瘤胃发育过程中微生物菌群和microRNA的调控作用
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摘要
传统的藏羔羊生产方式因营养因素造成羔羊胃肠道发育迟缓、断奶过渡期长,影响了羔羊生产潜力发挥及断奶后的育肥。成年动物瘤胃已建立了十分成熟稳定的微生物生态系统,其瘤胃宿主与微生物菌群之间存在很强的特异性,外源性干预一旦停止,瘤胃微生物菌群结构和发酵谱又恢复到初始状态或干预前的状态。然而,新生或出生早期反刍动物瘤胃的发育为改变或干预瘤胃微生物生态系统提供了唯一的机会。因此,羔羊瘤胃的发育规律及瘤胃与瘤胃微生物和相关基因之间的关系成为当前反刍动物研究的热点。
Due to the lack of forage and nutrition supply,the traditional Tibetan lamb production mode caused the slow development of lamb gastrointestinal tract and long weaning transition period,which seriously affected the productivity of lambs and their fattening after weaning.Adult animal rumen has established a mature and stable microbial ecosystem,which has a strong specificity between the host and the rumen microflora.So once the exogenous intervention is stopped,rumen microflora structure and fermentation of spectrum would restore to the initial state or state before the intervention.However,the rumen development of newly born ruminants or ruminants at early stage provides the sole opportunity to change or interfere with the rumen microbial ecosystem.Therefore,the relationship among lamb's rumen development and rumen microbes and related genes has become a hot topic of current research in ruminants.
Due to the lack of forage and nutrition supply,the traditional Tibetan lamb production mode caused the slow development of lamb gastrointestinal tract and long weaning transition period,which seriously affected the productivity of lambs and their fattening after weaning.Adult animal rumen has established a mature and stable microbial ecosystem,which has a strong specificity between the host and the rumen microflora.So once the exogenous intervention is stopped,rumen microflora structure and fermentation of spectrum would restore to the initial state or state before the intervention.However,the rumen development of newly born ruminants or ruminants at early stage provides the sole opportunity to change or interfere with the rumen microbial ecosystem.Therefore,the relationship among lamb's rumen development and rumen microbes and related genes has become a hot topic of current research in ruminants.
引文
[1]杨思维.河西走廊草原畜牧业主要生产模式优化研究[D].兰州:甘肃农业大学,2010.
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[14]ROEHE R,DEWHURST R J,DUTHIE C A,et al.Bovine host genetic variation influences rumen microbial methane production with best selection criterion for low methane emitting and efficiently feed converting hosts based on metagenomic gene abundance[J].Plos Genetics,2016,12(2):e1005846.
[15]周亚文,张玉杰,林波,等.瘤胃甲烷生成过程中微生物之间的相互关系[J].动物营养学报,2011,23(4):556-562.
[16]ZHANG Z,XU D,WANG L,et al.Convergent evolution of rumen microbiomes in high-altitude mammals[J].Current Biology,2016,26(14):1 873-1 879.
[17]MCCANN J C,LUAN S,CARDOSO F C,et al.Induction of subacute ruminal acidosis affects the ruminal microbiome and epithelium[J].Frontiers in Microbiology,2016,7(169):701.
[18]OTT S J,MUSFELDT M,WENDEROTH D F,et al.Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease[J].Gut,2004,53:685-693.
[19]FLIER L G V D,CLEVERS H.Stem cells,self-Renewal,and differentiation in the intestinal epithelium[J].Annual Review of Physiology,2009,71(71):241-260.
[20]JAMI E,WHITE B A,MIZRAHI I.Potential role of the bovine rumen microbiome in modulating milk composition and feed efficiency[J].Plos One,2014,9(1):e85423.
[21]YEZ-RUIZ D R,LETICIA A,NEWBOLD C J.Manipulating rumen microbiome and fermentation through interventions during early life:a review[J].Frontiers in Microbiology,2015,6:1 133.
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[23]ABECIA L,MARTN-GARCA A I,MARTNEZ G,et al.Nutritional intervention in early life to manipulate rumen microbial colonization and methane output by kid goats postweaning[J].Journal of Animal Science,2013,91(10):4 832-4 840.
[24]MORGAVI D P,RATHAHAOPARIS E,POPOVA M,et al.Rumen microbial communities influence metabolic phenotypes in lambs[J].Frontiers in Microbiology,2015,6(1060):1 060.
[25]BARBIERI D E,HEGARTY I,SILVEIRA R S,et al.Programming rumen bacterial communities in newborn Merino lambs[J].Small Ruminant Research,2015,129:48-59.
[26]SHIVDASANI R A.MicroRNAs:regulators of gene expression and cell differentiation[J].Blood,2006,108:3 646-3 653.
[27]GOMASE V S,PARUNDEKAR A N.microRNA:human disease and development[J].Int J Bioinform Res Appl,2009,5:479-500.
[28]O'CONNELL R M,RAO D S,CHAUDHURI A A,et al.Physiological and pathological roles for microRNAs in the immune system[J].Nat Rev Immunol,2010,10:111-122.
[29]DALMASSO G,NGUYEN H T T,YAN Y,et al.Microbiota modulate host gene expression via microRNAs[J].PLoS One,2011,6(4):e19293.
[30]ZHOU R,GONG A Y,EISCHEID A N,et al.miR-27btargets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection[J].PLOS Pathog,2012,8:e1002702.
[31]XUE X,FENG T,YAO S,et alMicrobiota downregulates dendritic cell expression of miR-10a,which targets IL-12/IL-23p40[J].J Immunol,2011,187:5 879-5 886.
[32]SINGH N,SHIRDEL E A,WALDRON L,et al.The murine caecal microRNA signature depends on the presence of the endogenous microbiota[J].Int J Biol Sci,2012,8:171-186.
[33]GIAHI L,AUMUELLER E,ELMADFA I,et al.Regulation of TLR4,p38MAPkinase,IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells[J].Beneficial microbes,2012,3(2):91-98.
[34]WANG D,XIA M,YAN X,et al.Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10bnovelty and significance[J].Circulation research,2012,111(8):967-981.
[35]BITON M,LEVIN A,SLYPER M,et al.Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk[J].Nature Immunology,2011,12(3):239.
[36]LIANG G,MALMUTHUGE N,MCFADDEN T B,et al.Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life[J].PloS one,2014,9(3):e92592.
[37]WANG D,LIANG G,WANG B,et al.Systematic microRNAome profiling reveals the roles of microRNAs in milk protein metabolism and quality:insights on low-quality forage utilization[J].Sci Rep,2016,6(7):21 194.
[2]张鹏坤.代乳品营养水平对高寒牧区羔羊生长及早期断奶对母羊体况的影响[D].兰州:甘肃农业大学,2010.
[3]VI R L B,MCLEOD K R,KLOTZ J L,et al.Rumen evelopment,intestinal growth and hepatic metabolism in the pre-and postweaning ruminant[J].Journal of Dairy Science,2004,87(1):55-65.
[4]WANG Y H,XU M,WANG F N,et al.Effect of dietary starch on rumen and small intestine morphology and digesta pH in goats[J].Livestock Science,2010,122(1):48-52.
[5]REY M,ENJALBERT F,MONTEILS V.Establishment of ruminal enzyme activities and fermentation capacity in dairy calves from birth through weaning[J].Journal of dairy science,2012,95(3):1 500-1 512.
[6]FOUTS D E,SZPAKOWSKI S,PURUSHE J,et al.Next generation sequencing to define prokaryotic and fungal diversity in the bovine rumen[J].Plos One,2012,7(11):e48289.
[7]LANE M A,BALDWIN R T,JESSE B W.Developmental changes in ketogenic enzyme gene expression during sheep rumen development[J].Journal of animal science,2002,80(6):1 538-1 544.
[8]CHO S J,KIMH YUNHD,CHO K M,et al.16SrDNA analysis of bacterial diversity in three fractions of cow rumen[J].J Microbiol Biotechnol,2006,16:92-101.
[9]JIAO J,LI X,BEAUCHEMIN K A,et al.Rumen development process in goats as affected by supplemental feeding v.grazing:age-related anatomic development,functional achievement and microbial colonisation[J].British Journal of Nutrition,2015,113(6):888-900.
[10]NILUSHA M,GRIEBEL P J,LUO G L.The Gut Microbiome and Its Potential Role in the Development and Function of Newborn Calf Gastrointestinal Tract[J].Frontiers in Veterinary Science,2015,2(4814):459-460.
[11]LEY R E,HAMADY M,LOZUPONE C,et al.Evolution of mammals and their gut microbes[J].Science,2008,320:1 647-1 651.
[12]QIN J,LI R,RAES J,et al.A human gut microbial gene catalogue established by metagenomic sequencing[J].Nature,2010,464:59-65.
[13]CARBERRY C A,KENNY D A,KELLY A K,et al.Quantitative analysis of ruminal methanogenic microbial populations in beef cattle divergent in phenotypic residual feed intake(RFI)offered contrasting diets[J].Journal of Animal Science and Biotechnology,2014,5(4):41.
[14]ROEHE R,DEWHURST R J,DUTHIE C A,et al.Bovine host genetic variation influences rumen microbial methane production with best selection criterion for low methane emitting and efficiently feed converting hosts based on metagenomic gene abundance[J].Plos Genetics,2016,12(2):e1005846.
[15]周亚文,张玉杰,林波,等.瘤胃甲烷生成过程中微生物之间的相互关系[J].动物营养学报,2011,23(4):556-562.
[16]ZHANG Z,XU D,WANG L,et al.Convergent evolution of rumen microbiomes in high-altitude mammals[J].Current Biology,2016,26(14):1 873-1 879.
[17]MCCANN J C,LUAN S,CARDOSO F C,et al.Induction of subacute ruminal acidosis affects the ruminal microbiome and epithelium[J].Frontiers in Microbiology,2016,7(169):701.
[18]OTT S J,MUSFELDT M,WENDEROTH D F,et al.Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease[J].Gut,2004,53:685-693.
[19]FLIER L G V D,CLEVERS H.Stem cells,self-Renewal,and differentiation in the intestinal epithelium[J].Annual Review of Physiology,2009,71(71):241-260.
[20]JAMI E,WHITE B A,MIZRAHI I.Potential role of the bovine rumen microbiome in modulating milk composition and feed efficiency[J].Plos One,2014,9(1):e85423.
[21]YEZ-RUIZ D R,LETICIA A,NEWBOLD C J.Manipulating rumen microbiome and fermentation through interventions during early life:a review[J].Frontiers in Microbiology,2015,6:1 133.
[22]WEIMER P J,STEVENSON D M,MANTOVANI H C,et al.Host specificity of the ruminal bacterial community in the dairy cow following near-total exchange of ruminal contents[J].J Dairy Sci,2010,93:5 902-5 912.
[23]ABECIA L,MARTN-GARCA A I,MARTNEZ G,et al.Nutritional intervention in early life to manipulate rumen microbial colonization and methane output by kid goats postweaning[J].Journal of Animal Science,2013,91(10):4 832-4 840.
[24]MORGAVI D P,RATHAHAOPARIS E,POPOVA M,et al.Rumen microbial communities influence metabolic phenotypes in lambs[J].Frontiers in Microbiology,2015,6(1060):1 060.
[25]BARBIERI D E,HEGARTY I,SILVEIRA R S,et al.Programming rumen bacterial communities in newborn Merino lambs[J].Small Ruminant Research,2015,129:48-59.
[26]SHIVDASANI R A.MicroRNAs:regulators of gene expression and cell differentiation[J].Blood,2006,108:3 646-3 653.
[27]GOMASE V S,PARUNDEKAR A N.microRNA:human disease and development[J].Int J Bioinform Res Appl,2009,5:479-500.
[28]O'CONNELL R M,RAO D S,CHAUDHURI A A,et al.Physiological and pathological roles for microRNAs in the immune system[J].Nat Rev Immunol,2010,10:111-122.
[29]DALMASSO G,NGUYEN H T T,YAN Y,et al.Microbiota modulate host gene expression via microRNAs[J].PLoS One,2011,6(4):e19293.
[30]ZHOU R,GONG A Y,EISCHEID A N,et al.miR-27btargets KSRP to coordinate TLR4-mediated epithelial defense against Cryptosporidium parvum infection[J].PLOS Pathog,2012,8:e1002702.
[31]XUE X,FENG T,YAO S,et alMicrobiota downregulates dendritic cell expression of miR-10a,which targets IL-12/IL-23p40[J].J Immunol,2011,187:5 879-5 886.
[32]SINGH N,SHIRDEL E A,WALDRON L,et al.The murine caecal microRNA signature depends on the presence of the endogenous microbiota[J].Int J Biol Sci,2012,8:171-186.
[33]GIAHI L,AUMUELLER E,ELMADFA I,et al.Regulation of TLR4,p38MAPkinase,IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells[J].Beneficial microbes,2012,3(2):91-98.
[34]WANG D,XIA M,YAN X,et al.Gut microbiota metabolism of anthocyanin promotes reverse cholesterol transport in mice via repressing miRNA-10bnovelty and significance[J].Circulation research,2012,111(8):967-981.
[35]BITON M,LEVIN A,SLYPER M,et al.Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk[J].Nature Immunology,2011,12(3):239.
[36]LIANG G,MALMUTHUGE N,MCFADDEN T B,et al.Potential regulatory role of microRNAs in the development of bovine gastrointestinal tract during early life[J].PloS one,2014,9(3):e92592.
[37]WANG D,LIANG G,WANG B,et al.Systematic microRNAome profiling reveals the roles of microRNAs in milk protein metabolism and quality:insights on low-quality forage utilization[J].Sci Rep,2016,6(7):21 194.