神经内分泌变化与冠心病合并焦虑症的关系
|
摘要
目的研究神经内分泌变化与冠心病(CHD)合并焦虑症的关系。方法选择从2014年7月-2017年3月在石家庄市第一医院接受诊治的CHD合并焦虑症患者86例记为A组,CHD无焦虑症患者94例记为B组,检测并对比两组临床资料,两组神经内分泌有关指标(去甲肾上腺素NE和血浆神经肽NPY),以及两组心率变异性指标(SDNN、SDANN、r MSSD和PNN50)。结果 A组的NE和NPY水平分别为(921.38±18.63)pg/ml、(158.24±21.36)pg/ml,均明显高于B组的(594.35±16.88)pg/ml、(112.32±16.37)pg/ml,差异均有统计学意义(t=123.560、16.267,均P<0.05)。A组的SDNN、SDANN、r MSSD和PNN50水平均明显低于B组,差异均有统计学意义(均P<0.05)。结论神经内分泌变化与CHD合并焦虑症之间具有紧密联系,具体表现在患者的NE和NPY水平明显上升,且HRV的异常程度更高,临床可监测相关指标的变化情况,从而辅助诊治。
引文
[1]肖珉,常佩芬,赵勇,等.郭维琴教授治疗心血管疾病合并焦虑症的临床经验[J].现代中医临床,2016,23(1):17-20.
[2]于庆云.心理护理在冠心病合并焦虑症患者中的应用[J].中国实用医药,2015,10(2):208-209.
[3]齐艳鹏,李殿芳,王玉柱,等.冠心病介入患者焦虑抑郁状况调查及其预后的相关性研究[J].中西医结合心血管病电子杂志,2015,3(8):189-190.
[4]Golimbet VE,Volel BA,Korovaitseva GI,et al.Association of inflammatory genes with neuroticism,anxiety and depression in male patients with coronary heart disease[J].Zh Nevrol Psikhiatr Im S S Korsakova,2017,117(1):74-79.
[5]任世福.氟西汀与罗布麻治疗冠心病合并焦虑症的临床效果探究[J].心理医生,2017,23(1):64-65.
[6]方晓江,钱宝庆,赵芊,等.中西医结合治疗冠心病合并焦虑症临床疗效及不良反应观察[J].中华中医药学刊,2014,32(9):2299-2301.
[7]刘燕,徐良雄,罗菊英.电话加短信随访对冠心病患者生活质量的影响[J].实用预防医学,2016,23(7):797-800.
[8]徐立彦.冠心病不稳定型心绞痛合并焦虑症患者综合治疗34例观察[J].医药前沿,2013,6(2):105-106.
[9]Lutfi MF.Anxiety level and cardiac autonomic modulations in coronary artery disease and cardiac syndrome X patients[J].PLo S One,2017,12(1):170086-170087.
[10]李庆民,刘兴德.冠心病并抑郁患者血浆NPY、NE、DA、5-HT的变化及其临床意义[J].中国现代医生,2008,46(1):47-48.
[11]郑桂杰.氟西汀与罗布麻治疗冠心病合并焦虑症的疗效观察[J].临床医药文献电子杂志,2016,3(14):2868-2869.
[12]Nasilowska-Barud A,Zapolski T,Barud M,et al.Overt and covert anxiety as a toxic factor in ischemic heart disease in women:the link between psychological factors and heart disease[J].Med Sci Monit,2017,10(23):751-758.
[13]杨继敏,苏亚玲.稳定型冠心病患者血清生化指标与焦虑抑郁状态的相关性研究[J].中国基层医药,2016,23(24):3781-3785.
[14]Farahani MA,Ghaffari F,Norouzinezhad F,et al.The effect of utilizing organizational culture improvement model of patient education on coronary artery bypass graft patients'anxiety and satisfaction:theory testing[J].Electr Physic,2016,8(11):3272-3278.
[15]赵海梅,徐春凤,谭翌,等.焦虑对老年冠心病患者心率变异的影响及意义[J].中国慢性病预防与控制,2014,22(1):99-100.
[16]Prugger C,Wellmann J,Heidrich J,et al.Regular exercise behaviour and intention and symptoms of anxiety and depression in coronary heart disease patients across Europe:results from the EUROASPIRE III survey[J].Eur J Prev Cardiol,2017,24(1):84-91.
[2]于庆云.心理护理在冠心病合并焦虑症患者中的应用[J].中国实用医药,2015,10(2):208-209.
[3]齐艳鹏,李殿芳,王玉柱,等.冠心病介入患者焦虑抑郁状况调查及其预后的相关性研究[J].中西医结合心血管病电子杂志,2015,3(8):189-190.
[4]Golimbet VE,Volel BA,Korovaitseva GI,et al.Association of inflammatory genes with neuroticism,anxiety and depression in male patients with coronary heart disease[J].Zh Nevrol Psikhiatr Im S S Korsakova,2017,117(1):74-79.
[5]任世福.氟西汀与罗布麻治疗冠心病合并焦虑症的临床效果探究[J].心理医生,2017,23(1):64-65.
[6]方晓江,钱宝庆,赵芊,等.中西医结合治疗冠心病合并焦虑症临床疗效及不良反应观察[J].中华中医药学刊,2014,32(9):2299-2301.
[7]刘燕,徐良雄,罗菊英.电话加短信随访对冠心病患者生活质量的影响[J].实用预防医学,2016,23(7):797-800.
[8]徐立彦.冠心病不稳定型心绞痛合并焦虑症患者综合治疗34例观察[J].医药前沿,2013,6(2):105-106.
[9]Lutfi MF.Anxiety level and cardiac autonomic modulations in coronary artery disease and cardiac syndrome X patients[J].PLo S One,2017,12(1):170086-170087.
[10]李庆民,刘兴德.冠心病并抑郁患者血浆NPY、NE、DA、5-HT的变化及其临床意义[J].中国现代医生,2008,46(1):47-48.
[11]郑桂杰.氟西汀与罗布麻治疗冠心病合并焦虑症的疗效观察[J].临床医药文献电子杂志,2016,3(14):2868-2869.
[12]Nasilowska-Barud A,Zapolski T,Barud M,et al.Overt and covert anxiety as a toxic factor in ischemic heart disease in women:the link between psychological factors and heart disease[J].Med Sci Monit,2017,10(23):751-758.
[13]杨继敏,苏亚玲.稳定型冠心病患者血清生化指标与焦虑抑郁状态的相关性研究[J].中国基层医药,2016,23(24):3781-3785.
[14]Farahani MA,Ghaffari F,Norouzinezhad F,et al.The effect of utilizing organizational culture improvement model of patient education on coronary artery bypass graft patients'anxiety and satisfaction:theory testing[J].Electr Physic,2016,8(11):3272-3278.
[15]赵海梅,徐春凤,谭翌,等.焦虑对老年冠心病患者心率变异的影响及意义[J].中国慢性病预防与控制,2014,22(1):99-100.
[16]Prugger C,Wellmann J,Heidrich J,et al.Regular exercise behaviour and intention and symptoms of anxiety and depression in coronary heart disease patients across Europe:results from the EUROASPIRE III survey[J].Eur J Prev Cardiol,2017,24(1):84-91.