脑缺血再灌注损伤发病机制的研究进展
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摘要
脑卒中因其居高不下的致死率及致残率给家庭和社会造成了严重负担,已威胁到人类生命安全。在众多脑卒中的发病机制中,脑缺血再灌注损伤在其中起着至关重要的作用。而对脑缺血再灌注损伤发病机制研究,可为以后临床治疗脑卒中打下坚实的基础。本文就脑缺血再灌注损伤发病机制的研究进展做一综述。
Stroke, because of its high mortality and disability rate, has caused a serious burden on families and society, and has threatened human life safety. Cerebral ischemia-reperfusion injury plays an important role in the pathogenesis of many stroke. The study on the pathogenesis of cerebral ischemia-reperfusion injury can lay a solid foundation for the future clinical treatment of stroke. This article reviews the progress in the pathogenesis of cerebral ischemia-reperfusion injury.
Stroke, because of its high mortality and disability rate, has caused a serious burden on families and society, and has threatened human life safety. Cerebral ischemia-reperfusion injury plays an important role in the pathogenesis of many stroke. The study on the pathogenesis of cerebral ischemia-reperfusion injury can lay a solid foundation for the future clinical treatment of stroke. This article reviews the progress in the pathogenesis of cerebral ischemia-reperfusion injury.
引文
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[12]Lifa Huang,Chengwei Chen,Xin Zhang,et al.Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation[J].Journal of Molecular Neuroscience,2018,64(1):129-139.
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[17]Kun Liang,Yu Ye,Yong Wang,et al.Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway[J].Journal of the Neurological Sciences,2014,344:100-104.
[18]刘自然,霍东升,贾建新,等.5-(4-羟基-3-甲氧基苯亚甲基)罗丹宁对大鼠脑缺血再灌注损伤的保护作用及机制研究[J].中国比较医学杂志,2019,29(2):37-42.
[19]Huang J,Upadhyay UM,Tamargo RJ.Inflammation in stroke and focal cerebral ischemia[J].Surg Neurol,2006,66:232-245.
[20]詹舒仪,黄露露,龙思齐,等.丹参乙酸镁通过抑制TGF-β途径减轻脑缺血/再灌注损伤的保护作用及机制[J].转化医学杂志,2019,8(1):6-10.
[21]Wenbo Wang,Lejian Tang,Yong Li,et al.Biochanin A protects against focal cerebral ischemia/reperfusion in rats via inhibition of p38-mediated inflammatory responses[J].Journal of the Neurological Sciences,2015,348:121-125
[22]张小琴,侯丽颖,强国芳,等.片仔癀对局灶性脑缺血/再灌注大鼠皮质中NMDAR1和GluR2表达的影响[J].中国药理学通报,2019,35(2):288-292.
[23]张宏兵,孙小祥,罗秀琴,等.丁苯酚对缺氧缺糖条件下大鼠微血管内皮细胞保护作用的分子机制的研究[J].解放军医药杂志,2019,31(1):1-5.
[2]Paniker NV,Srivastava SK,Beutler E.Glutathuone metabolism of the cells:Effect of glutathione reductase deficiency on the stimu-lation of hexose monophosphate shunt under oxidative stress[J].Biochim Biophys Acta,1970,215(3):456-460.
[3]BABIOR B M,TAKEUCHI C,RUEDI J,et al.Investigating anti-bodycatalyzed ozone generation by human neutrophils[J].Proc Nata,1970,215(3):456-460.
[4]REITER RJ.Oxidative processes and antioxdative defense mecha-nisms in the aging brain[J].FASEB J,1995,9(7):526.
[5]Frantseva MV,Carlen PL,Perez-Velazquez JL.Dynamics of in-tracellular calcium and free radical production during ischemia in pyramidal neurons[J].Free Radic Biol Med,2001,31(10):1216-1227.
[6]Yrjanheikki J,Koistinaha J,Copin JC,et al.Spreading depres-sion-induced expression of c-fos and and cyclooxygenease-2in transgenic mice that overexpression human copper/zinc-super-oxide dismutase[J].J Neurotrauma,2002,17:713-718.
[7]Kezhong Zhang,PhD;and Randal J.Kaufman,PhD.The unfolded protein response:A stress signaling pathway critical for health and disease[J].Neurology,2005,66:S102-109.
[8]屈生彪.鹰嘴豆素A对大鼠脑缺血再灌注损伤的保护机制初步研究[D].广西桂林医学院2018.
[9]Fulda S.Autophagy and cell death[J].Autophagy 2012;8:1250-1251.
[10]Peng C,Rao W,Zhang,et al.Mitofusin 2 exerts a protec-tive role in ischemia reperfusion injury through increasing au-tophagy[J].Cell Physiol Biochem,2018,46:2311-2324.
[11]Yong Wang,Qianyao Ren,Xing Zhang,et al.Neuroprotective Mechanisms of Calycosin Against Focal Cerebral Ischemia and Reperfusion Injury in Rats[J].Cell Physiol Biochem,2018;45:537-546.
[12]Lifa Huang,Chengwei Chen,Xin Zhang,et al.Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation[J].Journal of Molecular Neuroscience,2018,64(1):129-139.
[13]董雅洁,高维娟.Bcl-2、Bax、Caspase-3在细胞凋亡中的作用及其关系[J].中国老年学杂,2012,32(21):4828-4830.
[14]Caog,Minami M,Pei W,et al.Intracellular Bax Translocation After Transient Cerebral Ischemia:Implications for a Role of the Mitochondria Apoptotic Signaling Pathway in Ischemic Neuronal Death[J].J Cereb Blood FlowMetab,2001,21(4):321-333.
[15]D egterev A,Lugovskoy A,Cardone M,et al.Identification of smallmolecule inhibitors of interaction between the BH3 domainand Bcl-xL[J].Nat Cell Biol,2001,3(2):173-182.
[16]Yuan CQ,Ding ZH.Structure and function of caspases[J].Guowai Yixue Fenzi Shengwuxue Fence,2002,24:146-151.
[17]Kun Liang,Yu Ye,Yong Wang,et al.Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway[J].Journal of the Neurological Sciences,2014,344:100-104.
[18]刘自然,霍东升,贾建新,等.5-(4-羟基-3-甲氧基苯亚甲基)罗丹宁对大鼠脑缺血再灌注损伤的保护作用及机制研究[J].中国比较医学杂志,2019,29(2):37-42.
[19]Huang J,Upadhyay UM,Tamargo RJ.Inflammation in stroke and focal cerebral ischemia[J].Surg Neurol,2006,66:232-245.
[20]詹舒仪,黄露露,龙思齐,等.丹参乙酸镁通过抑制TGF-β途径减轻脑缺血/再灌注损伤的保护作用及机制[J].转化医学杂志,2019,8(1):6-10.
[21]Wenbo Wang,Lejian Tang,Yong Li,et al.Biochanin A protects against focal cerebral ischemia/reperfusion in rats via inhibition of p38-mediated inflammatory responses[J].Journal of the Neurological Sciences,2015,348:121-125
[22]张小琴,侯丽颖,强国芳,等.片仔癀对局灶性脑缺血/再灌注大鼠皮质中NMDAR1和GluR2表达的影响[J].中国药理学通报,2019,35(2):288-292.
[23]张宏兵,孙小祥,罗秀琴,等.丁苯酚对缺氧缺糖条件下大鼠微血管内皮细胞保护作用的分子机制的研究[J].解放军医药杂志,2019,31(1):1-5.