注入电流式热声成像的声源重建
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摘要
为了实现对生物组织的内部深层信息的探测,本文提出了一种新型的无损医学成像方法,即注入电流式热声成像.注入电流式热声成像是一种以超声信号为传递媒介来反映生物组织电导率信息的医学成像方法.首先,本研究对注入电流式热声成像方法的原理进行了研究,将目标体内通入微秒级脉宽的高斯脉冲电流,目标体吸收焦耳热瞬时膨胀,向外发出超声信号,利用时间反演法对探测的超声信号进行处理,来重建目标体的声源分布,进而反映生物组织内部电导率信息;其次,以低电导率的椭圆模型和复杂模型为目标体,建立了仿真研究,借助有限元方法对注入电流式热声成像正、逆问题进行仿真,并重建模型的热声图像;最后,本文搭建了注入电流式热声成像实验装置,对凝胶仿体产生的声信号进行检测和采集,并重建目标体的声源分布.仿真和实验结果表明,重建的声源分布能展现目标体电导率的分布信息.本研究为注入电流式热声成像应用于生物组织的研究提供了较好的理论和实验基础.
In order to realize the detection of inner deep information of biological tissue, Applied Current Thermoacoustic Imaging(ACTAI) is introduced in this paper. ACTAI is a medical imaging method to reflect the conductivity information of biological tissue with ultrasonic signals as the transmitting medium. Firstly, in this paper, the principle of ACTAI is studied. When an s width Gauss pulse current is applied to an object, the object absorbs Joule heating and causes to send signals. The time reversal algorithm was used to process the detected signals and reconstruct the acoustic sources, which reflects the conductivity information of biological tissue. Secondly, low conductivity ellipsoidal and complex model were used as the simulation objects. And the finite element analysis was used to simulate the forward and inverse problem of ACTAI. The acoustic source of the models was reconstructed. At last, an experiment set on ACTAI was established to detect and collect the acoustic signals from the gel phantom. The acoustic sources distribution of the gel phantom was reconstructed. The simulation and experimental results revealed that ACTAI could effectively reconstruct acoustic source images and reflect the conductivity distribution of the model. In a word, the study can provide a better theoretical and experimental basis for ACTAI applied to biological tissue.
In order to realize the detection of inner deep information of biological tissue, Applied Current Thermoacoustic Imaging(ACTAI) is introduced in this paper. ACTAI is a medical imaging method to reflect the conductivity information of biological tissue with ultrasonic signals as the transmitting medium. Firstly, in this paper, the principle of ACTAI is studied. When an s width Gauss pulse current is applied to an object, the object absorbs Joule heating and causes to send signals. The time reversal algorithm was used to process the detected signals and reconstruct the acoustic sources, which reflects the conductivity information of biological tissue. Secondly, low conductivity ellipsoidal and complex model were used as the simulation objects. And the finite element analysis was used to simulate the forward and inverse problem of ACTAI. The acoustic source of the models was reconstructed. At last, an experiment set on ACTAI was established to detect and collect the acoustic signals from the gel phantom. The acoustic sources distribution of the gel phantom was reconstructed. The simulation and experimental results revealed that ACTAI could effectively reconstruct acoustic source images and reflect the conductivity distribution of the model. In a word, the study can provide a better theoretical and experimental basis for ACTAI applied to biological tissue.
引文
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2 Xu M H,Xu Y,Wang L V.Time-domain reconstruction algorithms and numerical simulations for thermoacoustic tomography in various geometries.IEEE Trans Biomed Eng,2003,50:1086-1099
3 Liu Z,Liu L,Xu Y,et al.Transcranial thermoacoustic tomography:A comparison of two imaging algorithms.IEEE Trans Med Imag,2013,32:289-294
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5毕欣,黄林,杜劲松,等.脉冲微波辐射场空间分布的热声成像研究.物理学报,2015,64:125-130
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11刘广东,张业荣.乳腺癌检测的三维微波热声成像技术.物理学报,2011,60:074303
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15 Feng X H,Gao F,Zheng Y J.Magnetically mediated thermoacoustic imaging toward deeper penetration.Appl Phys Lett,2013,103:083704
16 Feng X H,Gao F,Zheng Y J.Modulatable magnetically mediated thermoacoustic imaging with magnetic nanoparticles.Appl Phys Lett,2015,106:153702
17 Gabriel C,Gabriel S,Corthout E.The dielectric properties of biological tissues:I.Literature survey.Phys Med Biol,1996,41:2231-2249
18王侃,董秀珍,付峰,等.基于电阻抗扫描的乳腺组织阻抗频谱特性测量实验.生物物理学报,2008,24:474-480
19 Qiao G F,Wang W,Duan W,et al.Bioimpedance analysis for the characterization of breast cancer cells in suspension.IEEE Trans Biomed Eng,2012,59:2321-2329
20徐桂芝,杨硕,李颖,等.电阻抗断层成像技术综述.河北工业大学学报,2004,33:35-40
21杨琳,徐灿华,付峰,等.一种基于加权频差阻尼最小二乘的准静态EIT算法.仪器仪表学报,2013,34:1879-1885
22肖理庆,王化祥.基于聚类电阻层析成像静态图像重建算法.仪器仪表学报,2016,37:1258-1266
23刘国强.磁声成像技术.北京:科学出版社,2014.138-156
24陈晶,刘国强,夏慧.基于LabVIEW的感应式磁声成像系统的设计.电工电能新技术,2015,34:76-80
25王世刚,游敏娟,常亮,等.电流注入式磁声耦合成像技术仿真研究.中国医学物理学杂志,2016,33:72-75
26凤天宏.正交各向异性磁共振电阻抗成像问题的唯一性.吉林大学学报(理学版),2012,50:945-948
27李刚,陈瑞娟,郝丽玲,等.基于环形电极的开放式MREIT三维重建.仪器仪表学报,2012,33:2263-2268
28 Sajib S Z K,Kim J E,Jeong W C,et al.Reconstruction of apparent orthotropic conductivity tensor image using magnetic resonance electrical impedance tomography.J Appl Phys,2015,117:104701
29 IEEE.IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields,3 kHz to 300 GHz.IEEE Std C95.1,1999 Ed.New York:Institute of Electrical and Electronics Engineers,Inc.,1999.1-73
30 Xu Y,Feng D Z,Wang L V.Exact frequency-domain reconstruction for thermoacoustic tomography.I.Planar geometry.IEEE Trans Med Imag,2002,21:823-828
31计钟,娄存广,杨思华.三维微波热声成像系统及早期乳腺肿瘤检测研究.激光生物学报,2012,21:465-469
32黄欣.注入电流式磁声成像的基础研究.博士学位论文.北京:中国科学院大学,2013
33 Wang S,Ma R,Zhang S,et al.Translational-circular scanning for magneto-acoustic tomography with current injection.Biomed Eng Online,2016,15:10
2 Xu M H,Xu Y,Wang L V.Time-domain reconstruction algorithms and numerical simulations for thermoacoustic tomography in various geometries.IEEE Trans Biomed Eng,2003,50:1086-1099
3 Liu Z,Liu L,Xu Y,et al.Transcranial thermoacoustic tomography:A comparison of two imaging algorithms.IEEE Trans Med Imag,2013,32:289-294
4刘立新.面向医学应用的热声层析成像研究.硕士学位论文.成都:电子科技大学,2013
5毕欣,黄林,杜劲松,等.脉冲微波辐射场空间分布的热声成像研究.物理学报,2015,64:125-130
6 Gao F,Feng X H,Zheng Y J.Advanced photoacoustic and thermoacoustic sensing and imaging beyond pulsed absorption contrast.J Opt,2016,18:074006
7 Beard P.Biomedical photoacoustic imaging.Interf Focus,2011,1:602-631
8龚小竞,孟静,陈健桦,等.生物医学光声成像技术及其临床应用进展.集成技术,2013,2:53-59
9曾礼漳,杨思华,邢达.光声成像技术及其医学应用进展.华南师范大学学报(自然科学版).2016,48:9-15
10 Cao Y,Hui J,Kole A,et al.High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design.Sci Rep,2016,6:25236
11刘广东,张业荣.乳腺癌检测的三维微波热声成像技术.物理学报,2011,60:074303
12黄林.用于乳腺癌检测的微波热声成像技术研究.博士学位论文.成都:电子科技大学,2015
13 Song J,Zhao Z,Wang J,et al.Evaluation of contrast enhancement by carbon nanotubes for microwave-induced thermoacoustic tomography.IEEE Trans Biomed Eng,2015,62:930-938
14 Dewantari A,Jeon S Y,Kim S,et al.Analysis of microwave-induced thermoacoustic signal generation using computer simulation.J Electromagn Eng Sci,2016,16:1-6
15 Feng X H,Gao F,Zheng Y J.Magnetically mediated thermoacoustic imaging toward deeper penetration.Appl Phys Lett,2013,103:083704
16 Feng X H,Gao F,Zheng Y J.Modulatable magnetically mediated thermoacoustic imaging with magnetic nanoparticles.Appl Phys Lett,2015,106:153702
17 Gabriel C,Gabriel S,Corthout E.The dielectric properties of biological tissues:I.Literature survey.Phys Med Biol,1996,41:2231-2249
18王侃,董秀珍,付峰,等.基于电阻抗扫描的乳腺组织阻抗频谱特性测量实验.生物物理学报,2008,24:474-480
19 Qiao G F,Wang W,Duan W,et al.Bioimpedance analysis for the characterization of breast cancer cells in suspension.IEEE Trans Biomed Eng,2012,59:2321-2329
20徐桂芝,杨硕,李颖,等.电阻抗断层成像技术综述.河北工业大学学报,2004,33:35-40
21杨琳,徐灿华,付峰,等.一种基于加权频差阻尼最小二乘的准静态EIT算法.仪器仪表学报,2013,34:1879-1885
22肖理庆,王化祥.基于聚类电阻层析成像静态图像重建算法.仪器仪表学报,2016,37:1258-1266
23刘国强.磁声成像技术.北京:科学出版社,2014.138-156
24陈晶,刘国强,夏慧.基于LabVIEW的感应式磁声成像系统的设计.电工电能新技术,2015,34:76-80
25王世刚,游敏娟,常亮,等.电流注入式磁声耦合成像技术仿真研究.中国医学物理学杂志,2016,33:72-75
26凤天宏.正交各向异性磁共振电阻抗成像问题的唯一性.吉林大学学报(理学版),2012,50:945-948
27李刚,陈瑞娟,郝丽玲,等.基于环形电极的开放式MREIT三维重建.仪器仪表学报,2012,33:2263-2268
28 Sajib S Z K,Kim J E,Jeong W C,et al.Reconstruction of apparent orthotropic conductivity tensor image using magnetic resonance electrical impedance tomography.J Appl Phys,2015,117:104701
29 IEEE.IEEE standard for safety levels with respect to human exposure to radio frequency electromagnetic fields,3 kHz to 300 GHz.IEEE Std C95.1,1999 Ed.New York:Institute of Electrical and Electronics Engineers,Inc.,1999.1-73
30 Xu Y,Feng D Z,Wang L V.Exact frequency-domain reconstruction for thermoacoustic tomography.I.Planar geometry.IEEE Trans Med Imag,2002,21:823-828
31计钟,娄存广,杨思华.三维微波热声成像系统及早期乳腺肿瘤检测研究.激光生物学报,2012,21:465-469
32黄欣.注入电流式磁声成像的基础研究.博士学位论文.北京:中国科学院大学,2013
33 Wang S,Ma R,Zhang S,et al.Translational-circular scanning for magneto-acoustic tomography with current injection.Biomed Eng Online,2016,15:10