益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效及安全性分析
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摘要
目的观察和探讨益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效和安全性。方法选取2017年1～12月在我院进行剖宫产的84例产妇作为研究对象,采用随机数字表法将其分为两组,每组各42例。观察组产妇采用益母草注射液联合缩宫素预防产后出血,对照组产妇给予宫缩素预防产后出血。观察比较两组产妇的临床疗效及安全性。结果两组产妇的术前出血量比较,差异无统计学意义(P>0.05)。观察组产妇术中、术后2 h和术后24 h的出血量均显著少于对照组,差异有统计学意义(P<0.05)。观察组产妇术中、术后2 h和术后24 h的出血量均显著多于术前,差异有统计学意义(P<0.05);对照组产妇术中、术后2 h和术后24 h的出血量均显著多于术前,差异有统计学意义(P<0.05)。观察组产妇的宫缩持续时间和恶露持续时间均显著短于对照组,差异有统计学意义(P<0.05)。观察组产妇的宫底下降速度低于对照组,差异有统计学意义(P<0.05)。两组产妇的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效确切,效果显著,安全性高,值得临床推广应用。
Objective To observe and explore the clinical efficacy and safety of Leonurus Heterophyllus Injection combined with Oxytocin in the prevention of postpartum hemorrhage during cesarean section. Methods A total of 84 cases of cesarean section who were treated in our hospital from January to December 2017 were selected as the research subjects, they were randomly divided into two groups by number table method, 42 cases in each group. The observation group was treated with Leonurus Heterophyllus Injection combined with Oxytocin to prevent postpartum hemorrhage.The control group was treated with Oxytocin to prevent postpartum hemorrhage. The clinical efficacy and safety of the two groups were observed and compared. Results There was no significant difference in the amount of bleeding before operation between the two groups(P>0.05). The amount of bleeding during the operation, 2 h after the operation and 24 h after the operation in the observation group were significantly fewer than those of the control group, the differences were statistically significant(P<0.05). In the observation group, the amount of bleeding during the operation, 2 h after the operation and 24 h after the operation were significantly higher than before operation, the differences were statistically significant(P<0.05). The amount of bleeding during the operation, 2 h after the operation and 24 h after the operation in the control group were significantly higher than before operation, the differences were statistically significant(P <0.05). The duration of uterine contraction and the duration of lochia in the observation group were significantly shorter than those in the control group, the differences were statistically significant(P<0.05). The descent rate of fundus was lower than that in the control group, the difference was statistically significant(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Leonurus Heterophyllus Injection combined with Oxytocin for the prevention of postpartum hemorrhage during cesarean section, the clinical effect is definite, the effect is significant and the safety is high. It is worthy of clinical application.
Objective To observe and explore the clinical efficacy and safety of Leonurus Heterophyllus Injection combined with Oxytocin in the prevention of postpartum hemorrhage during cesarean section. Methods A total of 84 cases of cesarean section who were treated in our hospital from January to December 2017 were selected as the research subjects, they were randomly divided into two groups by number table method, 42 cases in each group. The observation group was treated with Leonurus Heterophyllus Injection combined with Oxytocin to prevent postpartum hemorrhage.The control group was treated with Oxytocin to prevent postpartum hemorrhage. The clinical efficacy and safety of the two groups were observed and compared. Results There was no significant difference in the amount of bleeding before operation between the two groups(P>0.05). The amount of bleeding during the operation, 2 h after the operation and 24 h after the operation in the observation group were significantly fewer than those of the control group, the differences were statistically significant(P<0.05). In the observation group, the amount of bleeding during the operation, 2 h after the operation and 24 h after the operation were significantly higher than before operation, the differences were statistically significant(P<0.05). The amount of bleeding during the operation, 2 h after the operation and 24 h after the operation in the control group were significantly higher than before operation, the differences were statistically significant(P <0.05). The duration of uterine contraction and the duration of lochia in the observation group were significantly shorter than those in the control group, the differences were statistically significant(P<0.05). The descent rate of fundus was lower than that in the control group, the difference was statistically significant(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion Leonurus Heterophyllus Injection combined with Oxytocin for the prevention of postpartum hemorrhage during cesarean section, the clinical effect is definite, the effect is significant and the safety is high. It is worthy of clinical application.
引文
[1]李玉梅,谭白菊.益母草注射液联合卡前列素氨丁三醇用于预防剖宫产产后出血的临床观察[J].中国药房,2017,28(9):1197-1200.
[2]张方芳,徐永莲,刘兴会,等.产后出血原因及相关危险因素135例临床分析[J].实用妇产科杂志,2014,30(2):144-146.
[3]黄丽娟.剖宫产术中益母草注射液联合缩宫素预防产后出血的临床观察[J].河北医学,2015,6(4):647-649.
[4]杜舞英.益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效及安全性分析[J].中国计划生育学杂志,2015,23(5):321-323,327.
[5]Charoenkwan K.Use of the Bakri postpartum balloon in a patient with intractable pelvic floor hemorrhage:when other methods failed to stop postcesarean bleeding,physicians tried something new[J].Am J Obstet Gynecol,2013,209(3):277,E1-5.
[6]陈茜.卡前列素氨丁三醇防治宫缩乏力性产后出血的临床观察[J].临床合理用药杂志,2013,16(6):42-43.
[7]韩文莹,柳伟伟,孙屹梅,等.益母草注射液联合缩宫素和米索前列醇治疗宫缩乏力性产后出血的疗效观察[J].现代药物与临床,2015,30(12):1515-1518.
[8]李善凤.益母草注射液联合卡前列素氨丁三醇预防剖宫产产后出血疗效观察[J].现代中西医结合杂志,2015,24(17):1884-1886.
[9]刘艳丽.益母草注射液联合缩宫素预防剖宫产产后出血[J].长春中医药大学学报,2016,32(3):578-580.
[10]刘胜华.益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效及安全性探析[J].北方药学,2015,12(10):116-117.
[11]纵艳艳,胡赛玲.产后出血221例临床分析[J].中国妇幼健康研究,2014,25(1):86-87.
[12]曾林森,俞晓莲,俞婷婷,等.益母草注射液联合缩宫素预防自然分娩产妇产后出血的分析[J].解放军医学杂志,2015,40(10):826-832.
[13]赵小梅,彭成.谢晓芳.益母草防治产后出血的临床与药理研究进展[J].中药与临床.2014,5(4):41-45.
[14]张琴,曹珊珊.缩宫素联合益母草注射液对经阴道分娩和剖宫产产后出血的治疗效果[J].中国妇幼保健,2017,32(3):446-448.
[15]朱红娣,蒋松.卡前列素氨丁三醇在双胎妊娠及前置胎盘剖宫产术中的应用[J].中国妇幼卫生杂志,2013,2(1):64,67.
[2]张方芳,徐永莲,刘兴会,等.产后出血原因及相关危险因素135例临床分析[J].实用妇产科杂志,2014,30(2):144-146.
[3]黄丽娟.剖宫产术中益母草注射液联合缩宫素预防产后出血的临床观察[J].河北医学,2015,6(4):647-649.
[4]杜舞英.益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效及安全性分析[J].中国计划生育学杂志,2015,23(5):321-323,327.
[5]Charoenkwan K.Use of the Bakri postpartum balloon in a patient with intractable pelvic floor hemorrhage:when other methods failed to stop postcesarean bleeding,physicians tried something new[J].Am J Obstet Gynecol,2013,209(3):277,E1-5.
[6]陈茜.卡前列素氨丁三醇防治宫缩乏力性产后出血的临床观察[J].临床合理用药杂志,2013,16(6):42-43.
[7]韩文莹,柳伟伟,孙屹梅,等.益母草注射液联合缩宫素和米索前列醇治疗宫缩乏力性产后出血的疗效观察[J].现代药物与临床,2015,30(12):1515-1518.
[8]李善凤.益母草注射液联合卡前列素氨丁三醇预防剖宫产产后出血疗效观察[J].现代中西医结合杂志,2015,24(17):1884-1886.
[9]刘艳丽.益母草注射液联合缩宫素预防剖宫产产后出血[J].长春中医药大学学报,2016,32(3):578-580.
[10]刘胜华.益母草注射液联合缩宫素预防剖宫产产后出血的临床疗效及安全性探析[J].北方药学,2015,12(10):116-117.
[11]纵艳艳,胡赛玲.产后出血221例临床分析[J].中国妇幼健康研究,2014,25(1):86-87.
[12]曾林森,俞晓莲,俞婷婷,等.益母草注射液联合缩宫素预防自然分娩产妇产后出血的分析[J].解放军医学杂志,2015,40(10):826-832.
[13]赵小梅,彭成.谢晓芳.益母草防治产后出血的临床与药理研究进展[J].中药与临床.2014,5(4):41-45.
[14]张琴,曹珊珊.缩宫素联合益母草注射液对经阴道分娩和剖宫产产后出血的治疗效果[J].中国妇幼保健,2017,32(3):446-448.
[15]朱红娣,蒋松.卡前列素氨丁三醇在双胎妊娠及前置胎盘剖宫产术中的应用[J].中国妇幼卫生杂志,2013,2(1):64,67.