A型肉毒毒素咬肌注射重塑面下部1/3轮廓的有效性及安全性分析
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摘要
目的探讨A型肉毒毒素咬肌注射重塑面下部1/3轮廓的临床应用效果及安全性。方法选取本院整形外科于2016年6月至2017年10月期间收治的56例面下部1/3轮廓重塑患者作为研究对象,对所有患者给予A型肉毒毒素(50单位)咬肌注射并辅以玻尿酸颏部填充治疗。观察患者治疗及随访期间的不良反应情况及临床有效性。结果本次56例面部重塑患者均顺利完成手术治疗,治疗过程及随访期间均未出现血管损伤、神经损伤以及瘢痕遗留等任何不良反应。随访6个月后,51例取得显著疗效,4例有效,1例为无效(面部皮肤松弛),总有效为55例,总有效率为98.21%(55/56)。结论 A型肉毒毒素咬肌注射对面下部1/3轮廓的重塑效果好,有效率高,术后并发症少,安全性高,在面下部轮廓塑形中具有重要的应用价值。
Objective To investigate the clinical efficacy and safety of botulinum toxin type A injection of masseter square-shape contour 1/3.Methods 56 patients with 1/3 profile remodeling in the lower surface of the lower face were selected from the plastic surgery of our hospital in June2016 to 2017 October. All patients were given A botulinum toxin(50 unit) masseter muscle and supplemented with hyaluronic chin filling. The ad-verse reactions and clinical efficacy of patients during treatment and follow-up period were observed. Results All the 56 cases of facial remodelingwere treated successfully. No adverse reactions such as vascular injury, nerve injury and scar left over during the treatment and follow-up period werenot found. After 6 months follow-up, 51 cases achieved significant curative effect, 4 cases were effective, 1 cases were ineffective(facial skin laxity),the total effective rate was 55 cases, the total effective rate was 98.21%. Conclusion The masseter muscle injection of botulinum toxin A has goodremolding effect, high efficiency, less postoperative complications and high safety. It has important application value in the contour of the lower surface of 1/3.
Objective To investigate the clinical efficacy and safety of botulinum toxin type A injection of masseter square-shape contour 1/3.Methods 56 patients with 1/3 profile remodeling in the lower surface of the lower face were selected from the plastic surgery of our hospital in June2016 to 2017 October. All patients were given A botulinum toxin(50 unit) masseter muscle and supplemented with hyaluronic chin filling. The ad-verse reactions and clinical efficacy of patients during treatment and follow-up period were observed. Results All the 56 cases of facial remodelingwere treated successfully. No adverse reactions such as vascular injury, nerve injury and scar left over during the treatment and follow-up period werenot found. After 6 months follow-up, 51 cases achieved significant curative effect, 4 cases were effective, 1 cases were ineffective(facial skin laxity),the total effective rate was 55 cases, the total effective rate was 98.21%. Conclusion The masseter muscle injection of botulinum toxin A has goodremolding effect, high efficiency, less postoperative complications and high safety. It has important application value in the contour of the lower surface of 1/3.
引文
[1]李中峰.磨截联合法下颌角成形术临床应用价值分析[J].河南医学研究,2016,25(4):714-714.
[2]郭彩春,小刀.注射微整形技术在颌面部软组织美容修复中的应用[J].中国医疗美容,2016,6(6):24-26.
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[5]宋海金.A型肉毒素咬肌注射联合玻尿酸颏部注射填充微整形术重塑面下部1/3轮廓的临床手术效果观察[J].药品评价,2016,13(15):52-54.
[6]陈小平,金柱翰,吴国平,等.面部轮廓整形后嗅觉障碍的治疗[J].中华医学美学美容杂志,2016,22(1):38-41.
[7] Zhang J, Xu BN, Hou YZ, et al. Facial and CochlearNerve Complications following Microsurgical Resec-tion of Vestibular Schwannomas in a Series of 221Cases[J]. Medical Science Monitor International Med-ical Journal of Experimental&Clinical Research,2015,21(3-4):1674-1678.
[8]王虹,袁华,牟翔,等.A型肉毒毒素联合重复经颅磁刺激对脑卒中后下肢痉挛状态的疗效观察[J].中国康复医学杂志,2016,31(9):936-940.
[9] Park SY, Park YW, Ji YJ, et al. Effects of a botuli-num toxin type A injection on the masseter muscle:An animal model study[J]. Maxillofacial Plastic&Reconstructive Surgery, 2015,37(1):10.
[10]童慧,蔡卓莺.A型肉毒杆菌毒素对良性咬肌肥大的治疗应用[J].浙江创伤外科,2014,19(4):598-600.
[11]刘中林.玻尿酸颏部填充+A型肉毒素注射(咬肌、颏肌劲阔肌)在重塑下面部轮廓应用中的临床分析[J].中国医疗美容,2016,6(5):5-7.
[12]王川颖.玻尿酸注射美容填充50例临床体会分析[J].中国继续医学教育,2016,8(26):152-153.
[13]蒋娜.颈面部术后瘢痕的玻尿酸预防效果研究[J].中国现代药物应用,2016,10(18):84-85.
[2]郭彩春,小刀.注射微整形技术在颌面部软组织美容修复中的应用[J].中国医疗美容,2016,6(6):24-26.
[3]中华医学会整形外科学分会微创美容专业学组A型肉毒毒素在整形外科中的临床应用指南[J].中国美容整形外科杂志,2016,27(7):385-387.
[4]张雪,兰东,宁淑华,等.A型肉毒毒素对增生性瘢痕成纤维细胞的抑制作用及机制[J].重庆医学,2017,46(5):580-582.
[5]宋海金.A型肉毒素咬肌注射联合玻尿酸颏部注射填充微整形术重塑面下部1/3轮廓的临床手术效果观察[J].药品评价,2016,13(15):52-54.
[6]陈小平,金柱翰,吴国平,等.面部轮廓整形后嗅觉障碍的治疗[J].中华医学美学美容杂志,2016,22(1):38-41.
[7] Zhang J, Xu BN, Hou YZ, et al. Facial and CochlearNerve Complications following Microsurgical Resec-tion of Vestibular Schwannomas in a Series of 221Cases[J]. Medical Science Monitor International Med-ical Journal of Experimental&Clinical Research,2015,21(3-4):1674-1678.
[8]王虹,袁华,牟翔,等.A型肉毒毒素联合重复经颅磁刺激对脑卒中后下肢痉挛状态的疗效观察[J].中国康复医学杂志,2016,31(9):936-940.
[9] Park SY, Park YW, Ji YJ, et al. Effects of a botuli-num toxin type A injection on the masseter muscle:An animal model study[J]. Maxillofacial Plastic&Reconstructive Surgery, 2015,37(1):10.
[10]童慧,蔡卓莺.A型肉毒杆菌毒素对良性咬肌肥大的治疗应用[J].浙江创伤外科,2014,19(4):598-600.
[11]刘中林.玻尿酸颏部填充+A型肉毒素注射(咬肌、颏肌劲阔肌)在重塑下面部轮廓应用中的临床分析[J].中国医疗美容,2016,6(5):5-7.
[12]王川颖.玻尿酸注射美容填充50例临床体会分析[J].中国继续医学教育,2016,8(26):152-153.
[13]蒋娜.颈面部术后瘢痕的玻尿酸预防效果研究[J].中国现代药物应用,2016,10(18):84-85.