红景天治疗慢性心肌梗死合并心力衰竭患者的临床效果
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摘要
目的探讨红景天治疗慢性心肌梗死合并心力衰竭的临床疗效及对左心室重构、血清炎症介质水平的影响。方法选取2018年1月至2019年1月解放军联勤保障部队第968医院收治的46例慢性心肌梗死合并心力衰竭患者作为研究对象,采用掷硬币法分为对照组与研究组,每组23例。对照组采用常规方法进行治疗,研究组患者在对照组治疗基础上采用红景天治疗,比较两组患者的治疗效果。结果治疗前两组患者左心室重构指标与血清炎症介质水平比较差异均无统计学意义(均P>0.05);治疗后两组患者左心室重构指标与血清炎症介质水平均优于治疗前(均P<0.05),且研究组患者左心室重构指标与血清炎症介质水平均优于对照组(均P<0.05)。结论红景天治疗慢性心肌梗死合并心力衰竭临床效果显著,可有效抑制患者左心室重构,减轻炎症反应。
Objective To explore the clinical efficacy of Radix et Rhizoma Rhodiolae Crenulatae on chronic myocardial infarction complicated with heart failure and its influence on left ventricular remodeling and serum inflammatory mediator level.Methods From January 2018 to January 2019, 46 patients with chronic myocardial infarction complicated with heart failure in the No. 968 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army(PLA) were selected as the study subjects. They were divided into control group and study group by coin tossing method, with 23 cases in each group. The control group was treated with routine methods, while the study group was treated with Radix et Rhizoma Rhodiolae Crenulatae on the treatment basis of the control group. The therapeutic effects of the 2 groups were compared. Results Before the treatment, there was no significant difference in the left ventricular remodeling index and the serum inflammatory mediator level between the 2 groups(P>0.05); after the treatment, there were better left ventricular remodeling index and serum inflammatory mediator level in both groups than those before the treatment(P<0.05), and there were better left ventricular remodeling index and serum inflammatory mediator level in the study group than those in the control group(P<0.05). Conclusion Radix et Rhizoma Rhodiolae Crenulatae has remarkable clinical efficacy in treating chronic myocardial infarction complicated with myocardial failure.It can effectively inhibit patients' left ventricular remodeling and alleviate inflammation.
Objective To explore the clinical efficacy of Radix et Rhizoma Rhodiolae Crenulatae on chronic myocardial infarction complicated with heart failure and its influence on left ventricular remodeling and serum inflammatory mediator level.Methods From January 2018 to January 2019, 46 patients with chronic myocardial infarction complicated with heart failure in the No. 968 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army(PLA) were selected as the study subjects. They were divided into control group and study group by coin tossing method, with 23 cases in each group. The control group was treated with routine methods, while the study group was treated with Radix et Rhizoma Rhodiolae Crenulatae on the treatment basis of the control group. The therapeutic effects of the 2 groups were compared. Results Before the treatment, there was no significant difference in the left ventricular remodeling index and the serum inflammatory mediator level between the 2 groups(P>0.05); after the treatment, there were better left ventricular remodeling index and serum inflammatory mediator level in both groups than those before the treatment(P<0.05), and there were better left ventricular remodeling index and serum inflammatory mediator level in the study group than those in the control group(P<0.05). Conclusion Radix et Rhizoma Rhodiolae Crenulatae has remarkable clinical efficacy in treating chronic myocardial infarction complicated with myocardial failure.It can effectively inhibit patients' left ventricular remodeling and alleviate inflammation.
引文
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[6]刘丹,徐敏,李杰,等.经皮冠脉介入手术时机对急性心肌梗死后左室重构及心功能的影响[J].中国老年学杂志, 2016, 36(16):3942-3943, 3944.
[7]于清.中西医结合治疗心肌梗死后慢性心力衰竭伴频发室性期前收缩的临床疗效观察[J].中医临床研究, 2017, 9(1):111-112.
[8]陈慧杰.急诊PCI治疗对急性心肌梗死患者血清炎症因子水平及心功能的影响[J].临床医学, 2017, 37(10):78-80.
[9]黄伟胜,杜颜利,张贤元,等. NT-pro-BNP联合CRP检测在老年心肌梗死伴慢性心力衰竭患者中的诊断价值[J].海南医学院学报, 2015, 21(4):467-469.
[10]肖阳,张艳,孙铭鸿.中医药治疗不稳定型心绞痛研究进展[J].辽宁中医药大学学报, 2017, 19(2):222-224.
[11]冯小智,刁杰,方婷,等.中医辨证治疗对行介入疗法的急性心肌梗死患者心肌再灌注和心功能的改善作用[J].中华中医药学刊, 2018, 36(11):2760-2763.
[12]张明发,沈雅琴.红景天苷的血管药理作用研究进展[J].药物评价研究, 2017, 40(5):717-724.
[13]沈洁,钱海燕,周小健,等.红景天治疗慢性心肌梗死伴心力衰竭对左室重构及血清炎症因子水平的影响[J].海南医学院学报, 2017, 23(2):266-269.
[14]廖占林,刘鹏程,张蕾,等.红景天苷对高糖损伤人脐静脉内皮细胞的保护作用研究[J].疑难病杂志, 2018, 17(5):494-497, 502.
[2]李新伟.急性心肌梗死并发首次心力衰竭患者在院死亡率及临床预后分析[J].临床医药文献电子杂志, 2017, 4(62):12158.
[3]张普.大株红景天注射液对冠心病心肌梗死患者血清胱抑素C、髓过氧化物酶活性的影响及其疗效[J].中国老年学杂志, 2013,33(24):6258-6259.
[4]中华医学会心血管病学分会,中华心血管病杂志编辑委员会,《中国循环杂志》编辑委员会.急性心肌梗死诊断和治疗指南[J].中华心血管病杂志, 2001, 29(12):710-725.
[5]中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南(2014)[J].中华心血管病杂志, 2014,42(2):98-122.
[6]刘丹,徐敏,李杰,等.经皮冠脉介入手术时机对急性心肌梗死后左室重构及心功能的影响[J].中国老年学杂志, 2016, 36(16):3942-3943, 3944.
[7]于清.中西医结合治疗心肌梗死后慢性心力衰竭伴频发室性期前收缩的临床疗效观察[J].中医临床研究, 2017, 9(1):111-112.
[8]陈慧杰.急诊PCI治疗对急性心肌梗死患者血清炎症因子水平及心功能的影响[J].临床医学, 2017, 37(10):78-80.
[9]黄伟胜,杜颜利,张贤元,等. NT-pro-BNP联合CRP检测在老年心肌梗死伴慢性心力衰竭患者中的诊断价值[J].海南医学院学报, 2015, 21(4):467-469.
[10]肖阳,张艳,孙铭鸿.中医药治疗不稳定型心绞痛研究进展[J].辽宁中医药大学学报, 2017, 19(2):222-224.
[11]冯小智,刁杰,方婷,等.中医辨证治疗对行介入疗法的急性心肌梗死患者心肌再灌注和心功能的改善作用[J].中华中医药学刊, 2018, 36(11):2760-2763.
[12]张明发,沈雅琴.红景天苷的血管药理作用研究进展[J].药物评价研究, 2017, 40(5):717-724.
[13]沈洁,钱海燕,周小健,等.红景天治疗慢性心肌梗死伴心力衰竭对左室重构及血清炎症因子水平的影响[J].海南医学院学报, 2017, 23(2):266-269.
[14]廖占林,刘鹏程,张蕾,等.红景天苷对高糖损伤人脐静脉内皮细胞的保护作用研究[J].疑难病杂志, 2018, 17(5):494-497, 502.