学研究与实践,2016,1(3):18.
[10]钟宏文,刘江梅,朱丽康.2型糖尿病血小板参数、凝血功能及血液流变学相关性研究[J].实验与检验医学,2016,34(3):354-357.
[11]刘根斌,陈端英,何孙本.评价温度和时间对血凝四项PT、FIB、APTT和TT结果的影响研究[J].现代预防医学,2016,43(5):887-890.
[12]宋予娟,祝传贵,耿岚.血凝四项与D-二聚体联合检测对临产孕妇的临床意义[J].中国实用医药,2016,11(27):44-45.
[13]成厚丕,兰军.原发性肝癌介入治疗前后患者凝血、纤溶功能和血小板变化的临床意义[J].血栓与止血学,2017,23(4):656-658.
[14]徐兰娟,李保林,沈景桂.血管内降温对重度颅脑损伤早期凝血功能的影响[J].中国实用神经疾病杂志,2017,20(11):55-57.
[15]司丽,程喜富.降纤酶在脑梗死急性期治疗过程中对活化部分凝血活酶时间、血浆凝血酶原时间及血液流变学的影响[J].中国实用医药,2016,11(15):138-139.
[16]于广名.不同凝血分析仪检测系统测定凝血指标的差异性分析[J].中国现代药物应用,2017,11(20):193-194.