空间环境及模拟微重力对肠道沙门菌影响的研究进展
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摘要
空间环境中微重力等因素可以诱导肠道沙门菌在生长、抵抗力、毒力、遗传特性等方面发生重大变化。本文就空间环境及模拟微重力对肠道沙门菌生物学效应的影响及其相关机制进行综述,以期为太空飞行中感染性疾病的预防和治疗提供新的策略。
Space environment and simulated microgravity may lead to significant changes in growth, stress responses, virulence and genetic characteristic of Salmonella enterica. This article reviews the effects of space environment and simulated microgravity on Salmonella enteria's biological behavior and relative mechanism to provide a new strategy on the preventing and treating infectious disease in space flight.
Space environment and simulated microgravity may lead to significant changes in growth, stress responses, virulence and genetic characteristic of Salmonella enterica. This article reviews the effects of space environment and simulated microgravity on Salmonella enteria's biological behavior and relative mechanism to provide a new strategy on the preventing and treating infectious disease in space flight.
引文
1 Horneck G,Klaus DM,Mancinelli RL.Space microbiology[J].Microbiol Mol Biol Rev,2010,74(1):121-156.
2 Kim W,Tengra FK,Shong J,et al.Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability[J].BMC Microbiol,2013,13:241.
3 Benoit MR,Klaus DM.Microgravity,bacteria,and the influence of motility[J].Adv Space Res,2007,39(7):1225-1232.
4 Rosado H,Doyle M,Hinds J,et al.Low-shear modelled microgravity alters expression of virulence determinants of Staphylococcus aureus[J].Acta Astronautica,2010,66(3):408-413.
5 刘长庭.基于空间微生物变异规律探索重要感染疾病防控新策略研究[J].解放军医学院学报,2014,35(10):981-983,1003.
6 Putcha L,Taylor PW,Boyd JL.Biopharmaceutical challenges of therapeutics in space:formulation and packaging considerations[J].Ther Deliv,2011,2(11):1373-1376.
7 刘长庭.利用空间环境服务于人类健康[J].解放军医学院学报,2013,34(1):1-2.
8 Rychlik I,Barrow PA.Salmonella stress management and its relevance to behaviour during intestinal colonisation and infection[J].FEMS Microbiol Rev,2005,29(5):1021-1040.
9 Adkins JN,Mottaz HM,Norbeck AD,et al.Analysis of the Salmonella typhimurium proteome through environmental response toward infectious conditions[J].Mol Cell Proteomics,2006,5(8):1450-1461.
10 Rosenzweig JA,Chopra AK.The effect of low shear force on the virulence potential of Yersinia pestis:new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen[J].Front Cell Infect Microbiol,2012,2:107.
11 Hammond TG,Stodieck L,Birdsall HH,et al.Effects of microgravity on the virulence of Listeria monocytogenes,Enterococcus faecalis,Candida albicans,and methicillin-resistant Staphylococcus aureus[J].Astrobiology,2013,13(11):1081-1090.
12 黄玉玲,杨建武,易勇,等.微重力及太空飞行对微生物影响的研究进展[J].北京生物医学工程,2014,33(1):84-88.
13 Taylor PW.Impact of space flight on bacterial virulence and antibiotic susceptibility[J].Infect Drug Resist,2015,8:249-262.
14 张燕玲,薛小平,谢琼.空间环境对微生物生理生化性状的影响及机理研究概述[J].航天医学与医学工程,2011,24(1):71-74.
15 Hammond TG,Hammond JM.Optimized suspension culture:the rotating-wall vessel[J].Am J Physiol Renal Physiol,2001,281(1):F12-F25.
16 Foster JS,Khodadad CL,Ahrendt SR,et al.Impact of simulated microgravity on the normal developmental time line of an animalbacteria symbiosis[J].Sci Rep,2013,3:1340.
17 Rosado H,O'Neill AJ,Blake KL,et al.Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus[J].Int J Astrobiology,2011,11(2):71-81.
18 Nickerson CA,Ott CM,Mister SJ,et al.Microgravity as a novel environmental signal affecting Salmonella enterica serovar Typhimurium virulence[J].Infect Immun,2000,68(6):3147-3152.
19 Wilson JW,Ott CM,Ramamurthy R,et al.Low-Shear Modeled Microgravity Alters the Salmonella enterica Serovar Typhimurium Stress Response in an Rpo S-Independent Manner[J].Appl Environ Microbiol,2002,68(11):5408-5416.
20 Soni A,O’Sullivan L,Quick LN,et al.Conservation of the Lowshear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response[J].Open Microbiol J,2014,8(1):51-58.
21 Chopra V,Fadl AA,Sha J,et al.Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions[J].J Toxicol Environ Health Part A,2006,69(14):1345-1370.
22 Wilson JW,Ott CM,Quick L,et al.Media ion composition controls regulatory and virulence response of Salmonella in spaceflight[J].PLo S ONE,2008,3(12):e3923.
23 Wilson JW,Ramamurthy R,Porwollik S,et al.Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon[J].Proc Natl Acad Sci USA,2002,99(21):13807-13812.
24 Wilson JW,Ott CM,H?ner zu Bentrup K,et al.Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq[J].Proc Natl Acad Sci USA,2007,104(41):16299-16304.
25 Figueroa-Bossi N,Lemire S,Maloriol D,et al.Loss of Hfq activates the sigma E-dependent envelope stress response in Salmonella enterica[J].Mol Microbiol,2006,62(3):838-852.
26 Sittka A,Pfeiffer V,Tedin K,et al.The RNA chaperone Hfq is essential for the virulence of Salmonella typhimurium[J].Mol Microbiol,2007,63(1):193-217.
27 徐绸,何平,刘长庭.空间环境对肠道菌群的影响[J].航天医学与医学工程,2016,29(4):297-300.
28 Nickerson CA,Ott CM,Wilson JW,et al.Microbial responses to microgravity and other low-shear environments[J].Microbiol Mol Biol Rev,2004,68(2):345-361.
29 Rosenzweig JA,Abogunde O,Thomas K,et al.Spaceflight and modeled microgravity effects on microbial growth and virulence[J].Appl Microbiol Biotechnol,2010,85(4):885-891.
2 Kim W,Tengra FK,Shong J,et al.Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability[J].BMC Microbiol,2013,13:241.
3 Benoit MR,Klaus DM.Microgravity,bacteria,and the influence of motility[J].Adv Space Res,2007,39(7):1225-1232.
4 Rosado H,Doyle M,Hinds J,et al.Low-shear modelled microgravity alters expression of virulence determinants of Staphylococcus aureus[J].Acta Astronautica,2010,66(3):408-413.
5 刘长庭.基于空间微生物变异规律探索重要感染疾病防控新策略研究[J].解放军医学院学报,2014,35(10):981-983,1003.
6 Putcha L,Taylor PW,Boyd JL.Biopharmaceutical challenges of therapeutics in space:formulation and packaging considerations[J].Ther Deliv,2011,2(11):1373-1376.
7 刘长庭.利用空间环境服务于人类健康[J].解放军医学院学报,2013,34(1):1-2.
8 Rychlik I,Barrow PA.Salmonella stress management and its relevance to behaviour during intestinal colonisation and infection[J].FEMS Microbiol Rev,2005,29(5):1021-1040.
9 Adkins JN,Mottaz HM,Norbeck AD,et al.Analysis of the Salmonella typhimurium proteome through environmental response toward infectious conditions[J].Mol Cell Proteomics,2006,5(8):1450-1461.
10 Rosenzweig JA,Chopra AK.The effect of low shear force on the virulence potential of Yersinia pestis:new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen[J].Front Cell Infect Microbiol,2012,2:107.
11 Hammond TG,Stodieck L,Birdsall HH,et al.Effects of microgravity on the virulence of Listeria monocytogenes,Enterococcus faecalis,Candida albicans,and methicillin-resistant Staphylococcus aureus[J].Astrobiology,2013,13(11):1081-1090.
12 黄玉玲,杨建武,易勇,等.微重力及太空飞行对微生物影响的研究进展[J].北京生物医学工程,2014,33(1):84-88.
13 Taylor PW.Impact of space flight on bacterial virulence and antibiotic susceptibility[J].Infect Drug Resist,2015,8:249-262.
14 张燕玲,薛小平,谢琼.空间环境对微生物生理生化性状的影响及机理研究概述[J].航天医学与医学工程,2011,24(1):71-74.
15 Hammond TG,Hammond JM.Optimized suspension culture:the rotating-wall vessel[J].Am J Physiol Renal Physiol,2001,281(1):F12-F25.
16 Foster JS,Khodadad CL,Ahrendt SR,et al.Impact of simulated microgravity on the normal developmental time line of an animalbacteria symbiosis[J].Sci Rep,2013,3:1340.
17 Rosado H,O'Neill AJ,Blake KL,et al.Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus[J].Int J Astrobiology,2011,11(2):71-81.
18 Nickerson CA,Ott CM,Mister SJ,et al.Microgravity as a novel environmental signal affecting Salmonella enterica serovar Typhimurium virulence[J].Infect Immun,2000,68(6):3147-3152.
19 Wilson JW,Ott CM,Ramamurthy R,et al.Low-Shear Modeled Microgravity Alters the Salmonella enterica Serovar Typhimurium Stress Response in an Rpo S-Independent Manner[J].Appl Environ Microbiol,2002,68(11):5408-5416.
20 Soni A,O’Sullivan L,Quick LN,et al.Conservation of the Lowshear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response[J].Open Microbiol J,2014,8(1):51-58.
21 Chopra V,Fadl AA,Sha J,et al.Alterations in the virulence potential of enteric pathogens and bacterial-host cell interactions under simulated microgravity conditions[J].J Toxicol Environ Health Part A,2006,69(14):1345-1370.
22 Wilson JW,Ott CM,Quick L,et al.Media ion composition controls regulatory and virulence response of Salmonella in spaceflight[J].PLo S ONE,2008,3(12):e3923.
23 Wilson JW,Ramamurthy R,Porwollik S,et al.Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon[J].Proc Natl Acad Sci USA,2002,99(21):13807-13812.
24 Wilson JW,Ott CM,H?ner zu Bentrup K,et al.Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq[J].Proc Natl Acad Sci USA,2007,104(41):16299-16304.
25 Figueroa-Bossi N,Lemire S,Maloriol D,et al.Loss of Hfq activates the sigma E-dependent envelope stress response in Salmonella enterica[J].Mol Microbiol,2006,62(3):838-852.
26 Sittka A,Pfeiffer V,Tedin K,et al.The RNA chaperone Hfq is essential for the virulence of Salmonella typhimurium[J].Mol Microbiol,2007,63(1):193-217.
27 徐绸,何平,刘长庭.空间环境对肠道菌群的影响[J].航天医学与医学工程,2016,29(4):297-300.
28 Nickerson CA,Ott CM,Wilson JW,et al.Microbial responses to microgravity and other low-shear environments[J].Microbiol Mol Biol Rev,2004,68(2):345-361.
29 Rosenzweig JA,Abogunde O,Thomas K,et al.Spaceflight and modeled microgravity effects on microbial growth and virulence[J].Appl Microbiol Biotechnol,2010,85(4):885-891.