中医药治疗脊髓型颈椎病的机理研究概况
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摘要
文章总结近10年的脊髓型颈椎病的中医药治疗研究文献,发现中药可以促进血液循环、消除炎性反应、清除自由基、减少内皮素(Endo Thelin,ET)、减少神经细胞坏死与凋亡、提高神经营养因子含量,从而在脊髓型颈椎病的保守治疗及颈椎病的术后康复过程中发挥独特的优势。
This paper is to review the literature on Chinese herbal medicine treating cervical spondylotic myelopathy in recent 10 years.It is found that Chinese herbal medicine has superior advantages in conservative treatment and postoperative rehabilitation,as it may promote blood circulation,eliminate inflammation,clear away radical,improve neurotrophic factor content,inhibite the release of ET,reduce neurons necrosis and prevent neurons apoptosis.
This paper is to review the literature on Chinese herbal medicine treating cervical spondylotic myelopathy in recent 10 years.It is found that Chinese herbal medicine has superior advantages in conservative treatment and postoperative rehabilitation,as it may promote blood circulation,eliminate inflammation,clear away radical,improve neurotrophic factor content,inhibite the release of ET,reduce neurons necrosis and prevent neurons apoptosis.
引文
[1]吴佳润,赵斌霞.颈椎病易发群体发病率与主要发病原因的研究[J].当代体育科技,2015,5(23):26-27.
[2]K.Gorter.Influence of laminectomy on the course of cervical myelopathy[J].Acta Neurochirurgica,1976,33(3-4):333.
[3]Vedantam A,Revanappa KK,Rajshekhar V.Changes in the range of motion of the cervical spine and adjacent segments at≥24 months after uninstrumented corpectomy for cervical spondylotic myelopathy.[J].Acta Neurochirurgica,2011,153(5):995-1001.
[4]Karadimas SK,Erwin WM,Ely CG,et al.Pathophysiology and natural history of cervical spondylotic myelopathy[J].Spine,2013,38(22S):S21-S36.
[5]Takahashi K,Ozawa H,Sakamoto N,et al.Influence of intramedullary stress on cervical spondylotic myelopathy[J].Spinal cord,2013,51(10):761-764.
[6]蓝鋆,姚敏,王晶,等.颈椎病不同中医证候分型的研究概况[J].中国中医骨伤科杂志,2015,23(4):67-70.
[7]Baptiste DC,Fehlings MG.pathophysiology of cervical myelopathy[J].Spine J,2006,6(6 Suppl):190S-197S.
[8]KalsiRyan S,Karadimas SK,Fehlings MG.Cervical spondylotic myelopathy:the clinical phenomenon and the current pathobiology of an increasingly prevalent and devastating disorder[J].Neuroscientist,2013,19(4):409-421.
[9]陈锋,施杞,韦贵康,等.脊髓型颈椎病脊髓微循环改变及中药效应观察[J].中医正骨,2004,16(10):3-4.
[10]葛鸿庆,林定坤,邓晋丰,等.补肾活血方对脊髓型颈椎病动物模型VEGF及其mRNA达的影响[J].新中医,2009,41(2):107-108.
[11]闫素敏.活血软坚方对兔颈脊髓慢性受压纤维化微血管血供的影响[D].西宁:广西中医药大学,2014.
[12]Yu WR,Liu T,Kiehl TR,Fehlings MG(2011)Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy[J].Brain 134:1277-1292.
[13]Baptiste DC,Fehlings MG.Pathophysiology of cervical myelopathy[J].Spine J,2006,6(6 Suppl):190S-197S.
[14]Karadimas SK,Moon ES,Yu WR,et al.A novel experimental model of cervical spondylotic myelopathy(CSM)to facilitate translational research[J].Neurobiol Dis,2013,5(4):43-58.
[15]周军,方素萍,霍海如,等.葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响[J].中国骨伤,2002,12:26-28.
[16]林石明,许书亮,李兆文,等.颈痛宁对颈椎间盘髓核炎症介质影响的实验研究[J].中医药学刊,2004,37(11):2043-2046,2054.
[17]刘新宇,刘春娜,张晓妍,等.参黄颈康片镇痛抗炎作用及对炎症因子影响研究[J].中成药,2011,33(7):1223-1225.
[18]张向阳,马玉玲,杨际平.颈椎病、腰椎间盘突出症与自由基损伤的探讨[J].颈腰痛杂志,1995,(4):202-203.
[19]都兴林,田伟,孔焕宇.丹参舒颈丸对抗脊髓型颈椎病模型大鼠氧自由基损伤[J].中国临床康复,2006,10(27):32-34.
[20]施立奇.丹参酮对兔上颈髓早期继发性损伤细胞凋亡的干预研究[D].武汉:湖北中医药大学,2014.
[21]王辉,吕志宇,陈锋.中医药治疗脊髓型颈椎病疗效机理研究概况[J].山西中医学院学报,2008,9(3):58-60.
[22]王羽丰.补肾活血方治疗脊髓型颈椎病疗效及与内皮素关系的研究[D].广州:广州中医药大学,2002.
[23]黄有荣,赵明明,张春松.芍药木瓜汤对脊髓受压实验兔血管内皮素与脊髓神经细胞凋亡的影响[J].中国中医骨伤科杂志,2010,18(4):1-4.
[24]Moussellard Hp,Meyer A,Biot D,et al.Early neurological recovery course after surgical treatment of cervical spondylotic myelopathy:a prospective study with 2-year follow-up using three different functional assessment tests[J].Eur Spine J,2014,23(7):1508-1514.
[25]徐远坤,陈久毅.中药健身丹对脊髓型颈椎病神经细胞凋亡相关基因表达影响的研究[J].贵州医药,2009,33(6):490.
[26]Buf fum M,Buf fum JC.No steroidal anti-infammatory drugs in the elderly[J].Pain Manag Nurs,2000,1(2):40.
[27]Ikeda O,Mu rakami M,Ino H,et al.Acute up-regulation of brainderived neurot rophic factor expression resultion f rom experiment ally indrced injury in the rat spinal cord[J].Acct a Neu ropathol2001,102(3):239.
[28]姬军风,朱艳,张智慧,等.醒髓汤对大鼠实验性脊髓损伤受损组织中NGF的影响[J].中医正骨,2006,18(5):11-12.
[29]周赟,胡建中,吕红斌,等.川芎嗪对脊髓急性损伤大鼠神经营养因子表达的影响[J].现代中西医结合杂志,2010,19(9):1058-1060.
[2]K.Gorter.Influence of laminectomy on the course of cervical myelopathy[J].Acta Neurochirurgica,1976,33(3-4):333.
[3]Vedantam A,Revanappa KK,Rajshekhar V.Changes in the range of motion of the cervical spine and adjacent segments at≥24 months after uninstrumented corpectomy for cervical spondylotic myelopathy.[J].Acta Neurochirurgica,2011,153(5):995-1001.
[4]Karadimas SK,Erwin WM,Ely CG,et al.Pathophysiology and natural history of cervical spondylotic myelopathy[J].Spine,2013,38(22S):S21-S36.
[5]Takahashi K,Ozawa H,Sakamoto N,et al.Influence of intramedullary stress on cervical spondylotic myelopathy[J].Spinal cord,2013,51(10):761-764.
[6]蓝鋆,姚敏,王晶,等.颈椎病不同中医证候分型的研究概况[J].中国中医骨伤科杂志,2015,23(4):67-70.
[7]Baptiste DC,Fehlings MG.pathophysiology of cervical myelopathy[J].Spine J,2006,6(6 Suppl):190S-197S.
[8]KalsiRyan S,Karadimas SK,Fehlings MG.Cervical spondylotic myelopathy:the clinical phenomenon and the current pathobiology of an increasingly prevalent and devastating disorder[J].Neuroscientist,2013,19(4):409-421.
[9]陈锋,施杞,韦贵康,等.脊髓型颈椎病脊髓微循环改变及中药效应观察[J].中医正骨,2004,16(10):3-4.
[10]葛鸿庆,林定坤,邓晋丰,等.补肾活血方对脊髓型颈椎病动物模型VEGF及其mRNA达的影响[J].新中医,2009,41(2):107-108.
[11]闫素敏.活血软坚方对兔颈脊髓慢性受压纤维化微血管血供的影响[D].西宁:广西中医药大学,2014.
[12]Yu WR,Liu T,Kiehl TR,Fehlings MG(2011)Human neuropathological and animal model evidence supporting a role for Fas-mediated apoptosis and inflammation in cervical spondylotic myelopathy[J].Brain 134:1277-1292.
[13]Baptiste DC,Fehlings MG.Pathophysiology of cervical myelopathy[J].Spine J,2006,6(6 Suppl):190S-197S.
[14]Karadimas SK,Moon ES,Yu WR,et al.A novel experimental model of cervical spondylotic myelopathy(CSM)to facilitate translational research[J].Neurobiol Dis,2013,5(4):43-58.
[15]周军,方素萍,霍海如,等.葛根汤对大鼠退变颈椎间盘组织前列腺素E2及环氧合酶的影响[J].中国骨伤,2002,12:26-28.
[16]林石明,许书亮,李兆文,等.颈痛宁对颈椎间盘髓核炎症介质影响的实验研究[J].中医药学刊,2004,37(11):2043-2046,2054.
[17]刘新宇,刘春娜,张晓妍,等.参黄颈康片镇痛抗炎作用及对炎症因子影响研究[J].中成药,2011,33(7):1223-1225.
[18]张向阳,马玉玲,杨际平.颈椎病、腰椎间盘突出症与自由基损伤的探讨[J].颈腰痛杂志,1995,(4):202-203.
[19]都兴林,田伟,孔焕宇.丹参舒颈丸对抗脊髓型颈椎病模型大鼠氧自由基损伤[J].中国临床康复,2006,10(27):32-34.
[20]施立奇.丹参酮对兔上颈髓早期继发性损伤细胞凋亡的干预研究[D].武汉:湖北中医药大学,2014.
[21]王辉,吕志宇,陈锋.中医药治疗脊髓型颈椎病疗效机理研究概况[J].山西中医学院学报,2008,9(3):58-60.
[22]王羽丰.补肾活血方治疗脊髓型颈椎病疗效及与内皮素关系的研究[D].广州:广州中医药大学,2002.
[23]黄有荣,赵明明,张春松.芍药木瓜汤对脊髓受压实验兔血管内皮素与脊髓神经细胞凋亡的影响[J].中国中医骨伤科杂志,2010,18(4):1-4.
[24]Moussellard Hp,Meyer A,Biot D,et al.Early neurological recovery course after surgical treatment of cervical spondylotic myelopathy:a prospective study with 2-year follow-up using three different functional assessment tests[J].Eur Spine J,2014,23(7):1508-1514.
[25]徐远坤,陈久毅.中药健身丹对脊髓型颈椎病神经细胞凋亡相关基因表达影响的研究[J].贵州医药,2009,33(6):490.
[26]Buf fum M,Buf fum JC.No steroidal anti-infammatory drugs in the elderly[J].Pain Manag Nurs,2000,1(2):40.
[27]Ikeda O,Mu rakami M,Ino H,et al.Acute up-regulation of brainderived neurot rophic factor expression resultion f rom experiment ally indrced injury in the rat spinal cord[J].Acct a Neu ropathol2001,102(3):239.
[28]姬军风,朱艳,张智慧,等.醒髓汤对大鼠实验性脊髓损伤受损组织中NGF的影响[J].中医正骨,2006,18(5):11-12.
[29]周赟,胡建中,吕红斌,等.川芎嗪对脊髓急性损伤大鼠神经营养因子表达的影响[J].现代中西医结合杂志,2010,19(9):1058-1060.